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1. 发明授权

US10380376B2 System and method for protecting and controlling access to analytical results of a diagnostic test assay 有权
公开(公告)号：US10380376B2
公开(公告)日：2019-08-13
申请号：US15029579
申请日：2014-10-15
申请人： One Drop Diagnostics Sàrl
发明人： Luc Gervais , Jörg Ziegler
IPC分类号： H04L29/06 , G06F21/62 , G16H10/40 , G06F19/00
摘要： A reader unit (31) is configured to be operationally coupled with an assay unit (11) that is capable of performing one or more diagnostic tests (13) on one or more physiological samples (15), and is configured (32, 36) to obtain test raw data (73) of diagnostic tests performed on an assay unit operationally coupled with the reader unit. The reader unit comprises an encryption module (33) that is configured to encrypt input data with locking key data (75), the input data comprising the test raw data, or data derived from said test raw data. The reader unit is configured to provide access to the encrypted data (77), but not to the input data.

2. 发明申请

US20170016827A1 FLUORESCENSE-DETECTED ASSAYS ON MICROFLUIDIC CHIPS 审中-公开
标题翻译：荧光检测对微流感检测的荧光检测
公开(公告)号：US20170016827A1
公开(公告)日：2017-01-19
申请号：US15123965
申请日：2015-03-05
申请人： ONE DROP DIAGNOSTICS SÀRL
发明人： Luc Gervais , Jörg ZIEGLER , Nicolas DESCHARMES
IPC分类号： G01N21/64 , G01N33/543 , B01L3/00 , G01N21/77
CPC分类号： G01N21/648 , B01L3/502715 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , G01N21/6428 , G01N21/7703 , G01N21/7746 , G01N33/54306 , G01N2021/6439 , G01N2021/7736 , G01N2021/7786 , G01N2201/08
摘要： An assay unit for carrying-out fluorescence-detected assays on physiological samples comprises a microfluidic chip with a microfluidic system to convey a physiological sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures arranged on the chip to guide excitation light in the near IR, visible, or near UV range. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel. In the assay areas, one or more capture spots are located on the surface of the waveguide core, the capture spots comprising a coating of capture antibodies of the immunoassay, immobilized on said core surface.
摘要翻译：用于在生理样品上进行荧光检测测定的测定单元包括具有微流体系统的微流体芯片，以通过布置在芯片上的一个或多个微流体通道传送生理样品或分析物溶液，以及具有两个或更多个矩形的光子系统波导结构布置在芯片上以引导近红外，可见或近紫外范围的激发光。微流体通道和波导结构在检测位置彼此交叉。在测定区域中，其中某个微流体通道和某一波导结构彼此交叉，波导结构的芯的一个或多个侧表面至少部分地面对微流体通道的内部体积，使得消逝的光场在波导结构内引导与微流体通道的内部体积的某一部分重叠。在测定区域中，一个或多个捕获点位于波导芯的表面上，捕获点包含固定在所述芯表面上的免疫测定的捕获抗体的包被。

3. 发明授权

US11808704B2 Fluorescence-detected assays on microfluidic chips 有权
公开(公告)号：US11808704B2
公开(公告)日：2023-11-07
申请号：US15123965
申请日：2015-03-05
申请人： ONE DROP DIAGNOSTICS SÀRL
发明人： Luc Gervais , Jörg Ziegler , Nicolas Descharmes
IPC分类号： G01N21/64 , G01N21/77 , B01L3/00 , G01N33/543
CPC分类号： G01N21/648 , B01L3/502715 , G01N21/6428 , G01N21/7703 , G01N21/7746 , G01N33/54306 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , G01N2021/6439 , G01N2021/7736 , G01N2021/7786 , G01N2201/08
摘要： An assay unit for carrying-out fluorescence-detected assays having a microfluidic chip with a microfluidic system to convey a sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel.

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