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    • 4. 发明授权
    • Systems and methods for delivery of materials
    • 材料交付的系统和方法
    • US08524259B2
    • 2013-09-03
    • US12746178
    • 2008-12-03
    • David D. TaftSteven BitlerQiang ZhengStelios TzannisAdam BellWei-Guo DaiSandra N. OttensmannNatarajan Balachander
    • David D. TaftSteven BitlerQiang ZhengStelios TzannisAdam BellWei-Guo DaiSandra N. OttensmannNatarajan Balachander
    • C08G63/06
    • A61K9/0024A61K9/0019A61K9/146
    • Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
    • 用于输送释放材料的系统和方法,例如药物和其他生物活性材料。 称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在,例如长链正烷基部分,这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度,例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 对于一些用途,特别是药物的递送,优选使用生物侵蚀性CYC载体。
    • 6. 发明授权
    • Side chain crystalline polymer as rheology modifier for crosslinked polymer
    • 侧链结晶聚合物作为交联聚合物的流变改性剂
    • US06492462B2
    • 2002-12-10
    • US09741530
    • 2000-12-19
    • Steven P. BitlerDavid D. TaftRay F. Stewart
    • Steven P. BitlerDavid D. TaftRay F. Stewart
    • C08L5100
    • C08F8/00C08F20/00
    • The rheological properties of a crosslinkable resin system are modified by the presence of a side chain crystalline (SCC) polymer (or a similar crystalline polymer which melts over a narrow temperature range). The polymer dissolves in the curable system at temperatures above the melting point of the crystalline polymer (Tp), but when the system is then cooled to a temperature below Tp, at least partially forms a separate phase in the curable system. Below Tp, this separate phase substantially increases the viscosity of the curable system (i.e. makes it thicker than the same system without the crystalline polymer). This is particularly valuable for sheet molding composites (SMCs) in which the increase in viscosity makes the composites less tacky, and for dry film resists (DFRs). Above Tp, the curable system containing the dissolved crystalline polymer has a viscosity which is substantially less than its viscosity below Tp.
    • 可交联树脂体系的流变性质通过侧链结晶(SCC)聚合物(或在窄温度范围内熔融的类似结晶聚合物)的存在而改性。 聚合物在高于结晶聚合物(Tp)的熔点的温度下溶解在可固化体系中,但是当系统被冷却到低于Tp的温度时,至少部分地在可固化体系中形成单独的相。 在Tp之下,该分离相基本上增加了可固化体系的粘度(即使其比没有结晶聚合物的相同系统厚)。 这对于其中粘度增加使得复合材料较不粘性以及用于干膜抗蚀剂(DFR)的片状模塑复合材料(SMC)尤其有用。 含有溶解的结晶聚合物的可固化体系在Tp之上的粘度基本上小于其粘度低于Tp的粘度。
    • 9. 发明授权
    • Method of using low profile additives for crosslinkable resins
    • 低交联添加剂用于交联树脂的方法
    • US06544453B2
    • 2003-04-08
    • US09734434
    • 2000-12-11
    • David D. TaftSteven P. Bitler
    • David D. TaftSteven P. Bitler
    • B29B1106
    • C08L101/00C08L2666/02
    • Shrinkage of cured resins is reduced by mixing the crosslinkable resin with a low profile additive (LPA). The LPA is in the form of particles which comprise an SCC polymer (or a similar crystalline polymer which melts over a narrow temperature range). The system is cured at a temperature above the melting point of the crystalline polymer (Tp), and the system and the LPA are such that at least part of the LPA remains as a separate phase in the curable resin at temperatures below Tp. It is believed that at least part of the crystalline polymer remains as a separate phase in the resin as it cures. Preferably at least part of the crystalline polymer forms a separate phase in the cured polymer after it has cooled.
    • 通过将可交联树脂与低轮廓添加剂(LPA)混合来降低固化树脂的收缩。 LPA是包含SCC聚合物(或在窄温度范围内熔化的类似结晶聚合物)的颗粒形式。 该系统在高于结晶聚合物(Tp)的熔点的温度下固化,并且系统和LPA使得至少部分LPA在低于Tp的温度下保持为可固化树脂中的分离相。 据信至少部分结晶聚合物在树脂固化时保持为树脂的独立相。 在固化的聚合物冷却后,优选至少部分结晶聚合物形成分离的相。