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1. 发明申请

US20100087535A1 EXTERNAL COMPOSITION FOR SKIN 审中-公开
标题翻译：皮肤外用组合物
公开(公告)号：US20100087535A1
公开(公告)日：2010-04-08
申请号：US12450095
申请日：2008-03-19
申请人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
发明人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
IPC分类号： A61K31/195 , C07C229/26
CPC分类号： A61Q19/007 , A61K8/44 , A61K8/64 , A61K31/197
摘要： A moisturizing agent comprising one or more than one compound selected from the group consisting of lysyl-β-alanine represented by the following general formula (1) and a salt thereof:
摘要翻译：一种保湿剂，其包含一种或多于一种选自下列通式（1）表示的赖氨酰 - 丙氨酸及其盐的化合物：

2. 发明申请

US20100094054A1 COMPOSITION FOR EXTERNAL APPLICATION TO SKIN 有权
标题翻译：外用于皮肤的组合物
公开(公告)号：US20100094054A1
公开(公告)日：2010-04-15
申请号：US12449143
申请日：2008-01-24
申请人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
发明人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
IPC分类号： C07C237/06
CPC分类号： A61Q19/08 , A61K8/42 , A61K31/16 , C07C237/06
摘要： The present invention provides a composition for external application to skin containing one type or two or more types of compounds selected from the group consisting of aminoacetoamide compounds represented by the following general formula (1) and salts thereof.
摘要翻译：本发明提供一种皮肤外用组合物，含有选自下述通式（1）表示的氨基乙酰胺化合物及其盐的一种或两种以上的化合物。

3. 发明申请

US20120157388A1 EXTERNAL COMPOSITION FOR SKIN 审中-公开
标题翻译：皮肤外用组合物
公开(公告)号：US20120157388A1
公开(公告)日：2012-06-21
申请号：US13403336
申请日：2012-02-23
申请人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
发明人： Makoto Tsunenaga , Nobuhiko Ochiai , Mikiko Kaminuma , Masaru Suetsugu
IPC分类号： A61K8/64 , A61P19/00
CPC分类号： A61Q19/007 , A61K8/44 , A61K8/64 , A61K31/197
摘要： A moisturizing agent comprising one or more than one compound selected from the group consisting of lysyl-β-alanine represented by the following general formula (1) and a salt thereof:
摘要翻译：一种保湿剂，其包含一种或多于一种选自下列通式（1）表示的赖氨酰 - 丙氨酸及其盐的化合物：

4. 发明授权

US08138374B2 Composition for external application to skin 有权
标题翻译：外用于皮肤的组合物
公开(公告)号：US08138374B2
公开(公告)日：2012-03-20
申请号：US12449143
申请日：2008-01-24
申请人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
发明人： Mikiko Kaminuma , Masaru Suetsugu , Nobuhiko Ochiai , Makoto Tsunenaga
IPC分类号： C07C233/05 , A61K31/16
CPC分类号： A61Q19/08 , A61K8/42 , A61K31/16 , C07C237/06
摘要： The present invention provides a composition for external application to skin containing one type or two or more types of compounds selected from the group consisting of aminoacetoamide compounds represented by the following general formula (1) and salts thereof.
摘要翻译：本发明提供一种皮肤外用组合物，其含有选自下述通式（1）表示的氨基乙酰胺化合物及其盐的一种或两种以上的化合物。

5. 发明授权

US08173705B2 Agent for alleviating wrinkles 有权
标题翻译：减轻皱纹的代理
公开(公告)号：US08173705B2
公开(公告)日：2012-05-08
申请号：US12530841
申请日：2008-03-14
申请人： Makoto Tsunenaga , Mikiko Kaminuma , Masaru Suetsugu , Chika Katagiri
发明人： Makoto Tsunenaga , Mikiko Kaminuma , Masaru Suetsugu , Chika Katagiri
IPC分类号： A61K31/195
CPC分类号： A61K8/44 , A61K8/466 , A61K31/197 , A61Q19/08
摘要： The present invention provides an agent for preventing and alleviating wrinkles which has excellent effects of preventing and alleviating wrinkles formed by decreased barrier function of the skin owing to aging or photo aging, that is graphic wrinkles or linear wrinkles. The agent for preventing and alleviating wrinkles consisting of one or more compounds selected from the group consisting of gamma-aminobutyric acid derivatives represented by the following formula (1) or N,N,N-trimethyl gamma-aminobutyric acid represented by the following formula (3) and salts thereof: wherein R1 and R2 independently represent any of a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a benzyloxycarbonyl group, a cyclohexyl group, a cyclohexanemethyl group, a cyclohexanecarbonyl group, a guanidino group formed with nitrogen atom in the formula (1), an ureido group formed with nitrogen atom in the formula (1), and a group represented by following formula (2). Additionally, R1 and R2 may jointly form a piperidine ring, morpholine ring, or pyrrolidine ring. Both of R1 and R2 are not simultaneously a hydrogen atom.
摘要翻译：本发明提供一种防止和减轻皱纹的试剂，其具有优异的防止和减轻由于老化或照片老化导致的皮肤屏障功能形成的皱纹，即图形皱纹或线状皱纹的效果。用于预防和减轻由一种或多种选自由下式（1）表示的γ-氨基丁酸衍生物或由下式（N）表示的N，N，N-三甲基γ-氨基丁酸组成的组中的化合物组成的皱纹的试剂 3）及其盐：其中R 1和R 2独立地表示氢原子，具有1至3个碳原子的烷基，苄氧基羰基，环己基，环己烷甲基，环己烷羰基，与氮形成的胍基式（1）中的原子，式（1）中由氮原子形成的脲基和由下式（2）表示的基团。此外，R 1和R 2可以共同形成哌啶环，吗啉环或吡咯烷环。 R1和R2两者不同时为氢原子。

6. 发明申请

US20110065794A1 Wrinkle-preventing and improving composition 审中-公开
标题翻译：防皱，改善成分
公开(公告)号：US20110065794A1
公开(公告)日：2011-03-17
申请号：US12926351
申请日：2010-11-12
申请人： Makoto Tsunenaga , Haruhi Iwaki , Toshii Iida , Mikiko Kaminuma , Masaru Suetsugu , Keiko Takada , Shinji Inomata
发明人： Makoto Tsunenaga , Haruhi Iwaki , Toshii Iida , Mikiko Kaminuma , Masaru Suetsugu , Keiko Takada , Shinji Inomata
IPC分类号： A61K31/197 , A61Q19/08
CPC分类号： A61K8/44 , A61K8/445 , A61Q19/08
摘要： A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.
摘要翻译：一种防皱和改善组合物，其包含一种或多于一种选自下列通式（1）表示的α-氨基酸衍生物及其盐的化合物：其中，R 1表示氢原子，CH 3基或CH 2 OH 基团，R 2和R 3各自独立地表示氢原子，具有1至4个碳的烷基，条件是R 2和R 3不能同时为氢原子，或者R 2和R 3与它们所连接的N原子可以形成环总碳数为4〜6的结构，在这种情况下，所述环结构可任选地含有氧原子作为杂原子，R4表示氢原子，具有1至18个碳原子的烷基，其中当R 1和R 4为氢原子时，不能是R2和R3之一是苄氧基羰基，另一个是氢原子。

7. 发明申请

US20120165409A1 WRINKLE-IMPROVING AGENT 审中-公开
标题翻译：缠绕剂改性剂
公开(公告)号：US20120165409A1
公开(公告)日：2012-06-28
申请号：US13410612
申请日：2012-03-02
申请人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
发明人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
IPC分类号： A61K31/195 , A61P17/00
CPC分类号： A61K8/44 , A61Q19/08
摘要： A wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.
摘要翻译：具有改善皱纹的效果的皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。发现N-苯甲酰基 - 丙氨酸，其他特定的β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有一种或两种以上活性成分的皱纹改善剂的选自由这些特异性＆amp; - 丙氨酸衍生物组成的组的化合物及其盐。

8. 发明申请

US20100035881A1 WRINKLE-IMPROVING AGENT 审中-公开
标题翻译：缠绕剂改性剂
公开(公告)号：US20100035881A1
公开(公告)日：2010-02-11
申请号：US12067267
申请日：2006-09-15
申请人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
发明人： Mikiko Kaminuma , Masaru Suetsugu , Makoto Tsunenaga , Kiyotaka Hasegawa , Shinji Inomata
IPC分类号： A61K8/36 , A61K8/49 , A61K8/42 , A61K8/46 , A61Q19/08
CPC分类号： A61K8/44 , A61Q19/08
摘要： The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.
摘要翻译：本发明提供了具有改善皱纹的效果的新型皱纹改善剂，即使施用于皮肤也不会引起安全性或疼痛的问题，并且含有作为活性成分的非常安全的物质。发现N-苯甲酰基-β-丙氨酸，其它特定β-丙氨酸衍生物及其盐具有皱纹改善效果，由此可以提供含有作为活性成分的一种或两种以上化合物的皱纹改善剂选自由这些特异性β-丙氨酸衍生物及其盐组成的组。

9. 发明申请

US20090215893A1 Parakeratosis inhibitor, pore-shrinking agent,or rough skin preventing/ameliorating agent, and external composition for skin 审中-公开
标题翻译：角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂，以及皮肤外用组合物
公开(公告)号：US20090215893A1
公开(公告)日：2009-08-27
申请号：US11920848
申请日：2006-05-09
申请人： Mikiko Kaminuma , Masaru Suetsugu , Maki Kaneko , Toshii Iida , Shinji Inomata
发明人： Mikiko Kaminuma , Masaru Suetsugu , Maki Kaneko , Toshii Iida , Shinji Inomata
IPC分类号： A61K31/19
CPC分类号： A61K8/0212 , A61K8/44 , A61K8/46 , A61Q1/02 , A61Q19/00
摘要： The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.
摘要翻译：本发明提供了具有角化不全抑制，孔收缩或粗糙皮肤抑制/消瘦等功能的角化不全抑制剂，孔收缩剂或粗糙皮肤防止/缓解剂，不会引起感觉刺激等安全性问题，而且并且为了进一步提供添加了具有上述功能的化合物的皮肤的外用组合物。角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂包含一种，两种或更多种选自α-氨基酸衍生物及其盐的化合物。用于皮肤的外用组合物包含一种，两种或更多种选自上述角化不力抑制剂的α-氨基酸衍生物及其盐，孔收缩剂或粗糙皮肤防止/减量剂的化合物。

10. 发明申请

US20070225380A1 Parakeratosis Inhibitor and Skin Preparation for External use 有权
标题翻译：角化不全抑制剂和外用皮肤准备
公开(公告)号：US20070225380A1
公开(公告)日：2007-09-27
申请号：US10580471
申请日：2004-11-22
申请人： Mikiko Kaminuma , Masaru Suetsugu , Toshii Iida , Shinji Inomata , Keiko Takada , Yuji Katsuta
发明人： Mikiko Kaminuma , Masaru Suetsugu , Toshii Iida , Shinji Inomata , Keiko Takada , Yuji Katsuta
IPC分类号： A61K47/12
CPC分类号： A61K8/0212 , A61K8/44 , A61K8/466 , A61Q1/02 , A61Q19/00
摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.
摘要翻译：提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸，β-丙氨酸衍生物和这些衍生物的盐。此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。此外，提供了包含这些化合物的外用皮肤制剂。

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