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    • 10. 发明授权
    • Manufacture of medical implants
    • 医疗植入物的制造
    • US09345806B2
    • 2016-05-24
    • US12303348
    • 2007-06-07
    • Claudio TonelliPiero GavezottiRitalba Lamendola
    • Claudio TonelliPiero GavezottiRitalba Lamendola
    • A61L27/14A61L28/00A61L29/04A61L31/04
    • A61L27/14A61L28/0026A61L29/049A61L31/04
    • The invention pertains to a process for the manufacture cola medical implant, said process comprising: reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
    • 本发明涉及制造可乐医用植入物的方法,所述方法包括:使包含羟基端基的非官能,单官能和双功能全氟聚醚的混合物反应,其中平均官能度为至少1.97 [混合物(M)]与 用于生产热塑性弹性体的合适的反应物; 模制如此获得的热塑性弹性体以产生医用植入物的至少一部分。 已经令人惊奇地发现,通过使用具有高官能度的全氟聚醚的混合物,有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被降低的生物流体的化学品提取的医用植入物。