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1. 发明授权

US07473398B2 Biosensor 有权
公开(公告)号：US07473398B2
公开(公告)日：2009-01-06
申请号：US09866030
申请日：2001-05-25
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , John T. Austera , Wolfgang O. L. Reiser
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , John T. Austera , Wolfgang O. L. Reiser
IPC分类号： G01N30/00
CPC分类号： C12Q1/001 , G01N27/3272
摘要： The present invention relates to a biosensor. The biosensor includes a support substrate having first and second ends, electrodes positioned on the support substrate, the electrodes cooperating with one another to define electrode arrays situated adjacent to the first end, a spacer substrate positioned on the support substrate, and a cover positioned on the spacer substrate. The cover cooperates with the support substrate to define a channel. The channel includes an inlet adjacent to the first end and opposite ends. Each electrode array is positioned in the channel adjacent to one of the ends.

2. 发明授权

US06767440B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06767440B1
公开(公告)日：2004-07-27
申请号：US09840843
申请日：2001-04-24
申请人： Raghbir S. Bhullar , John T. Austera , Brian S. Hill , Christopher D. Wilsey
发明人： Raghbir S. Bhullar , John T. Austera , Brian S. Hill , Christopher D. Wilsey
IPC分类号： G01N27327
CPC分类号： G01N27/3272 , Y10T29/49002
摘要： A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support substrate, a sensor support substrate coupled to the electrode support substrate, and electrically conductive tracks positioned on the sensor support substrate. Each track is in electrical communication with one of the electrodes.
摘要翻译：根据本发明提供生物传感器。生物传感器包括电极支撑基板，位于电极支撑基板上的电极，耦合到电极支撑基板的传感器支撑基板和位于传感器支撑基板上的导电轨迹。每个轨道与一个电极电连通。

3. 发明授权

US07479211B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07479211B2
公开(公告)日：2009-01-20
申请号：US10845434
申请日：2004-05-13
申请人： Raghbir S. Bhullar , John T. Austera , Brian S. Hill , Christopher D. Wilsey
发明人： Raghbir S. Bhullar , John T. Austera , Brian S. Hill , Christopher D. Wilsey
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , Y10T29/49002
摘要： A method of forming a biosensor is provided in accordance with the present invention. The method includes providing a metallized electrode support substrate and a sensor support, ablating the electrode support substrate to form electrodes, coupling the sensor support substrate to the electrode support substrate, and positioning spaced-apart electrically conductive tracks across the sensor support substrate so that each track is in electrical communication with one electrode.
摘要翻译：根据本发明提供了形成生物传感器的方法。该方法包括提供金属化电极支撑衬底和传感器支撑件，消融电极支撑衬底以形成电极，将传感器支撑衬底连接到电极支撑衬底，以及跨越传感器支撑衬底定位间隔开的导电轨迹，轨道与一个电极电连通。

4. 发明授权

US06755949B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06755949B1
公开(公告)日：2004-06-29
申请号：US09974434
申请日：2001-10-09
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , John T. Austera
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , John T. Austera
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , G01N27/3272 , Y10T29/49002
摘要： A biosensor is provided in accordance with the present invention. The biosensor includes a substrate and a cover extending across at least a portion of the substrate. The cover includes a first surface facing the substrate and a second surface. At least a portion of the first surface is removed to define a capillary channel. The capillary channel has a surface energy ranging from about 60 mN/m to about 72 mN/m.
摘要翻译：根据本发明提供生物传感器。生物传感器包括衬底和延伸穿过衬底的至少一部分的覆盖物。盖包括面向基板的第一表面和第二表面。去除第一表面的至少一部分以限定毛细通道。毛细管通道具有约60mN / m至约72mN / m的表面能。

5. 发明授权

US06319719B1 Capillary hematocrit separation structure and method 失效
标题翻译：毛细血细胞比容分离结构及方法
公开(公告)号：US06319719B1
公开(公告)日：2001-11-20
申请号：US09428691
申请日：1999-10-28
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Jeffrey N. Shelton
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Jeffrey N. Shelton
IPC分类号： G01N3386
CPC分类号： G01N33/491 , B01L3/502746 , B01L3/502753 , B01L2300/0681 , B01L2300/0825 , B01L2400/0406 , B01L2400/086 , Y10T436/25125 , Y10T436/25375
摘要： A capillary hematocrit separation structure is included within a housing having a fluid inlet port, a reaction region, and a capillary pathway connecting the inlet port and the reaction region. The capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of obstructions are fixed in the capillary pathway, each obstruction having a concave portion facing toward the vented reaction region on the down stream side of the obstructions as viewed with reference to a liquid flowing from the inlet port to the reaction region. The capillary pathway in a hematocrit separation structure for a single drop sample size includes about 105 obstructions, each obstruction including a concave portion having a volume of between about 10−4 to 10−5 &mgr;l for selectively receiving hematocrit.
摘要翻译：毛细管血细胞比容分离结构包括在具有连接入口和反应区域的流体入口，反应区域和毛细管道的壳体内。毛细管路径的尺寸被设计成使得液体通过毛细通路的运动的驱动力由毛细管压力引起。多个障碍物固定在毛细管路径中，每个阻塞件相对于从入口流向反应区域的液体观察，在障碍物的下游侧具有面向通气的反应区域的凹部。用于单滴样品尺寸的血细胞比容分离结构中的毛细血管通路包括约105个障碍物，每个梗阻包括体积在约10-4至10-5μm之间的凹部，用于选择性地接受血细胞比容。

6. 发明授权

US06645359B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06645359B1
公开(公告)日：2003-11-11
申请号：US09684257
申请日：2000-10-06
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
IPC分类号： G01N27327
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译：提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。生物传感器还包括位于反应区上的试剂。在优选的实施方案中，凹部限定反应区的至少一部分。

7. 发明授权

US06447657B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06447657B1
公开(公告)日：2002-09-10
申请号：US09729296
申请日：2000-12-04
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
IPC分类号： G01N2726
CPC分类号： G01N27/3272
摘要： A biosensor is provided that includes first and second plate elements, wherein each plate elements has first and second ends and first and second lateral borders. In addition, the biosensor includes a spacer positioned to lie between the first and second plate elements so that at least a portion of the first and second plate elements cooperate with one another to form opposite walls of a capillary space. Further, the first ends and at least a portion of the lateral borders define a fluid sample-receiving portion in communication with the capillary space. Electrodes are positioned in the capillary space of the biosensor.
摘要翻译：提供了包括第一和第二板元件的生物传感器，其中每个板元件具有第一和第二端以及第一和第二横向边界。此外，生物传感器包括定位成位于第一和第二板元件之间的间隔件，使得第一和第二板元件的至少一部分彼此配合以形成毛细管空间的相对壁。此外，第一端部和横向边界的至少一部分限定了与毛细管空间连通的流体样品接收部分。电极位于生物传感器的毛细管空间中。

8. 发明授权

US07287318B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07287318B2
公开(公告)日：2007-10-30
申请号：US10703408
申请日：2003-11-07
申请人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
发明人： Raghbir S. Bhullar , Christopher D. Wilsey , Brian S. Hill
IPC分类号： H01R43/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译：提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。生物传感器还包括位于反应区上的试剂。在优选的实施方案中，凹部限定反应区的至少一部分。

9. 发明申请

US20120263879A1 VACUUM ASSISTED SLOT DIE COATING TECHNIQUES 有权
标题翻译：真空辅助槽涂层技术
公开(公告)号：US20120263879A1
公开(公告)日：2012-10-18
申请号：US13088078
申请日：2011-04-15
申请人： Christopher D. Wilsey , Abner D. Joseph , Sergio Buccilli
发明人： Christopher D. Wilsey , Abner D. Joseph , Sergio Buccilli
IPC分类号： B05D1/26 , B05C11/02
CPC分类号： B05C5/0254 , B05C11/10 , B05C11/1005 , B05D1/265 , B05D3/0493 , G01N27/3272
摘要： Systems, apparatuses, techniques and processes for applying a wet film to a substrate using a slot die are provided. In one form, the air pressure around at least a portion of the discharge end of the slot die is adjustable by the application of a vacuum force in order to control the width and thickness of the wet film being applied to the substrate. In one aspect of this form, the wet film is a narrow, continuous stripe of reagent material applied to a moving web of the substrate from which a plurality of test elements will be obtained. However, different forms and applications are also envisioned.
摘要翻译：提供了使用槽模将湿膜施加到基板的系统，设备，技术和工艺。在一种形式中，通过施加真空力来调节狭缝模头的排出端的至少一部分周围的空气压力，以便控制施加到基底上的湿膜的宽度和厚度。在该形式的一个方面，湿膜是施加到基材的移动纤维网上的窄的，连续的试剂材料条，将从中获得多个测试元件。但是，也可以设想不同的形式和应用。

10. 发明申请

US20120181187A1 DETERMINATION OF BLOOD GLUCOSE IN A SMALL VOLUME AND IN A SHORT TEST TIME 有权
标题翻译：在小容量和短时间内测定血糖
公开(公告)号：US20120181187A1
公开(公告)日：2012-07-19
申请号：US13432648
申请日：2012-03-28
申请人： Christopher D. Wilsey
发明人： Christopher D. Wilsey
IPC分类号： G01N33/66 , G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , G01N27/307 , G01N27/3273 , G01N27/3275
摘要： Analytes in a liquid sample are determined by methods utilizing sample volumes of less than about 1.0 μl and test times within about six seconds. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.
摘要翻译：通过使用小于约1.0μl的样品体积和在约6秒内测试时间的方法来测定液体样品中的分析物。该方法优选使用包括通过毛细管作用填充样品的样品接收室的小测试条进行。

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