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1. 发明申请

US20230001193A1 COMPOSITIONS AND METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS 有权
公开(公告)号：US20230001193A1
公开(公告)日：2023-01-05
申请号：US17841968
申请日：2022-06-16
申请人： Novocure GMBH
发明人： Lilach Avigdor , Tali Voloshin-Sela
IPC分类号： A61N1/36 , A61K45/06
摘要： Disclosed herein are methods of increasing sensitivity of a cancer cell to alternating electric fields comprising exposing the cancer cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the cancer cell to an IGFR1 inhibitor, JNK inhibitor, RPS6 inhibitor or ERK inhibitor. Disclosed are methods of increasing treatment efficacy comprising applying an alternating electric field to a target site of the subject for a period of time, the alternating electric field having a frequency and field strength, wherein the target site comprises one or more cancer cells, and administering a therapeutically effective amount of one or more of an IGF1R inhibitor, JNK inhibitor, RPS6 inhibitor, and/or ERK inhibitor to the subject. Disclosed are methods of treating a subject having cancer comprising applying an alternating electric field to a target site of the subject for a period of time, the alternating electric field having a frequency and field strength, wherein the target site comprises one or more cancer cells, and administering a therapeutically effective amount of one or more of an IGF1R inhibitor, JNK inhibitor, RPS6 inhibitor, and/or ERK inhibitor to the subject. Disclosed are methods of reducing viability of cancer cells using an alternating electric field for a period of time, the alternating electric field having a frequency and field strength in combination with either an IGF1R inhibitor, JNK inhibitor, RPS6 inhibitor, and/or ERK inhibitor. Disclosed are methods of increasing apoptosis of a cancer cell comprising exposing the cancer cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength; and exposing the cancer cell to an IGFR1 inhibitor, JNK inhibitor, RPS6 inhibitor or ERK inhibitor.

2. 发明授权

US11179322B2 Methods and compositions for treating tumors with TTFields and sorafenib 有权
公开(公告)号：US11179322B2
公开(公告)日：2021-11-23
申请号：US16506008
申请日：2019-07-09
申请人： Novocure GmbH
发明人： Karnit Gotlib , Einav Zeevi , Rosa S. Schnaiderman , Tali Voloshin-Sela , Moshe Giladi , Adrian Kinzel , Eilon Kirson , Uri Weinberg , Yoram Palti , Shiri Davidi
IPC分类号： A61N1/20 , A61K31/4418 , A61K9/00 , A61P35/00
摘要： Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.

3. 发明申请

US20210346691A1 COMPOSITIONS AND METHODS OF APPLYING ALTERNATING ELECTRIC FIELDS TO PLURIPOTENT STEM CELLS 有权
公开(公告)号：US20210346691A1
公开(公告)日：2021-11-11
申请号：US17314659
申请日：2021-05-07
申请人： NOVOCURE GMBH
发明人： Tali Voloshin-Sela
IPC分类号： A61N1/36
摘要： Disclosed are methods and compositions for preventing or disrupting mitosis of pluripotent stem cells, killing pluripotent stem cells, preventing or disrupting division of pluripotent stem cells, reducing the viability of pluripotent stem cells, slowing the progression or differentiation of pluripotent stem cells, and treating an ectopic pregnancy.

4. 发明授权

US11607543B2 Delivering tumor treating fields (TTFields) using implantable transducer arrays 有权
公开(公告)号：US11607543B2
公开(公告)日：2023-03-21
申请号：US17942910
申请日：2022-09-12
申请人： Novocure GmbH
发明人： Yoram Wasserman , Zeev Bomzon , Hadas Sara Hershkovich , Ariel Naveh , Moshe Giladi , Eilon Kirson , Golan Bar-Tal , Tali Voloshin-Sela
IPC分类号： A61N1/05 , A61N1/36 , A61N1/378
摘要： Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

5. 发明申请

US20230000980A1 COMPOSITIONS AND METHODS FOR USING ALTERNATING ELECTRIC FIELDS TO DISRUPT LIPID CAPSULES 有权
公开(公告)号：US20230000980A1
公开(公告)日：2023-01-05
申请号：US17841975
申请日：2022-06-16
申请人： Novocure GMBH
发明人： Lilach Avigdor , Tali Voloshin-Sela , Uri Weinberg
IPC分类号： A61K41/00 , A61N1/40 , A61K9/48 , A61K9/127
摘要： Disclosed are methods of delivering a therapeutic to a target site of a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic from lipid capsule at the target site of the subject. Disclosed are methods of increasing target site specific release of a therapeutic agent in a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject, thereby increasing the target site specific release of the therapeutic agent. Disclosed are methods of treating comprise administering a lipid capsule to a target site of a subject in need thereof, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject in need thereof. Disclosed are methods of killing a cell comprising administering a lipid capsule to a target site, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field for a period of time, to the target site, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site, wherein the target site comprises a cell, wherein the therapeutic kills the cell.

6. 发明授权

US11529511B2 Using alternating electric fields to increase cell membrane permeability 有权
公开(公告)号：US11529511B2
公开(公告)日：2022-12-20
申请号：US16502282
申请日：2019-07-03
申请人： The Board of Trustees of the Leland Stanford Junior University , Novocure GmbH
发明人： Edwin Chang , Chirag B. Patel , Sanjiv S. Gambhir , Tali Voloshin-Sela , Yaara Porat , Moshe Giladi
IPC分类号： A61N1/32 , A61N1/36 , A61P35/00 , A61K41/00 , A61N1/02 , A61F7/00
摘要： Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

7. 发明授权

US11471676B2 Delivering tumor treating fields (TTFields) using implantable transducer arrays 有权
公开(公告)号：US11471676B2
公开(公告)日：2022-10-18
申请号：US16801972
申请日：2020-02-26
申请人： Novocure GmbH
发明人： Yoram Wasserman , Zeev Bomzon , Hadas Sara Hershkovich , Ariel Naveh , Moshe Giladi , Eilon Kirson , Golan Bar-Tal , Tali Voloshin-Sela
IPC分类号： A61N1/05 , A61N1/36 , A61N1/378
摘要： Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

8. 发明申请

US20210178173A1 Compositions And Methods Of Altering The Electric Impedance To An Alternating Electric Field 有权
公开(公告)号：US20210178173A1
公开(公告)日：2021-06-17
申请号：US17106531
申请日：2020-11-30
申请人： NOVOCURE GMBH
发明人： Hadas Hershkovich , Tali Voloshin-Sela , Ze'ev Bomzon
IPC分类号： A61N1/40 , G06T7/00 , A61N1/32 , A61N1/36
摘要： Disclosed are methods of altering the electric impedance to an alternating electric field in a target site of a subject, comprising introducing a nanoparticle to a target site in the subject; and applying an alternating electric field to the target site of the subject, wherein the electric impedance in the target site of the subject to the alternating current is altered. Disclosed are methods for improving transport of a nanoparticle across a cell membrane of a cell, the method comprising applying an alternating electric field to the cell for a period of time, wherein application of the alternating electric field increases permeability of the cell membrane; and introducing the nanoparticle to the cell, wherein the increased permeability of the cell membrane enables the nanoparticle to cross the cell membrane. Disclosed are methods of imaging a cancer cell, the method comprising applying a first alternating electric field at a first frequency to the cancer cell for a first period of time, wherein application of the first alternating electric field at the first frequency to the cancer cell for the first period of time increases permeability of cell membranes of the cancer cell; introducing a nanoparticle to the cancer cell, wherein the increased permeability of the cell membranes enables the nanoparticle to cross the cancer cell membrane; and imaging the cancer cell.

9. 发明授权

US11583675B2 Inhibiting viral infection using alternating electric fields 有权
公开(公告)号：US11583675B2
公开(公告)日：2023-02-21
申请号：US16506633
申请日：2019-07-09
申请人： Novocure GmbH
发明人： Noa Kaynan , Tali Voloshin-Sela , Moshe Giladi , Eilon Kirson
IPC分类号： A61N1/32 , A61M37/00
摘要： Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.

10. 发明申请

US20220203088A1 Methods And Compositions For Using Alternating Electric Fields In Gene Therapy 有权
公开(公告)号：US20220203088A1
公开(公告)日：2022-06-30
申请号：US17559228
申请日：2021-12-22
申请人： NOVOCURE GMBH
发明人： Tali Voloshin-Sela , Lilach Avigdor , Yaara Porat , Helena Mumblat
IPC分类号： A61N1/32 , A61N1/36 , A61K48/00 , A61K31/711 , A61K31/7105 , A61K38/46 , A61K35/763 , A61K35/76
摘要： Disclosed are compositions for methods of transporting of a vector, therapeutic, detectable, or combination thereof across a cell membrane of a cell. Also disclosed are methods of detecting and/or treating a tumor or cancer cell using a vector, therapeutic, detectable, or combination thereof either alone or in combination with applying alternating electric fields.

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