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1. 发明授权

US10441194B2 Ingestible event marker systems 有权
公开(公告)号：US10441194B2
公开(公告)日：2019-10-15
申请号：US14341636
申请日：2014-07-25
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B5/00 , H01M6/00 , H04B5/00 , A61B5/07 , A61J3/00 , H01Q1/27 , A61B5/145 , G01N27/327 , G01N27/00 , H01Q1/00 , A61B5/0205
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.

2. 发明授权

US10207093B2 Miniature ingestible device 有权
公开(公告)号：US10207093B2
公开(公告)日：2019-02-19
申请号：US15429128
申请日：2017-02-09
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , Hooman Hafezi , Raymond Schmidt
IPC分类号： A61M31/00 , A61J3/07 , A61K9/48
摘要： The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

3. 发明申请

US20170290513A1 INGESTIBLE EVENT MARKER DATA FRAMEWORK 审中-公开
公开(公告)号：US20170290513A1
公开(公告)日：2017-10-12
申请号：US15498396
申请日：2017-04-26
申请人： Proteus Digital Health, Inc.
发明人： David O'Reilly , Erika Karplus , Andrew Thompson , George Savage , Mark Zdeblick , Timothy Robertson , Lawrence Arne , Yahar Behzadi , Gregory Moon , Patrick Beaulieu
IPC分类号： A61B5/00 , A61B5/07 , G06F19/00
CPC分类号： A61B5/07 , A61B5/0022 , A61B5/021 , G06F19/3418 , G06F19/3456
摘要： The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). The functions and utilities include data and/or information having an aspect of data derived from, collected by, aggregated by, or otherwise associated with, an ingestion event.

4. 发明授权

US09433371B2 In-body device with virtual dipole signal amplification 有权
公开(公告)号：US09433371B2
公开(公告)日：2016-09-06
申请号：US14161582
申请日：2014-01-22
申请人： Proteus Digital Health, Inc.
发明人： Hooman Hafezi , Benedict Costello , Timothy Robertson , Maria Casillas Holen
IPC分类号： A61B5/00 , H01Q1/00 , H04B13/00 , A61B5/07 , A61B5/145 , H01Q1/22 , H01Q1/27 , H01Q9/16
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/0028 , A61B5/028 , A61B5/14539 , A61B5/14546 , A61B2562/02 , A61B2562/162 , A61B2562/182 , H01Q1/2208 , H01Q1/273 , H01Q9/16 , H04B13/005 , Y10S128/902
摘要： Virtual dipole signal amplification for in-body devices, such as implantable and ingestible devices, is provided. Aspects of the in-body deployable antennas of the invention include antennas configured to go from a first configuration to a second configuration following placement in a living body, e.g., via ingestion or implantation. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

5. 发明授权

US09271897B2 Techniques for manufacturing ingestible event markers comprising an ingestible component 有权
标题翻译：用于制造包含可摄入组分的可摄入事件标记物的技术
公开(公告)号：US09271897B2
公开(公告)日：2016-03-01
申请号：US14415937
申请日：2013-07-22
申请人： Proteus Digital Health, Inc.
发明人： Benedict Costello , Timothy Robertson , Patricia Johnson , Robert Duck , Richard Huang , Rod Nicholas , Brad Cozad , Hooman Hafezi , Kurt Scheinpflug , Zahedeh Hatamkhany
IPC分类号： A61B5/07 , A61J3/10 , B65B69/00 , B32B37/15 , B32B38/00 , B32B38/10 , B30B11/34 , A61B5/145
CPC分类号： A61J3/10 , A61B5/07 , A61B5/14539 , A61J2200/70 , B30B11/34 , B32B37/15 , B32B38/0012 , B32B38/10 , B32B2457/00 , B65B69/00
摘要： Method and systems for manufacturing a tablet comprising an electronic device are disclosed. In one method, a powdered material is provided into a die cavity of a tablet press and an electronic device is dispensed from a tape-and-reel carrier tape operatively coupled to the tablet press into the die cavity. The powdered material and the electronic device are compressing to form a tablet. A system comprises a tablet press comprising a die cavity for receiving a powdered material and an electronic device therein, an upper punch, and a lower punch. The upper and lower punches are operative to form the powdered material and the electronic device into a tablet. A tape-and-reel carrier tape is operatively coupled to the tablet press, where the carrier tape is configured for holding the electronic device. A transfer mechanism is used to transfer the electronic device from the tape carrier to the die cavity.
摘要翻译：公开了用于制造包括电子设备的片剂的方法和系统。在一种方法中，将粉末材料提供到压片机的模腔中，并且电子装置从可操作地连接到压片机的模具腔中的带盘式载带分配。粉末材料和电子设备被压缩以形成片剂。一种系统包括压片机，包括用于接收粉末材料的模腔和其中的电子装置，上冲头和下冲头。上冲头和下冲头可操作以将粉末材料和电子装置形成片剂。带式载带可操作地耦合到压片机，其中载带被配置用于保持电子装置。传送机构用于将电子设备从带载体传送到模腔。

6. 发明授权

US09258035B2 Multi-mode communication ingestible event markers and systems, and methods of using the same 有权
标题翻译：多模式通信可摄取事件标记和系统及其使用方法
公开(公告)号：US09258035B2
公开(公告)日：2016-02-09
申请号：US14699809
申请日：2015-04-29
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , Mark Zdeblick
IPC分类号： H04Q5/22 , H04B5/00 , A61B5/00 , A61B5/07 , G06K7/10
CPC分类号： H04B5/0062 , A61B5/0031 , A61B5/073 , A61B5/4833 , A61B5/4839 , A61B5/4848 , A61B5/6861 , A61B2562/08 , A61B2562/162 , G06K7/10297
摘要： A device including an integrated circuit, a partial power source, including first and second materials associated with the integrated circuit is disclosed. The first and second materials are configured to provide a voltage potential difference when in contact with a conductive fluid to power up the device. A signal amplification element secured around the integrated circuit relative to the first and second materials is configured to facilitate extension of a current flow path between the first and second materials. A modulator is configured to control conductance between the first and second materials to generate a detectable signal that is partially defined by the current flow extending through the conductive fluid. A communication module is coupled to the partial power source and is configured to communicate with a receiver and an antenna electrically coupled to the communication module, which uses the antenna to communicate with the receiver.
摘要翻译：公开了一种包括集成电路，部分电源的装置，包括与集成电路相关联的第一和第二材料。第一和第二材料配置成当与导电流体接触时提供电压电位差，以使设备加电。围绕集成电路相对于第一和第二材料固定的信号放大元件构造成有助于在第一和第二材料之间扩展电流流动路径。调制器被配置为控制第一和第二材料之间的电导，以产生由延伸穿过导电流体的电流部分地限定的可检测信号。通信模块耦合到部分电源，并且被配置为与接收器和电连接到通信模块的天线进行通信，所述通信模块使用天线与接收机进行通信。

7. 发明申请

US20150365115A1 ACTIVE SIGNAL PROCESSING PERSONAL HEALTH SIGNAL RECEIVERS 有权
标题翻译：主动信号处理个人健康信号接收器
公开(公告)号：US20150365115A1
公开(公告)日：2015-12-17
申请号：US14735915
申请日：2015-06-10
申请人： Proteus Digital Health, Inc.
发明人： Lawrence Arne , Kit Yee Au-Yeung , Kenneth C. Crandall , Timothy Robertson
IPC分类号： H04B1/10 , H04B13/00 , H04L27/22 , H04B1/12 , H04L27/152
CPC分类号： H04B1/1027 , A61B5/0028 , A61B5/0031 , A61B5/7257 , A61B2560/0209 , G06F19/00 , H04B1/123 , H04B13/005 , H04L1/0036 , H04L1/0045 , H04L27/152 , H04L27/22 , H04L27/2271 , H04L27/2273
摘要： The invention provides a receiver associated with a body, e.g., located inside or within close proximity to a body, configured to receive and decode a signal from an in vivo transmitter which located inside the body. Signal receivers of the invention provide for accurate signal decoding of a low-level signal, even in the presence of significant noise, using a small-scale chip, e.g., where the chip consumes very low power. Also provided are systems that include the receivers, as well as methods of using the same.
摘要翻译：本发明提供一种与身体相关联的接收器，例如位于身体内部或紧邻身体，被配置为接收和解码来自位于体内的体内发射器的信号。本发明的信号接收机即使在存在显着噪声的情况下也能使用小尺寸芯片（例如芯片消耗非常低的功率）来提供对低电平信号的精确信号解码。还提供了包括接收器的系统，以及使用它们的方法。

8. 发明申请

US20150051465A1 Ingestible Event Marker Systems 审中-公开
标题翻译：可食事件标记系统
公开(公告)号：US20150051465A1
公开(公告)日：2015-02-19
申请号：US14341636
申请日：2014-07-25
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , George Savage , Mark Zdeblick , Yashar Behzadi , Benedict Costello , Jeremy Frank , Hooman Hafezi , Tariq Haniff , David O'Reilly
IPC分类号： A61B5/07 , G01N27/327 , A61B5/145
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译：提供了包含可摄入事件标记（即IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施方案包括标识符，其可以或可以不存在于生理上可接受的载体中。标识符的特征在于与身体的目标内部生理部位（例如消化道内部靶位点）接触时被激活。个人信号接收器被配置为与身体内部或身体上的生理位置相关联并且接收IEM的信号。在使用期间，IEM广播由个人信号接收机接收的信号。

9. 发明申请

US20180279910A1 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
公开(公告)号：US20180279910A1
公开(公告)日：2018-10-04
申请号：US15880085
申请日：2018-01-25
申请人： Proteus Digital Health, Inc.
发明人： Marc Jensen , Robert Leichner , Patrick Beaulieu , Kit Yee Au-Yeung , Lawrence Arne , Mark Zdeblick , Andrew Thompson , George Savage , Timothy Robertson , Yashar Behzadi
IPC分类号： A61B5/07 , G16H10/60 , G06F19/00 , H04B13/00 , A61B5/00 , G16H50/20 , G16H20/00 , G16H20/10 , A61B5/021 , A61B5/11 , A61B5/024
摘要： A system including a sensor, a mobile device, and a computer system is disclosed. The sensor is configured to detect physiologic data from the body of the patient. The mobile device includes a patient data input device. The computer system, communicatively coupled to the mobile device, includes a patient record indicating: patient data comprising a plurality of patient activities, and detected physiological data received from the sensor via the mobile device. The computer system is configured to identify an unhealthy physiological data value from the detected physiological data of the patient record, correlate the unhealthy physiological data value to a patient activity of the patient data, select a therapeutic recommendation to address the unhealthy physiological data value, and transmit the selected therapeutic recommendation to the patient, via the mobile device, at a future time associated with the patient activity correlated to the unhealthy physiological data value.

10. 发明申请

US20180096547A1 PERSONAL AUTHENTICATION APPARATUS SYSTEM AND METHOD 审中-公开
公开(公告)号：US20180096547A1
公开(公告)日：2018-04-05
申请号：US15592423
申请日：2017-05-11
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , George Savage , Benedict Costello , David O'Reilly
IPC分类号： G07C9/00 , A61B5/00 , A61B5/0404
CPC分类号： G07C9/00158 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/117 , A61B5/145 , A61B5/14532 , A61B5/6898 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , G06F21/34 , G06K9/00885 , G06K2009/00939 , H04B13/005
摘要： A target authentication device includes an electrode to detect an electrical signal associated with a user of the device. The electrical signal represents an authentication code for the device. An authentication receiver module is coupled to the electrode. The module receives the electrical signal from the electrode and determines whether the electrical signal matches a predetermined criterion to authenticate the identity of the user based on the electrical signal. An authentication module is also disclosed. The authentication module includes one electrode to couple an electrical signal associated with a user to a user of a target authentication device, the electrical signal represents an authentication code for the device. An authentication transmission module is coupled to the electrode. The authentication transmission module transmits the electrical signal from the electrode. A method of authenticating the identity of a user of a target authentication device also is disclosed.

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