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1. 发明授权

US06429010B1 DNA encoding the human synapsin III gene and uses thereof 失效
标题翻译：编码人突触蛋白III基因的DNA及其用途
公开(公告)号：US06429010B1
公开(公告)日：2002-08-06
申请号：US09129668
申请日：1998-08-05
申请人： Paul Greengard , Barbara Porton , Hung-Teh Kao
发明人： Paul Greengard , Barbara Porton , Hung-Teh Kao
IPC分类号： C12N1500
CPC分类号： C07K14/47 , A61K38/00
摘要： A new synapsin protein, designated synapsin III, its amino acid sequence, and its human gene have been isolated and characterized. Furthermore, isoforms of synapsin III, e.g., synapsin IIIa, IIIb and IIIc, and have isolated and characterized, and cDNA encoding these isoforms has also been isolated and characterized. The synapsin III gene is located on human chromosome 22, in the vicinity of a region previously identified as a susceptibility locus for schizophrenia. The information and experimental tools provided by this discovery can be used to generate new therapeutic agents or diagnostic assays for this new protein, its associated mRNA or its associated genomic DNA. Due to its role in neurotransmission and synaptogenesis, isoforms of synapsin III are associated with the symptoms of psychiatric diseases, especially schizophrenia.
摘要翻译：已经分离并表征了新的突触蛋白，命名为突触蛋白III，其氨基酸序列及其人基因。此外，已经分离并表征了突触蛋白III的同种型，例如突触蛋白IIIa，IIIb和IIIc，并且已经分离和表征，以及编码这些同种型的cDNA。突触素III基因位于人类染色体22上，在先前鉴定为精神分裂症易感基因座的区域附近。该发现提供的信息和实验工具可用于为该新蛋白，其相关mRNA或其相关基因组DNA产生新的治疗剂或诊断测定。由于其在神经传递和突触发生中的作用，突触素III的同种型与精神疾病，特别是精神分裂症的症状有关。

2. 发明授权

US6040168A DNA encoding the human synapsin III gene and uses thereof 失效
标题翻译：编码人突触蛋白III基因的DNA及其用途
公开(公告)号：US6040168A
公开(公告)日：2000-03-21
申请号：US906865
申请日：1997-08-06
申请人： Paul Greengard , Barbara Porton , Hung-Teh Kao
发明人： Paul Greengard , Barbara Porton , Hung-Teh Kao
IPC分类号： A61K38/00 , A61P25/18 , C07K14/47 , C12N1/21 , C12N15/12 , C12N15/85 , C07H21/04 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： A new synapsin protein, designated synapsin III, its amino acid sequence, and its human gene have been isolated and characterized. The synapsin III gene is located on human chromosome 22, in the vicinity of a region previously identified as a susceptibility locus for schizophrenia. The information and experimental tools provided by this discovery can be used to generate new therapeutic agents or diagnostic assays for this new protein, its associated mRNA or its associated genomic DNA. Due to its role in neurotransmission and synaptogenesis, this synapsin III is associated with the symptoms of psychiatric diseases, especially schizophrenia.
摘要翻译：已经分离并表征了新的突触蛋白，命名为突触蛋白III，其氨基酸序列及其人基因。突触素III基因位于人类染色体22上，在先前鉴定为精神分裂症易感基因座的区域附近。该发现提供的信息和实验工具可用于为该新蛋白，其相关mRNA或其相关基因组DNA产生新的治疗剂或诊断测定。由于其在神经传递和突触发生中的作用，这种突触素III与精神疾病，特别是精神分裂症的症状有关。

3. 发明授权

US06383762B1 Methods of obtaining compounds that interact with a human serotonin (5-HT2) receptor 失效
标题翻译：获得与人血清素（5-HT2）受体相互作用的化合物的方法
公开(公告)号：US06383762B1
公开(公告)日：2002-05-07
申请号：US09145864
申请日：1998-09-02
申请人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
发明人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： C07K14/70571
摘要： The present invention provides a method of obtaining a composition which comprises determining whether a chemical compound binds to a human 5-HT2 receptor expressed on the surface of a mammalian cell transfected with a vector adapted for expressing the receptor in the cell, and if the compound binds to the receptor, admixing the compound with a carrier. The present invention further provides a method of obtaining a composition which comprises determining whether a chemical compound binds to and activates or binds to and inhibits activation of a human 5-HT2 receptor expressed on the surface of a mammalian cell, wherein the human 5-HT2 receptor is expressed on the surface of a mammalian cell transfected with a vector adapted for expressing the receptor in the cell, and if the compound binds to and activates or binds to and inhibits activation of the receptor, admixing the compound with a carrier.
摘要翻译：本发明提供一种获得组合物的方法，其包括确定化学化合物是否结合在用适于在细胞中表达受体的载体转染的哺乳动物细胞表面上表达的人5-HT2受体，如果化合物与受体结合，将化合物与载体混合。本发明还提供一种获得组合物的方法，其包括确定化学化合物是否结合并激活或结合并抑制在哺乳动物细胞表面上表达的人5-HT 2受体的活化，其中人5-HT2 受体在用适于在细胞中表达受体的载体转染的哺乳动物细胞的表面上表达，并且如果化合物结合并激活或结合并抑制受体活化，则将化合物与载体混合。

4. 发明申请

US20120252698A1 ISOLATED AUSTRALIAN CORAL REEF FLUORESCENT PROTEINS AND CELL-BASED KINASE OR PHOSPHATASE PLATFORMS FOR CANCER DRUG DEVELOPMENT 有权
标题翻译：分离的澳大利亚CORAL REEF荧光蛋白和基于细胞的激酶或磷酸化酶平台用于癌症药物开发
公开(公告)号：US20120252698A1
公开(公告)日：2012-10-04
申请号：US13496574
申请日：2010-09-16
申请人： David Gruber , Hung-Teh Kao , Vincent Pieribone
发明人： David Gruber , Hung-Teh Kao , Vincent Pieribone
IPC分类号： G01N21/64 , C12N15/63 , C12N1/21 , C07K19/00 , C12N5/10 , C07K14/00 , C12N15/11 , C40B30/08 , C12N1/15
CPC分类号： C07K14/43504 , C07K2319/60 , C12Q1/485 , G01N2333/43504
摘要： The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are also provided. For example, methods to detect protein-protein interactions, to develop novel fluorescent reagents, to monitor cellular events, as well as cell-based methods for screening for kinase or phosphatase inhibitors, are set forth. Kits to carry out the methods of the invention are also taught.
摘要翻译：本发明涉及新型分离的荧光蛋白，其变体，以及编码该荧光蛋白的多核苷酸。还提供了制备和使用多肽和多核苷酸的方法。例如，阐述了检测蛋白质 - 蛋白质相互作用，开发新型荧光试剂，监测细胞事件以及用于筛选激酶或磷酸酶抑制剂的基于细胞的方法的方法。还教导了实施本发明方法的试剂盒。

5. 发明授权

US5661024A DNA encoding a human serotonic (5-HT.sub.2) receptor and uses thereof 失效
标题翻译：编码人血清素（5-HT2）受体的DNA及其用途
公开(公告)号：US5661024A
公开(公告)日：1997-08-26
申请号：US347591
申请日：1994-11-30
申请人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
发明人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
IPC分类号： C07K14/705 , C12N5/00 , C07H21/02 , C12N7/00 , C12N15/00
CPC分类号： C07K14/70571
摘要： The present invention provides an isolated nucleic acid molecule encoding an 5-HT.sub.2 receptor, and an isolated protein which is a human 5-HT.sub.2 receptor.The invention also provides vectors comprising DNA molecules encoding a human 5-HT.sub.2 receptor, and vectors adapted for expression of the 5-HT.sub.2 receptor in bacterial, yeast, or mammalian cells.In addition, the invention provides a DNA probe useful for detecting nucleic acid encoding the 5-HT.sub.2 receptor, a method for determining whether a ligand which is not known to be capable of binding to the 5-HT.sub.2 receptor can bind to the 5-HT.sub.2 receptor, a method for detecting the presence of 5-HT.sub.2 receptor on the surface of a cell, and a method of screening drugs to identify drugs which specifically interact with, and bind to, the 5-HT.sub.2 receptor.The invention herein also concerns an antibody directed to the human 5-HT.sub.2 receptor, such as a monoclonal antibody directed to an epitope of the 5-HT.sub.2 receptor present on the surface of a cell and having an amino acid sequence included within the amino acid sequence shown in FIG. 2.
摘要翻译：本发明提供编码5-HT2受体的分离的核酸分子和作为人5-HT 2受体的分离的蛋白质。本发明还提供了包含编码人5-HT2受体的DNA分子的载体和适于在细菌，酵母或哺乳动物细胞中表达5-HT2受体的载体。此外，本发明提供了可用于检测编码5-HT2受体的核酸的DNA探针，确定未知能够结合5-HT2受体的配体是否可以结合5-HT2受体的方法受体，用于检测细胞表面上5-HT2受体的存在的方法，以及筛选药物以鉴定与5-HT2受体特异性相互作用并结合的药物的方法。本发明还涉及针对人类5-HT2受体的抗体，例如针对细胞表面上存在的5-HT2受体的表位的单克隆抗体，并具有包含在氨基酸序列内的氨基酸序列如图1所示。 2。

6. 发明授权

US08709981B2 Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development 有权
标题翻译：孤立的澳大利亚珊瑚礁荧光蛋白和用于癌症药物开发的基于细胞的激酶或磷酸酶平台
公开(公告)号：US08709981B2
公开(公告)日：2014-04-29
申请号：US13496574
申请日：2010-09-16
申请人： David Gruber , Hung-Teh Kao , Vincent Pieribone
发明人： David Gruber , Hung-Teh Kao , Vincent Pieribone
IPC分类号： C40B40/10
CPC分类号： C07K14/43504 , C07K2319/60 , C12Q1/485 , G01N2333/43504
摘要： The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are also provided. For example, methods to detect protein-protein interactions, to develop novel fluorescent reagents, to monitor cellular events, as well as cell-based methods for screening for kinase or phosphatase inhibitors, are set forth. Kits to carry out the methods of the invention are also taught.
摘要翻译：本发明涉及新型分离的荧光蛋白，其变体，以及编码该荧光蛋白的多核苷酸。还提供了制备和使用多肽和多核苷酸的方法。例如，阐述了检测蛋白质 - 蛋白质相互作用，开发新型荧光试剂，监测细胞事件以及用于筛选激酶或磷酸酶抑制剂的基于细胞的方法的方法。还教导了实施本发明方法的试剂盒。

7. 发明授权

US5885785A DNA encoding a human serotonin (5-HT2) receptor and uses thereof 失效
标题翻译：编码人5-羟色胺（5-HT2）受体的DNA及其用途
公开(公告)号：US5885785A
公开(公告)日：1999-03-23
申请号：US613044
申请日：1996-03-08
申请人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
发明人： Hung-Teh Kao , Paul R. Hartig , Theresa Branchek
IPC分类号： C07K14/705 , G01N33/566 , C12N5/16 , C12N15/12
CPC分类号： C07K14/70571
摘要： The present invention provides an isolated nucleic acid molecule encoding a 5-HT.sub.2 receptor, and an isolated protein which is a human 5-HT.sub.2 receptor. The invention also provides vectors comprising DNA molecules encoding a human 5-HT.sub.2 receptor, and vectors adapted for expression of the 5-HT.sub.2 receptor in bacterial, yeast, or mammalian cells. In addition, the invention provides a DNA probe useful for detecting nucleic acid encoding the 5-HT.sub.2 receptor, a method for determining whether a ligand which is not known to be capable of binding to the 5-HT.sub.2 receptor can bind to the 5-HT.sub.2 receptor, a method for detecting the presence of 5-HT.sub.2 receptor on the surface of a cell, and a method of screening drugs to identify drugs which specifically interact with, and bind to, the 5-HT.sub.2 receptor. The invention herein also concerns an antibody directed to the human 5-HT.sub.2 receptor, such as a monoclonal antibody directed to an epitope of the 5-HT.sub.2 receptor present on the surface of a cell and having an amino acid sequence included within the amino acid sequence shown in FIGS. 2A-2G.
摘要翻译：本发明提供编码5-HT2受体的分离的核酸分子和作为人5-HT 2受体的分离的蛋白质。本发明还提供了包含编码人5-HT2受体的DNA分子的载体和适于在细菌，酵母或哺乳动物细胞中表达5-HT2受体的载体。另外，本发明提供了可用于检测编码5-HT2受体的核酸的DNA探针，一种不知道能够结合5-HT2受体的配体是否可以结合5-HT2受体的方法受体，用于检测细胞表面上5-HT2受体的存在的方法，以及筛选药物以鉴定与5-HT2受体特异性相互作用并结合的药物的方法。本发明还涉及针对人类5-HT2受体的抗体，例如针对细胞表面上存在的5-HT2受体的表位的单克隆抗体，并具有包含在氨基酸序列内的氨基酸序列如图1和2所示。 2A-2G。

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