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1. 发明申请

US20180036470A1 Blood Purification Apparatus 审中-公开
公开(公告)号：US20180036470A1
公开(公告)日：2018-02-08
申请号：US15788040
申请日：2017-10-19
申请人： Nikkiso Company Limited
发明人： Shinya Hasegawa , Tomohiro Furuhashi , Satoshi Takeuchi
IPC分类号： A61M1/30 , A61M1/36
摘要： A blood purification apparatus employing a single-needle double-pump method and being capable of automatically discharging a priming solution that has undergone substitution from a blood circuit during blood removal. A blood purification apparatus includes a blood circuit to which an only puncture needle is connectable, a dialyzer that purifies blood flowing in the blood circuit, a first blood pump, a second blood pump, and a control device that allows the blood of a patient to be extracorporeally circulated through the blood circuit by causing the first blood pump and the second blood pump to alternately undergo normal rotation. During blood removal, the control device operates to substitute a priming solution in the blood circuit with the blood of the patient and to discharge the priming solution having undergone the substitution from the blood circuit by causing the first blood pump to undergo normal rotation and the second blood pump to undergo reverse rotation.

2. 发明授权

US09878083B2 Blood purification apparatus with recognition and control means 有权
公开(公告)号：US09878083B2
公开(公告)日：2018-01-30
申请号：US14497369
申请日：2014-09-26
申请人： Nikkiso Company Limited
发明人： Tomohiro Furuhashi , Satoshi Takeuchi , Akira Sugioka , Masahiro Toyoda
IPC分类号： B01J49/00 , A61M1/16 , A61M1/34 , B01D11/00 , B01D61/00 , C02F1/44 , A61M1/36
CPC分类号： A61M1/1603 , A61M1/1615 , A61M1/342 , A61M1/3458 , A61M1/3626 , A61M1/3646 , A61M1/367 , A61M2202/0413 , A61M2205/3306 , A61M2205/331 , A61M2205/75
摘要： A blood purification apparatus which can perform actions and operations according to the final stage of blood-return. Accordingly, a blood purification apparatus comprising a blood circuit including an arterial blood circuit and a venous blood circuit for extracorporeally circulating blood of a patient from a tip end of the arterial blood circuit to a tip end of the venous blood circuit; a blood purification means arranged between the arterial blood circuit and the venous blood circuit of the blood circuit and purifying blood flowing through the blood circuit; a substitution solution supplying means for supplying substitution solution to the blood circuit; and performing blood-return by substituting the blood in the blood circuit with the substitution solution supplied from the substitution solution supplying means after the blood purification treatment wherein the blood purification apparatus comprises a detecting means arranged at predetermined positions in the arterial blood circuit and the venous blood circuit and detecting presence or absence or blood concentration of the blood flowing in the arterial blood circuit and the venous blood circuit at said predetermined positrons, and a recognition means for recognizing a final stage of blood-return which is a condition near the end of the substitution of blood with the substitution solution based on the presence or absence of the blood or blood concentration detected by the detecting means.

3. 发明申请

US20170095602A1 BLOOD PURIFICATION APPARATUS 审中-公开
公开(公告)号：US20170095602A1
公开(公告)日：2017-04-06
申请号：US15387913
申请日：2016-12-22
申请人： Nikkiso Company Limited
发明人： Fumihiko Ishizaki , Satoshi Takeuchi
IPC分类号： A61M1/16 , B01D61/14 , A61M1/36 , B01D61/22 , A61M1/26 , A61M39/24
CPC分类号： A61M1/1605 , A61M1/14 , A61M1/16 , A61M1/1694 , A61M1/267 , A61M1/3465 , A61M1/3638 , A61M1/3653 , A61M1/3656 , A61M39/24 , A61M2205/15 , A61M2205/3331 , B01D61/145 , B01D61/22
摘要： A blood purification apparatus is provided that can easily and accurately determine before treatment whether or not blocking of liquid by a check valve is appropriate. In the blood purification apparatus including a blood circuit, a dialyzer, a dialysate introduction line and a dialysate discharge line, pressure detection device, a dialysate extraction device, a dialysate supply line, and a check valve that blocks flow of a liquid from the blood circuit to the dialysate introduction line, there are provided a control means that makes it possible to generate a pressure difference between a side of the blood circuit and a side of the dialysate introduction line across the check valve, a monitor means that makes it possible to monitor a change in a detection value of the pressure detection device based on the pressure difference, and a determination means that makes it possible to determine whether or not blocking of liquid by the check valve is appropriate based on the change in the detection value of the pressure detection device.

4. 发明申请

US20200093976A1 Blood Purification Apparatus 审中-公开
公开(公告)号：US20200093976A1
公开(公告)日：2020-03-26
申请号：US16695584
申请日：2019-11-26
申请人： Nikkiso Company Limited
发明人： Yuki Katayama , Satoshi Takeuchi , Hideto Maki
IPC分类号： A61M1/30 , A61M1/36 , A61M1/10 , A61M1/34 , A61M1/16
摘要： A blood purification apparatus is provided in which parameters related to ultrafiltration can be changed assuredly and smoothly at the restart of blood purification treatment suspended with the release of the patient from a blood circuit during the blood purification treatment. A blood purification apparatus in which the blood purification treatment that is suspended with the release of the patient from a blood circuit during the blood purification treatment is restartable includes a touch panel (M) capable of displaying, simultaneously on one particular screen, a plurality of variable amounts related to the patients body weight that changes with the suspension and restart of the blood purification treatment.

5. 发明申请

US20150151036A1 BLOOD PURIFICATION APPARATUS AND PRIMING METHOD FOR THE SAME 有权
标题翻译：血液净化装置及其制备方法
公开(公告)号：US20150151036A1
公开(公告)日：2015-06-04
申请号：US14615839
申请日：2015-02-06
申请人： Nikkiso Company Limited
发明人： Tomohiro Furuhashi , Satoshi Takeuchi , Akira Sugioka , Masahiro Toyoda
IPC分类号： A61M1/36
CPC分类号： A61M1/3643 , A61M1/1682 , A61M1/3465 , A61M1/3638 , A61M1/3644 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M2205/3379
摘要： The present teachings provide a blood purification apparatus and a priming method, which can reduce or dispense with dedicated components used for automated priming and which can reduce manufacturing costs of a blood circuit while achieving the automated priming. The present teachings further provide a blood purification apparatus including a liquid level adjustment device that can optionally introduce or discharge air into or from an upper portion of a venous air trap chamber, a control device that can adjust a liquid level formed inside the venous air trap chamber to have the height at any desired position by operating the liquid level adjustment device, and a priming solution supplying line that can supply a priming solution to an arterial blood circuit and a venous blood circuit. As taught herein, during priming, the control device can fill the arterial blood circuit and the venous blood circuit with priming solution supplied from the priming solution supplying line by operating the liquid level adjustment device at any desired timing.
摘要翻译：本教导提供了一种血液净化装置和起动方法，其可以减少或省去用于自动引燃的专用部件，并且可以在实现自动启动的同时降低血液回路的制造成本。本发明进一步提供了一种血液净化装置，其包括：液位调节装置，其可以可选地将空气引入或排出静脉吸气室的上部;或者可以调节在静脉空气阱内形成的液面的控制装置通过操作液位调节装置，在任何期望位置具有高度，以及可向动脉血液回路和静脉血液回路提供起动溶液的起动溶液供应管线。如本文所教导的，在灌注期间，控制装置可以通过在任何期望的时间操作液位调节装置，用起动溶液供应管线提供的起动溶液来填充动脉血液回路和静脉血液回路。

6. 发明授权

US10751459B2 Blood purification apparatus 有权
公开(公告)号：US10751459B2
公开(公告)日：2020-08-25
申请号：US15788040
申请日：2017-10-19
申请人： Nikkiso Company Limited
发明人： Shinya Hasegawa , Tomohiro Furuhashi , Satoshi Takeuchi
IPC分类号： A61M1/30 , A61M1/36
摘要： A blood purification apparatus employing a single-needle double-pump method and being capable of automatically discharging a priming solution that has undergone substitution from a blood circuit during blood removal. A blood purification apparatus includes a blood circuit to which an only puncture needle is connectable, a dialyzer that purifies blood flowing in the blood circuit, a first blood pump, a second blood pump, and a control device that allows the blood of a patient to be extracorporeally circulated through the blood circuit by causing the first blood pump and the second blood pump to alternately undergo normal rotation. During blood removal, the control device operates to substitute a priming solution in the blood circuit with the blood of the patient and to discharge the priming solution having undergone the substitution from the blood circuit by causing the first blood pump to undergo normal rotation and the second blood pump to undergo reverse rotation.

7. 发明授权

US10653827B2 Blood purification apparatus 有权
公开(公告)号：US10653827B2
公开(公告)日：2020-05-19
申请号：US15952419
申请日：2018-04-13
申请人： Nikkiso Company Limited
发明人： Satoshi Takeuchi , Kazuya Tsuji
IPC分类号： A61M1/36 , A61M1/34 , A61M1/26 , F16K37/00 , G01M3/28 , A61M1/16
摘要： The present teachings relate to a blood purification apparatus in which the connection of a substitution line to a collecting port can be checked accurately and instantly and even during blood purification treatment. A blood purification apparatus includes a blood circuit, a dialyzer, a dialysate introduction line, a dialysate drain line, a substitution line one end of which is connected to a collecting port provided at a predetermined position of the dialysate introduction line and an other end of which is connected to the blood circuit, a substitution pump configured to form a pressure-increasing portion that includes the collecting port, and a pressure-measuring device capable of measuring a pressure in the pressure-increasing portion. The blood purification apparatus performs a testing process by increasing a liquid pressure in the pressure-increasing portion by utilizing a liquid-feeding pressure applied from a liquid-feeding device and measuring the pressure with the pressure-measuring device.

8. 发明授权

US10314957B2 Blood purification apparatus 有权
公开(公告)号：US10314957B2
公开(公告)日：2019-06-11
申请号：US15387913
申请日：2016-12-22
申请人： Nikkiso Company Limited
发明人： Fumihiko Ishizaki , Satoshi Takeuchi
IPC分类号： A61N1/14 , A61M1/16 , A61M1/14 , A61M1/26 , A61M1/36 , A61M39/24 , B01D61/14 , B01D61/22 , A61M1/34
摘要： A blood purification apparatus is provided that can easily and accurately determine before treatment whether or not blocking of liquid by a check valve is appropriate. In the blood purification apparatus including a blood circuit, a dialyzer, a dialysate introduction line and a dialysate discharge line, pressure detection device, a dialysate extraction device, a dialysate supply line, and a check valve that blocks flow of a liquid from the blood circuit to the dialysate introduction line, there are provided a control means that makes it possible to generate a pressure difference between a side of the blood circuit and a side of the dialysate introduction line across the check valve, a monitor means that makes it possible to monitor a change in a detection value of the pressure detection device based on the pressure difference, and a determination means that makes it possible to determine whether or not blocking of liquid by the check valve is appropriate based on the change in the detection value of the pressure detection device.

9. 发明申请

US20150021244A1 BLOOD PURIFICATION APPARATUS 有权
标题翻译：血液净化装置
公开(公告)号：US20150021244A1
公开(公告)日：2015-01-22
申请号：US14497369
申请日：2014-09-26
申请人： Nikkiso Company Limited
发明人： Tomohiro Furuhashi , Satoshi Takeuchi , Akira Sugioka , Masahiro Toyoda
IPC分类号： A61M1/16
CPC分类号： A61M1/1603 , A61M1/1615 , A61M1/342 , A61M1/3458 , A61M1/3626 , A61M1/3646 , A61M1/367 , A61M2202/0413 , A61M2205/3306 , A61M2205/331 , A61M2205/75
摘要： A blood purification apparatus which can perform actions and operations according to the final stage of blood-return. Accordingly, a blood purification apparatus comprising a blood circuit including an arterial blood circuit and a venous blood circuit for extracorporeally circulating blood of a patient from a tip end of the arterial blood circuit to a tip end of the venous blood circuit; a blood purification means arranged between the arterial blood circuit and the venous blood circuit of the blood circuit and purifying blood flowing through the blood circuit; a substitution solution supplying means for supplying substitution solution to the blood circuit; and performing blood-return by substituting the blood in the blood circuit with the substitution solution supplied from the substitution solution supplying means after the blood purification treatment wherein the blood purification apparatus comprises a detecting means arranged at predetermined positions in the arterial blood circuit and the venous blood circuit and detecting presence or absence or blood concentration of the blood flowing in the arterial blood circuit and the venous blood circuit at said predetermined positrons, and a recognition means for recognizing a final stage of blood-return which is a condition near the end of the substitution of blood with the substitution solution based on the presence or absence of the blood or blood concentration detected by the detecting means.
摘要翻译：一种血液净化装置，其可以根据血液回流的最后阶段执行动作和操作。因此，一种血液净化装置，包括：血液回路，其包括动脉血回路和静脉血回路，用于使患者的血液从动脉血回路的前端向静脉血回路的前端体外循环; 血液净化装置，配置在血液回路的动脉血液回路和静脉血液回路之间，净化血液循环的血液; 用于向血液回路提供替代溶液的置换溶液供给装置; 并且在血液净化处理之后用从替代溶液供给装置供给的置换溶液代替血液回路中的血液进行血液回流，其中，血液净化装置包括布置在动脉血液回路中的预定位置的检测装置和静脉血液回路，检测在所述预定正电子体中在动脉血回路和静脉血回路中流动的血液的存在或不存在或血液浓度，以及识别装置，用于识别作为接近终点的状态的血液回流的最后阶段基于由检测装置检测到的血液或血液浓度的存在或不存在，用取代溶液代替血液。

10. 发明申请

US20220031922A1 BLOOD PURIFICATION APPARATUS 有权
公开(公告)号：US20220031922A1
公开(公告)日：2022-02-03
申请号：US17490102
申请日：2021-09-30
申请人： Nikkiso Company Limited
发明人： Kazuya Tsuji , Satoshi Takeuchi
IPC分类号： A61M1/36 , A61M1/16 , A61M1/26
摘要： A blood purification apparatus including a line section through which working dialysate to be introduced into a blood purifier or drain liquid discharged from the blood purifier is caused to flow; a delivery unit that delivers liquid in the line section; an introduction port connected to a supply route through which undiluted dialysate or the working dialysate is supplied, the introduction port allowing the undiluted dialysate or the working dialysate in the supply route to be introduced into the apparatus; an introduction route connected to the introduction port and through which the undiluted dialysate or the working dialysate introduced from the introduction port flows into the line section; a valve unit provided to the introduction route and being capable of opening or closing the introduction route by being opened or closed; and a control unit that controls an operation of opening or closing the valve unit. The control unit is capable of executing a flushing step in which when a cleaning solution or a disinfecting solution is caused to flow through the supply route, the valve unit is opened to allow the cleaning solution or the disinfecting solution flowing in the supply route to flow into the introduction route and through the line section to be discharged to an outside of the apparatus.

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