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1. 发明授权

US07482147B2 Ubiquitin protease 失效
标题翻译：泛素蛋白酶
公开(公告)号：US07482147B2
公开(公告)日：2009-01-27
申请号：US11313836
申请日：2005-12-21
申请人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
发明人： Maria A. Glucksmann , Mark J. Williamson , Fong-Ying Tsai , Laura A. Rudolph-Owen , Rosanna Kapeller-Libermann , Rachel E. Meyers , Lillian Wei-Ming Chiang , John J. Hunter
IPC分类号： C12N9/48 , C12N15/00 , C12Q1/00 , C12Q1/68 , C12P21/04 , C07H21/04
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明授权

US08252915B2 Human transferase family members and uses thereof 失效
标题翻译：人转移酶家族成员及其用途
公开(公告)号：US08252915B2
公开(公告)日：2012-08-28
申请号：US12828319
申请日：2010-07-01
申请人： Rachel E. Meyers , John J. Hunter , Fong-Ying Tsai
发明人： Rachel E. Meyers , John J. Hunter , Fong-Ying Tsai
IPC分类号： C07H1/00 , C07H5/04 , C07H5/05 , C07H21/02 , C07H21/04 , C08B37/00 , C12P21/06 , C12N5/00 , C12N5/02 , C12N15/00
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

3. 发明申请

US20110182879A1 NOVEL HUMAN TRANSFERASE FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：新人类转移家族成员及其用途
公开(公告)号：US20110182879A1
公开(公告)日：2011-07-28
申请号：US12828319
申请日：2010-07-01
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： A61K39/395 , C07H21/04 , C12N5/10 , C07K14/435 , C07K16/18 , C12P21/02 , G01N33/50 , G01N33/53 , A61K38/02 , A61P43/00
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人转移酶家族成员的分离的核酸分子，命名为33877,47179,26886,4673,27417,32252和53320核酸分子。本发明还提供反义核酸分子，含有33877,47179,26886,4673,27417,32252或53320核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人类转基因动物，其中33877 ，47179,26886,46743,27417,32.252或53320基因已被引入或破坏。本发明还进一步提供了分离的33877,47179,26886,46743,27417,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179,26886,46743,27417,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

4. 发明授权

US07301016B2 Human transferase family members and uses thereof 失效
标题翻译：人转移酶家族成员及其用途
公开(公告)号：US07301016B2
公开(公告)日：2007-11-27
申请号：US10184648
申请日：2002-06-27
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： C07H1/00 , C07H5/00 , C07H19/00 , C07H21/00 , C07H21/02 , C08B37/00 , C12Q1/68 , C12P21/06 , C12P19/34 , C12N1/12 , C12N1/20 , C12N15/00 , C12N15/06
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员。本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或中断了本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。还提供了利用本发明组合物的诊断方法。

5. 发明授权

US07879989B2 16836, A human phospholipase C family member, nucleic acids and uses thereof 失效
标题翻译： 16836，人类磷脂酶C家族成员，核酸及其用途
公开(公告)号：US07879989B2
公开(公告)日：2011-02-01
申请号：US11980299
申请日：2007-10-30
申请人： Rachel E. Meyers , John J. Hunter
发明人： Rachel E. Meyers , John J. Hunter
IPC分类号： C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K2319/00
摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863 和32252个核酸分子。本发明还提供反义核酸分子，重组表达载体，其含有13237,18480,2245,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216575,42755,32229 ，22325,46863和32252核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中13237,18480,2362,46169,3677,26320,46869,38166,16836,46867,21617,26173,26169，已经引入或破坏了55562,39228,62088,4675,23155,21657,42755,32229,22325,46863或32252基因。本发明还进一步提供分离的13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,21657,42755,32229,22325,46863或32252蛋白质，融合蛋白，抗原肽和抗-13237,18480,2225,16228,7677,26320,4619,33166,16836,46867,21617,55562,39228,62088,46745,23155,216547,42755,32229,22325,46863 或32252抗体。还提供了利用本发明组合物的诊断和治疗方法。

6. 发明授权

US07776577B2 Ubiquitin protease 失效
标题翻译：泛素蛋白酶
公开(公告)号：US07776577B2
公开(公告)日：2010-08-17
申请号：US12316681
申请日：2008-12-16
申请人： Rosanna Kapeller-Libermann , John J. Hunter
发明人： Rosanna Kapeller-Libermann , John J. Hunter
IPC分类号： C12N9/48 , C12P21/04 , C12Q1/00 , C12Q1/37 , A01N25/00 , C07H21/04 , C12Q1/68 , C12N15/00 , C12N1/20
CPC分类号： C12N9/1288 , A01K2217/05 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K48/00 , A61K2039/505 , C07K14/4747 , C07K2319/00 , C12N9/14 , C12N9/16 , C12N9/6472 , G01N33/5011 , G01N33/57407 , G01N33/57484 , G01N2500/10
摘要： The invention provides isolated nucleic acids molecules and proteins, designated 27411, 23413, 22438, 23553, 25278, 26212, NARC SC1, NARC 10A, NARC 1, NARC 12, NARC 13, NARC17, NARC 25, NARC 3, NARC 4, NARC 7, NARC 8, NARC 11, NARC 14A, NARC 15, NARC 16, NARC 19, NARC 20, NARC 26, NARC 27, NARC 28, NARC 30, NARC 5, NARC 6, NARC 9, NARC 10C, NARC 8B, NARC 9, NARC2A, NARC 16B, NARC 1C, NARC 1A, NARC 25, 86604 and 32222 nucleic acid molecules and proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, nonhuman transgenic animals in which a said genes have been introduced or disrupted, fusion proteins, antigenic peptides and antibodies to said proteins. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和蛋白质，命名为27411,23413,22438,23553,25278,26212，NARC SC1，NARC 10A，NARC 1，NARC 12，NARC 13，NARC 17，NARC 25，NARC 3，NARC 4，NARC 7，NARC 8，NARC 11，NARC 14A，NARC 15，NARC 16，NARC 19，NARC 20，NARC 26，NARC 27，NARC 28，NARC 30，NARC 5，NARC 6，NARC 9，NARC 10C，NARC 8B， NARC 9，NARC2A，NARC 16B，NARC 1C，NARC 1A，NARC 25，86604和32222核酸分子和蛋白质。本发明还提供了反义核酸分子，含有所述核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，其中所述基因已导入或破坏的非人类转基因动物，融合蛋白，抗原肽和抗体到蛋白质。还提供了利用本发明组合物的诊断和治疗方法。

7. 发明授权

US4709946A Lined pipe joint 失效
标题翻译：内衬管接头
公开(公告)号：US4709946A
公开(公告)日：1987-12-01
申请号：US17174
申请日：1987-02-20
申请人： John J. Hunter
发明人： John J. Hunter
IPC分类号： E21B17/042 , F16L58/18 , F16L9/14
CPC分类号： F16L58/182
摘要： Disclosed is a method and apparatus for forming a pipe joint for securing lined pipe sections together. A portion of the liners of adjacent pipe sections are overlapped and compressed when the pipe joint is made up so as to seal against the migration of pressurized fluids from within the pipe sections.
摘要翻译：公开了一种用于形成用于将衬里管段固定在一起的管接头的方法和装置。当管接头构成时，相邻管段的衬垫的一部分被重叠和压缩，以便与管段内的加压流体的迁移密封。

8. 发明授权

US4541655A Pipe coupling joint 失效
标题翻译：管接头
公开(公告)号：US4541655A
公开(公告)日：1985-09-17
申请号：US464349
申请日：1983-02-07
申请人： John J. Hunter
发明人： John J. Hunter
IPC分类号： B21D39/04 , B23P19/02 , F16L13/16 , F16L13/14
CPC分类号： F16L13/161 , B21D39/04 , B23P19/02 , F16L13/163 , Y10S285/915
摘要： Disclosed is a pipe coupling joint comprising an interference fit coupling of unthreaded pipe sections. The end of the outer pipe in a telescoped interference fit coupling is radially compressed to form a groove in the inner pipe. The crimped end is compressed into the groove to securely couple the pipe sections together. Lined pipe joints and methods and apparatus for forming the improved interference fit joint are also disclosed.
摘要翻译：公开了一种管连接接头，其包括无螺纹管段的过盈配合联接件。伸缩式过盈配合联轴器中的外管的端部被径向压缩以在内管中形成凹槽。压接端被压入槽中以将管段牢固地连接在一起。还公开了衬里管接头以及用于形成改进的过盈配合接头的方法和装置。

9. 发明授权

US5837837A Nucleic acids molecules encoding Caspase-8h and Caspase-8i 失效
标题翻译：编码Caspase-8h和Caspase-8i的核酸分子
公开(公告)号：US5837837A
公开(公告)日：1998-11-17
申请号：US807200
申请日：1997-02-27
申请人： John J. Hunter , Andrew W. Shyjan , Grace H. W. Wong
发明人： John J. Hunter , Andrew W. Shyjan , Grace H. W. Wong
IPC分类号： A61K38/00 , A61K48/00 , C12N9/64 , C07H21/02 , C07K1/00
CPC分类号： C12N9/6475 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The present invention concerns the Caspase-8h gene and the Caspase-8i gene. The Caspase-8h gene encodes a 220 amino acid polypeptide having two FADD death effector domains. The Caspase-8i gene encodes an 81 amino acid polypeptide having one FADD death effector domain. The invention encompasses nucleic acid molecules encoding Caspase-8h or Caspase-8i, vectors containing these nucleic acid molecules, and cells harboring such vectors.
摘要翻译：本发明涉及Caspase-8h基因和Caspase-8i基因。 Caspase-8h基因编码具有两个FADD死亡效应子结构域的220个氨基酸的多肽。 Caspase-8i基因编码具有一个FADD死亡效应子结构域的81个氨基酸多肽。本发明包括编码Caspase-8h或Caspase-8i的核酸分子，含有这些核酸分子的载体和含有这些载体的细胞。

10. 发明授权

US4297868A Pipe sizing and grooving apparatus 失效
标题翻译：管道尺寸和开槽设备
公开(公告)号：US4297868A
公开(公告)日：1981-11-03
申请号：US81778
申请日：1979-10-04
申请人： John J. Hunter
发明人： John J. Hunter
IPC分类号： B21D39/04 , B21D17/02 , B21D41/04
CPC分类号： B21D17/02 , Y10T29/49929
摘要： Disclosed is apparatus for forming an annular groove or recess in the external surface of a pipe section at a predetermined distance from the open end of the pipe. The grooving apparatus comprises a cylindrical body with a tapered external surface at one end, the external diameter of the tapered end increasing with axial distance from the open end. An inwardly projecting lip is formed on the internal surface of the grooving tool and axial slots cut into the tapered surface and the lip. The grooving tool cooperates with a sizing tool having a correspondingly tapered internal surface. The open end of a pipe section is forced through the sizing tool to form a sized end portion of predetermined length. The grooving tool is then forced axially into the sizing tool radially compressing the tapered surface of the grooving tool and deforming the inwardly projecting lip on the internal surface thereof into the pipe to form an annular groove or recess in the external surface of the pipe at a predetermined distance from the open end of the sized pipe.
摘要翻译：公开了一种用于在管部的外表面中与管的开口端隔开预定距离处形成环形槽或凹部的装置。切槽装置包括一端具有锥形外表面的圆柱体，锥形端的外径随着与开口端的轴向距离而增加。向内突出的唇缘形成在切槽工具的内表面上，并且切入锥形表面和唇缘的轴向槽。切槽工具与具有对应的锥形内表面的定径工具配合。管段的开口端被迫通过定径工具以形成预定长度的尺寸的端部。然后将切槽工具轴向地压入定径工具中，径向压缩开槽工具的锥形表面，并使内表面上的向内突出的唇缘变形成管，以在管的外表面中形成环形槽或凹槽距离尺寸的管道的开口端的预定距离。

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