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1. 发明授权

US4970213A Benzo(1,8)naphthyridine derivatives as intermediates 失效
标题翻译：苯并（1,8）萘啶衍生物作为中间体
公开(公告)号：US4970213A
公开(公告)日：1990-11-13
申请号：US465329
申请日：1990-01-16
申请人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
发明人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
IPC分类号： A61K31/435 , A61P31/04 , C07D471/04
CPC分类号： C07D471/04
摘要： New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy, alkylamino or protected alkylamino radical, Hal is F, Cl or Br if R' is hydrogen, or Hal and R' are F, and Alk is an alkyl radical, and their preparation.These new products can be used as intermediates for the preparation of biologically active products. ##STR1##
摘要翻译：其中R为氢原子或烷基，氟代烷基，环烷基（3至6 C），烷氧基，烷基氨基或保护的烷基氨基的通式（I）的新苯并[b] [1,8]萘啶衍生物，Hal为F ，如果R'为氢，Cl或Br，或Hal和R'为F，Alk为烷基，及其制备。这些新产品可用作制备生物活性产品的中间体。（一）

2. 发明授权

US4990515A Benzo[1,8]naphthyridine derivatives as antimicrobials 失效
标题翻译：苯并[1,8]萘啶衍生物作为抗微生物剂
公开(公告)号：US4990515A
公开(公告)日：1991-02-05
申请号：US465316
申请日：1990-01-16
申请人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
发明人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
IPC分类号： A01N43/90 , A61K31/435 , A61K31/4375 , A61P31/04 , C07D471/04
CPC分类号： C07D471/04
摘要： New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical or an amine protective radical and either Hal is a fluorine, chlorine or bromine atom and R' is a hydrogen atom or Hal and R' are simultaneously fluorine atoms, their salts, their preparation and the compositions which contain them.These new products can be used as antimicrobial agents for topical application or as synthesis intermediates. ##STR1##
摘要翻译：其中R为氢原子或烷基，氟烷基，环烷基（3至6个C），烷氧基或烷基氨基或胺保护基的新的苯并[b] [1,8]萘啶衍生物， Hal是氟，氯或溴原子，R'是氢原子，或Hal和R'同时是氟原子，它们的盐，它们的制备和含有它们的组合物。这些新产品可用作局部应用的抗微生物剂或合成中间体。（一）

3. 发明授权

US5004745A Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them 失效
标题翻译：苯并[1,8]萘啶衍生物，其制备方法和含有它们的组合物
公开(公告)号：US5004745A
公开(公告)日：1991-04-02
申请号：US465483
申请日：1990-01-16
申请人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
发明人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
IPC分类号： A01N43/90 , A01P1/00 , A61K31/495 , A61K31/55 , A61P31/04 , C07D471/04
CPC分类号： C07D471/04
摘要： New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R.sub.1 is a hydrogen atom or an alkyl or hydroxyalkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical and R.sub.3 is alkyl, R.sub.4 and R.sub.5 are different and are hydrogen or alkyl, or R.sub.3 is H, alkyl or cycloalkyl and R.sub.4 and R.sub.5 are hydrogen, R.sub.6 is hydrogen or fluorine and n is equal to 1 or 2, their salts, their preparation and the compositions which contain them.These new products are used as antimicrobial agents ##STR1##
摘要翻译： R1为氢原子或烷基或羟基烷基的通式（I）的新苯并[b] [1,8]二氮杂萘衍生物，R2为氢原子或烷基，氟烷基，环烷基（3〜6C），烷氧基或烷基氨基，R 3是烷基，R 4和R 5不同并且是氢或烷基，或者R 3是H，烷基或环烷基，R 4和R 5是氢，R 6是氢或氟并且n等于1或2，它们的盐，它们的制备和含有它们的组合物。这些新产品用作抗微生物剂（I）

4. 发明授权

US5053509A Benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them 失效
标题翻译：苯并[1,8]萘啶衍生物，其制备方法和含有它们的组合物
公开(公告)号：US5053509A
公开(公告)日：1991-10-01
申请号：US605340
申请日：1990-10-30
申请人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
发明人： Michel Antoine , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Guy Picaut
IPC分类号： C07D401/14 , A61K31/4375 , A61K31/44 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/54 , A61P31/04 , A61P31/12 , C07D471/04
CPC分类号： C07D471/04
摘要： New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R.sub.1 is a hydrogen atom or a hydroxyl or alkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R.sub.3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R.sub.3 is a heterocyclic radical, and R.sub.4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them.These new products are useful as antimicrobials, or in the treatment of AIDS. ##STR1##
摘要翻译：其中R1是氢原子或羟基或烷基的新的苯并[b] [1,8]萘啶衍生物，其中R 2是氢原子或烷基，氟烷基，环烷基（3至6个碳原子），烷氧基或烷基氨基，R3是被一个或多个卤素原子或烷基，环烷基（3至6个C），烷氧基，氰基，氨基，烷基氨基，二烷基氨基，烷氧基烷基，羟基烷基，羟基烷氧基，亚甲二氧基，氨基烷基，烷基氨基烷基或二烷基氨基烷基，或R3是杂环基，R4是氢原子或氟原子，烷基（1-4C）是直链或支链的，它们的盐，它们的制备和含有它们的组合物。这些新产品可用作抗菌药物或用于治疗艾滋病。（一）

5. 发明授权

US5556861A 1,8 benzonaphthyridine derivatives and antimicrobial compositions 失效
标题翻译： 1,8苯并萘啶衍生物和抗微生物组合物
公开(公告)号：US5556861A
公开(公告)日：1996-09-17
申请号：US472766
申请日：1995-06-07
申请人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
发明人： Eric Bacque , Michel Barreau , Jean-Francois Desconclois , Philippe Girard , Michel Kryvenko , Marc P. Lavergne , Jean-Marc Paris , Guy Picaut
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.
摘要翻译：本发明涉及通式（I）的新颖的1,8-苯并[b]萘啶衍生物，其中R是H或羟基，任选被氨基或羟基取代的氨基或烷基氨基，或R是烷基部分可以与氮原子形成的二烷基氨基，其任选地含有选自氮，氧或硫的另外的杂原子的5-或6-元杂环，或R是C 3-6环烷基氨基或烷基氨基，烷基N-烷基氨基或氨基烷基苯基氨基; R1和R2相同或不同，位于2和3位，代表H，烷基，C2-4烯基，苯基或取代苯基，或R1和R2位于2位，代表烷基; R3是H或烷基，氟代烷基，羧基烷基，C3-6环烷基，氟苯基，二氟苯基，烷氧基或烷基氨基; R4是H或F，其中C1-4烷基和烷基是直链或支链的; 其立体异构形式或它们的混合物; 及其盐和水合形式。这些新型衍生物可用作抗微生物剂。

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