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1. 发明申请

US20050228007A1 Isoquinoline derivatives and methods of use thereof 审中-公开
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：US20050228007A1
公开(公告)日：2005-10-13
申请号：US11066824
申请日：2005-02-25
申请人： Prakash Jagtap , Erkan Baloglu , John Van Duzer , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams , Alexander Nivorozhkin
发明人： Prakash Jagtap , Erkan Baloglu , John Van Duzer , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams , Alexander Nivorozhkin
IPC分类号： A61K31/473 , A61K31/4745 , A61K31/55 , C07D221/18
CPC分类号： A61K31/473 , A61K31/4745 , A61K31/55 , C07D221/18
摘要： The present invention relates to Isoquinoline Derivatives, compositions comprising an effective amount of a Isoquinoline Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease other than a cardiovascular disease, cardiovascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Isoquinoline Derivative.
摘要翻译：本发明涉及异喹啉衍生物，包含有效量的异喹啉衍生物的组合物和治疗或预防炎性疾病，再灌注损伤，缺血状况，肾衰竭，糖尿病，糖尿病并发症，除心血管疾病，心脏病，由器官移植引起的再氧化损伤，帕金森病或癌症，包括向有需要的动物施用有效量的异喹啉衍生物。

2. 发明申请

US20080262016A1 ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：US20080262016A1
公开(公告)日：2008-10-23
申请号：US12140120
申请日：2008-06-16
申请人： Prakash Jagtap , Erkan Baloglu , John H. van Duzer , Csaba Szabo , Andrew L. Salzman , Aloka Roy , William Williams , Alexander Nivorozhkin
发明人： Prakash Jagtap , Erkan Baloglu , John H. van Duzer , Csaba Szabo , Andrew L. Salzman , Aloka Roy , William Williams , Alexander Nivorozhkin
IPC分类号： A61K31/4738 , C07D221/02 , C12N5/00 , A61P9/00 , A61P3/10 , A61P29/00 , A61K31/473
CPC分类号： C07D495/04 , A61K31/435 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D221/18 , C07D471/04 , C07D491/04 , Y02A50/422
摘要： The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
摘要翻译：本发明提供了新类别的异喹啉衍生物。还描述了制备和使用化合物的药物组合物和方法。

3. 发明授权

US07268143B2 Isoquinoline derivatives and methods of use thereof 失效
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：US07268143B2
公开(公告)日：2007-09-11
申请号：US10963293
申请日：2004-10-12
申请人： Prakash Jagtap , Csaba Szabo , Andrew L. Salzman , Aloka Roy , William Williams
发明人： Prakash Jagtap , Csaba Szabo , Andrew L. Salzman , Aloka Roy , William Williams
IPC分类号： A61K31/4745 , A61K31/5377 , C07D471/06 , C07D413/14
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
摘要翻译：本发明提供了新类别的异喹啉衍生物。还描述了制备和使用化合物的药物组合物和方法。

4. 发明申请

US20070249653A1 Tetracyclic benzamide derivatives and methods of use thereof 审中-公开
标题翻译：四环苯甲酰胺衍生物及其使用方法
公开(公告)号：US20070249653A1
公开(公告)日：2007-10-25
申请号：US11786627
申请日：2007-04-12
申请人： Prakash Jagtap , William Williams , Alexander Nivorozhkin , Csaba Szabo
发明人： Prakash Jagtap , William Williams , Alexander Nivorozhkin , Csaba Szabo
IPC分类号： A61K31/4355 , A61K31/4418 , A61P13/12 , A61P3/10 , A61P9/00
CPC分类号： C07H17/00 , C07D221/18 , C07D471/04 , C07D471/14 , C07D491/04 , C07D495/04 , C07D495/14
摘要： The invention relates to Tetracyclic Benzamide Derivatives; compositions comprising a Tetracyclic Benzamide Derivative; and methods for treating or preventing an inflammatory disease, a reperfusion disease, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Benzamide Derivative.
摘要翻译：本发明涉及四环苯甲酰胺衍生物; 包含四环苯甲酰胺衍生物的组合物; 以及用于治疗或预防炎性疾病，再灌注疾病，缺血性疾病，肾功能衰竭，糖尿病，糖尿病并发症，血管疾病或癌症的方法，包括向有需要的受试者施用有效量的四环苯甲酰胺衍生物。

5. 发明申请

US20050282848A1 Isoquinoline derivatives and methods of use thereof 失效
公开(公告)号：US20050282848A1
公开(公告)日：2005-12-22
申请号：US11177161
申请日：2005-07-08
申请人： Prakash Jagtap , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams
发明人： Prakash Jagtap , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams
IPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4745 , A61K31/473
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.

6. 发明申请

US20050261288A1 Tetracyclic lactam derivatives and uses thereof 审中-公开
标题翻译：四环内酰胺衍生物及其用途
公开(公告)号：US20050261288A1
公开(公告)日：2005-11-24
申请号：US11067324
申请日：2005-02-25
申请人： Prakash Jagtap , William Williams , Csaba Szabo
发明人： Prakash Jagtap , William Williams , Csaba Szabo
IPC分类号： A61K31/473 , A61K31/4745 , A61K31/5377 , A61P29/00 , A61P35/00 , C07D221/18 , C07D403/12 , C07D471/02 , C07D471/04
CPC分类号： C07D221/18 , C07D403/12 , C07D471/04
摘要： The present invention relates to Tetracyclic Lactam Derivatives, compositions comprising an effective amount of a Tetracyclic Lactam Derivative and methods for treating or preventing an inflammatory disease, a reperfusion injury, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease, reoxygenation injury resulting from organ transplantation, Parkinson's disease, or cancer, comprising administering to an animal in need thereof an effective amount of a Tetracyclic Lactam Derivative.
摘要翻译：本发明涉及四环内酰胺衍生物，包含有效量的四环内酰胺衍生物的组合物和治疗或预防炎性疾病，再灌注损伤，缺血状况，肾衰竭，糖尿病，糖尿病并发症，血管疾病，由器官移植，帕金森病或癌症引起的再氧化损伤，包括向有需要的动物施用有效量的四环内酰胺衍生物。

7. 发明申请

US20050049270A1 Isoquinoline derivatives and methods of use thereof 失效
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：US20050049270A1
公开(公告)日：2005-03-03
申请号：US10963293
申请日：2004-10-12
申请人： Prakash Jagtap , Erkan Baloglu , John van Duzer , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams , Alexander Nivoroshkin
发明人： Prakash Jagtap , Erkan Baloglu , John van Duzer , Csaba Szabo , Andrew Salzman , Aloka Roy , William Williams , Alexander Nivoroshkin
IPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04 , C07D221/22 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
摘要翻译：本发明提供了新类别的异喹啉衍生物。还描述了制备和使用化合物的药物组合物和方法。

8. 发明申请

US20080009473A1 Pyridyl-substituted porphyrin compounds and methods of use thereof 审中-公开
公开(公告)号：US20080009473A1
公开(公告)日：2008-01-10
申请号：US11880068
申请日：2007-07-19
申请人： William Williams , Garry Southan , Csaba Szabo
发明人： William Williams , Garry Southan , Csaba Szabo
IPC分类号： A61K31/555 , A61P39/06
CPC分类号： C07D487/22 , C07F11/005 , C07F13/005 , C07F15/025
摘要： The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

9. 发明授权

US07393955B2 Isoquinoline derivatives and methods of use thereof 失效
标题翻译：异喹啉衍生物及其使用方法
公开(公告)号：US07393955B2
公开(公告)日：2008-07-01
申请号：US11177161
申请日：2005-07-08
申请人： Prakash Jagtap , Aloka Roy , William Williams
发明人： Prakash Jagtap , Aloka Roy , William Williams
IPC分类号： C07D413/12 , C07D221/18
CPC分类号： C07D221/18 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
摘要翻译：本发明提供了新类别的异喹啉衍生物。还描述了制备和使用化合物的药物组合物和方法。

10. 发明申请

US20060003982A1 Pyridyl-substituted porphyrin compounds and methods of use thereof 失效
标题翻译：吡啶基取代的卟啉化合物及其使用方法
公开(公告)号：US20060003982A1
公开(公告)日：2006-01-05
申请号：US11090447
申请日：2005-03-25
申请人： William Williams , Garry Southan , Csaba Szabo
发明人： William Williams , Garry Southan , Csaba Szabo
IPC分类号： A61K31/555 , C07F15/02
CPC分类号： C07D487/22 , C07F11/005 , C07F13/005 , C07F15/025
摘要： The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.
摘要翻译：本发明涉及吡啶基取代的卟啉化合物，包含有效量的吡啶基取代的卟啉化合物的组合物和用于治疗或预防由于暴露于反应性物质引起的损伤，由于手术引起的勃起功能障碍，肺部疾病，高氧，神经变性疾病，肝脏疾病，心脏停搏期间的心肌损伤，炎症状况，再灌注损伤，缺血状况，心血管疾病，糖尿病，糖尿病并发症，癌症，癌症化疗的副作用或辐射诱发的损伤，或延长易氧化化合物的半衰期，包括向有需要的受试者施用有效量的吡啶基取代的卟啉化合物。

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