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1. 发明授权

US5710628A Automated electrophoresis and fluorescence detection apparatus and method 失效
标题翻译：自动电泳和荧光检测装置及方法
公开(公告)号：US5710628A
公开(公告)日：1998-01-20
申请号：US353932
申请日：1994-12-12
申请人： Paul Waterhouse , John A. Renfrew , John K. Stevens
发明人： Paul Waterhouse , John A. Renfrew , John K. Stevens
IPC分类号： G01N21/64 , G01N27/447 , G01N21/00
CPC分类号： G01N27/44721
摘要： Improved detection methods and apparatus which may be used individually or in various combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated.
摘要翻译：可以单独或以各种组合使用的改进的检测方法和装置增强电泳装置在短时间内检测荧光团标记的材料的能力。一种这样的设备包括适于接收电泳凝胶保持器的壳体; 电磁辐射的激发源具有有效地诱导来自荧光团的电磁辐射的发射的频率; 用于将来自激发源的电磁辐射传递到凝胶保持器上的激发/检测部位的线性阵列的多个光纤，用于将电磁辐射顺序地引导到几个预定义的光纤组中的一个中的光开关装置; 检测装置，例如光电倍增管或用于检测由来自激发源的辐射引起的荧光团发射的光电倍增管阵列; 以及用于将检测到的发射与激发电磁辐射的切换相关联的装置，使得给定的发射可以与被照射的激发/检测部位相关联。

2. 发明授权

US5627022A Microgels for use in medical diagnosis and holders useful in fabricating same 失效
标题翻译：用于医疗诊断的微凝胶和用于制造相同的支架
公开(公告)号：US5627022A
公开(公告)日：1997-05-06
申请号：US332577
申请日：1994-11-01
申请人： John A. Renfrew , Paul Waterhouse , John K. Stevens
发明人： John A. Renfrew , Paul Waterhouse , John K. Stevens
IPC分类号： G01N27/447 , C12Q1/00 , C12M1/40
CPC分类号： G01N27/44743 , G01N27/44704 , G01N27/44747
摘要： An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The spacer establishes a separation of from 25 to 250 microns between the top substrate and the bottom substrate. A gel compartment is formed by partially sealing the top substrate to the bottom substrate, while leaving an opening for the introduction of unpolymerized gel. The gel compartment is then filled with an unpolymerized gel, which is polymerized in the gel compartment. Electrodes may be printed on the substrates, may be contacts to an exposed edge of gel, or may be applied through windows cut into one of the substrates. One type of gel holder makes use of graded beads having a diameter of 25 to 250 microns slurried in an adhesive such as an acrylate adhesive as the spacer. The slurry is printed onto the surface of one or both substrates to form a spacer of the desired shape, and then hardened using heat or light. If desired, the spacer can establish lanes within the gel.
摘要翻译：在凝胶保持器中形成电泳微凝胶。凝胶保持器包括顶部基底，底部基底和设置在顶部基底和底部基底之间的间隔物。间隔物在顶部基底和底部基底之间建立了从25至250微米的间隔。通过将顶部基底部分地密封到底部基底而形成凝胶室，同时留下用于引入未聚合凝胶的开口。然后用凝胶隔室填充未聚合的凝胶，其在凝胶隔室中聚合。电极可以印刷在基底上，可以与凝胶的暴露边缘接触，或者可以通过切割成一个基底的窗口来施加。一种类型的凝胶保持器使用在诸如丙烯酸酯粘合剂的粘合剂中作为间隔物浆化的直径为25至250微米的分级珠粒。将浆料印刷到一个或两个基材的表面上以形成所需形状的间隔物，然后使用热或光硬化。如果需要，间隔物可以在凝胶内建立泳道。

3. 发明授权

US6005663A Automated electrophoresis and fluorescence detection apparatus and method 失效
公开(公告)号：US6005663A
公开(公告)日：1999-12-21
申请号：US849662
申请日：1997-08-18
申请人： Paul Waterhouse , John A. Renfrew , John K. Stevens
发明人： Paul Waterhouse , John A. Renfrew , John K. Stevens
IPC分类号： G01N21/64 , G01N27/447 , G01N21/00
CPC分类号： G01N27/44721
摘要： Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated. For example, the optical switching means may alternate between directing radiation from the source into every other optical fiber, or may provide radiation in rotation to every third or fourth fiber. Alternatively, a spot array generation grating can be used for dividing an incident beam of coherent radiation into an array of excitation beamlets and directing each excitation beamlets to an excitation/detection site on the electrophoresis gel. Light emitting diode disposed to deliver excitation energy to an array of excitation/detection sites may also be used. This latter form of the apparatus is particularly advantageous due to the low costs of light emitting diodes (LEDs) compared to coherent light sources (e.g. lasers).

4. 发明授权

US5885431A Microgels for use in medical diagnosis and methods of making and using same 失效
标题翻译：用于医学诊断的微凝胶及其制造和使用方法
公开(公告)号：US5885431A
公开(公告)日：1999-03-23
申请号：US836269
申请日：1997-05-01
申请人： John A. Renfrew , Paul Waterhouse , John K. Stevens , Henryk Zaleski
发明人： John A. Renfrew , Paul Waterhouse , John K. Stevens , Henryk Zaleski
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44743 , G01N27/44704 , G01N27/44747
摘要： An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The spacer establishes a separation of from 25 to 250 microns between the top substrate and the bottom substrate. A gel compartment is formed by partially sealing the top substrate to the bottom substrate, while leaving an opening for the introduction of unpolymerized gel. The gel compartment is then filled with an unpolymerized gel, which is polymerized in the gel compartment. Electrodes may be printed on the substrates, may be contacts to an exposed edge of gel, or may be applied through windows cut into one of the substrates. One type of gel holder makes use of graded beads having a diameter of 25 to 250 microns slurried in an adhesive such as an acrylate adhesive as the spacer. The slurry is printed onto the surface of one or both substrates to form a spacer of the desired shape, and then hardened using heat or light. If desired, the spacer can establish lanes within the gel.
摘要翻译： PCT No.PCT / US95 / 14531 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年10月31日PCT公布。出版物WO96 / 日期1996年5月9日在凝胶保持器中形成电泳微凝胶。凝胶保持器包括顶部基底，底部基底和设置在顶部基底和底部基底之间的间隔物。间隔物在顶部基底和底部基底之间建立了从25至250微米的间隔。通过将顶部基底部分地密封到底部基底而形成凝胶室，同时留下用于引入未聚合凝胶的开口。然后用凝胶隔室填充未聚合的凝胶，其在凝胶隔室中聚合。电极可以印刷在基底上，可以与凝胶的暴露边缘接触，或者可以通过切割成一个基底的窗口来施加。一种类型的凝胶保持器使用在诸如丙烯酸酯粘合剂的粘合剂中作为间隔物浆化的直径为25至250微米的分级珠粒。将浆料印刷到一个或两个基材的表面上以形成所需形状的间隔物，然后使用热或光硬化。如果需要，间隔物可以在凝胶内建立泳道。

5. 发明授权

US6014213A High dynamic range apparatus for separation and detection of polynucleotide fragments 失效
标题翻译：用于分离和检测多核苷酸片段的高动态范围装置
公开(公告)号：US6014213A
公开(公告)日：2000-01-11
申请号：US819910
申请日：1997-03-18
申请人： Paul Waterhouse , Alexandre M. Izmailov , Henryk Zaleski , John A. Renfrew , James W. Cassidy
发明人： Paul Waterhouse , Alexandre M. Izmailov , Henryk Zaleski , John A. Renfrew , James W. Cassidy
IPC分类号： G01N27/447 , G01N30/86 , G01N21/00
CPC分类号： G01N30/8603 , G01N27/44721
摘要： A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with fluorophore-labeled samples; one or more laser diodes for providing radiation of a frequency suitable for excitation of the fluorophore which irradiates a an array of excitation/detection sites on the electrophoresis gel; an array of detectors aligned with the excitation/detection sites for collecting fluorescent emissions; and one or more components for increasing the dynamic range of the instrument by at least an order of magnitude. These components, which can be used individually or in combination include detectors that are connected to a signal processing system that modulates the period of signal integration employed so that large signals are totaled at short time intervals and smaller signals are totaled at longer time intervals; the use of a beam splitter to produces a high intensity beam of emitted light and a low intensity beam of emitted light from each excitation/detection site; and a device for modulating the intensity of the excitation beam can be used to improve the dynamic range of the instrument.
摘要翻译：用于分离和检测多核苷酸片段的高动态范围装置具有适于接收含有装载有荧光团标记的样品的电泳凝胶的电泳凝胶保持器的壳体; 用于提供适于激发荧光团的频率的辐射的一个或多个激光二极管，其照射电泳凝胶上的激发/检测位点阵列; 与用于收集荧光发射的激发/检测部位对准的检测器阵列; 以及用于将仪器的动态范围增加至少一个数量级的一个或多个组件。可以单独或组合使用的这些组件包括连接到信号处理系统的检测器，该信号处理系统调制所采用的信号积分的周期，以便以较短的时间间隔合计大信号，并以更长的时间间隔合计较小的信号; 使用分束器产生高强度发射光束和来自每个激发/检测部位的低强度发射光束; 并且可以使用用于调制激发光束的强度的装置来改善仪器的动态范围。

6. 发明授权

US08026819B2 Radio tag and system 有权
标题翻译：无线电标签和系统
公开(公告)号：US08026819B2
公开(公告)日：2011-09-27
申请号：US11639857
申请日：2006-12-15
申请人： Jason August , John K. Stevens , Paul Waterhouse
发明人： Jason August , John K. Stevens , Paul Waterhouse
IPC分类号： G08B21/22 , G08B21/18
CPC分类号： G06K19/07767 , G06K19/07749 , G08B13/2417 , G08B13/242 , G08B13/2431 , G08B13/2434 , G08B13/2445 , G08B13/2448 , G08B13/2462 , G08B13/2477 , G08B13/2482
摘要： Passive tags use two antennas with only limited mutual coupling, one of which receives a power/clock field and the other of which receives a data signal. An area-reading antenna, or two or more antennas, are deployed to generate the power/clock field, from a base station. The base station, or active tags, or both, generate the data signals from time to time. This topology together with the use of low frequencies permits area reads, and permits small and economical passive tags, and further permits localization of a particular passive tag as being nearby to a particular active tag.
摘要翻译：无源标签使用两个只有有限互耦的天线，其中一个接收功率/时钟域，另一个接收数据信号。部署区域读取天线或两个或更多个天线以从基站产生功率/时钟字段。基站或有源标签或两者都不时产生数据信号。这种拓扑结构与低频率的使用一起允许区域读取，并允许小型且经济的无源标签，并且还允许将特定无源标签定位在特定活动标签附近。

7. 发明授权

US07900824B2 Watch for transacting financial transactions 有权
标题翻译：注意交易金融交易
公开(公告)号：US07900824B2
公开(公告)日：2011-03-08
申请号：US11829247
申请日：2007-07-27
申请人： John K. Stevens , Paul Waterhouse
发明人： John K. Stevens , Paul Waterhouse
IPC分类号： G06K5/00
CPC分类号： G04G21/04 , G04R60/00
摘要： An alternative for smart card financial transactions is provided in which the smart card functionality is provided as part of a watch containing a RuBee antenna and transceiver for transmitting the authorization information to a receiver separate from the watch. This form factor allows the user to maintain the card in a readily usable and convenient location. In addition, the watch can be used to allow the user to specifically authorize or override a financial transaction, and to view and/or store information about the financial transaction, as well as conventional functionality such as alarms, and calendars. The watch of the invention can also provide access control or identification in corporate environments if desired.
摘要翻译：提供智能卡金融交易的替代方案，其中提供智能卡功能作为包含用于将授权信息发送到与手表分开的接收器的RuBee天线和收发器的手表的一部分。这种形式允许用户将卡片保持在易于使用和方便的位置。此外，手表可以用于允许用户专门授权或覆盖金融交易，以及查看和/或存储关于金融交易的信息以及诸如警报和日历的常规功能。如果需要，本发明的手表还可以在公司环境中提供访问控制或识别。

8. 发明授权

US07646301B2 Auditable security for cargo containers and other repositories 有权
标题翻译：货物集装箱和其他仓库的可靠安全
公开(公告)号：US07646301B2
公开(公告)日：2010-01-12
申请号：US11275029
申请日：2005-12-03
申请人： Paul Waterhouse , Jason August , John K Stevens
发明人： Paul Waterhouse , Jason August , John K Stevens
IPC分类号： G08B13/14
CPC分类号： G06K17/00 , G06K2017/0045 , G06K2017/0077 , G08B13/1895 , G08B13/2402
摘要： This invention relates to a method and system for authenticating and for preventing alteration of histories of events occurring within at least one repository (e.g. a cargo container, fixed warehouse or a movable vehicle) for objects (e.g. auto parts, pharmaceutical materials, computer parts, laptops, etc.) held for a period of time, where the repository is exposed to an unauthorized intrusion therewithin (and potential theft of said objects therefrom and potential insertion of dangerous items therewithin). The events include changes in environmental conditions (e.g. light levels, infrared levels, temperature, air pressure, etc) which indicate an unauthorized intrusion.
摘要翻译：本发明涉及一种用于认证和防止在物品（例如汽车零部件，药物材料，计算机部件等）的至少一个仓库（例如货物集装箱，固定仓库或可移动车辆）内发生的事件的历史变更的方法和系统，笔记本电脑等）持有一段时间，其中储存库暴露于其中未经授权的侵入（并且潜在地窃取所述物品并潜在地在其中插入危险物品）。这些事件包括指示未经授权的入侵的环境条件（例如，光照水平，红外线水平，温度，空气压力等）的变化。

9. 发明申请

US20090195389A1 Networked Tags for Tracking Files and Documents 有权
标题翻译：用于跟踪文件和文档的联网标签
公开(公告)号：US20090195389A1
公开(公告)日：2009-08-06
申请号：US12036047
申请日：2008-02-22
申请人： Jason August , Robert Griffin , John K. Stevens , Paul Waterhouse
发明人： Jason August , Robert Griffin , John K. Stevens , Paul Waterhouse
IPC分类号： G08B13/14
CPC分类号： G06Q10/08 , G06K2017/0045
摘要： A system for tracking files and documents includes: a plurality of programmable networked tags operable at a low radio frequency not exceeding one megahertz; a plurality of files with the programmable networked tag affixed to each file; a container for the plurality of files; a base station configured for transmission of signals to and from the plurality of programmable networked tags; and a computer in communication with the base station. The computer includes software for enabling real-time transmissions and a graphical user interface for enabling a user to read and write data to be transmitted to and from the plurality of programmable networked tags.
摘要翻译：用于跟踪文件和文档的系统包括：可操作的频率不超过1兆赫的多个可编程网络标签; 多个文件，可编程网络标签贴在每个文件上; 用于所述多个文件的容器; 基站，被配置为向多个可编程网络标签传输信号; 以及与基站通信的计算机。计算机包括用于实现实时传输的软件和图形用户界面，用于使用户能够读取和写入要发送到多个可编程网络标签的数据。

10. 发明申请

US20090045965A1 Networked RF tag for tracking baggage 有权
公开(公告)号：US20090045965A1
公开(公告)日：2009-02-19
申请号：US11677035
申请日：2007-02-20
申请人： Paul Waterhouse , Christopher W. Verge , Michael J. Vandenberg , Kenneth Truong , John K. Stevens , M. Jason August
发明人： Paul Waterhouse , Christopher W. Verge , Michael J. Vandenberg , Kenneth Truong , John K. Stevens , M. Jason August
IPC分类号： G08B23/00
CPC分类号： G06K17/00 , G06K19/077 , G06K2017/0045
摘要： The invention disclosed provides a method, system, and associated tag for detection and tracking of inanimate and animate objects. The novel method broadly comprises the steps of: a) attaching a low radio frequency detection tag to each of the objects, each tag comprising a tag antenna operable at a low radio frequency not exceeding 1 megahertz (preferably not exceeding 300 kilohertz), a transceiver operatively connected to the tag's antenna, the transceiver being operable to transmit and receive data signals at the low radio frequency, a data storage device operable to store data comprising identification data for identifying said detection tag, a programmed data processor operable to process data received from the transceiver and the data storage device and to send data to cause the transceiver to emit an identification signal based upon the identification data stored in said data storage device, and an energy source for activating the tag's transceiver and data processor; b) storing, in the data storage device of each tag, shipping data selected from object description data, address-of-origin data, destination address data, object vulnerability data, and object status data; c) commingling the objects in a repository selected from a warehouse and a truck, the repository being provided with at least one large loop field antenna operable at said low radio frequency; the field antenna being disposed at a distance from each object that permits effective communication therewith at the low radio frequency, d) reading the identification data and shipping data from the transceiver of each tag by interrogating all tags commingled in said repository with data signals, such as specific IP addresses or other identification codes, via said field antenna; and e) transmitting the identification data and shipping data from each tag to a central data processor to provide a tally of the objects in said repository.

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