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1. 发明申请

US20150137794A1 NANOSCALE SENSORS FOR INTRACELLULAR AND OTHER APPLICATIONS 有权
标题翻译：纳米级传感器用于细胞和其他应用
公开(公告)号：US20150137794A1
公开(公告)日：2015-05-21
申请号：US14396542
申请日：2013-05-02
申请人： President and Fellows of Harvard College
发明人： Charles M. Lieber , Ruixuan Gao , Steffen Strehle , Xiaojie Duan , Bozhi Tian , Itzhaq Cohen-Karni , Ping Xie , Quan Qing
IPC分类号： G01R1/30 , G01R3/00 , H01L29/772 , H01L21/283 , H01L29/423 , B82Y99/00 , B82Y40/00 , G01R1/067 , H01L29/41
CPC分类号： G01R1/30 , B82Y40/00 , B82Y99/00 , G01N27/4146 , G01N33/48728 , G01R1/06705 , G01R1/06755 , G01R3/00 , H01L21/283 , H01L29/413 , H01L29/42316 , H01L29/772
摘要： The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells. Other aspects of the invention are generally directed to methods of making or using such probes, kits involving such probes, devices involving such probes, or the like.
摘要翻译：本发明一般涉及用于传感器和其它应用的纳米尺度线。在各种实施例中，提供了包括纳米管（或其他纳米线）的探针，其可以直接插入细胞中以确定细胞的性质，例如电性质。在某些情况下，只有纳米线的尖端插入电池中; 该尖端相对于细胞可能非常小，允许非常精确的研究。在一些方面，探针的尖端由例如以一定角度定位在基底上的保持构件保持，这使得探针更容易插入细胞中。纳米尺寸的导线也可以连接到电极和/或形成晶体管的一部分，使得可以确定纳米线的性质，从而确定电池的性质。这种探针也可用于研究细胞外的其它样品。本发明的其他方面通常涉及制造或使用这种探针，涉及这种探针的试剂盒，涉及这种探针的装置等的方法。

2. 发明授权

US09638717B2 Nanoscale sensors for intracellular and other applications 有权
公开(公告)号：US09638717B2
公开(公告)日：2017-05-02
申请号：US14396542
申请日：2013-05-02
申请人： President and Fellows of Harvard College
发明人： Charles M. Lieber , Ruixuan Gao , Steffen Strehle , Xiaojie Duan , Bozhi Tian , Itzhaq Cohen-Karni , Ping Xie , Quan Qing
IPC分类号： G01R1/30 , B82Y40/00 , G01R1/067 , G01R3/00 , H01L29/772 , H01L29/41 , H01L29/423 , B82Y99/00 , H01L21/283 , G01N27/414 , G01N33/487
CPC分类号： G01R1/30 , B82Y40/00 , B82Y99/00 , G01N27/4146 , G01N33/48728 , G01R1/06705 , G01R1/06755 , G01R3/00 , H01L21/283 , H01L29/413 , H01L29/42316 , H01L29/772
摘要： The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells. Other aspects of the invention are generally directed to methods of making or using such probes, kits involving such probes, devices involving such probes, or the like.

3. 发明申请

US20160282303A1 BENT NANOWIRES AND RELATED PROBING OF SPECIES 审中-公开
标题翻译： BENT NANOWIRES和相关物种的探索
公开(公告)号：US20160282303A1
公开(公告)日：2016-09-29
申请号：US15047267
申请日：2016-02-18
申请人： President and Fellows of Harvard College
发明人： Charles M. Lieber , Bozhi Tian , Ping Xie , Thomas J. Kempa , Itzhaq Cohen-Karni , Quan Qing , Xiaojie Duan
IPC分类号： G01N27/414 , H01L51/00 , H01L29/06 , H01L21/02
CPC分类号： G01N27/4146 , B82Y10/00 , B82Y15/00 , G01N33/48728 , H01L21/02603 , H01L29/045 , H01L29/0665 , H01L29/0669 , H01L51/0048
摘要： The present invention generally relates to nanoscale devices and methods, including bent nanowires and other bent nanoscale objects, and in particular, the ability to probe cells with nanoscale objects. In some aspects, nanoscale objects, including nanowires, are provided that facilitate cell probing, e.g. nanowires that are surface modified such that cells can fuse with the nanowires. Devices including nanoscale objects are provided that allow small or large scale (e.g., multiplexed) probing of cells, and related methods of making such nanoscale objects and devices, and methods of investigating cells, are provided by certain embodiments of the invention. In a related set of embodiments, the present invention is generally related to bent nanowires and other bent nanoscale objects. For instance, in one aspect, the present invention is generally related to a semiconductor nanoscale wire having at least one kink. The semiconductor nanoscale wire may be formed out of any suitable semiconductor, e.g., Si, CdS, Ge, or the like. In some embodiments, a kink in the semiconductor nanoscale wire may be at an angle of about 120° or a multiple thereof. Yet other aspects of the invention are generally directed to methods of using such nanoscale wires, kits involving such nanoscale wires, devices involving such nanoscale wires, or the like.
摘要翻译：本发明一般涉及纳米级器件和方法，包括弯曲的纳米线和其他弯曲的纳米尺度物体，特别是涉及用纳米尺度物体探测细胞的能力。在一些方面，提供纳米级物体，包括纳米线，其促进细胞探测，例如，表面改性的纳米线使得电池可以与纳米线熔合。提供包括纳米尺度物体的装置，其通过本发明的某些实施例提供允许细胞的小规模（例如，多路复用）探测，以及制造这种纳米级物体和装置的相关方法以及调查细胞的方法。在相关的一组实施例中，本发明通常涉及弯曲的纳米线和其它弯曲的纳米尺度物体。例如，一方面，本发明通常涉及具有至少一个扭结的半导体纳米级线。半导体纳米线可以由任何合适的半导体形成，例如Si，CdS，Ge等。在一些实施例中，半导体纳米尺度线中的扭结可以是大约120°的角度或其倍数。本发明的其它方面通常涉及使用这种纳米级线材的方法，涉及这种纳米线材的套件，涉及这种纳米级线材的装置等。

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