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1. 发明授权

US07769059B2 High power Q-switched laser for soft tissue ablation 有权
标题翻译：用于软组织消融的大功率Q开关激光器
公开(公告)号：US07769059B2
公开(公告)日：2010-08-03
申请号：US11962823
申请日：2007-12-21
申请人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
发明人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
IPC分类号： H01S3/11
CPC分类号： H01S3/117 , A61B18/20 , A61B2017/00274 , A61B2018/00547 , H01S3/0014 , H01S3/0809 , H01S3/0941 , H01S3/10038 , H01S3/1022 , H01S3/1068 , H01S3/109
摘要： The present invention discloses a high power Q-switched, intracavity frequency-doubled laser for laser ablation of soft tissue. Operating a high power Q-switched laser in a frequent on-off mode is highly desirable for laser prostatectomy. Giant first pulse may occur when a Q-switched laser is switched from laser-ready mode to pulse-on mode due to sudden depletion of stored energy in the gain medium. Such a giant first pulse may cause power damage of intracavity optics. Besides, temperature shock induced by sudden onset of a high power pulse train may cause optical damage on surface coating of intracavity optics. The present invention contemplates to suppress these giant first pulses and temperature shocks through pre-lasing and ramping profile of laser parameters. Reliable and frequent on-off operation of a diode-pumped, Q-switched, frequency-doubled Nd:YAG laser is demonstrated for output power up to 100 W.
摘要翻译：本发明公开了一种用于软组织激光烧蚀的大功率Q开关腔内倍频激光器。激光前列腺切除术非常需要操作频繁开关模式下的高功率Q开关激光器。由于增益介质中存储的能量突然耗尽，当Q开关激光器从激光就绪模式切换到脉冲开启模式时，可能会发生巨大的第一脉冲。这样巨大的第一脉冲可能会导致腔内光学器件的功率损坏。此外，突发高功率脉冲串引起的温度冲击可能会对腔内光学器件的表面涂层造成光学损伤。本发明考虑通过激光参数的预激光和斜面分布来抑制这些巨大的第一脉冲和温度冲击。二极管泵浦，Q开关，倍频Nd：YAG激光器的可靠和频繁的开关操作被证明用于高达100W的输出功率。

2. 发明授权

US08137340B2 Apparatus and method for soft tissue ablation employing high power diode-pumped laser 有权
标题翻译：使用高功率二极管泵浦激光的软组织消融的装置和方法
公开(公告)号：US08137340B2
公开(公告)日：2012-03-20
申请号：US11155079
申请日：2005-06-17
申请人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
发明人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B2018/2272
摘要： The present invention discloses a high power diode-pumped laser for laser ablation of soft tissue. The present invention contemplates to operate the high power diode-pumped solid-state laser at a continuous Q-switching mode and at a big number of transverse modes. The present invention also contemplates to reduce beam divergence and beam spot size and thus to increase power density of the laser on target tissue to improve the speed of tissue ablation. The present invention further contemplates to minimize power consumption such that external water-cooling or secondary cooling loop can be eliminated. The present invention even further contemplates to implement combined mechanisms to protect intracavity optics from power damage. Finally, the present invention contemplates hospitals and surgeon offices to use the high power diode-pumped laser for soft tissue ablation with standard electrical wall-plug outlet and elimination of inconvenient external water-cooling or secondary cooling loop.
摘要翻译：本发明公开了一种用于软组织激光烧蚀的高功率二极管泵浦激光器。本发明考虑以连续Q开关模式和大量横向模式操作高功率二极管泵浦固态激光器。本发明还考虑减少光束发散和光斑尺寸，从而增加激光在靶组织上的功率密度，以提高组织消融的速度。本发明进一步考虑到最小化功率消耗，使得可以消除外部水冷或二次冷却回路。本发明甚至进一步设想实现组合机构以保护腔内光学器件免受功率损坏。最后，本发明考虑到医院和外科医生办公室将高功率二极管泵浦激光器用于具有标准电壁插座出口的软组织消融，并消除了不方便的外部水冷或二次冷却回路。

3. 发明申请

US20080086118A1 Apparatus and method for diode-pumped laser ablation of soft tissue 审中-公开
标题翻译：软组织二极管激光烧蚀的装置和方法
公开(公告)号：US20080086118A1
公开(公告)日：2008-04-10
申请号：US11804556
申请日：2007-05-17
申请人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
发明人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
IPC分类号： A61B18/20
CPC分类号： A61B18/20
摘要： The present invention fulfils a need to advance a diode-pumped solid-state laser (DPSSL) and to employ laser-induced thermal explosive ablation (LITEA) for prostate surgery. The present invention operates a quasi-CW Q-switched DPSSL at a lower repetition rate of 5 kHz to 20 kHz to produce bigger pulse energy of 2.5 mJ to 10 mJ, while maintaining optimal average power. The present invention also employs two AO Q-switches or one EO Q-switch to obtain shorter pulse duration of 40 ns to 150 ns and to obtain higher peak power of 50 kW to 100 kW, leading to a pulse fluence of 250 mJ/cm2 to 1000 mJ/cm2 on target tissues. The present invention further applies electronic control to suppress amplitude fluctuation below 5% to ensure smoother ablation profile.
摘要翻译：本发明满足了推进二极管泵浦固态激光器（DPSSL）和采用激光诱导的热爆炸消融（LITEA）用于前列腺手术的需要。本发明以5kHz至20kHz的较低重复频率操作准CW切换DPSSL以产生2.5mJ至10mJ的较大脉冲能量，同时保持最佳平均功率。本发明还采用两个AO Q开关或一个EO Q开关来获得40ns至150ns的较短脉冲持续时间，并获得50 kW至100 kW的较高峰值功率，从而产生250 mJ / cm的脉冲能量密度在靶组织上<2>至1000mJ / cm 2> 。本发明进一步应用电子控制以抑制低于5％的振幅波动，以确保更平滑的消融轮廓。

4. 发明申请

US20070038207A1 Surgical system that ablates soft tissue 有权
标题翻译：消融软组织的手术系统
公开(公告)号：US20070038207A1
公开(公告)日：2007-02-15
申请号：US11454828
申请日：2006-06-19
申请人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo
发明人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo
IPC分类号： A61B18/04
CPC分类号： A61B18/20 , A61B18/24 , A61B2017/00274 , A61B2018/00017 , A61B2018/00547 , A61B2018/2035 , A61B2018/2255
摘要： A surgical system that ablates soft tissue. The system may include a fiber laser oscillator as the gain medium that emits electromagnetic radiation. The system may process the electromagnetic radiation, and direct the electromagnetic radiation on to the soft tissue to be ablated. Due at least in part to the nature of the electromagnetic radiation emitted by the fiber laser oscillator, the system may provide various enhancements, such as a higher power conversion efficiency, a longer lifetime, less heat dissipation, a more compact design, and/or other enhancements, for example. The system may also generate electromagnetic radiation with a relatively high beam quality. This may reduce beam divergence and beam spot size on targeted soft tissue, thereby enhancing power density in the electromagnetic radiation guided to the soft tissue. This enhanced power density may facilitate effective ablation.
摘要翻译：一种消融软组织的手术系统。该系统可以包括作为发射电磁辐射的增益介质的光纤激光振荡器。该系统可以处理电磁辐射，并将电磁辐射引导到要消融的软组织上。至少部分地由于光纤激光振荡器发射的电磁辐射的性质，系统可以提供各种增强，例如更高的功率转换效率，更长的寿命，更少的散热，更紧凑的设计和/或其他增强功能，例如。该系统还可以产生具有相对较高光束质量的电磁辐射。这可以减少目标软组织上的束发散和束斑大小，从而增强被引导到软组织的电磁辐射中的功率密度。这种增强的功率密度可以促进有效的消融。

5. 发明授权

US07862556B2 Surgical system that ablates soft tissue 有权
标题翻译：消融软组织的手术系统
公开(公告)号：US07862556B2
公开(公告)日：2011-01-04
申请号：US11454828
申请日：2006-06-19
申请人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo
发明人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo
IPC分类号： A61B18/04
CPC分类号： A61B18/20 , A61B18/24 , A61B2017/00274 , A61B2018/00017 , A61B2018/00547 , A61B2018/2035 , A61B2018/2255
摘要： A surgical system that ablates soft tissue. The system may include a fiber laser oscillator as the gain medium that emits electromagnetic radiation. The system may process the electromagnetic radiation, and direct the electromagnetic radiation on to the soft tissue to be ablated. Due at least in part to the nature of the electromagnetic radiation emitted by the fiber laser oscillator, the system may provide various enhancements, such as a higher power conversion efficiency, a longer lifetime, less heat dissipation, a more compact design, and/or other enhancements, for example. The system may also generate electromagnetic radiation with a relatively high beam quality. This may reduce beam divergence and beam spot size on targeted soft tissue, thereby enhancing power density in the electromagnetic radiation guided to the soft tissue. This enhanced power density may facilitate effective ablation.
摘要翻译：一种消融软组织的手术系统。该系统可以包括作为发射电磁辐射的增益介质的光纤激光振荡器。该系统可以处理电磁辐射，并将电磁辐射引导到要消融的软组织上。至少部分地由于光纤激光振荡器发射的电磁辐射的性质，系统可以提供各种增强，例如更高的功率转换效率，更长的寿命，更少的散热，更紧凑的设计和/或其他增强功能，例如。该系统还可以产生具有相对较高光束质量的电磁辐射。这可以减少目标软组织上的束发散和束斑大小，从而增强被引导到软组织的电磁辐射中的功率密度。这种增强的功率密度可以促进有效的消融。

6. 发明申请

US20080095201A1 HIGH POWER Q-SWITCHED LASER FOR SOFT TISSUE ABLATION 有权
标题翻译：高功率Q开关激光软组织消除
公开(公告)号：US20080095201A1
公开(公告)日：2008-04-24
申请号：US11962823
申请日：2007-12-21
申请人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
发明人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
IPC分类号： H01S3/11
CPC分类号： H01S3/117 , A61B18/20 , A61B2017/00274 , A61B2018/00547 , H01S3/0014 , H01S3/0809 , H01S3/0941 , H01S3/10038 , H01S3/1022 , H01S3/1068 , H01S3/109
摘要： The present invention discloses a high power Q-switched, intracavity frequency-doubled laser for laser ablation of soft tissue. Operating a high power Q-switched laser in a frequent on-off mode is highly desirable for laser prostatectomy. Giant first pulse may occur when a Q-switched laser is switched from laser-ready mode to pulse-on mode due to sudden depletion of stored energy in the gain medium. Such a giant first pulse may cause power damage of intracavity optics. Besides, temperature shock induced by sudden onset of a high power pulse train may cause optical damage on surface coating of intracavity optics. The present invention contemplates to suppress these giant first pulses and temperature shocks through pre-lasing and ramping profile of laser parameters. Reliable and frequent on-off operation of a diode-pumped, Q-switched, frequency-doubled Nd:YAG laser is demonstrated for output power up to 100 W.
摘要翻译：本发明公开了一种用于软组织激光烧蚀的大功率Q开关腔内倍频激光器。激光前列腺切除术非常需要操作频繁开关模式下的高功率Q开关激光器。由于增益介质中存储的能量突然耗尽，当Q开关激光器从激光就绪模式切换到脉冲开启模式时，可能会发生巨大的第一脉冲。这样巨大的第一脉冲可能会导致腔内光学器件的功率损坏。此外，突发高功率脉冲串引起的温度冲击可能会对腔内光学器件的表面涂层造成光学损伤。本发明考虑通过激光参数的预激光和斜面分布来抑制这些巨大的第一脉冲和温度冲击。二极管泵浦，Q开关，倍频Nd：YAG激光器的可靠和频繁的开关操作被证明用于高达100W的输出功率。

7. 发明授权

US07313155B1 High power Q-switched laser for soft tissue ablation 失效
标题翻译：用于软组织消融的大功率Q开关激光器
公开(公告)号：US07313155B1
公开(公告)日：2007-12-25
申请号：US11056671
申请日：2005-02-12
申请人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
发明人： Liyue Mu , Ming Lai , Kangze Cai , Weiguo Luo , Libo Zeng
IPC分类号： H01S3/11
CPC分类号： H01S3/117 , A61B18/20 , A61B2017/00274 , A61B2018/00547 , H01S3/0014 , H01S3/0809 , H01S3/0941 , H01S3/10038 , H01S3/1022 , H01S3/1068 , H01S3/109
摘要： The present invention discloses a high power Q-switched, intracavity frequency-doubled laser for laser ablation of soft tissue. Operating a high power Q-switched laser in a frequent on-off mode is highly desirable for laser prostatectomy. Giant first pulse may occur when a Q-switched laser is switched from laser-ready mode to pulse-on mode due to sudden depletion of stored energy in the gain medium. Such a giant first pulse may cause power damage of intracavity optics. Besides, temperature shock induced by sudden onset of a high power pulse train may cause optical damage on surface coating of intracavity optics. The present invention contemplates to suppress these giant first pulses and temperature shocks through pre-lasing and ramping profile of laser parameters. Reliable and frequent on-off operation of a diode-pumped, Q-switched, frequency-doubled Nd:YAG laser is demonstrated for output power up to 100 W.
摘要翻译：本发明公开了一种用于软组织激光烧蚀的大功率Q开关腔内倍频激光器。激光前列腺切除术非常需要操作频繁开关模式下的高功率Q开关激光器。由于增益介质中存储的能量突然耗尽，当Q开关激光器从激光就绪模式切换到脉冲开启模式时，可能会发生巨大的第一脉冲。这样巨大的第一脉冲可能会导致腔内光学器件的功率损坏。此外，突发高功率脉冲串引起的温度冲击可能会对腔内光学器件的表面涂层造成光学损伤。本发明考虑通过激光参数的预激光和斜面分布来抑制这些巨大的第一脉冲和温度冲击。二极管泵浦，Q开关，倍频Nd：YAG激光器的可靠和频繁的开关操作被证明用于高达100W的输出功率。

8. 发明申请

US20050288653A1 Apparatus and method for soft tissue ablation employing high power diode-pumped laser 有权
标题翻译：使用高功率二极管泵浦激光的软组织消融的装置和方法
公开(公告)号：US20050288653A1
公开(公告)日：2005-12-29
申请号：US11155079
申请日：2005-06-17
申请人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
发明人： Ming Lai , Liyue Mu , Kangze Cai , Weiguo Luo
IPC分类号： A61B18/20 , A61B18/22
CPC分类号： A61B18/22 , A61B2018/2272
摘要： The present invention discloses a high power diode-pumped laser for laser ablation of soft tissue. The present invention contemplates to operate the high power diode-pumped solid-state laser at a continuous Q-switching mode and at a big number of transverse modes. The present invention also contemplates to reduce beam divergence and beam spot size and thus to increase power density of the laser on target tissue to improve the speed of tissue ablation. The present invention further contemplates to minimize power consumption such that external water-cooling or secondary cooling loop can be eliminated. The present invention even further contemplates to implement combined mechanisms to protect intracavity optics from power damage. Finally, the present invention contemplates hospitals and surgeon offices to use the high power diode-pumped laser for soft tissue ablation with standard electrical wall-plug outlet and elimination of inconvenient external water-cooling or secondary cooling loop.
摘要翻译：本发明公开了一种用于软组织激光烧蚀的高功率二极管泵浦激光器。本发明考虑以连续Q开关模式和大量横向模式操作高功率二极管泵浦固态激光器。本发明还考虑减少光束发散和光斑尺寸，从而增加激光在靶组织上的功率密度，以提高组织消融的速度。本发明进一步考虑到最小化功率消耗，使得可以消除外部水冷或二次冷却回路。本发明甚至进一步设想实现组合机构以保护腔内光学器件免受功率损坏。最后，本发明考虑到医院和外科医生办公室将高功率二极管泵浦激光器用于具有标准电壁插座出口的软组织消融，并消除了不方便的外部水冷或二次冷却回路。

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