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1. 发明授权

US10271782B2 Liquid collecting apparatus and liquid collecting method 有权
公开(公告)号：US10271782B2
公开(公告)日：2019-04-30
申请号：US14425317
申请日：2012-09-03
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Hiroshi Toyama , Takashi Yamada
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Hiroshi Toyama , Takashi Yamada
IPC分类号： A61B5/155 , A61B5/15 , A61B5/153 , A61B5/157
摘要： A suction drain device of a disclosed liquid collecting apparatus actively pushes and pulls blood. This achieves liquid collection at high speed even under decreased pressure depending on a physiological state of an animal. Moreover, the liquid collecting apparatus includes a first flow path and a second flow path having a given length. Accordingly, the flow path with a given length set in advance and thus a known volume allows collection of a given amount volume of blood without measuring a length and an amount of blood using a volume measuring device. Accordingly, no need of the measuring device allows reduction in size of the liquid collecting apparatus. Consequently, the liquid collecting apparatus can be installed adjacent to the animal to achieve reduction in dead volume. Moreover, blood is flown to a fourth flow path branched with a connecting terminal, and is also flown to the second flow path branched with a connecting terminal. The blood flown in the second flow path is collected at the highest priority. This obtains collection of fresh blood from a collecting source as a blood supply source.

2. 发明授权

US09498154B2 Measuring system capable of separating liquid and determining boundary of separated liquid 有权
标题翻译：能分离液体并确定分离液体边界的测量系统
公开(公告)号：US09498154B2
公开(公告)日：2016-11-22
申请号：US13636946
申请日：2010-12-28
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Tomoaki Tsuda , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Tomoaki Tsuda , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： A61B5/153 , A61B5/155 , A61B5/157 , G01N15/04 , G01N15/05 , G01N33/49 , G01N21/07 , G01N21/64 , A61B5/15
CPC分类号： A61B5/1427 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/153 , A61B5/155 , A61B5/157 , G01N15/042 , G01N15/05 , G01N21/07 , G01N21/6428 , G01N33/491 , G01N2015/045
摘要： A boundary calculating unit is provided for determining boundaries between separated plasma and blood cell or air and plasma whose image is picked up by an image pickup unit. With such boundary calculating unit provided, the boundaries between the separated plasma and blood cell or air and plasma can be determined, and areas of the separated air, plasma, and blood cell can be determined accurately. Particularly, a straight line drawing unit is provided for drawing, on the image picked up, a plurality of straight lines parallel to grooves in a disk which performs plasma separation. The boundary calculating unit can easily determine the boundaries by determining the boundaries based on a profile of the plurality of straight lines drawn by the straight line drawing unit.
摘要翻译：提供了一种边界计算单元，用于确定分离的等离子体与图像由图像拾取单元拾取的血细胞或空气和血浆之间的边界。通过设置这样的边界计算单元，可以确定分离的血浆和血细胞或空气和血浆之间的边界，并且可以精确地确定分离的空气，血浆和血细胞的区域。特别地，提供了直线描绘单元，用于在拍摄的图像上绘制平行于执行等离子体分离的盘中的凹槽的多条直线。边界计算单元可以通过基于由直线描绘单元绘制的多条直线的轮廓确定边界来容易地确定边界。

3. 发明授权

US08783121B2 Liquid collecting system and a method therefor 有权
标题翻译：液体收集系统及其方法
公开(公告)号：US08783121B2
公开(公告)日：2014-07-22
申请号：US13256221
申请日：2009-03-19
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： G01N35/10 , G01N1/10
CPC分类号： G01N35/1097 , A61B5/02042 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150992 , A61B5/155 , A61B5/157 , G01N35/1004 , G01N2035/00237
摘要： A blood collecting apparatus includes a cleaning solution piping. The cleaning solution piping feeds into a flow path a heparin solution which is a liquid other than blood to be measured, in order to return the blood present in the flow path to a catheter disposed upstream of a blood inlet of the flow path. Thus, the blood having flowed into the flow path in an amount more than is necessary for blood collection, which corresponds to a portion returned to the upstream catheter of the blood to be measured present in the flow path, can be used in a next blood collection. As a result, the amount of collected blood can be reduced. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured.
摘要翻译：血液采集装置包括清洁溶液管道。清洗溶液管道将流过路径中的血液返回到设置在流路的血液入口上游的导管的流路中，供给作为被测血液以外的液体的肝素溶液。因此，流入流路的血液以比血液收集所必需的量多，对应于返回到存在于流路中的待测血液的上游导管的部位，可以用于下一血液采集。结果，可以减少收集的血液的量。待测量的液体通过气体分开，并且以不会在流路中不留杂质的方式清洁流路，从而防止杂质混入待测量的液体中。

4. 发明申请

US20130010108A1 MEASURING SYSTEM 有权
标题翻译：测量系统
公开(公告)号：US20130010108A1
公开(公告)日：2013-01-10
申请号：US13636946
申请日：2010-12-28
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Tomoaki Tsuda , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Tomoaki Tsuda , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： A61B5/1427 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150755 , A61B5/153 , A61B5/155 , A61B5/157 , G01N15/042 , G01N15/05 , G01N21/07 , G01N21/6428 , G01N33/491 , G01N2015/045
摘要： A boundary calculating unit is provided for determining boundaries between separated plasma and blood cell or air and plasma whose image is picked up by an image pickup unit. With such boundary calculating unit provided, the boundaries between the separated plasma and blood cell or air and plasma can be determined, and areas of the separated air, plasma, and blood cell can be determined accurately. Particularly, a straight line drawing unit is provided for drawing, on the image picked up, a plurality of straight lines parallel to grooves in a disk which performs plasma separation. The boundary calculating unit can easily determine the boundaries by determining the boundaries based on a profile of the plurality of straight lines drawn by the straight line drawing unit.
摘要翻译：提供了一种边界计算单元，用于确定分离的等离子体与图像由图像拾取单元拾取的血细胞或空气和血浆之间的边界。通过设置这样的边界计算单元，可以确定分离的血浆和血细胞或空气和血浆之间的边界，并且可以精确地确定分离的空气，血浆和血细胞的区域。特别地，提供了直线描绘单元，用于在拍摄的图像上绘制平行于执行等离子体分离的盘中的凹槽的多条直线。边界计算单元可以通过基于由直线描绘单元绘制的多条直线的轮廓确定边界来容易地确定边界。

5. 发明申请

US20120000297A1 LIQUID COLLECTING SYSTEM AND A METHOD THEREFOR 有权
标题翻译：液体收集系统及其方法
公开(公告)号：US20120000297A1
公开(公告)日：2012-01-05
申请号：US13256221
申请日：2009-03-19
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： G01N1/20
CPC分类号： G01N35/1097 , A61B5/02042 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150992 , A61B5/155 , A61B5/157 , G01N35/1004 , G01N2035/00237
摘要： A blood collecting apparatus includes a cleaning solution piping. The cleaning solution piping feeds into a flow path a heparin solution which is a liquid other than blood to be measured, in order to return the blood present in the flow path to a catheter disposed upstream of a blood inlet of the flow path. Thus, the blood having flowed into the flow path in an amount more than is necessary for blood collection, which corresponds to a portion returned to the upstream catheter of the blood to be measured present in the flow path, can be used in a next blood collection. As a result, the amount of collected blood can be reduced. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured.
摘要翻译：血液采集装置包括清洁溶液管道。清洗溶液管道将流过路径中的血液返回到设置在流路的血液入口上游的导管的流路中，供给作为被测血液以外的液体的肝素溶液。因此，流入流路的血液以比血液收集所必需的量多，对应于返回到存在于流路中的待测血液的上游导管的部位，可以用于下一血液采集。结果，可以减少收集的血液的量。待测量的液体通过气体分开，并且以不会在流路中不留杂质的方式清洁流路，从而防止杂质混入待测量的液体中。

6. 发明申请

US20150289793A1 LIQUID CONTROLLING METHOD 审中-公开
标题翻译：液体控制方法
公开(公告)号：US20150289793A1
公开(公告)日：2015-10-15
申请号：US14425279
申请日：2012-09-03
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto
IPC分类号： A61B5/15
摘要： Upon blood collection with a disclosed blood collecting apparatus, a part of a flow path adjacent to a suction drain mechanism is filled with a liquid different from the blood. A gas is inserted in the flow path between the liquid with which the part of the flow path adjacent to the suction drain mechanism is filled and a target blood to be collected. The suction drain mechanism pushes and pulls the gas by pushing and pulling the liquid during a standby time between collection and next collection, thereby controlling movement of the target blood. The suction drain mechanism pushes and pulls the liquid and the gas during the standby time, whereby the target blood is continuously moved. This allows prevention of coagulation of the target blood in the flow path.
摘要翻译：在利用公开的血液采集装置进行血液采集时，与吸血排放机构相邻的流路的一部分填充有不同于血液的液体。将气体插入与填充有与吸引排出机构相邻的流路的一部分的液体与要收集的目标血液之间的流路。抽吸排出机构在收集和下一次收集之间的待机时间内推动和拉动液体，从而控制目标血液的运动。抽吸排出机构在待机时间内推动和拉动液体和气体，由此目标血液连续移动。这允许防止流路中的目标血液的凝结。

7. 发明授权

US10463289B2 Liquid controlling method 有权
公开(公告)号：US10463289B2
公开(公告)日：2019-11-05
申请号：US14425279
申请日：2012-09-03
申请人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto
发明人： Nobuya Hashizume , Keishi Kitamura , Takahiro Nishimoto
IPC分类号： A61B5/15 , A61B5/155 , G01T7/02 , A61B5/153 , A61B5/157
摘要： Upon blood collection with a disclosed blood collecting apparatus, a part of a flow path adjacent to a suction drain mechanism is filled with a liquid different from the blood. A gas is inserted in the flow path between the liquid with which the part of the flow path adjacent to the suction drain mechanism is filled and a target blood to be collected. The suction drain mechanism pushes and pulls the gas by pushing and pulling the liquid during a standby time between collection and next collection, thereby controlling movement of the target blood. The suction drain mechanism pushes and pulls the liquid and the gas during the standby time, whereby the target blood is continuously moved. This allows prevention of coagulation of the target blood in the flow path.

8. 发明授权

US08358405B2 Measuring apparatus, and liquid collecting and measuring system having the same 有权
标题翻译：测量装置和具有该测量装置的液体收集和测量系统
公开(公告)号：US08358405B2
公开(公告)日：2013-01-22
申请号：US12863968
申请日：2008-01-22
申请人： Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： G01N33/48
CPC分类号： G01F3/38 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B2503/40 , G01F13/00 , G01F13/006 , G01N21/07 , G01N21/6428 , G01N21/645
摘要： A blood collecting apparatus includes a main flow path and a pressure generator. The pressure generator is provided in an intermediate position of the main flow path to insert a gas as separators at designated predetermined intervals, thereby to take out blood to be measured, as separated in a time series. The blood can be taken out in minute volumes by inserting the separators consisting of the gas while feeding the blood continuously into the main flow path in this way. And consumption of the blood can be held down, and the amount of collected blood can be minimized. Since the operation to insert the separators is excellent in speed, repeated collection in a short time, i.e. frequency of blood collection, can be secured.
摘要翻译：血液采集装置包括主流路和压力发生器。压力发生器设置在主流路的中间位置，以指定的预定间隔插入作为分离器的气体，从而以时间序列分离取出待测血液。通过插入由气体组成的分离器，以这种方式将血液连续地供给到主流路中，可以以微量的体积取出血液。可以抑制血液的消耗，并且可以将收集的血液量减至最少。由于插入分离器的操作速度极佳，所以可以确保在短时间内进行重复收集，即采集频率。

9. 发明申请

US20100294950A1 MEASURING APPARATUS, AND LIQUID COLLECTING AND MEASURING SYSTEM HAVING THE SAME 有权
标题翻译：测量装置和液体收集和测量系统
公开(公告)号：US20100294950A1
公开(公告)日：2010-11-25
申请号：US12863968
申请日：2008-01-22
申请人： Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
发明人： Keishi Kitamura , Takahiro Nishimoto , Yuichi Kimura , Chie Seki , Iwao Kanno
IPC分类号： G01J1/58 , G01N35/08
CPC分类号： G01F3/38 , A61B5/14503 , A61B5/14546 , A61B5/15003 , A61B5/150229 , A61B5/150755 , A61B5/150946 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B2503/40 , G01F13/00 , G01F13/006 , G01N21/07 , G01N21/6428 , G01N21/645
摘要： A blood collecting apparatus includes a main flow path and a pressure generator. The pressure generator is provided in an intermediate position of the main flow path to insert a gas as separators at designated predetermined intervals, thereby to take out blood to be measured, as separated in a time series. The blood can be taken out in minute volumes by inserting the separators consisting of the gas while feeding the blood continuously into the main flow path in this way. And consumption of the blood can be held down, and the amount of collected blood can be minimized. Since the operation to insert the separators is excellent in speed, repeated collection in a short time, i.e. frequency of blood collection, can be secured.
摘要翻译：血液采集装置包括主流路和压力发生器。压力发生器设置在主流路的中间位置，以指定的预定间隔插入作为分离器的气体，从而以时间序列分离取出待测血液。通过插入由气体组成的分离器，以这种方式将血液连续地供给到主流路中，可以以微量的体积取出血液。可以抑制血液的消耗，并且可以将收集的血液量减至最少。由于插入分离器的操作速度极佳，所以可以确保在短时间内进行重复收集，即采集频率。

10. 发明申请

US20110001050A1 TWO-DIMENSIONAL POSITION MAP CORRECTING METHOD (AS AMENDED) 有权
标题翻译：二维位置校正方法（如修改）
公开(公告)号：US20110001050A1
公开(公告)日：2011-01-06
申请号：US12919431
申请日：2008-03-21
申请人： Masanobu Sato , Yoshihiro Yamada , Nobuya Hashizume , Keishi Kitamura
发明人： Masanobu Sato , Yoshihiro Yamada , Nobuya Hashizume , Keishi Kitamura
IPC分类号： G01T1/20 , G01T1/161
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/1647 , G01T7/005
摘要： A radiation detecting apparatus of this invention includes an arithmetic processing device which has a first adding step for adding signal strengths in one portion of a two-dimensional position map, draws respective boundaries based on results of addition in the first adding step, and corrects the two-dimensional position map based on signal strengths enclosed by these boundaries. The signal strengths of one portion of the two-dimensional position map, and not all the areas of the two-dimensional position map, are added. As a result, incident positions can be discriminated efficiently, and radiation detecting positions can be determined efficiently.
摘要翻译：本发明的放射线检测装置包括运算处理装置，该运算处理装置具有第一加法步骤，用于在二维位置图的一部分中加入信号强度，根据第一加法步骤中的相加结果绘制相应的边界，并校正基于由这些边界包围的信号强度的二维位置图。添加二维位置图的一部分的信号强度，而不是二维位置图的全部区域。结果，可以有效地区分入射位置，并且可以有效地确定放射线检测位置。

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