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1. 发明申请

US20060040970A1 Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group 有权
标题翻译：尿频或尿失禁的补救措施或预防措施以及含有氮杂环基的吗啡喃衍生物
公开(公告)号：US20060040970A1
公开(公告)日：2006-02-23
申请号：US10530664
申请日：2003-10-08
申请人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
发明人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
IPC分类号： A61K31/473
CPC分类号： C07D489/08
摘要： The invention provides a morphinan derivative of the Formula (I): (wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(═O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like) or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.
摘要翻译：本发明提供式（I）的吗啡喃衍生物：其中R 1是甲基，环丙基甲基等; R 2和R 3 O >是羟基，甲氧基，乙酰氧基等; Y和Z都是价键，-C（-O） - 等; X是C 2 -C 5 构成环结构的一部分的碳链（其中一个碳原子可以被氧，硫或氮取代）等;（R 4）是取代或未取代的苯稠环，羰基等; R 9是氢等; R 10和R 11，必须代表-O-等，R 6是氢等）或其药学上可接受的酸加成盐。本发明还提供了用于尿频或尿失禁的治疗或预防剂，其包含吗啡喃衍生物或其药学上可接受的酸加成盐作为有效成分; 一种治疗或预防疾病的方法。

2. 发明申请

US20090176818A1 Antitussive Agent 有权
标题翻译：镇咳药
公开(公告)号：US20090176818A1
公开(公告)日：2009-07-09
申请号：US12158100
申请日：2006-12-15
申请人： Naoki Izumimoto , Koji Kawai
发明人： Naoki Izumimoto , Koji Kawai
IPC分类号： A61K31/4748 , C07D489/02 , A61P11/14
CPC分类号： C07D489/08 , A61K31/485
摘要： An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic substituent or a pharmaceutically acceptable acid addition salt thereof, having a specific structure, such as the compound below [N-(17-cyclopeopylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide]. The antitussive has an excellent therapeutic or prophylactic effect against coughing and the side effects thereof are small.
摘要翻译：公开了可用于治疗或预防咳嗽的镇咳药。镇咳药包含具有特定结构的含氮环状取代基的吗啡喃衍生物或其药学上可接受的酸加成盐，例如[N-（17-环戊基甲基-4,4α-环氧 - 3,14-二羟基 - 吗啡喃-6β-基）-3,4,5,6-四氢邻苯二甲酰亚胺]。止咳剂对咳嗽具有优异的治疗或预防作用，其副作用小。

3. 发明授权

US08106065B2 Antitussive agent 有权
标题翻译：镇咳药
公开(公告)号：US08106065B2
公开(公告)日：2012-01-31
申请号：US12158100
申请日：2006-12-15
申请人： Naoki Izumimoto , Koji Kawai
发明人： Naoki Izumimoto , Koji Kawai
IPC分类号： A61K31/4748 , A61P11/14 , C07D489/02
CPC分类号： C07D489/08 , A61K31/485
摘要： An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic substituent or a pharmaceutically acceptable acid addition salt thereof, having a specific structure, such as the compound below [N-(17-cyclopeopylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide]. The antitussive has an excellent therapeutic or prophylactic effect against coughing and the side effects thereof are small.
摘要翻译：公开了可用于治疗或预防咳嗽的镇咳药。止咳剂作为有效成分包含具有特定结构的含氮环状取代基的吗啡喃衍生物或其药学上可接受的酸加成盐，例如[N-（17-环戊基甲基-4,5α-环氧 - 3,14-二羟基 - 吗啡喃-6'-基）-3,4,5,6-四氢邻苯二甲酰亚胺]。止咳剂对咳嗽具有优异的治疗或预防作用，其副作用小。

4. 发明授权

US07718664B2 Anti-itching agent 有权
标题翻译：抗痒剂
公开(公告)号：US07718664B2
公开(公告)日：2010-05-18
申请号：US11547441
申请日：2005-03-30
申请人： Naoki Izumimoto , Toshikazu Komagata , Toshiyuki Honda , Koji Kawai
发明人： Naoki Izumimoto , Toshikazu Komagata , Toshiyuki Honda , Koji Kawai
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D489/08 , A61K31/485
摘要： A method of inhibiting or reducing occurrence or intensity of pruritus including administering to a patient an effective amount of one or more of the morphinan derivative having a nitrogen-containing cyclic group of the Formula (Ia): wherein R1 is cyclopropylmethyl; R2 and R3 are independently hydrogen, hydroxy, C1-C5 alkoxy, C3-C7 alkenyloxy, C7-C13 aralkyloxy or C1-C5 alkanoyloxy; and the Formula (Ia) includes (+), (−) and (±) isomers or the pharmaceutically acceptable acid addition salt thereof.
摘要翻译：一种抑制或减少瘙痒的发生或强度的方法，包括向患者施用有效量的一种或多种具有式（Ia）的含氮环状基团的吗啡喃衍生物：其中R1是环丙基甲基; R2和R3独立地是氢，羟基，C1-C5烷氧基，C3-C7链烯氧基，C7-C13芳烷氧基或C1-C5烷酰氧基; 式（Ia）包括（+），（ - ）和（±）异构体或其药学上可接受的酸加成盐。

5. 发明申请

US20080275074A1 Anti-Itching Agent 有权
标题翻译：抗痒剂
公开(公告)号：US20080275074A1
公开(公告)日：2008-11-06
申请号：US11547441
申请日：2005-03-30
申请人： Naoki Izumimoto , Toshikazu Komagata , Toshiyuki Honda , Koji Kawai
发明人： Naoki Izumimoto , Toshikazu Komagata , Toshiyuki Honda , Koji Kawai
IPC分类号： A61K31/485 , A61P17/00
CPC分类号： C07D489/08 , A61K31/485
摘要： A novel antipruritic useful for the treatment of pruritus accompanying various diseases is disclosed. The antipruritic comprises a specific morphinan derivative having a nitrogen-containing cyclic group or the pharmaceutically acceptable acid addition salt thereof such as N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-phthalimide hydrochloric acid salt or N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide tartaric acid salt.
摘要翻译：公开了一种用于治疗伴随各种疾病的瘙痒的新型止痒剂。止痒剂包含具有含氮环状基团的具体吗啡喃衍生物或其药学上可接受的酸加成盐，例如N-（17-环丙基甲基-4,5α-环氧-3,14-二羟基 - 吗啡喃-6β-基） - 邻苯二甲酰亚胺盐酸盐或N-（17-环丙基甲基-4,5α-环氧-3,14-二羟基 - 吗啡喃-6β-基）-3,4,5,6-四氢邻苯二甲酰亚胺酒石酸盐。

6. 发明授权

US07320984B2 Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group 有权
标题翻译：尿频或尿失禁的补救措施或预防措施以及含有氮杂环基的吗啡喃衍生物
公开(公告)号：US07320984B2
公开(公告)日：2008-01-22
申请号：US10530664
申请日：2003-10-08
申请人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
发明人： Naoki Izumimoto , Koji Kawai , Kuniaki Kawamura , Morihiro Fujimura , Toshikazu Komagata
IPC分类号： A61K31/485 , C07D489/00
CPC分类号： C07D489/08
摘要： The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, —C(═O)— or the like; X is C2-C5 carbon chain (one of the carbon atoms may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R4)k is substituted or non-substituted benzene fused ring, carbonyl group or the like; R9 is hydrogen or the like; R10 and R11 are bound to represent —O—, or the like, and R6 is hydrogen or the like or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphinan derivative or the pharmaceutically acceptable acid addition salt thereof; a method for therapy or prophylaxis of the diseases.
摘要翻译：本发明提供式（I）的吗啡喃衍生物：其中R 1是甲基，环丙基甲基等; R 2和R 3是羟基，甲氧基，乙酰氧基等; Y和Z都是价键，-C（-O） - 等; X是C 2 -C 5 -C 5碳链（其中一个碳原子可以被氧，硫或氮取代）构成环结构的一部分等 ; （R 4）k是取代或未取代的苯稠环，羰基等; R 9是氢等; R 10和R 11结合表示-O-等，R 6是氢等或其药学上可接受的其酸加成盐。本发明还提供了用于尿频或尿失禁的治疗或预防剂，其包含吗啡喃衍生物或其药学上可接受的酸加成盐作为有效成分; 一种治疗或预防疾病的方法。

7. 发明授权

US09128488B2 Movement direction control apparatus and computer program 有权
标题翻译：运动方向控制装置和计算机程序
公开(公告)号：US09128488B2
公开(公告)日：2015-09-08
申请号：US13232149
申请日：2011-09-14
申请人： Shigeru Tsuji , Shigeki Fukunaga , Mitsuhiro Namura , Koji Kawai , Kenichi Shirato
发明人： Shigeru Tsuji , Shigeki Fukunaga , Mitsuhiro Namura , Koji Kawai , Kenichi Shirato
IPC分类号： G05D1/02 , B62K1/00 , G05D1/08 , A63H17/25
CPC分类号： G05D1/027 , A63H17/25 , B60L15/20 , B60L2200/14 , B60L2240/12 , B60L2240/14 , B60L2240/22 , B60L2240/24 , B60L2240/423 , B60L2260/34 , B60L2260/44 , B62K1/00 , G05D1/0891 , Y02T10/645 , Y02T10/72 , Y02T10/7275
摘要： In a movement direction control apparatus and a non-transitory computer readable medium, a reaction torque accompanying rotation of a rotor is utilized to control a rotation angle of a body in a yaw direction. A specification of a yaw angle of a wheel as a target of the movement direction is received, and information of a friction torque is acquired. A rotation angular acceleration in the yaw direction is calculated, based on the yaw angle, the specification of which has been received, and the reaction torque is calculated, based on the calculated rotation angular acceleration in the yaw direction. An operation instruction to a motor for yaw is generated, based on the calculated reaction torque and the acquired information of the friction torque.
摘要翻译：在运动方向控制装置和非瞬时计算机可读介质中，利用伴随转子旋转的反作用转矩来控制身体在偏航方向上的旋转角度。接收作为移动方向的目标的车轮的偏航角的规格，并且获得摩擦转矩的信息。基于所计算的偏航方向的旋转角加速度，基于已经接收到其指定的偏航角，并计算反作用力矩来计算偏航方向上的旋转角加速度。基于计算出的反作用转矩和获取的摩擦转矩信息，生成用于偏航的电动机的操作指令。

8. 发明授权

US07748814B2 Ink-jet recording apparatus 有权
标题翻译：喷墨记录装置
公开(公告)号：US07748814B2
公开(公告)日：2010-07-06
申请号：US12057196
申请日：2008-03-27
申请人： Koji Kawai
发明人： Koji Kawai
IPC分类号： B41J2/205
CPC分类号： H04N1/52
摘要： An ink-jet recording apparatus of the present invention records an image on a recording medium by having ink landed on the recording medium. The apparatus includes ink-jet heads, a dot position memory unit, an image data memory unit, a print data generating unit and a head controller. The dot position memory unit stores therein dot positions which include: black dot positions where only ink droplets of black ink are landed and chromatic color dot positions where only ink droplets of chromatic color ink are landed. The head controller causes the ink-jet heads to eject the ink droplets to the dot positions, so that: only the ink droplets of the black ink lands in the black dot positions stored in the dot position memory unit; and only the ink droplets of the chromatic color ink lands in the chromatic color dot positions stored in the dot position memory unit.
摘要翻译：本发明的喷墨记录装置通过使油墨着落在记录介质上将图像记录在记录介质上。该装置包括喷墨头，点位置存储单元，图像数据存储单元，打印数据生成单元和头控制器。点位置存储单元存储点位置，其中包括仅黑色墨水墨滴落的黑点位置和仅彩色墨水的墨滴着落的彩色色点位置。头部控制器使得喷墨头将墨滴喷射到点位置，使得：只有黑色墨水的墨滴位于存储在点位置存储单元中的黑点位置; 并且只有彩色墨水的墨滴位于存储在点位置存储单元中的彩色色点位置。

9. 发明申请

US20090111843A1 Therapeutic or Prophylactic Agent for Functional Bowel Disorder 有权
标题翻译：功能性肠病的治疗或预防剂
公开(公告)号：US20090111843A1
公开(公告)日：2009-04-30
申请号：US12084633
申请日：2006-11-07
申请人： Koji Kawai , Morihiro Fujimura , Sayoko Kanie , Yohei Noro
发明人： Koji Kawai , Morihiro Fujimura , Sayoko Kanie , Yohei Noro
IPC分类号： A61K31/485 , C07D489/00 , A61P1/00
CPC分类号： C07D489/08 , A61K31/485
摘要： A therapeutic or prophylactic agent for functional bowel disorders comprising as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic group or a pharmaceutically acceptable acid addition salt thereof is disclosed. The therapeutic or prophylactic agent for functional bowel disorders comprises as an effective ingredient a morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, having a specific structure, such as N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-3,4,5,6-tetrahydrophthalimide tartaric acid salt (Compound 10).
摘要翻译：公开了包含作为有效成分的具有含氮环状基团的吗啡喃衍生物或其药学上可接受的酸加成盐的功能性肠病的治疗或预防剂。功能性肠病的治疗或预防剂包括作为有效成分的具有特定结构的吗啡喃衍生物或其药学上可接受的酸加成盐，例如N-（17-环丙基甲基-4,5α-环氧-3,14- 二氢羟基吗啡喃-6β-基）-3,4,5,6-四氢邻苯二甲酰亚胺酒石酸盐（化合物10）。

10. 发明申请

US20050228155A1 Metallocene compound, process for preparing metallocene compund, olefin polymerization catalyst, process for preparing polyolefin, and polyolefin 有权
标题翻译：茂金属化合物，金属茂化合物的制备方法，烯烃聚合催化剂，制备聚烯烃的方法和聚烯烃
公开(公告)号：US20050228155A1
公开(公告)日：2005-10-13
申请号：US11054597
申请日：2005-02-10
申请人： Koji Kawai , Masahiro Yamashita , Yasushi Tohi , Nobuo Kawahara , Kenji Michiue , Hiromu Kaneyoshi , Ryoji Mori
发明人： Koji Kawai , Masahiro Yamashita , Yasushi Tohi , Nobuo Kawahara , Kenji Michiue , Hiromu Kaneyoshi , Ryoji Mori
IPC分类号： C07F17/00 , C08F4/64 , C08F4/659 , C08F4/6592 , C08F10/00 , C08F110/06 , C08F4/72
CPC分类号： C07F17/00 , C08F4/65912 , C08F4/65916 , C08F10/00 , C08F110/06 , Y10S526/943 , C08F4/65927 , C08F2500/12 , C08F2500/03 , C08F2500/15 , C08F210/16 , C08F210/08 , C08F2500/17
摘要： The metallocene compound according to the invention and the olefin polymerization catalyst containing the compound are intended to produce a catalyst capable of preparing an isotactic polymer with a high polymerization activity. The metallocene compound contains a substituted cyclopentadienyl group and a (substituted) fluorenyl group and has a structure wherein these groups are bridged by a hydrocarbon group or the like. The process for preparing a metallocene compound according to the invention is intended to selectively prepare a specific metallocene compound so as not to produce an isomer, and in this process an intermediate product is synthesized by a specific method. The process for preparing a polyolefin according to the invention is intended to prepare a polyolefin having excellent impact resistance and transparency, and this process comprises homopolymerizing an α-olefin of 3 to 8 carbon-atoms or copolymerizing an olefin of 3 to 8 carbon atoms and another α-olefin in the presence of an olefin polymerization catalyst containing the above-mentioned metallocene compound.
摘要翻译：根据本发明的茂金属化合物和含有该化合物的烯烃聚合催化剂旨在制备能够制备具有高聚合活性的全同立构聚合物的催化剂。茂金属化合物含有取代的环戊二烯基和（取代的）芴基，并且具有这些基团被烃基等桥接的结构。根据本发明的制备茂金属化合物的方法是为了选择性地制备特定的茂金属化合物以便不产生异构体，并且在该方法中通过具体方法合成中间产物。根据本发明的制备聚烯烃的方法旨在制备具有优异的耐冲击性和透明性的聚烯烃，该方法包括使3至8个碳原子的α-烯烃均聚或将3至8个碳原子的烯烃共聚，和在含有上述茂金属化合物的烯烃聚合催化剂存在下，制备另一种α-烯烃。

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