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1. 发明授权

US08433039B1 Gamma-ray microscopy methods 有权
标题翻译：伽玛射线显微镜法
公开(公告)号：US08433039B1
公开(公告)日：2013-04-30
申请号：US12773005
申请日：2010-05-03
申请人： Nathaniel Tue Tran
发明人： Nathaniel Tue Tran
IPC分类号： G21G4/00
CPC分类号： G02B21/00 , G21G4/06 , G21K7/00
摘要： This invention teaches a method of performing gamma-ray microscopy and how to build a gamma-ray microscope. While the beam of gamma rays can not be manipulated like a beam of light or a beam of electrons, magnification is possible using a single-point source of gamma radiation. With this design, gamma rays originate from a tiny point in space and radiate outward as they travel away from the source. This results in magnification when a sample is placed between this single-point source and a detector array. The magnification factor is equal to the source-to-detector distance divided by the source-to-sample distance. A single-point source of gamma rays can be made by crossing a beam of positrons with a beam of electrons. The finer and more focused these beams are, the smaller the single-point source can be, and the higher the resolution can be. Methods of making and focusing electron beams are known in the art of making electron microscopy. These methods can be adapted to accelerate and focus positrons into a fine beam. Positrons can be harvested from radioactive isotopes that emit positrons and trapped by electric fields and magnetic fields for use when necessary. Mini versions of particle accelerator can trap positrons in an orbit for regulated or pulsed beam of positrons to be generated.
摘要翻译：本发明教导了一种执行伽马射线显微镜的方法以及如何构建伽马射线显微镜。虽然伽马射线束不能像光束或电子束一样被操纵，但是可以使用单点伽马射线源进行放大。通过这种设计，伽马射线起源于太空中的一个微小点，并且在远离光源时向外辐射。当样品放置在该单点源和检测器阵列之间时，这导致放大。放大系数等于源到检测器的距离除以源到样本的距离。可以通过将正电子束与电子束交叉来形成单点γ射线源。这些光束越精细，越集中，单点光源可以越小，分辨率越高。制造和聚焦电子束的方法在制造电子显微镜技术中是已知的。这些方法可以适应于加速和将正电子聚焦成精细光束。正电子可以从发射正电子的放射性同位素中收集，并在必要时被电场和磁场捕获。微型加速器的微型版本可以将正电子俘获在轨道中，以产生用于调节或脉冲的正电子束。

2. 发明授权

US07175986B2 Methods and reagents for differential proteomic analysis 有权
标题翻译：差异蛋白质组学分析方法和试剂
公开(公告)号：US07175986B2
公开(公告)日：2007-02-13
申请号：US10835027
申请日：2004-04-28
申请人： Nathaniel Tue Tran
发明人： Nathaniel Tue Tran
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/60
摘要： Methods and reagents for labeling molecules of interest in a plurality of samples, and then combining and selecting labeled molecules away from unlabeled molecules for use in simultaneous co-assaying analysis. The reagents comprise labeling means of distinguishable radioactive isotopes which remain with the labeled molecules. Additionally, the reagents also comprise selection means which can be affinity tags, beads, or immobilized surface which may remain or be cleaved off through cleavable linkers. A set of labeling reagent can be used to label a plurality of samples, combine them before or after selecting/enriching for labeled molecules and co-assay together for reliable comparison. This invention has many applications in comparing and panning for differentially abundant molecules or differential modification of molecules for proteomics, glycomics, phospho-proteomics, metabolomics, epi-genomics . . . studies.
摘要翻译：用于在多个样品中标记目标分子的方法和试剂，然后组合并选择远离未标记分子的标记分子，以用于同时共同测定分析。试剂包括与标记分子保留的可区分放射性同位素的标记方法。另外，试剂还包括可以是可以通过可切割接头保留或被切割的亲和标签，珠粒或固定化表面的选择方法。可以使用一组标记试剂来标记多个样品，在选择/富集标记分子之前或之后组合它们，并共同测定以进行可靠的比较。本发明在蛋白质组学，糖组学，磷蛋白质组学，代谢组学，表型基因组学的分子差异丰富的分子或差异修饰的比较和平移中具有许多应用。。。学习。

3. 发明申请

US20060084065A1 RADIOACTIVE MULTIPLEXING ANALYTICAL METHODS FOR BIOMARKERS DISCOVERY 失效
标题翻译：用于生物识别发现的放射性多重分析方法
公开(公告)号：US20060084065A1
公开(公告)日：2006-04-20
申请号：US10680277
申请日：2003-10-07
申请人： Nathaniel Tue Tran
发明人： Nathaniel Tue Tran
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6848 , G01N33/60 , G01N2030/77 , G01N2458/15
摘要： A novel analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to any separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The novel technique exploits the differences in radiation energy or half-life between isotopes to make differential detection and quantification of labels possible. Detailed methods for differential detection and quantification are also described as well as the construction and application of hardware and software to enable and enhance such a process. This method is useful in finding molecular differences between two samples in differential proteomics, phosphor-proteomics, glycomics, metabolomics, transcriptomics, genomics and diagnostic applications.
摘要翻译：一种新颖的分析方法包括用不同的放射性标记试剂标记样品，混合并使混合物进行任何分离技术，然后差异检测和定量每个样品的亚组分进行比较。该技术利用了同位素辐射能量或半衰期的差异，使标签的差异检测和量化成为可能。还描述了差分检测和量化的详细方法以及硬件和软件的构建和应用，以实现和增强这种过程。该方法可用于在差异蛋白质组学，荧光蛋白质组学，糖组学，代谢组学，转录组学，基因组学和诊断应用中发现两个样品之间的分子差异。

4. 发明授权

US07029855B1 Radioactive multiplexing analytical methods for biomarkers discovery 失效
标题翻译：用于生物标志物发现的放射多重分析方法
公开(公告)号：US07029855B1
公开(公告)日：2006-04-18
申请号：US10680277
申请日：2003-10-07
申请人： Nathaniel Tue Tran
发明人： Nathaniel Tue Tran
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6848 , G01N33/60 , G01N2030/77 , G01N2458/15
摘要： A novel analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to any separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The novel technique exploits the differences in radiation energy or half-life between isotopes to make differential detection and quantification of labels possible. Detailed methods for differential detection and quantification are also described as well as the construction and application of hardware and software to enable and enhance such a process. This method is useful in finding molecular differences between two samples in differential proteomics, phosphor-proteomics, glycomics, metabolomics, transcriptomics, genomics and diagnostic applications.
摘要翻译：一种新颖的分析方法包括用不同的放射性标记试剂标记样品，混合并使混合物进行任何分离技术，然后差异检测和定量每个样品的亚组分进行比较。该技术利用了同位素辐射能量或半衰期的差异，使标签的差异检测和量化成为可能。还描述了差分检测和量化的详细方法以及硬件和软件的构建和应用，以实现和增强这种过程。该方法可用于在差异蛋白质组学，荧光蛋白质组学，糖组学，代谢组学，转录组学，基因组学和诊断应用中发现两个样品之间的分子差异。

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