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1. 发明授权

US06261798B1 Methods for producing [S,S]-ethylenediamine-N,N′-disuccinate 有权
标题翻译： [S，S] - 乙二胺-N，N'-二琥珀酸盐的制备方法
公开(公告)号：US06261798B1
公开(公告)日：2001-07-17
申请号：US09582171
申请日：2000-06-22
申请人： Osamu Kato , Makoto Kaneko , Takakazu Endo
发明人： Osamu Kato , Makoto Kaneko , Takakazu Endo
IPC分类号： C12P1302
CPC分类号： C12P13/02
摘要： The present invention relates to a method of producing [S,S]-ethylenediamine-N,N′-disuccinate wherein a microorganism having malate isomerase activity or matter processed therefrom and a microorganism having ethylenediamine-N,N′-disuccinate ethylenediamine lyase activity or matter processed therefrom are allowed to act on a substrate solution containing maleic acid, maleic anhydride, or a maleic acid salt, and ethylenediamine, in the presence of at least one metal ion selected from the group consisting of alkaline earth metals, iron, zinc, copper, nickel, aluminum, titanium and manganese. The present invention enables to accumulate [S,S]-ethylenediamine-N,N′-disuccinate in a higher yield and at a high concentration within a reaction system using maleic acid as a raw material.
摘要翻译：本发明涉及一种生产[S，S] - 乙二胺-N，N'-二琥珀酸盐的方法，其中具有苹果酸异构酶活性的微生物或由其处理的物质和具有乙二胺-N，N'-二琥珀酸乙二胺裂解酶活性的微生物或在其中处理的物质可以在至少一种选自碱土金属，铁，锌，锌等的金属离子的存在下作用于含有马来酸，马来酸酐或马来酸盐和乙二胺的底物溶液，铜，镍，铝，钛和锰。本发明能够以马来酸为原料，在反应体系内以更高的收率和高浓度积累[S，S] - 乙二胺-N，N'-二琥珀酸盐。

2. 发明授权

US6103508A Method for removing fumarase activity, microorganisms obtainable by the method, and production of optically active aminopolycarboxylic acids using the microorganisms 有权
标题翻译：消除富马酸酶活性的方法，通过该方法获得的微生物和使用微生物制备光学活性氨基多羧酸的方法
公开(公告)号：US6103508A
公开(公告)日：2000-08-15
申请号：US179966
申请日：1998-10-28
申请人： Mami Kato , Makoto Kaneko , Takakazu Endo
发明人： Mami Kato , Makoto Kaneko , Takakazu Endo
IPC分类号： C12N1/38 , C12N9/00 , C12N9/99 , C12P13/04 , C12P13/00 , C12N9/04
CPC分类号： C12N9/93 , C12N1/38 , C12N9/99 , C12P13/04 , Y10S435/80 , Y10S435/82 , Y10S435/822 , Y10S435/83 , Y10S435/848 , Y10S435/874
摘要： This invention relates to a method for removing fumarase activity from a microorganism or processed product thereof having ethylenediamine-N,N'-disuccinic acid ethylenediamine lyase activity, which includes treating the microorganism or processed product thereof with an aqueous alkaline solution at a pH of 8.0 to 10.5 in the presence of at least one salt with a concentration of 5 mM to 1000 mM. The salt is preferably selected from the group consisting of sodium, potassium, ammonium and C.sub.2-6 alkanediamine salts of boric acid, phosphoric acid, hydrochloric acid, sulfuric acid, acetic acid, oxalic acid, fumaric acid, maleic acid and ethylenediamine-N,N'-disuccinic acid, and mixtures thereof. This invention also relates to a microorganism or processed product thereof having reduced fumarase activity obtainable by the above described method, and to a method for producing an optically active aminopolycarboxylic acid from fumaric acid and a compound having amino group in the presence of the microorganim or processed product thereof having reduced fumarase activity as a catalyst.
摘要翻译：本发明涉及一种从具有乙二胺-N，N'-二琥珀酸乙二胺裂解酶活性的微生物或其加工产物中除去富马酸酯活性的方法，其包括用pH为8.0的碱性水溶液处理微生物或其加工产物在存在至少一种浓度为5mM至1000mM的盐的情况下为10.5。该盐优选选自硼酸，磷酸，盐酸，硫酸，乙酸，草酸，富马酸，马来酸和乙二胺-N的钠，钾，铵和C 2-6烷二胺盐， N'-二琥珀酸，及其混合物。本发明还涉及通过上述方法获得的具有降低的延胡索酸酶活性的微生物或其加工产物，以及在微生物存在下由富马酸和具有氨基的化合物制备光学活性氨基多羧酸的方法或加工其产物具有降低的富马酸酯活性作为催化剂。

3. 发明授权

US5981238A Process for producing optically active aminopolycarboxylic acid 失效
标题翻译：光学活性氨基多羧酸的制备方法
公开(公告)号：US5981238A
公开(公告)日：1999-11-09
申请号：US841663
申请日：1997-04-30
申请人： Makoto Kaneko , Yoshihiro Hashimoto , Takakazu Endo , Mami Kato , Wataru Mizunashi
发明人： Makoto Kaneko , Yoshihiro Hashimoto , Takakazu Endo , Mami Kato , Wataru Mizunashi
IPC分类号： C12P13/04 , C12P13/20
CPC分类号： C12P13/04
摘要： A process for producing an optically active aminopolycarboxylic acid, such as S,S-ethylenediamine-N,N'-disuccinic acid, from a mixture of a diamine, such as ethylenediamine, with fumaric acid using a microorganism having a lyase activity, wherein at least one metal ion selected from the group consisting of an alkaline earth metal, iron, zinc, copper, nickel, aluminum, titanium and manganese is added to the reaction system. According to this process, aminopolycarboxylic acids, such as S,S-ethylenediamine-N,N'-disuccinic acid, or metal complexes thereof, can be appropriately and efficiently produced while improving the reaction yield.
摘要翻译：使用具有裂解酶活性的微生物从二胺（例如乙二胺）与富马酸的混合物制备光学活性氨基多羧酸如S，S-乙二胺-N，N'-二琥珀酸的方法，其中在将至少一种选自碱土金属，铁，锌，铜，镍，铝，钛和锰的金属离子加入到反应体系中。根据该方法，可以在提高反应收率的同时，适当且有效地制造氨基多元羧酸，如S，S-乙二胺-N，N'-二琥珀酸或其金属络合物。

4. 发明授权

US6136573A Process for producing alkali metal [S,S]-ethylenediamine-n,n'-disuccinates 有权
标题翻译：制备碱金属[S，S] - 乙二胺-N，N'-二琥珀酸盐的方法
公开(公告)号：US6136573A
公开(公告)日：2000-10-24
申请号：US446195
申请日：1999-12-17
申请人： Makoto Kaneko , Takakazu Endo , Toshihiko Fukuda , Mami Kato
发明人： Makoto Kaneko , Takakazu Endo , Toshihiko Fukuda , Mami Kato
IPC分类号： C12P13/00
CPC分类号： C12P13/001
摘要： A process for producing an [S,S]-ethylenediamine-N,N'-disuccinic acid alkali metal salt which comprises reacting fumaric acid with ethylenediamine in an aqueous medium in the presence of an ion of at least one metal selected from the group consisting of alkaline earth metals and transition metals by the action of ethylenediamine-disuccinic acid ethylenediamine lyase of microorganism origin, adding an alkali hydroxide to a reaction product mixture thereby to separate and recover the metal ion as an insoluble precipitate, and obtaining an [S,S]-ethylenediamine-N,N'-disuccinic acid alkali metal salt.
摘要翻译： PCT No.PCT / JP99 / 02003 Sec。 371 1999年12月17日第 102（e）1999年12月17日PCT PCT 1999年4月15日PCT公布。 WO99 / 54492 PCT出版物日期1999年10月28日制备[S，S] - 乙二胺-N，N'-二琥珀酸碱金属盐的方法，其包括在水性介质中在至少一种金属离子存在下使富马酸与乙二胺反应选自微生物来源的乙二胺 - 二琥珀酸乙二胺裂解酶的作用，由碱土金属和过渡金属组成的组中选择，向反应产物混合物中加入碱金属氢氧化物，从而将金属离子分离并回收为不溶性沉淀，得到 [S，S] - 乙二胺-N，N'-二琥珀酸碱金属盐。

5. 发明授权

US07125692B2 Process for producing monomer 有权
标题翻译：制备单体的方法
公开(公告)号：US07125692B2
公开(公告)日：2006-10-24
申请号：US10488253
申请日：2002-09-11
申请人： Eiji Satou , Makoto Kaneko , Naoshi Murata
发明人： Eiji Satou , Makoto Kaneko , Naoshi Murata
IPC分类号： C07P17/04 , C07P17/06
CPC分类号： C12P41/004 , C12P17/02 , C12P17/04 , C12P17/06
摘要： A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2, R3 and R4 each independently represent hydrogen or a substituent; and X, Y and Z each independently represent a direct bond or an optionally substituted alkylene group with 1 to 3 chain members, the process comprising carrying out esterification or transesterification in the presence of a biocatalyst.
摘要翻译：由以下通式1表示的用于制备抗蚀剂用单体的方法：其中R 1表示氢或任选取代的烷基; R 2，R 3和R 4各自独立地表示氢或取代基; 并且X，Y和Z各自独立地表示直链键或具有1至3个链成员的任选取代的亚烷基，该方法包括在生物催化剂存在下进行酯化或酯交换。

6. 发明授权

US06872141B2 Crawler driving device and game device 失效
标题翻译：履带式驾驶装置和游戏装置
公开(公告)号：US06872141B2
公开(公告)日：2005-03-29
申请号：US09959124
申请日：2001-02-23
申请人： Makoto Kaneko
发明人： Makoto Kaneko
IPC分类号： A63F9/14 , A63H18/14 , A63H23/02
CPC分类号： A63F9/143 , A63F2250/0414 , A63H18/14 , A63H23/02
摘要： A crawler driving apparatus and a game apparatus in which a storage battery mounted on a crawler is charged with electricity in a state that the crawler is adjacent to or not separated from a runway surface. In the crawler driving apparatus, the crawler 50 has a storage battery to self run by electric power of the storage battery, a charger 70 is disposed at a stand-by position of the crawler, and the storage battery is charged with electricity by the charger in a state that the crawler is not separated from a runway surface.
摘要翻译：履带驱动装置和游戏装置，其中安装在履带上的蓄电池在履带相邻或不与跑道表面分离的状态下被充电。在履带驱动装置中，履带50具有通过蓄电池的电力自行运行的蓄电池，充电器70设置在履带的待机位置，蓄电池被充电器充电在履带不与跑道表面分离的状态下。

7. 发明申请

US20050061062A1 Surface hardness distribution measuring method and apparatus 有权
标题翻译：表面硬度分布测量方法和装置
公开(公告)号：US20050061062A1
公开(公告)日：2005-03-24
申请号：US10940731
申请日：2004-09-15
申请人： Makoto Kaneko , Shinji Tanaka , Tomohiro Kawahara , Shinji Takeuchi
发明人： Makoto Kaneko , Shinji Tanaka , Tomohiro Kawahara , Shinji Takeuchi
IPC分类号： G01N3/40 , G01N3/06 , G01N33/02 , G01N3/00
CPC分类号： G01N33/025 , G01N2203/0042 , G01N2203/0647
摘要： It is possible to blast air on a surface portion of a measured object from a hole of pressing means, project illumination light in a concentric pattern with an optical element and shoot the measured object with a CCD so as to visually grasp hardness distribution on the surface portion from distortion of the concentric pattern displayed on an observed image. As for the hardness distribution, it is possible to detect luminance distribution of a measured object image obtained by the CCD so as to display the concentric pattern which is the luminance distribution as a conspicuous representation of the hardness distribution. And the luminance distribution can also be represented in the concentric pattern by multiplying a luminance value by an overflowing coefficient.
摘要翻译：可以从按压装置的孔中将被测物体的表面部分的空气喷射成与光学元件同心的图案的投影照明光并用CCD拍摄被测物体，以目视地掌握表面上的硬度分布部分来自显示在观察图像上的同心图案的变形。对于硬度分布，可以检测由CCD获得的测量对象图像的亮度分布，以便将作为亮度分布的同心图案显示为硬度分布的显眼表示。并且亮度分布也可以通过将亮度值乘以溢出系数而以同心图案表示。

8. 发明授权

US06619242B2 Combustion control apparatus for engine 失效
标题翻译：发动机燃烧控制装置
公开(公告)号：US06619242B2
公开(公告)日：2003-09-16
申请号：US10075773
申请日：2002-02-13
申请人： Makoto Kaneko
发明人： Makoto Kaneko
IPC分类号： F02B6906
CPC分类号： F02D13/0215 , F01L9/04 , F02B1/04 , F02B1/12 , F02B3/06 , F02B69/06 , F02B2075/025 , F02B2075/027 , F02B2275/32 , F02D13/0265 , F02D13/0269 , F02D13/028 , F02D41/3035 , F02D41/3058 , F02F2001/245 , Y02T10/142
摘要： A combustion control apparatus for an engine having a variable valve timing mechanism capable of varying valve timings of an exhaust valve and an intake valve establishes a combustion mode to either of following three modes, a four-cycle compression ignition combustion mode at a low and medium load area, a two-cycle spark ignition combustion mode at a high load area, and a four-cycle spark ignition combustion mode at a high speed area. When the combustion mode is established to the compression ignition combustion mode, the apparatus establishes the valve timings of the exhaust and intake valves so as to form a negative overlap period in which both exhaust and intake valves concurrently close in the neighborhood of the exhaust top dead center (TDC).
摘要翻译：具有能够改变排气门和进气门的气门正时的可变气门正时机构的发动机的燃烧控制装置建立了以下三种模式之一的燃烧模式：中低压四点压缩点火燃烧模式负载区域，高负荷区域的双循环火花点火燃烧模式和高速区域的四循环火花点火燃烧模式。当燃烧模式建立到压缩点火燃烧模式时，该装置建立排气和进气阀的气门正时，从而形成负重叠时段，排气门和进气门同时在排气顶端附近闭合中心（TDC）。

9. 发明授权

US06503739B1 Processes for producing S,S-2-hydroxypropylenediamine-N-N′-disuccinic acid 有权
标题翻译：制备S，S-2-羟丙基二胺-N-N'-二琥珀酸的方法
公开(公告)号：US06503739B1
公开(公告)日：2003-01-07
申请号：US09926386
申请日：2001-10-24
申请人： Makoto Kaneko
发明人： Makoto Kaneko
IPC分类号： C12P1304
CPC分类号： C12P13/02 , C07B2200/07 , C07C227/06 , C07C229/24
摘要： Provided is an industrially advantageous process for producing S,S-2-hydroxypropylenediamine-N,N′-disuccinic acid which does not use expensive optically active substances. S,S-2-hydroxypropylenediamine-N,N′-disuccinic acid is stereospecifically produced from fumaric acid and 2-hydroxypropylenediamine by the action of ethylenediamine disuccinic acid ethylenediamine lyase (EDDS-ase) or from maleic acid and 2-hydroxypropylenediamine by combining the action of EDDS-ase with the action of maleic acid isomerase.
摘要翻译：提供了一种工业上有利的生产不使用昂贵光学活性物质的S，S-2-羟基丙
二胺-N，N'-二琥珀酸的方法。 S，S-2-羟基丙二胺-N，N'-二琥珀酸是由乙二胺二琥珀酸乙二胺裂解酶（EDDS-ase）或马来酸和2-羟基丙二胺的作用，由富马酸和2-羟丙基二胺制备的， EDDS-ase与马来酸异构酶作用的作用。

10. 发明授权

US4779083A Display control system 失效
标题翻译：显示控制系统
公开(公告)号：US4779083A
公开(公告)日：1988-10-18
申请号：US824952
申请日：1986-01-31
申请人： Takatoshi Ishii , Makoto Kaneko
发明人： Takatoshi Ishii , Makoto Kaneko
IPC分类号： G06T3/40 , G09G3/20 , G09G3/36 , H04N3/12 , G06F3/14 , G09G3/10 , G09G3/28
CPC分类号： H04N3/127 , G06T3/40 , G09G3/3611 , G09G3/3644 , G09G3/3685 , G09G3/2018
摘要： A display control system can implement a gray-scale display of an image composed of a plurality of display dots on a display screen. A plurality of luminance data each representing an intensity level of a corresponding one of the plurality of display dots are first generated. Each luminance data is then converted into a pulse signal whose pulse number corresponds to an intensity level of the corresponding display dot represented by the luminance data. And, each display dot on the display screen is activated in accordance with a corresponding one of the thus produced pulse signals. To eliminate flicker of the display dots, the display dots on the display screen are grouped into a plurality of display sections each composed of a predetermined number of adjacent display dots, and if the display dots in one display section are equal in intensity level, these display dots are activated by the pulse signals which are equal in pulse-number but different in phase.
摘要翻译：显示控制系统可以在显示屏上实现由多个显示点组成的图像的灰度显示。首先生成表示多个显示点中对应的一个显示点的强度水平的多个亮度数据。然后将每个亮度数据转换为其脉冲数对应于由亮度数据表示的相应显示点的强度水平的脉冲信号。并且，显示屏幕上的每个显示点根据如此产生的脉冲信号中的相应一个被激活。为了消除显示点的闪烁，显示屏幕上的显示点被分组成多个显示部分，每个显示部分由预定数量的相邻显示点组成，并且如果一个显示部分中的显示点的强度水平相等，则这些显示部分显示点由脉冲数相等但相位不同的脉冲信号激活。

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