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1. 发明申请

US20160090365A1 PREPARATION METHOD FOR AZOXYSTROBIN 有权
标题翻译： AZOXYSTROBIN的制备方法
公开(公告)号：US20160090365A1
公开(公告)日：2016-03-31
申请号：US14889299
申请日：2014-03-20
申请人： NUTRICHEM COMPANY LIMITED , SHANGYU NUTRICHEM CO., LTD.
发明人： Wenjun Wang , Jianwei Chen , Jianhong Chi , Yongchang Zhao , Xufang Deng , Long Wang , Hua'nan You
IPC分类号： C07D239/52
CPC分类号： C07D239/52
摘要： Disclosed in the present invention is a preparation method of azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an etherification reaction by reacting the compound having a structure shown by formula (2) with 2-cyanophenol and/or a salt thereof under the catalysis of an azabicyclo tertiary amine compound and/or a salt thereof as the catalyst in a butyl acetate medium to obtain a butyl acetate solution containing azoxystrobin; and b) cooling the butyl acetate solution containing azoxystrobin to precipitate Azoxystrobin having a structure as shown by formula (1) from the butyl acetate solution. Using the method provided by the present invention to prepare azoxystrobin can significantly improve the yield of azoxystrobin, and can obtain azoxystrobin products having high purity.
摘要翻译：本发明公开了具有式（1）所示结构的嘧菌酯的制备方法，该方法包括：a）使具有式（2）所示结构的化合物与2-氰基苯酚和 /或其盐在氮化二叔胺化合物和/或其盐催化下作为催化剂在乙酸丁酯介质中催化，得到含有嘧菌酯的乙酸丁酯溶液; 和b）冷却含有嘧菌酯的乙酸丁酯溶液，以从乙酸丁酯溶液中沉淀具有如式（1）所示结构的嘧菌酯。使用本发明提供的方法制备嘧菌酯可显着提高嘧菌酯的产量，并可获得纯度高的嘧菌酯产品。

2. 发明授权

US09920015B2 Methods for preparing azoxystrobin and intermediate thereof 有权
公开(公告)号：US09920015B2
公开(公告)日：2018-03-20
申请号：US14916888
申请日：2014-03-11
申请人： Nutrichem Company Limited , Shangyu Nutrichem Co., Ltd.
发明人： Jianwei Chen , Wenjun Wang , Jianhong Chi , Yongchang Zhao , Xufang Deng , Long Wang , Wentao Jin , Guobin Chen
IPC分类号： C07D239/34 , C07D239/52
CPC分类号： C07D239/34 , C07D239/52
摘要： The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.

3. 发明申请

US20180141918A1 METHOD FOR PREPARING AZOXYSTROBIN AND ITS INTERMEDIATES 审中-公开
公开(公告)号：US20180141918A1
公开(公告)日：2018-05-24
申请号：US15875569
申请日：2018-01-19
申请人： Nutrichem Company Limited , Shangyu Nutrichem CO., LTD.
发明人： Jianwei Chen , Wenjun Wang , Jianhong Chi , Yongchang Zhao , Xufang Deng , Long Wang , Wentao Jin , Guobin Chen
IPC分类号： C07D239/34 , C07D239/52
CPC分类号： C07D239/34 , C07D239/52
摘要： The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.

4. 发明授权

US10253001B2 Method for preparing azoxystrobin and its intermediates 有权
公开(公告)号：US10253001B2
公开(公告)日：2019-04-09
申请号：US15875569
申请日：2018-01-19
申请人： Nutrichem Company Limited , Shangyu Nutrichem CO., LTD.
发明人： Jianwei Chen , Wenjun Wang , Jianhong Chi , Yongchang Zhao , Xufang Deng , Long Wang , Wentao Jin , Guobin Chen
IPC分类号： C07D239/34 , C07D239/52
摘要： The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.

5. 发明授权

US09611226B2 Preparation method for azoxystrobin 有权
公开(公告)号：US09611226B2
公开(公告)日：2017-04-04
申请号：US14889299
申请日：2014-03-20
申请人： NUTRICHEM COMPANY LIMITED , SHANGYU NUTRICHEM CO., LTD.
发明人： Wenjun Wang , Jianwei Chen , Jianhong Chi , Yongchang Zhao , Xufang Deng , Long Wang , Hua'nan You
IPC分类号： C07D239/52
CPC分类号： C07D239/52
摘要： Disclosed in the present invention is a preparation method of azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an etherification reaction by reacting the compound having a structure shown by formula (2) with 2-cyanophenol and/or a salt thereof under the catalysis of an azabicyclo tertiary amine compound and/or a salt thereof as the catalyst in a butyl acetate medium to obtain a butyl acetate solution containing azoxystrobin; and b) cooling the butyl acetate solution containing azoxystrobin to precipitate Azoxystrobin having a structure as shown by formula (1) from the butyl acetate solution. Using the method provided by the present invention to prepare azoxystrobin can significantly improve the yield of azoxystrobin, and can obtain azoxystrobin products having high purity.

6. 发明授权

US09556128B2 Preparation method for acrylate compound 有权
标题翻译：丙烯酸酯化合物的制备方法
公开(公告)号：US09556128B2
公开(公告)日：2017-01-31
申请号：US14778336
申请日：2014-03-20
申请人： NUTRICHEM COMPANY LIMITED , SHANGYU NUTRICHEM CO., LTD.
发明人： Xufang Deng , Wenjun Wang , Jianwei Chen , Yongchang Zhao , Jianhong Chi , Long Wang , Hua'nan You
IPC分类号： C07C69/618 , C07D239/52 , C07C67/31 , C07D239/34 , C07D213/64 , C07C67/327
CPC分类号： C07D239/52 , C07C67/31 , C07C67/327 , C07D213/64 , C07D239/34 , C07C69/734
摘要： The present invention relates to a method for preparing an acrylate compound. The acrylate compound has a structure as shown in formula (I). The method includes: subjecting a compound with a structure of formula (II) or a mixture of compounds with structures of formula (I) and formula (II), and a catalyst to a contact reaction in the absence of an anhydride, and removing the resulting methanol by pressure reduced distillation during the contact reaction process. In the formulas (I) and (II), R is selected from one of: an alkoxy with a carbon number of 1-5, a substituent-containing phenoxyl with a carbon number of 6-20, a substituent-containing heteroaryloxy with a carbon number of 4-20, a substituent-containing heteroaryloxymethyl with a carbon number of 4-20, a substituent-containing phenoxymethyl with a carbon number of 5-20, and a substituent-containing alkyl with a carbon number of 2-20. According to the method for preparing an acrylate compound provided in the invention, the conversion rate and selectivity of the reaction can be substantially improved.
摘要翻译：本发明涉及丙烯酸酯化合物的制备方法。丙烯酸酯化合物具有式（I）所示的结构。该方法包括：使具有式（II）结构的化合物或具有式（I）和式（II）结构的化合物的混合物和在不存在酸酐的情况下进行接触反应的催化剂，在接触反应过程中通过减压蒸馏得到甲醇。在式（I）和（II）中，R选自碳数为1〜5的烷氧基，碳数为6〜20的含取代基的苯氧基，含有取代基的杂芳氧基与碳原子数4-20，碳数为4-20的含取代基的杂芳氧基甲基，碳数为5-20的含取代基的苯氧基甲基和碳数为2-20的含取代基的烷基。根据本发明提供的丙烯酸酯化合物的制备方法，能够显着提高反应的转化率和选择性。

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