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1. 发明授权

US06281277B1 Homogeneously surface-fluorinated metal oxide particulates, process for manufacturing the same, and use of the same 失效
标题翻译：均匀的表面氟化金属氧化物颗粒，其制造方法及其用途
公开(公告)号：US06281277B1
公开(公告)日：2001-08-28
申请号：US09296667
申请日：1999-04-22
申请人： Nobuaki Ishii , Koichi Wada , Kazuo Sekiguchi , Hiroyuki Takahashi
发明人： Nobuaki Ishii , Koichi Wada , Kazuo Sekiguchi , Hiroyuki Takahashi
IPC分类号： C08K300
CPC分类号： B82Y30/00 , C01B13/145 , C01B33/18 , C01F7/021 , C01P2004/62 , C01P2004/64 , C01P2004/80 , C01P2006/12 , C01P2006/80 , C08K9/02 , C09C1/3045 , C09C1/3653 , C09C3/06
摘要： The present invention provides homogeneously surface-fluorinated metal oxide particulates, characterized in that a metal oxide particulate such as Ti, Al, Si, Ag, Cu, Fe, Zr, Ce, Mn, Sn, Ge and Ta is surface reacted with fluorine gas while allowing the metal oxide particulate to flow, and also provides a process for manufacturing the metal oxide particulates. The homogeneously surface-fluorinated metal oxide particulates according to the present invention are useful as an additive for a weatherproof coating material, a weatherproof resin or a cosmetic material. Furthermore, according to the process of the present invention, the surface of a metal oxide particulate can be homogeneously fluorinated at any ratio in a very simple and efficient manner. Even when the homogeneously surface-fluorinated titanium oxide is incorporated as a white pigment into a thermoplastic resin in a high concentration, the resin coated substrate can maintain the surface smoothness without causing any partial defect and troubles can be greatly prevented from occurring at the melt extrusion coating for obtaining the resin coated substrate.
摘要翻译：本发明提供均匀的表面氟化金属氧化物微粒，其特征在于，诸如Ti，Al，Si，Ag，Cu，Fe，Zr，Ce，Mn，Sn，Ge和Ta的金属氧化物颗粒与氟气表面反应同时允许金属氧化物颗粒流动，并且还提供用于制造金属氧化物颗粒的方法。根据本发明的均匀的表面氟化的金属氧化物颗粒可用作耐候性涂料，防风雨树脂或化妆品材料。此外，根据本发明的方法，金属氧化物颗粒的表面可以以非常简单和有效的方式以任何比例均匀地氟化。即使将均匀的表面氟化的氧化钛作为白色颜料以高浓度结合到热塑性树脂中，树脂涂布的基材也可以保持表面光滑度而不会产生任何部分缺陷，并且可以极大地防止在熔融挤出时发生麻烦用于获得树脂涂覆的基底的涂层。

2. 发明授权

US06235270B1 Cosmetics, silica-coated metal oxide powder and production method therefor 失效
标题翻译：化妆品，二氧化硅包覆金属氧化物粉末及其制备方法
公开(公告)号：US06235270B1
公开(公告)日：2001-05-22
申请号：US09062560
申请日：1998-04-20
申请人： Nobuaki Ishii , Koichi Wada , Kazuo Sekiguchi , Michihiro Takama , Shinobu Ito , Kotaro Yano , Yasuo Saito , Keiji Kawasaki
发明人： Nobuaki Ishii , Koichi Wada , Kazuo Sekiguchi , Michihiro Takama , Shinobu Ito , Kotaro Yano , Yasuo Saito , Keiji Kawasaki
IPC分类号： A61K742
CPC分类号： C09C3/063 , A61K8/11 , A61K8/29 , A61K2800/412 , A61K2800/43 , A61Q17/04 , B82Y30/00 , C01P2002/74 , C01P2002/82 , C01P2002/84 , C01P2004/04 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C01P2006/19 , C01P2006/60 , C01P2006/90 , C09C1/043 , C09C1/22 , C09C1/24 , C09C1/3661
摘要： Cosmetics comprising silica-coated metal oxide powder having a thickness of the silica coating of 0.1 to 100 nm, and a photocatalytic activity as measured by tetralin auto-oxidation method of 6 mmH2O/min or less. Silica-coated metal oxide powder coated with a silica coating having an absorption peak intensity ratio I (I=I1/I2, wherein I1 is an absorption peak intensity at 1,150 to 1,250 cm−1 and I2 is an absorption peak intensity at 1,000 to 1,100 cm−1) between the infrared absorption spectra in the region of 1,150 to 1,250 cm−1 and the region of 1,000 to 1,100 cm−1 of 0.2 or more, and having a refractive index of 1.435 or more.
摘要翻译：包含二氧化硅涂层的厚度为0.1〜100nm的由二氧化硅被覆的金属氧化物粉末构成的化妆品，以及通过四氢环丁烷自动氧化法测定的6mmH 2 O /分钟以下的光催化活性。涂覆有二氧化硅涂层的二氧化硅涂覆的金属氧化物粉末，其具有吸收峰强度比I（I = I1 / I2，其中I1是1,150至1,250cm-1处的吸收峰强度，I2是1,000至1,100的吸收峰强度 cm -1，红外线吸收光谱在1,150〜1250cm -1的范围内，1000〜1100cm -1的区域为0.2以上，折射率为1.435以上。

3. 发明授权

US06534044B1 Cosmetic preparation, surface-hydrophobized silica-coated metal oxide particles, sol of silica-coated metal oxide, and processes for producing these 有权
标题翻译：化妆品制备，表面疏水化二氧化硅涂覆的金属氧化物颗粒，二氧化硅涂覆的金属氧化物的溶胶及其制备方法
公开(公告)号：US06534044B1
公开(公告)日：2003-03-18
申请号：US09889048
申请日：2001-07-11
申请人： Koichi Wada , Nobuaki Ishii , Mitsuharu Irie , Kazuo Sekiguchi , Michihiro Takama
发明人： Koichi Wada , Nobuaki Ishii , Mitsuharu Irie , Kazuo Sekiguchi , Michihiro Takama
IPC分类号： A61K742
CPC分类号： A61K8/585 , A61K8/0212 , A61K8/11 , A61K8/19 , A61K8/25 , A61K8/27 , A61K8/28 , A61K8/29 , A61K2800/262 , A61K2800/413 , A61Q1/02 , A61Q1/06 , A61Q17/04 , A61Q19/00 , B01J13/0047 , B01J13/0069 , B01J13/02 , B01J13/22 , B82Y30/00 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C09C1/043 , C09C1/3684 , C09C3/006 , C09C3/063 , C09C3/12
摘要： The invention relates to (1) a cosmetic material comprising silica-coated metal oxide particles further surface-treated with a hydrophobicizing agent, and (2) metal oxide particles having a specified infrared absorption spectrum intensity ratio and refractive index which are further treated with a hydrophobicizing agent, and to a process for their production. The invention further relates to a silica-coated metal oxide sol which gives such particles, and to a process for its production. The invention can give ultraviolet-screening cosmetic materials with an excellent transparent feel, wherein the particles are satisfactorily dispersed.
摘要翻译：本发明涉及（1）包含用疏水剂进一步表面处理的二氧化硅被覆的金属氧化物粒子的化妆品，（2）具有规定的红外吸收光谱强度比和折射率的金属氧化物粒子，其进一步用疏水剂，以及其生产方法。本发明还涉及给出这种颗粒的二氧化硅被覆金属氧化物溶胶及其制造方法。本发明可以赋予具有优异透明感的紫外线屏蔽化妆品材料，其中颗粒令人满意地分散。

4. 发明授权

US08551999B2 Heterocyclic compound and pharmaceutical composition thereof 失效
标题翻译：杂环化合物及其药物组合物
公开(公告)号：US08551999B2
公开(公告)日：2013-10-08
申请号：US12740684
申请日：2008-10-29
申请人： Takumi Sumida , Fujio Tabusa , Kazuo Sekiguchi , Takeshi Kodama , Koichi Yasumura , Yutaka Kojima , Masaaki Motoyama , Keisuke Miyajima , Kenji Yoshida , Keizo Kan , Makoto Sakamoto , Hideki Takasu , Takashi Nakagawa , Naoto Ohi , Yasuo Harada , Norikazu Hashimoto , Hironori Matsuyama , Masatoshi Iida , Shigekazu Fujita , Tae Fukushima
发明人： Takumi Sumida , Fujio Tabusa , Kazuo Sekiguchi , Takeshi Kodama , Koichi Yasumura , Yutaka Kojima , Masaaki Motoyama , Keisuke Miyajima , Kenji Yoshida , Keizo Kan , Makoto Sakamoto , Hideki Takasu , Takashi Nakagawa , Naoto Ohi , Yasuo Harada , Norikazu Hashimoto , Hironori Matsuyama , Masatoshi Iida , Shigekazu Fujita , Tae Fukushima
IPC分类号： A61K31/496 , A61K31/454 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , A61K31/506 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12
摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
摘要翻译：本发明提供由通式（1）表示的杂环化合物：其中R1为R5-Z1-基团等，Z1为低级亚烷基等，R5为通式所示的基团。其中R 13为氢原子等，m为1至5的整数; R2是氢原子：Y是CH或N：A1是选自吲哚二基的杂环，其中杂环可以具有至少一个取代基：T是-CO-等：R3是氢原子等：R4是任选被一个或多个羟基取代的低级烷基等：R 3和R 4与它们所键合的氮原子一起可以彼此结合形成5- 10元饱和杂环，其中杂环可以具有至少一个取代基。本发明的杂环化合物具有抑制胶原蛋白的生成和/或治疗肿瘤的优异效果。

5. 发明授权

US07932276B2 Agent for curing chronic obstructive pulmonary disease 有权
标题翻译：治疗慢性阻塞性肺疾病的药剂
公开(公告)号：US07932276B2
公开(公告)日：2011-04-26
申请号：US11760345
申请日：2007-06-08
申请人： Kazuo Sekiguchi , Katsumi Ikezono , Kazuhide Ohta , Takashi Maeda , Hisashi Nagamoto
发明人： Kazuo Sekiguchi , Katsumi Ikezono , Kazuhide Ohta , Takashi Maeda , Hisashi Nagamoto
IPC分类号： A01N43/78 , A61K31/425 , C07D277/60 , C07D417/00
CPC分类号： A61K31/4439 , A61K31/427
摘要： The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof represented by the general formula (1), wherein, R1 is a phenyl group which may have 1 to 3 lower alkoxy groups as the substituents on the phenyl ring; R2 is a pyridyl group which may have 1 to 3 carboxyl groups as the substituents on the pyridine ring.
摘要翻译：本发明提供了用于治疗慢性阻塞性肺疾病的有用和高度安全的药物，其包含作为有效成分的至少一种选自由通式（1）表示的噻唑衍生物及其盐的化合物，其中，R 1为可以具有1〜3个低级烷氧基作为苯环上的取代基的苯基; R2是可以具有1至3个羧基作为吡啶环上的取代基的吡啶基。

6. 发明授权

US5321220A Pressure switch 失效
标题翻译：压力开关
公开(公告)号：US5321220A
公开(公告)日：1994-06-14
申请号：US36698
申请日：1993-03-25
申请人： Kazuo Sekiguchi
发明人： Kazuo Sekiguchi
IPC分类号： H01H1/58 , H01H35/38
CPC分类号： H01H35/38 , H01H1/58
摘要： A pressure switch comprises an electrically conductive housing, a stationary contact stationarily installed in the housing and a movable contact movably received in the housing. The movable contact is movable to contact with the stationary contact. A hydraulically operated moving device is employed for moving the movable contact in accordance with a hydraulic pressure applied thereto. The stationary contact is formed with a blind bore. An end piece to which an end of an electric cable has been connected is press-fitted in the blind bore.
摘要翻译：压力开关包括导电壳体，固定接触件固定地安装在壳体中，以及可移动地接收在壳体中的可动触头。活动触点可移动以与固定触点接触。采用液压操作的移动装置根据施加到其上的液压来移动活动触点。固定触点形成有盲孔。连接有电缆端部的端部件被压入盲孔中。

7. 发明授权

US4898781A Water-soluble microcapsules 失效
标题翻译：水溶性微胶囊
公开(公告)号：US4898781A
公开(公告)日：1990-02-06
申请号：US118004
申请日：1987-11-09
申请人： Takashi Onouchi , Hironori Sugai , Kazuo Sekiguchi , Yoshikazu Hosoda , Eiichi Yoshida
发明人： Takashi Onouchi , Hironori Sugai , Kazuo Sekiguchi , Yoshikazu Hosoda , Eiichi Yoshida
IPC分类号： A61K8/00 , A61K8/04 , A61K8/11 , A61K8/18 , A61K8/66 , A61K9/16 , A61K9/50 , A61K9/52 , A61Q5/00 , A61Q5/02 , A61Q13/00 , A61Q19/10 , B01J13/02 , B01J13/04 , B01J13/12 , B01J13/16 , C11B9/00 , C11D3/386 , C11D17/00 , C11D17/08 , C12N11/08
CPC分类号： A61K8/11 , A61K8/66 , A61K9/1635 , A61K9/5026 , A61Q5/02 , B01J13/04 , B01J13/125 , B01J13/16 , C11D17/0039 , C11D3/38672 , A61K2800/412 , Y10T428/2987
摘要： Water-soluble microcapsules using a water-containing hydrophilic substance as a core material and at least one member selected from the group consisting of polyvinyl alcohol and modified polyvinyl alcohols as a coating material are stably retained in a concentrated aqeuous solution and are dissolved in water or a dilute aqueous solution.

8. 发明申请

US20100210661A1 STAT3/5 ACTIVATION INHIBITOR 失效
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：US20100210661A1
公开(公告)日：2010-08-19
申请号：US12311500
申请日：2007-10-02
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/496 , C07D401/14 , C07D405/10 , A61P3/04 , A61P25/28 , A61P3/10
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译：本发明的目的是提供一种STAT3 / 5激活抑制剂。本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂，其中，X1表示氮原子或-CH =，R1表示-Z-R6基，其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示其中R 3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

9. 发明申请

US20090258923A1 Carrier Composition for Nucleic Acid Transport 有权
标题翻译：核酸运输载体组成
公开(公告)号：US20090258923A1
公开(公告)日：2009-10-15
申请号：US12083727
申请日：2006-10-17
申请人： Hidekazu Toyobuku , Hideo Miyao , Masako Sato , Kazuo Sekiguchi
发明人： Hidekazu Toyobuku , Hideo Miyao , Masako Sato , Kazuo Sekiguchi
IPC分类号： A61K31/713 , A61K47/28
CPC分类号： A61K9/1272 , A61K47/543 , C12N15/88
摘要： An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as an siRNA into an animal-derived cell or organism, being capable of delivering efficiently the nucleic acids into the cells while protecting it from being degraded; and a nucleic acid deliver composition containing the carrier and a nucleic acid.The carrier composition for delivery of a nucleic acid is prepared by mixing (A) a cationic lipid having a steroid skeleton with (B) a tertiary ammonium salt-type cationic lipid. The nucleic acid delivery composition is prepared by mixing the nucleic acid delivery carrier with a nucleic acid.
摘要翻译：本发明的目的是提供一种低毒性和高安全性的核酸递送载体组合物，该载体组合物当用于将诸如siRNA的核酸施用于动物来源的细胞或生物体时，能够递送将核酸有效地进入细胞同时保护其免于降解; 以及含有载体和核酸的核酸递送组合物。用于递送核酸的载体组合物通过将（A）具有类固醇骨架的阳离子脂质与（B）叔铵盐型阳离子脂质混合来制备。通过将核酸递送载体与核酸混合来制备核酸递送组合物。

10. 发明申请

US20120322807A1 STAT3/5 ACTIVATION INHIBITOR 审中-公开
标题翻译： STAT3 / 5激活抑制剂
公开(公告)号：US20120322807A1
公开(公告)日：2012-12-20
申请号：US13526283
申请日：2012-06-18
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/496 , A61P37/08
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group
摘要翻译：本发明提供含有由通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，其中X1表示氮原子或-CH =，R1表示-Z-R6基团，其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示基团

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