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1. 发明申请

US20190093100A1 MODIFYING BACTERIOPHAGE 审中-公开
公开(公告)号：US20190093100A1
公开(公告)日：2019-03-28
申请号：US16092087
申请日：2017-04-07
申请人： Phico Therapeutics Ltd
发明人： Heather FAIRHEAD , Adam WILKINSON , Emmanuele SEVERI
IPC分类号： C12N15/10 , C12N7/00
摘要： A method for producing one or more hybrid bacteriophage host range determinant (HRD) sequences, which comprises: (1) identifying at least two DNA sequences, each encoding an HRD in a series of regions in the DNA sequence, wherein the HRDs are different from one another, (2) incorporating each region into a vector in which each region is flanked by a recognition site of a restriction enzyme capable of cutting DNA at a specific cleavage site outside of the recognition sequence, so that the cleavage site of the restriction enzyme is situated at the boundary of each region, wherein the cleavage site sequences of the regions from an individual series are different from one another and wherein the cleavage site sequences at the boundaries of corresponding regions from different series are the same; (3) treating the vectors with a restriction enzyme capable of cutting DNA at a specific cleavage site outside of the recognition sequence so as to generate a mixture of the regions; and (4) treating the mixture of the regions with a ligase to ligate them to form an array of DNA sequences encoding an array of hybrid HRDs.

2. 发明申请

US20190119651A1 MODIFIED BACTERIOPHAGE 审中-公开
公开(公告)号：US20190119651A1
公开(公告)日：2019-04-25
申请号：US16092096
申请日：2017-04-07
申请人： Phico Therapeutics Ltd
发明人： Heather FAIRHEAD , Adam WILKINSON
IPC分类号： C12N7/00
摘要： A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage includes a toxin gene encoding a toxin protein which is toxic to the target bacteria; wherein the bacteriophage is lytic; and wherein the bacteriophage expresses host range determinant proteins which have a plurality of bacterial host specificities.

3. 发明公开

US20230416694A1 MODIFIED BACTERIOPHAGE 审中-公开
公开(公告)号：US20230416694A1
公开(公告)日：2023-12-28
申请号：US18315255
申请日：2023-05-10
申请人： Phico Therapeutics Ltd
发明人： Heather FAIRHEAD , Adam WILKINSON
IPC分类号： C12N7/00 , A61K39/07 , A61K39/104 , A61K35/76
CPC分类号： C12N7/00 , A61K39/07 , A61K39/104 , A61K35/76 , C12N2795/00021 , C12N2795/00032 , C12N2795/10121 , C12N2795/00031 , C12N2795/10132 , C12N2795/10131 , C12N2795/00043 , C12N2795/00045
摘要： A modified bacteriophage capable of infecting a plurality of different target bacteria, which bacteriophage includes a toxin gene encoding a toxin protein which is toxic to the target bacteria; wherein the bacteriophage is lytic; and wherein the bacteriophage expresses host range determinant proteins which have a plurality of bacterial host specificities.

4. 发明申请

US20170306298A1 MULTIPLE HOST RANGE BACTERIOPHAGE WITH DIFFERENT TAIL FIBRES 审中-公开
公开(公告)号：US20170306298A1
公开(公告)日：2017-10-26
申请号：US15517656
申请日：2015-10-08
申请人： PHICO THERAPEUTICS LTD
发明人： Heather FAIRHEAD , Adam WILKINSON , Emmanuele SEVERI , Neil ANDERSON , Katy PITTS , Anne BARNARD
IPC分类号： C12N7/00 , A61K35/74 , A61K35/76
CPC分类号： C12N7/00 , A61K35/74 , A61K35/76 , C12N2795/00011 , C12N2795/00032 , C12N2795/00043 , C12N2795/00045
摘要： Modified bacteriophage, uses thereof, and compositions containing the modified bacteriophage are described. The compositions are useful for human treatment and may treat various conditions, including bacterial infections.

5. 发明申请

US20170304378A1 MODIFYING BACTERIOPHAGE USING BETA-GALACTOSIDASE AS A SELECTABLE MARKER 审中-公开
公开(公告)号：US20170304378A1
公开(公告)日：2017-10-26
申请号：US15517718
申请日：2015-10-08
申请人： Phico Therapeutics Ltd
发明人： Heather FAIRHEAD , Adam WILKINSON , Neil ANDERSON , Katy PITTS , Anne BARNARD , Emmanuele SEVERI
IPC分类号： A61K35/76 , C12N7/00 , A61K35/00
CPC分类号： A61K35/76 , A61K35/00 , C12N7/00 , C12N2795/00032 , C12N2795/00041 , C12N2795/00043 , C12N2795/00045
摘要： A method for modifying the genome of a target phage is described. Compositions comprising such modified phage are also described. The compositions may be formulated as a medicament, which are useful for human treatment and may treat various conditions, including bacterial infections.

6. 发明公开

US20230265395A1 MULTIPLE HOST RANGE BACTERIOPHAGE WITH HYBRID TAIL FIBRES 审中-公开
公开(公告)号：US20230265395A1
公开(公告)日：2023-08-24
申请号：US17933267
申请日：2022-09-19
申请人： PHICO THERAPEUTICS LTD
发明人： Heather FAIRHEAD , Adam WILKINSON , Katy PITTS , Anne BARNARD , Emmanuele SEVERI , Neil ANDERSON
IPC分类号： C12N7/00 , A61K35/74 , A61K35/76
CPC分类号： C12N7/00 , A61K35/74 , A61K35/76 , C12N2795/00032 , C12N2795/00043 , C12N2795/00045 , C12N2795/00011
摘要： Modified bacteriophage, uses thereof, and compositions containing the modified bacteriophage are described. The compositions are useful for human treatment and may treat various conditions, including bacterial infections.

7. 发明申请

US20170313991A1 MULTIPLE HOST RANGE BACTERIOPHAGE WITH HYBRID TAIL FIBRES 审中-公开
公开(公告)号：US20170313991A1
公开(公告)日：2017-11-02
申请号：US15517664
申请日：2015-10-08
申请人： PHICO THERAPEUTICS LTD
发明人： Heather FAIRHEAD , Adam WILKINSON , Katy PITTS , Anne BARNARD , Emmanuele SEVERI , Neil ANDERSON
IPC分类号： C12N7/00 , A61K35/74 , A61K35/76
CPC分类号： C12N7/00 , A61K35/74 , A61K35/76 , C12N2795/00011 , C12N2795/00032 , C12N2795/00043 , C12N2795/00045
摘要： Modified bacteriophage, uses thereof, and compositions containing the modified bacteriophage are described. The compositions are useful for human treatment and may treat various conditions, including bacterial infections.

8. 发明申请

US20170304379A1 MODIFYING BACTERIOPHAGE 审中-公开
公开(公告)号：US20170304379A1
公开(公告)日：2017-10-26
申请号：US15517732
申请日：2015-10-08
申请人： PHICO THERAPEUTICS LTD
发明人： Heather FAIRHEAD , Adam WILKINSON , Anne BARNARD , Emmanuele SEVERI , Neil ANDERSON , Katy PITTS
IPC分类号： A61K35/76 , C12N7/00 , A61K35/00
CPC分类号： A61K35/76 , A61K35/00 , C12N7/00 , C12N2795/00011 , C12N2795/10121 , C12N2795/10144
摘要： A method for modifying the genome of a lytic target phage, uses of the method and products thereof are described. Compositions comprising such phage are also described. The compositions may be formulated as a medicament, which are useful for human treatment and may treat various conditions, including bacterial infections.

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