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    • 1. 发明授权
    • Two compartment cup for powdered sterilant reagent components
    • 两个隔间杯用于粉末灭菌剂组分
    • US5209909A
    • 1993-05-11
    • US793589
    • 1991-11-18
    • Norman L. SiegelRaymond C. KralovicKenneth E. Scheckelhoff
    • Norman L. SiegelRaymond C. KralovicKenneth E. Scheckelhoff
    • A61J1/05A01N25/34A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L15/44A61L15/46A61L31/16B65D81/32
    • A61L2/24A01N25/34A61L2/16A61L2/18A61L2/20A61L2/26B65D81/3216A61L2202/24
    • A front door (B) of a countertop decontamination unit is opened to gain access to a chamber (10) for receiving a cartridge (C) containing items to be sterilized and a chamber (12) for receiving a two compartment powdered anti-microbial agent carrying cup (D). The cup includes an outer cup portion (60) and an inner cup portion (70) that have peripheral walls (62, 72) affixed together at flanges (64, 74) and abutting base walls (66, 76). At least one of the base walls has a domed portion (68) constructed of plastic, whose plastic resiliency functions as a spring to urge the base walls continuously into engagement. The inner and outer cup portions peripheral walls define an annular chamber (86) therebetween. Preferably, the inner peripheral wall is generally conical to reinforce the outer cup base wall to prevent it from collapsing on impact with a cutting blade (14). The inner wall has a longitudinally elongated recess (80) which interacts with a filling aperture (84) surrounded by a flange portion (82). The longitudinal recess and filling aperture are configured such that a filling tube (92) is selectively insertable through the filling aperture and along the recess for filling the annular compartment with a powdered reagent. A permeable sheet (102) is affixed to the second cup portion flange for sealing both compartments.
    • 打开台面去污单元的前门(B)以进入容纳用于接收待灭菌物品的盒(C)的室(10)和用于接收两室粉末状抗菌剂的室(12) 携带杯(D)。 杯子包括外杯部分(60)和内杯部分(70),其具有在凸缘(64,74)和邻接的底壁(66,76)处固定在一起的周壁(62,72)。 基壁中的至少一个具有由塑料构成的圆顶部分(68),其塑性弹性用作弹簧以促使基壁连续地接合。 内杯部分和外杯部分周边壁在它们之间限定环形室(86)。 优选地,内周壁通常为圆锥形以加强外杯底壁,以防止其在与切割刀片(14)碰撞时塌陷。 内壁具有纵向细长的凹部(80),其与由凸缘部分(82)包围的填充孔(84)相互作用。 纵向凹部和填充孔被构造成使得填充管(92)可选择性地插入穿过填充孔并且沿着凹槽,用粉末试剂填充环形室。 可渗透片(102)固定到第二杯部凸缘上以密封两个隔室。
    • 2. 发明授权
    • Container for holding equipment during sterilization
    • 在灭菌过程中保存设备的容器
    • US5091343A
    • 1992-02-25
    • US349304
    • 1989-05-09
    • Edward T. SchneiderNorman L. SiegelRaymond C. Kralovic
    • Edward T. SchneiderNorman L. SiegelRaymond C. Kralovic
    • A01N25/34A61L2/16A61L2/18A61L2/20A61L2/24A61L15/44A61L15/46A61L31/16
    • A61L2/24A01N25/34A61L2/16A61L2/18A61L2/20
    • A liquid sterilizing system (A) defines a basin (10) in which a container (B) is removably disposed. The liquid sterilizing system selectively pumps sterile rinse liquids from a supply (24) and liquid sterilant solutions from a supply (70) into the basin filling the basin and the container. The container includes a lower shell having a bottom wall (34) that defines an aperture (32) for receiving sterilant and sterile rinse liquids. A nozzle plate (44) is mounted close to but spaced from the shell bottom wall to define a tortuous liquid distribution path (40) between the inlet aperture and nozzle plate apertures (90). A barrier (96) divides the liquid receiving portion and a drain portion of the liquid distribution path between the shell bottom surface and the nozzle plate. A cover (80) has a downward depending peripheral wall (82) which is offset from the shell peripheral wall (86) by the spacers (88) to define a tortuous vent path (48) therethrough. The container is lifted out by handles (100) which enable the container to be removed without disturbing the transparent cover, hence, without disturbing the sterile condition of the items within the container. In this manner, the sterilized items can be inventoried and maintained sterilized in the container for an extended duration.
    • 液体灭菌系统(A)限定了容器(B)可移除地设置在其中的盆(10)。 液体灭菌系统选择性地将来自供应源(24)的无菌漂洗液体和来自供应(70)的液体杀菌剂溶液泵入填充盆和容器的盆中。 容器包括具有限定用于接收消毒剂和无菌冲洗液体的孔(32)的底壁(34)的下壳体。 喷嘴板(44)安装成靠近壳体底壁但与壳体底壁间隔开,以限定入口孔和喷嘴板孔(90)之间的曲折的液体分配路径(40)。 隔板(96)将液体分配通道的液体接收部分和排出部分分隔在壳体底表面和喷嘴板之间。 盖(80)具有向下的周向壁(82),其通过间隔件(88)从壳体周壁(86)偏移,以限定通过其的曲折通气路径(48)。 容器通过手柄(100)提起,使得容器能够被移除而不干扰透明盖,因此不会干扰容器内物品的无菌状态。 以这种方式,可以将灭菌的物品进行盘存并在容器中维持长时间灭菌。
    • 3. 发明授权
    • Office size instrument sterilization system
    • 办公大小仪器灭菌系统
    • US5217698A
    • 1993-06-08
    • US681118
    • 1991-04-05
    • Norman L. SiegelDavid E. MinerovicRaymond C. KralovicBill R. SanfordPamela C. TannerDonald J. RebeleDouglas F. MarshallSamuel M. FungJohn L. Beiswenger
    • Norman L. SiegelDavid E. MinerovicRaymond C. KralovicBill R. SanfordPamela C. TannerDonald J. RebeleDouglas F. MarshallSamuel M. FungJohn L. Beiswenger
    • A01N25/34A61L2/16A61L2/18A61L2/20A61L2/24A61L15/44A61L15/46A61L31/16B65D77/22B65D81/32
    • A61L2/24A01N25/34A61L15/44A61L15/46A61L2/16A61L2/18A61L2/20B65D77/225B65D81/3216
    • The body portion (A) of a small portable sterilizer has a face panel (46) against which a door (B) is selectively closed. The face panel defines an access opening for a sterilization chamber (10) which receives a cassette (C), an access opening for an anti-microbial concentrate chamber (20) which receives a powdered or other sterilant concentrate, and an outlet opening (50) from a microbe filter which filters microbes from incoming rinse water. The face plate and the door define fluid flow channels (48, 52) therebetween for selectively directing sterilant solutions and rinse solutions among the anti-microbial concentrate chamber, the sterilization chamber, and the microbial filter. The cassette is configured to assure that it is inserted into the sterilization chamber with a unique orientation such that its fluid inlet apertures (114) and outlet apertures (124) are at preselected locations. The door includes generally U-shaped projections (116) which abut an outer surface of the cassette in the sterilization chamber partially surrounding the fluid inlet apertures. The U-shaped projections assure that the cassette is seated in the sterilization chamber and provide a well which directs the circulating fluids into the cassette inlet apertures. A pair of gaskets (56, 86) surround the active portion of the face panel. A vacuum pump (90) selectively draws a vacuum in an annular region (88) between the gaskets, which vacuum locks the door against the face plate in a sealed, closed position. To assure a fluid tight seal, the gaskets are O-rings which are pressed by the vacuum into V-shaped grooves (82, 84).
    • 小便携式消毒器的主体部分(A)具有面板(46),门(B)选择性地关闭。 面板限定用于接收盒(C)的消毒室(10)的入口,用于容纳粉状或其它消毒浓缩物的抗微生物浓缩物室(20)的入口和出口(50) )从微生物过滤器过滤器,其过滤来自冲洗水的微生物。 面板和门在其间限定流体流动通道(48,52),用于在抗微生物浓缩物室,消毒室和微生物过滤器之间选择性地引导消毒剂溶液和漂洗溶液。 盒被构造成确保其以独特的取向插入灭菌室,使得其流体入口孔(114)和出口孔(124)处于预选位置。 门包括大致U形突起(116),其邻接在部分地围绕流体入口孔的灭菌室中的盒的外表面。 U形突起确保盒被安置在灭菌室中,并提供一个将循环流体引导到盒入口孔中的孔。 一对垫圈(56,86)围绕面板的活动部分。 真空泵(90)选择性地在垫圈之间的环形区域(88)中抽真空,真空在密封的关闭位置中真空地将门锁定在面板上。 为了确保流体密封,垫圈是由真空压入V形槽(82,84)中的O形环。
    • 6. 发明授权
    • Self contained biological indicator
    • 自包含生物指标
    • US5736355A
    • 1998-04-07
    • US645259
    • 1996-05-13
    • Denis G. DykePaul S. MalcheskyRaymond C. KralovicDonna M. RichardsonJoseph J. Switka
    • Denis G. DykePaul S. MalcheskyRaymond C. KralovicDonna M. RichardsonJoseph J. Switka
    • C12M1/28C12Q1/18C12Q1/22C12M1/34
    • C12Q1/18C12M23/32C12M23/38C12M25/02C12M25/06C12M37/04C12Q1/22
    • A self contained biological indicator (A) determines an effectiveness of a microbial decontamination process. A dart (68) has a seal (80) engaged by rim (58) in detents (50C) in fins (36A-36F) of a cap (C). The dart has a cutting edge (76) aligned just above a foil seal (86) sealing a growth medium (F) in a medium housing (D). The dart has a chamber (72) in which challenge spores or other microorganisms on a paper disk (74) are housed. A microporous membrane (G) traps the challenge spores in the chamber while allowing a microbial decontamination fluid to flow through to contact the spores. The housing is lodged by a flange (56) in detents (50A) in fins (36A-36F). After the microbial decontamination process is complete, the cap is forced toward medium housing causing the rim and the flange to dislodge from their respective detents and lodge in detents (50B) resulting in the puncturing of the foil seal, the sealing of the dart within the medium housing and the immersion of the dart and the challenge spores into the growth medium.
    • 自给自足的生物指示剂(A)确定微生物净化过程的有效性。 飞镖(68)具有在盖(C)的翅片(36A-36F)中的掣子(50C)中与轮辋(58)接合的密封件(80)。 飞镖具有在密封培养基壳体(D)中的生长介质(F)的箔密封件(86)正上方对准的切割边缘(76)。 飞镖具有容纳在纸盘(74)上的挑战孢子或其他微生物的室(72)。 微孔膜(G)捕获腔室中的挑战孢子,同时允许微生物去污染液体流过以接触孢子。 壳体通过翼片(36A-36F)中的棘爪(50A)中的凸缘(56)放置。 微生物净化过程完成后,盖被迫朝向中等壳体,导致轮缘和凸缘从它们各自的棘爪上移开,并且卡在掣子(50B)中,导致穿刺箔片密封件,将飞镖密封在 中等住房和镖的浸入和挑战孢子进入生长培养基。
    • 7. 发明授权
    • Controlled oxygen/anti-microbial release films
    • 受控氧/抗微生物释放膜
    • US5407685A
    • 1995-04-18
    • US64391
    • 1993-05-18
    • Paul S. MalcheskyRaymond C. Kralovic
    • Paul S. MalcheskyRaymond C. Kralovic
    • A01N25/28A01N25/34A01N31/08A01N37/16A01N59/00A01N59/14A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L11/00A61L15/44A61L15/46A61L15/58A61L31/00A61L31/16B65D77/22B65D81/32C08J5/18C08J9/40A61F13/00
    • A61L2/208A01N25/34A01N31/08A01N37/16A01N59/00A01N59/14A61L11/00A61L15/44A61L15/46A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L31/16B65D77/225B65D81/3216A61L2202/24A61L2300/212A61L2300/404A61L2300/45A61L2300/608A61L2300/62
    • A film for releasing at least one of an anti-microbial agent, oxygen, and a medicament includes a flexible, porous layer (18) such as a woven, non-woven, or knitted cloth or a layer of open cell foam. A first dry reagent (12) and a second dry reagent (14) which react in the presence of a dilutant to form the anti-microbial agent, oxygen, or medicament attached to the flexible, porous layer. In one preferred embodiment, the two dry reagents are disposed on opposite sides of the flexible, porous layer such that the flexible porous layer keeps the two apart and prevents a premature reaction. Porous outer layers (20, 22) prevent the powdered reagents from being wiped off while permitting dilutant access. In a preferred embodiment, the powdered reagents include acetylsalicylic acid and a perborate which react in the presence of water to generate peracetic acid (an antimicrobial agent which breaks down in a matter of minutes to hours into oxygen) and salicylic acid (a topical keratotic). The rate at which the reaction occurs and the peracetic acid breaks down into oxygen is controlled by buffering the pH of the powdered reagents, by selectively micro-encapsulating the powdered reagents, by controlling the porosity of the layers, or the like. Optionally, surfactants, detergents, emollients, gels, and the like can be added to the dry reagents. Alternately, a single reagent which releases oxygen or forms a strong oxidant may be used.
    • 用于释放抗微生物剂,氧气和药物中的至少一种的膜包括柔性多孔层(18),例如编织物,无纺布或针织布或开孔泡沫层。 第一干试剂(12)和第二干试剂(14),其在稀释剂存在下反应以形成附着在柔性多孔层上的抗微生物剂,氧或药物。 在一个优选实施方案中,两个干试剂设置在柔性多孔层的相对侧上,使得柔性多孔层将两者分开并防止过早反应。 多孔外层(20,22)防止粉末试剂被擦除,同时允许稀释剂进入。 在优选的实施方案中,粉末试剂包括乙酰水杨酸和过水硼酸盐,其在水存在下反应以产生过乙酸(在几分钟至几分钟内分解成氧气的抗微生物剂)和水杨酸(局部角质形成) 。 反应发生的速率和过乙酸分解成氧气是通过缓冲粉末试剂的pH,通过选择性微囊化粉末试剂,通过控制层的孔隙率等来控制的。 任选地,可以将表面活性剂,洗涤剂,润肤剂,凝胶等添加到干试剂中。 或者,可以使用释放氧气或形成强氧化剂的单一试剂。
    • 8. 发明授权
    • Medical waste decontamination
    • 医疗废物净化
    • US5374394A
    • 1994-12-20
    • US23048
    • 1993-02-25
    • Raymond C. Kralovic
    • Raymond C. Kralovic
    • A01N25/34A01N31/08A01N37/16A01N59/00A01N59/14A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L11/00A61L15/44A61L15/46A61L31/16B65D77/22B65D81/32
    • A01N31/08A01N25/34A01N37/16A01N59/00A01N59/14A61L11/00A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26B65D77/225B65D81/3216
    • A bag (86) of medical wastes is inserted into a chamber (12) that contains a grinder (20). A package (48) is placed unopened in the chamber with the medical wastes. A selected volume of a dilutant such as water is added to the chamber (40, 42). The chamber is closed and the grinder operated for a selected duration. The grinder grinds the packaging, disposing of the packaging and permitting contained dry reagents (56, 58) such as acetylsalicylic acid and perborate to react with the dilutant, forming a peracetic acid solution or permitting a sterilant concentrate (70) to form an anti-microbial solution with the dilutant. The grinder continues to grind the packaging and the medical wastes into fine particulates forming a slurry with the peracetic acid solution. The continued operation of the grinder assures that the anti-microbial solution contacts all surfaces of the waste. In this manner, the medical wastes are microbially decontaminated. A color indicator (60, 78) is included with the packaging to provide a color indication as to whether the anti-microbial reaction is complete. For example, a Gentian Violet may be provided which fades to white to indicate completion of the decontamination process. Once decontaminated, the slurry is removed from the chamber and disposed of as non-contaminated waste materials. Optionally, fragrances and deodorants may be included in the package.
    • 医疗废物的袋子(86)被插入到包含磨床(20)的腔室(12)中。 包装(48)未被打开放置在与医疗废物的腔室中。 将选择体积的稀释剂例如水加入到室(40,42)中。 该室被关闭,研磨机在一段选定的时间内运行。 研磨机研磨包装,处理包装并允许含有干燥试剂(56,58)如乙酰水杨酸和过硼酸盐与稀释剂反应,形成过乙酸溶液或允许灭菌剂浓缩物(70)形成抗 - 微生物溶液用稀释剂。 研磨机继续将包装和医疗废物研磨成与过乙酸溶液形成浆料的微细颗粒。 研磨机的持续操作确保了抗微生物溶液接触废物的所有表面。 以这种方式,医疗废物被微生物净化。 包装中包括颜色指示器(60,78)以提供关于抗微生物反应是否完整的颜色指示。 例如,可以提供渐变为白色以表示净化过程完成的龙胆紫。 一旦净化,将浆料从室中取出并作为无污染的废料处理。 任选地,香料和除臭剂可以包括在包装中。
    • 9. 发明授权
    • Medical instrument decontamination and sterilization processor
    • 医疗器械去污杀菌处理器
    • US5225160A
    • 1993-07-06
    • US741788
    • 1991-08-06
    • Bill R. SanfordRaymond C. Kralovic
    • Bill R. SanfordRaymond C. Kralovic
    • A01N25/34A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26A61L15/44A61L15/46A61L31/16B65D77/22B65D81/32
    • B65D81/3216A01N25/34A61L2/16A61L2/18A61L2/20A61L2/24A61L2/26B65D77/225
    • An instrument (28) or other item to be sterilized is supported on a hanger (26) in a decontamination chamber (10). A container such as a sleeve (92), is supported at adjacent ends between supporting rings (90) such that the container surrounds and is displaced from the instrument. A pump (40) recirculates a sterilant or other antimicrobial solution that collects in a lower drain (48) and a reservoir (50) through spray nozzles (70, 96) and connectors (44) which are connected to interior passages of the instrument. In this manner, the internal passages of the instrument are sterilized by the flowing liquid and exterior surfaces are sterilized by sterilant solution mist which condenses on and coats the exterior surface. After the instrument is sterilized, a sterile rinse is sprayed on the instrument and interior of the container. The container and instrument are removed as a unit and the container is closed at its ends to prevent the instrument from becoming microbially contaminated from the ambient air. The instrument may be dried passively by a microbe blocking filter (98) in the container or by using a fan (80) to pump drying air longitudinally through the container.
    • 待消毒的仪器(28)或其他物品被支撑在净化室(10)中的衣架(26)上。 诸如套筒(92)的容器被支撑在支撑环(90)之间的相邻端处,使得容器围绕并从仪器移位。 泵(40)通过连接到仪器的内部通道的喷嘴(70,96)和连接器(44)再循环收集在下排水口(48)和贮存器(50)中的灭菌剂或其它抗微生物溶液。 以这种方式,仪器的内部通道被流动的液体灭菌,并且外表面通过冷凝在外表面上的灭菌溶液雾灭菌。 仪器灭菌后,将无菌冲洗液喷洒在仪器和容器内部。 容器和仪器作为一个单元被移除,并且容器在其端部被封闭,以防止仪器从环境空气中被微生物污染。 仪器可以通过容器中的微生物阻塞过滤器(98)被动地干燥或者通过使用风扇80将干燥空气纵向地泵送通过容器而被干燥。