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1. 发明公开

US20230202980A1 N-(2-Aminophenyl)-Prop-2-Enamide Derivatives, and Uses Thereof in the Treatment of Cancer 审中-公开
公开(公告)号：US20230202980A1
公开(公告)日：2023-06-29
申请号：US17638521
申请日：2020-08-28
申请人： National University of Singapore , The Brigham and Women’s Hospital, Inc. , Indian Institute of Chemical Technology
发明人： Sridhar Radhakrishnan , Daniel G. Tenen , Bee Hui Liu , Kim Anh Vu Le , Mei Lin Go , Li Chai , Chong Gao , Ahmed Kamal , Satish Sunkari , Venkata Subbarao Ayinampudi , Riyaz Syed , Miao Liu
IPC分类号： C07D213/72 , C07D401/12 , C07D401/14 , C07D417/14 , A61P35/00
CPC分类号： C07D213/72 , A61P35/00 , C07D401/12 , C07D401/14 , C07D417/14
摘要： Provided herein are N-(2-aminophenyl)-prop-2-enamide derivatives, such as those of Formula (I), methods for the synthesis thereof, and uses thereof in the treatment of cancer, such as SALL4-expressing cancer, in a cell or subject in need thereof.

2. 发明授权

US10793601B2 Therapeutic spalt-like transcription factor 4 (SALL4) peptide 有权
公开(公告)号：US10793601B2
公开(公告)日：2020-10-06
申请号：US16095603
申请日：2017-04-28
申请人： National University of Singapore , The Brigham and Women's Hospital, Inc. , Agency for Science, Technology and Research
发明人： Bee Hui Liu , Daniel Geoffrey Tenen , Li Chai , Cheng San Brian Chia , Anders Poulsen
IPC分类号： A61K38/00 , A61K38/08 , C07K7/06 , C07K7/08
摘要： Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.

3. 发明授权

US09365851B2 Spalt-like transcription factor 4 (SALL4) and uses thereof 有权
标题翻译：斯洛伐他汀转录因子4（SALL4）及其用途
公开(公告)号：US09365851B2
公开(公告)日：2016-06-14
申请号：US14345603
申请日：2012-09-20
申请人： National University of Singapore , Brigham and Women's Hospital
发明人： Li Chai , Todor Dimitrov , Daniel Geoffrey Tenen , Kol Jia Yong , Bee Hui Liu
IPC分类号： A61K38/10 , C07K16/18 , C07K7/08 , C12N15/113 , A61K38/17 , G01N33/574
CPC分类号： C12N15/113 , A61K38/1709 , C07K7/08 , C07K16/18 , C12N2310/122 , C12N2310/14 , C12N2310/531 , G01N33/57496
摘要： Described are methods of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4. In addition, the invention is directed to methods of detecting an aggressive cancer in an individual in need thereof as well as methods of detecting a poor prognosis of a patient with cancer in an individual in need thereof.
摘要翻译：描述了在有需要的个体中治疗表达斯氏样转录因子4（SALL4）和磷酸酶和凝聚素同源物（PTEN）的实体瘤的方法，包括向个体施用有效量的抑制SALL4的组合物。此外，本发明涉及检测有需要的个体中侵袭性癌症的方法以及在有需要的个体中检测患有癌症的患者的不良预后的方法。

4. 发明申请

US20190218253A1 Therapeutic SALL4 Peptide 审中-公开
公开(公告)号：US20190218253A1
公开(公告)日：2019-07-18
申请号：US16095603
申请日：2017-04-28
申请人： National University of Singapore , The Brigham and Women's Hospital, Inc. , Agency for Science, Technology and Research
发明人： Bee Hui Liu , Daniel Geoffrey Tenen , Li Chai , Cheng San Brian Chia , Anders Poulsen
IPC分类号： C07K7/06 , C07K7/08
摘要： The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation of SALL4 are also provided.

5. 发明申请

US20150080315A1 SALL4 And Uses Thereof 有权
标题翻译： SALL4及其用途
公开(公告)号：US20150080315A1
公开(公告)日：2015-03-19
申请号：US14345603
申请日：2012-09-20
申请人： National University of Singapore , Brigham and Women's Hospital
发明人： Li Chai , Todor Dimitrov , Daniel Geoffrey Tenen , Kol Jia Yong
IPC分类号： C12N15/113 , G01N33/574 , C07K7/08
CPC分类号： C12N15/113 , A61K38/1709 , C07K7/08 , C07K16/18 , C12N2310/122 , C12N2310/14 , C12N2310/531 , G01N33/57496
摘要： The invention is directed to methods of treating a solid tumor which expresses SALL4 and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4. In addition, the invention is directed methods of method of detecting an aggressive cancer in an individual in need thereof comprising detecting whether one or more cancer cells of the individual expresses SALL4, wherein if SALL4 is detected in the one or more cancer cells, then an aggressive cancer is detected in the individual, and methods of method of detecting a poor prognosis of a patient with cancer in an individual in need thereof, comprising detecting whether one or more cancer cells of the patient expresses SALL4, wherein if SALL4 is detected in the one or more cancer cells of the patient, then a poor prognosis is detected in the patient.
摘要翻译：本发明涉及在有需要的个体中治疗表达SALL4和磷酸酶和凝乳酶原性（PTEN）的实体瘤的方法，其包括向个体施用有效量的抑制SALL4的组合物。另外，本发明是针对有需要的个体检测侵袭性癌症的方法的方法，其特征在于，检测个体的一个以上的癌细胞是否表达SALL4，其中，如果在一个或多个癌细胞中检测到SALL4，则在个体中检测到侵袭性癌症，以及检测有需要的个体中癌症患者预后不良的方法，包括检测患者的一种或多种癌细胞是否表达SALL4，其中如果在SALL4中检测到SALL4，患者的一个或多个癌细胞，则在患者中检测到不良预后。

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