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1. 发明授权

US4950401A Centrifugal separator 失效
标题翻译：离心分离器
公开(公告)号：US4950401A
公开(公告)日：1990-08-21
申请号：US314762
申请日：1989-02-02
申请人： Peter Unger , Eric Westberg , Lars Ehnstrom
发明人： Peter Unger , Eric Westberg , Lars Ehnstrom
IPC分类号： B04B5/00 , B04B5/04
CPC分类号： B04B5/0442 , B04B9/08 , B04B2005/045 , B04B2005/0492
摘要： The invention concerns a centrifugal separator with a rotor (15), in which a flexible member (28), e.g. a hose, extends a distance along the periphery of the rotor. The hose defines two parallel channels (29, 30), which form a separation chamber in the rotor and extend from the peripheral part of the rotor towards the rotor center; from there axially out of the rotor (15) at one axially directed side thereof, around the rotor to its opposite side and to a point (27) aligned with the rotor axis (C). During the operation of the rotor the hose may be rotated intermittently around its longitudinal axis relative to the rotor body, so that the radially inner and outer walls of the separation chamber are changing places.
摘要翻译： PCT No.PCT / SE87 / 00399 Sec。 371日期1989年2月2日 102（e）日期1989年2月2日PCT提交1987年9月7日PCT公布。第WO88 / 01907号公报日本1988年3月24日。本发明涉及一种具有转子（15）的离心分离器，其中柔性构件（28）软管沿着转子周边延伸一段距离。软管限定两个平行的通道（29,30），它们在转子中形成分隔室，并从转子的周边部分向转子中心延伸; 从其轴向移出转子（15）的一个轴向定向侧，围绕转子到其相对侧以及与转子轴线（C）对准的点（27）。在转子操作期间，软管可以相对于转子主体围绕其纵向轴线间歇地旋转，使得分离室的径向内壁和外壁正在改变位置。

2. 发明授权

US4778444A Rotatable supply and discharge conduit of a centrifugal separator 失效
标题翻译：离心分离器的可旋转供排管
公开(公告)号：US4778444A
公开(公告)日：1988-10-18
申请号：US104860
申请日：1987-09-02
申请人： Eric Westberg , Lars Ehnstrom
发明人： Eric Westberg , Lars Ehnstrom
IPC分类号： B04B5/00 , B04B5/04 , B04B11/02 , B04B9/00 , B04B11/00
CPC分类号： B04B5/0442 , B04B2005/0492
摘要： In a centrifugal separator a flexible member for the transport of liquid to or from a centrifuge rotor is arranged to rotate around a rotating rotor in the same direction as the rotor but with only half of its rotational speed. By such rotation the flexible member may be firmly connected with both the rotor and a stationary member without being twisted. According to the invention the flexible member has a high torsional stiffness, good tensile strength and an outside having good wear resistance. The casing comprises interplaited threads which may be metal or plastic, some of which extend helically with a certain pitch around the flexible member and others of which extend helically with an opposite pitch around the member. The interplaiting of the threads is such that the casing per se is axially compressible and expandable under radial expansion and compression, respectively. As mounted, the casing is axially expanded so that through radial compression it is in frictional engagement with the flexible member.

3. 发明授权

US5723050A Bag set for use in centrifugal separation 失效
标题翻译：袋装用于离心分离
公开(公告)号：US5723050A
公开(公告)日：1998-03-03
申请号：US578585
申请日：1996-01-03
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： A61J1/05 , B04B5/00 , B04B5/04 , B01D21/26
CPC分类号： B04B5/0428 , B04B2005/045
摘要： Apparatus for centrifugal separation of liquid mixtures is disclosed including an inner circular bag and an outer annular bag which has an inner diameter corresponding to the outer diameter of the inner circular bag, a connecting channel for providing fluid communication between the inner and outer bags, and a rigid circular mount for mounting the outer annular bag for centrifugation in a manner such that the outer annular bag adopts a conical configuration by shortening its inner diameter. Methods for centrifugal separation of thrombocyte suspensions and bone marrow cells using this apparatus are also disclosed.
摘要翻译： PCT No.PCT / SE94 / 00638 Sec。 371日期1996年1月3日 102（e）日期1996年1月3日PCT提交1994年6月28日PCT公布。公开号WO95 / 01842 日期1995年1月19日公开了一种用于离心分离液体混合物的装置，包括内部圆形袋和外部环形袋，其具有对应于内部圆形袋的外径的内径，用于提供内部圆形袋之间的流体连通的连接通道和外袋，以及刚性圆形安装座，用于安装用于离心的外环形袋，使得外环形袋通过缩短其内径而采用圆锥形构造。还公开了使用该装置离心分离血小板悬浮液和骨髓细胞的方法。

4. 发明授权

US06315706B1 Method for separating cells, especially platelets, and bag assembly therefor 失效
标题翻译：用于分离细胞，特别是血小板和其组装的方法
公开(公告)号：US06315706B1
公开(公告)日：2001-11-13
申请号：US09125270
申请日：1998-08-13
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B712
CPC分类号： C12N5/0644 , A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0427 , B04B5/0428 , A61M2202/0071
摘要： Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation. An outlet tube transfers the enriched fraction to a storage bag and is placed in a position adjacent the periphery of the centrifuge rotor for further separation of the enriched fraction at transferring, during continued centrifugation, the enriched fraction through the outlet tube.
摘要翻译：在离心机中分离细胞的方法，优选用于产生血小板。将细胞悬浮液提供在处理袋中并离心。富集细胞的馏分通过出口管转移到储存袋中。出口管的一部分布置在与离心机的周边相邻的位置。当浓缩馏分通过置于离心机外围的出口管并在离心过程中转移时，出口管作为细胞捕获器进行操作，富集级分进一步分离。优选地，细胞悬浮液是血沉棕黄层，富集级分包含血小板。相应的袋组件包括用于封闭细胞悬浮液的处理袋。将处理袋放置在离心机转子中，通过离心将细胞分离成富集血小板的部分。出口管将富集的馏分转移到储存袋并且放置在离心机转子的周边附近的位置，用于在连续离心期间通过出口管转移富集部分，以进一步分离富集级分。

5. 发明授权

US06261217B1 Separation set having plate-like separation container with annular pinch valve for blood component preparation 失效
标题翻译：分离组具有带有用于血液成分制备的环形夹紧阀的板状分离容器
公开(公告)号：US06261217B1
公开(公告)日：2001-07-17
申请号：US09403015
申请日：1999-10-18
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B708
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428
摘要： A separation set for blood component preparation and similar separations for use in a centrifuge rotor, the set including a plate-like separation container made of a flexible material, an annular pinch valve which is mounted on and divides the separation container into a central section and an annular outer section, a first component container which is connected to the center of the separation container, a second component container which is connected to the circumference of the separation container, and a blood withdrawal tube for supplying blood to the outer section. The blood is separated in the outer section into plasma, buffy coat and red blood cells. Then the plasma is displaced to the first component container and the buffy coat to the central section where it is enclosed through the action of the pinch valve. The separation set with the pinch valve is then removed from the centrifuge and the red blood cells are transferred to the second component container.
摘要翻译：用于血液成分制备和用于离心转子的类似分离物的分离组件，该组件包括由柔性材料制成的板状分离容器，环形夹管阀，其安装在分离容器上并将分离容器分成中心部分，环状的外部部分，与分离容器的中心连接的第一部件容器，与分离容器的圆周连接的第二部件容器和用于向外部供给血液的抽血管。血液在外部分离成血浆，血沉棕黄层和红细胞。然后将等离子体移动到第一部件容器，将血沉棕黄层移至中间部分，在其中通过夹紧阀的作用被封闭。然后用离心机除去夹紧阀的分离装置，并将红细胞转移到第二组分容器中。

6. 发明授权

US06855102B2 Method for separating cells, especially platelets, and bag assembly therefor 失效
标题翻译：用于分离细胞，特别是血小板和其组装的方法
公开(公告)号：US06855102B2
公开(公告)日：2005-02-15
申请号：US09978428
申请日：2001-10-15
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： A61J1/05 , A61K35/14 , A61M1/02 , A61M1/36 , A61P7/00 , B04B5/04 , C12N5/00 , C12N5/078 , B04B11/00 , B04B13/00
CPC分类号： C12N5/0644 , A61M1/0209 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2202/0427 , B04B5/0428 , A61M2202/0071
摘要： Method of separating cells in a centrifuge, preferably for producing platelets. A cell suspension is provided in a processing bag and is centrifuged. The cell enriched fraction is transferred to a storage bag via an outlet tube. The outlet tube is arranged with a portion thereof in a position adjacent the periphery of the centrifuge. When the enriched fraction is transferred through the outlet tube placed at the periphery of the centrifuge and during centrifugation, the outlet tube operates as a cell trap and the enriched fraction is further separated. Preferably, the cell suspension is buffy coat and the enriched fraction comprises platelets. The corresponding bag assembly comprises a processing bag intended to enclose the cell suspension. The processing bag is placed in a centrifuge rotor for separating the cells into a fraction enriched on platelets by centrifugation. An outlet tube transfers the enriched fraction to a storage bag and is placed in a position adjacent the periphery of the centrifuge rotor for further separation of the enriched fraction at transferring, during continued centrifugation, the enriched fraction through the outlet tube.
摘要翻译：在离心机中分离细胞的方法，优选用于产生血小板。将细胞悬浮液提供在处理袋中并离心。富集细胞的馏分通过出口管转移到储存袋中。出口管的一部分布置在与离心机的周边相邻的位置。当浓缩馏分通过置于离心机外围的出口管并在离心过程中转移时，出口管作为细胞捕获器进行操作，富集级分进一步分离。优选地，细胞悬浮液是血沉棕黄层，富集级分包含血小板。相应的袋组件包括用于封闭细胞悬浮液的处理袋。将处理袋放置在离心机转子中，通过离心将细胞分离成富集血小板的部分。出口管将富集的馏分转移到储存袋并且放置在离心机转子的周边附近的位置，用于在连续离心期间通过出口管转移富集部分，以进一步分离富集级分。

7. 发明授权

US06689042B2 Centrifuge and container system for treatment of blood and blood components 有权
标题翻译：离心机和集装箱系统用于治疗血液和血液成分
公开(公告)号：US06689042B2
公开(公告)日：2004-02-10
申请号：US10054484
申请日：2002-01-22
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B712
CPC分类号： B04B5/0428
摘要： A centrifuge with an associated container system in the form of cassettes for separation and treatment of blood or blood components has been developed. The centrifuge includes a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around the cavity at the upper part thereof. A first container system is arranged in the rotor, for washing of blood cells, includes a round bag and two or more flexible secondary containers connected thereto, one of which contains a treatment liquid and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers are arranged in the sleeve to rest against each other and the round bag is mounted on a projecting flange at the upper part of the sleeve.
摘要翻译：已经开发了具有用于分离和处理血液或血液成分的盒形式的相关联的容器系统的离心机。离心机包括转子，该转子具有与转子的旋转轴线同心地延伸的管状轴腔形式的中央隔室，以及在其上部周围设置的环形隔室。第一容器系统布置在转子中，用于洗涤血细胞，包括圆形袋和连接到其上的两个或更多个柔性次级容器，其中一个容纳处理液体和适于转子的轴腔的管状套筒。次级容器布置在套筒中以相对于彼此搁置，并且圆形袋安装在套筒上部的突出的凸缘上。

8. 发明授权

US5114396A Method of washing blood cells and container assembly thereof 失效
标题翻译：洗涤血液细胞和容器组装方法
公开(公告)号：US5114396A
公开(公告)日：1992-05-19
申请号：US722351
申请日：1991-06-18
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： A61J1/05 , A61J3/00 , A61K35/14 , A61M1/02 , B04B5/04
CPC分类号： B04B5/0428
摘要： Thawed glycerolized red blood cells are washed in a system (1) of closed collapsible containers of flexible material which are positioned concentrically in a centrifuge rotor. The blood cells are held in an annular primary container (2) into which wash liquid is centrifugally fed from a c entral container (3) and from which supernatant is expressed into a central waste container (4) while the primary container is being compressed as a result of centrifugal action on an elastic body (24) in the rotor. A container assembly (1) for use in carrying out the washing comprises an annular collapsible primary container (2), a collapsible circular closed wash liquid container (3), a collapsible circular, closed waste container (4), and valve controlled conduits for passing liquid from the wash liquid container into the primary container and from the primary container into the waste container. The wash liquid container (3) and the waste container (4) are positioned one on top of the other in the circular area surrounded by the primary container (2).
摘要翻译：解冻的甘油化红血球在系统（1）中，该系统（1）是同心地位于离心机转子中的柔性材料的封闭的可收缩容器。血细胞被保持在一个环形的初级容器（2）中，洗涤液体从中间容器（3）离心加入到其中，并且将上清液表达到中央废物容器（4）中，同时将主容器压缩成对转子中的弹性体（24）的离心作用的结果。用于进行洗涤的容器组件（1）包括环形可折叠的主容器（2），可折叠的圆形封闭式洗涤液容器（3），可折叠的圆形封闭废物容器（4）和用于将液体从洗涤液体容器传送到主容器中并从初级容器传送到废物容器中。洗涤液容器（3）和废物容器（4）在由主容器（2）包围的圆形区域中一个位于另一个的顶部。

9. 发明授权

US06835171B2 Centrifuge and container system for treatment of blood and blood components 有权
标题翻译：离心机和集装箱系统用于治疗血液和血液成分
公开(公告)号：US06835171B2
公开(公告)日：2004-12-28
申请号：US10759767
申请日：2004-01-16
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B1500
CPC分类号： B04B5/0428
摘要： A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.
摘要翻译：提供离心机用于分离和/或处理由至少一个管连接到至少一个辅助袋的大致环形或部分环形分隔袋中的细胞。离心机包括连接在转子轴的上端的转子碗。转子轴包括限定用于容纳至少一个辅助袋的中央隔室的中空上部。转子碗包括用于接收分离袋的分隔室和位于分隔室内的可膨胀液压室，用于选择性地挤压分离室内的分离袋，以将分离的组分从分离袋转移到中心的二次袋中隔间液压系统通过延伸穿过转子轴的管道连接到液压室，用于向液压室泵送液压液体。

10. 发明授权

US06348031B1 Centrifuge and container system for treatment of blood and blood components 有权
标题翻译：离心机和集装箱系统用于治疗血液和血液成分
公开(公告)号：US06348031B1
公开(公告)日：2002-02-19
申请号：US09355930
申请日：1999-08-12
申请人： Peter Unger , Eric Westberg
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B708
CPC分类号： B04B5/0428
摘要： A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around said cavity at the upper part thereof. A first container system arranged in the rotor for washing of blood cells comprises a round bag with two or more flexible secondary containers connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers stand in the sleeve resting against each other, and the round bag is mounted on a projecting flange at the upper part of the sleeve. A second container system arranged in the rotor for separation of a thrombocyte suspension differs from the first in that the sleeve has a smaller diameter than the shaft cavity of the rotor and is adapted to be centered in the center of the cavity. An initially empty secondary container for receiving the separated components from the round bag is arranged in the centered sleeve.
摘要翻译：具有用于分离和/或治疗血液或血液成分的盒形式的相关联的容器系统的离心机。离心机包括转子，该转子具有与转子的旋转轴线同心地延伸的管状轴腔形式的中心隔室和在其上部围绕所述空腔布置的环形分隔室。布置在用于洗涤血细胞的转子中的第一容器系统包括具有两个或更多个柔性次级容器的圆形袋，其连接到其上，其中至少一个包含处理液体，以及适于转子的轴腔的管状套筒。次级容器站立在套筒中，彼此搁置，圆形袋子安装在套筒上部的突出的凸缘上。布置在转子中用于分离血细胞悬液的第二容器系统与第一容器系统的不同之处在于套筒具有比转子的轴腔更小的直径，并且适于在腔的中心居中。用于从圆形袋中接收分离的部件的初始空的次级容器布置在中心套筒中。

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