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    • 3. 发明授权
    • Method and apparatus for radiotherapy treatment planning
    • 放射治疗计划的方法和装置
    • US06792073B2
    • 2004-09-14
    • US09850533
    • 2001-05-07
    • Joseph O. DeasyMladen Victor Wickerhauser
    • Joseph O. DeasyMladen Victor Wickerhauser
    • A61N610
    • A61N5/1031A61N2005/1034
    • A computationally efficient and accurate procedure for calculating radiation dose distributions within a volume of interest in a patient incorporating variations in patient density and source particle energy, position, direction, and type. The procedure iteratively simulates energy depositions from source particles using the Monte Carlo radiation transport method and then applies methods for reducing noise inherent in Monte Carlo results to obtain an accurate and computationally efficient representation of an actual radiation dose distribution compared to that produced by Monte Carlo methods alone. The invention makes an analogy between real measured data and transformed Monte Carlo generated computer data and then applies data denoising techniques to reduce the noise in the Monte Carlo dose images. Conversely, the present invention can produce a dose distribution having a predetermined noise level in a reduced amount of computation time. Denoising techniques can include digital filtering, wavelet denoising, kernel smoothing and non-parametric regression smoothing.
    • 一种用于计算患者体内感兴趣的辐射剂量分布的计算效率和准确程序,其包括患者密度和源粒子能量,位置,方向和类型的变化。 该过程使用蒙特卡罗辐射传输方法迭代地模拟来自源粒子的能量沉积,然后应用用于减少蒙特卡罗结果固有的噪声的方法,以获得与蒙特卡罗方法相比的实际辐射剂量分布的精确和计算上有效的表示 单独。 本发明在真实测量数据和转换的蒙特卡罗生成的计算机数据之间进行类比,然后应用数据去噪技术来减少蒙特卡洛剂量图像中的噪声。 相反,本发明可以在减少的计算时间内产生具有预定噪声水平的剂量分布。 去噪技术可以包括数字滤波,小波去噪,内核平滑和非参数回归平滑。