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1. 发明授权

US07061405B2 Device and method for interfacing video devices over a fiber optic link 失效
标题翻译：通过光纤链路连接视频设备的设备和方法
公开(公告)号：US07061405B2
公开(公告)日：2006-06-13
申请号：US10966823
申请日：2004-10-15
申请人： Michael R. Boyd , Jason J. Beaudoin , Vincent Mui
发明人： Michael R. Boyd , Jason J. Beaudoin , Vincent Mui
IPC分类号： H03M7/00
CPC分类号： H04B10/278 , G09G5/006 , H04B10/27 , H04N5/765 , H04N5/77 , H04N5/775 , H04N5/85
摘要： A system and method for interfacing video devices over a link where electronic digital video data having a quantity (n) of bits of parallel data transmitted electronically at a first clock rate (R1) is converted to a stream of electronic serial data that is transmitted a second clock rate (R2=R1×n). The stream of electronic serial data is transmitted over a link that can be a fiber optic link or include one or more conductors. A receiver is employed to convert the data transmitted over the link into an output data stream having (n) bits of parallel data transmitted electronically at the first clock rate (R1). If the link is a fiber optic link, the receiver can convert the data transmitted over the link into to a second stream electronic serial data that is transmitted at the second clock rate (R2) and then to the output data stream.
摘要翻译：一种用于通过链路来连接视频设备的系统和方法，其中具有以第一时钟速率（R 1> 1）以电子方式发送的并行数据量的数量（n）的电子数字视频数据被转换为流以及第二时钟速率（R 2 2 = R 1 x n）的电子串行数据。电子串行数据流通过可以是光纤链路的链路传输，或者包括一个或多个导体。采用接收机将通过链路发送的数据转换成具有以第一时钟速率（R 1> 1）电子发送的（n）个并行数据位的输出数据流。如果链路是光纤链路，则接收机可以将通过链路传输的数据转换成以第二时钟速率（R 2> 2）发送的第二流电子串行数据，然后到输出数据流。

2. 发明授权

US09766491B2 System and method for LCD assembly having integrated color shift correction 有权
公开(公告)号：US09766491B2
公开(公告)日：2017-09-19
申请号：US13604144
申请日：2012-09-05
申请人： David R. Glover , Ching Fong , Joseph A. Pasek , Michael R. Boyd , Wesley R. Corrion
发明人： David R. Glover , Ching Fong , Joseph A. Pasek , Michael R. Boyd , Wesley R. Corrion
IPC分类号： G02F1/1335
CPC分类号： G02F1/133514 , G02F1/1336 , G02F2001/133562 , G02F2001/133624 , Y10T29/49002
摘要： A system is disclosed for correcting a color of light being generated by an LCD image system having an LED and an LCD glass component that is illuminated by the LED. A plurality of color correction filters are constructed, with each providing a predetermined, differing color shift to light being output by the LCD glass component, based on a measured color of the light being output from the LCD glass component. Each of the color correction filters is constructed based on a known range of color variations that may be present in a color of the light being output from the LCD glass component. Each filter provides a color shift that shifts the color of the light being output from the LCD glass component from outside a predetermined target color area back into the predetermined target color area.

3. 发明授权

US07381744B1 Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds 有权
标题翻译：包括液泡型（H +） - ATP酶抑制化合物的骨质疏松症治疗方法
公开(公告)号：US07381744B1
公开(公告)日：2008-06-03
申请号：US09914708
申请日：2000-03-02
申请人： Michael R. Boyd
发明人： Michael R. Boyd
IPC分类号： A61K31/335 , A61K31/70 , C07D313/00
CPC分类号： A61K31/366 , A61K31/357 , A61K31/365 , A61K31/39 , A61K31/536 , A61K45/06
摘要： The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a vacuolar-type (H+)-ATPase. The composition of the present invention comprises a compound of the present invention and a carrier. The method of the present invention includes administering a vacuolar-type (H+)-ATPase inhibiting-effective amount of a compound of the present invention. The compound of the present invention has formula (I) wherein R1 and R2 are H, saturated or unsaturated alkyl, aryl, R6CH2—, R6CO—, or R6SO2—, wherein R6 is H, saturated or unsaturated alkyl, or aryl; R3 is H, alkyl, aryl, an oxime, or an oxime methyl ether; the aromatic ring is unsubstituted or substituted; and Z is a contiguous linker comprising a chain of 0-10 atoms which, together with the five atoms beginning with the carbon of the aromatic ring in meta-relationship with OR1 and ending with the carbon directly attached to the alkyl oxygen of the lactone, integrally form a 5-17 membered ring; or a pharmaceutically acceptable salt, an ester, or a prodrug thereof.
摘要翻译：本发明提供液泡型（H +） - ATP酶抑制化合物，其组合物，以及使用它们来治疗或预防通过抑制液泡型（H +） - ATP酶可治疗的病症的方法。本发明的组合物包含本发明的化合物和载体。本发明的方法包括施用液泡型（H +） - ATP酶抑制有效量的本发明化合物。本发明的化合物具有式（I），其中R 1和R 2是H，饱和或不饱和的烷基，芳基，R 6， CH 2 - ， - NR 6 - ， - 或SO 6 SO 2 - ，其中R 6 H是饱和或不饱和的烷基或芳基; R 3是H，烷基，芳基，肟或肟甲基醚; 芳环是未取代的或取代的; 并且Z是包含0-10个原子的链的连续接头，其与从OR 1开始的五个原子与OR 1的间隔关系以及直接连接的碳结束与内酯的烷基氧一体形成5-17元环; 或其药学上可接受的盐，酯或前药。

4. 发明授权

US06245737B1 Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins 有权
标题翻译：抗病毒蛋白或肽与病毒或病毒包膜糖蛋白的结合物
公开(公告)号：US06245737B1
公开(公告)日：2001-06-12
申请号：US09137134
申请日：1998-08-19
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： A61K3808
CPC分类号： C07K14/195 , A61K38/164 , A61K47/645 , A61K47/6817 , A61L2/0088 , A61L2/18 , Y10S514/841
摘要： The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供抗病毒蛋白，肽和缀合物，以及获得这些试剂的方法。本发明的抗病毒蛋白质，肽和缀合物可以单独使用或与组合物中的其它抗病毒药物组合使用，例如药物组合物，以抑制病毒（例如逆转录病毒）的感染性，复制和细胞病变效应，特别是人类免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

5. 发明授权

US6140339A Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof 失效
标题翻译：单体和二聚芳基异喹啉生物碱及其衍生物
公开(公告)号：US6140339A
公开(公告)日：2000-10-31
申请号：US1801
申请日：1997-12-31
申请人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
发明人： Gerhard Bringmann , Michael R. Boyd , Matthias Wenzel
IPC分类号： A61K31/47 , A61K31/4725 , A61P33/06 , C07D217/02 , C07D217/04 , C07D217/24 , C07D401/04 , C07D401/10 , C07D491/04 , A61K31/472 , C07D217/06
CPC分类号： C07D491/04 , A61K31/47 , C07D217/02 , C07D217/04 , C07D217/24
摘要： The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers, wherein either or both of said monomer(s) is (are) monomeric compound(s) of the present invention. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically such as antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids. Monomeric and dimeric compounds of the present invention may be obtained in substantially pure form by total synthesis, partial synthesis, or derivatization from known synthetic or naturally occurring compounds, and by isolation and purification from plants of the Dioncophyllaceae and Ancistrocladaceae families.
摘要翻译：本发明提供了C-8'-7连接的萘基异喹啉生物碱二萜类植物D的新单体衍生物。本发明还提供新的C-4取代的单体芳基异喹啉生物碱衍生物。本发明还提供由偶联的第一和第二芳基异喹啉单体组成的新型二聚芳基异喹啉生物碱，其中所述单体中的一种或两种是本发明的单体化合物。本发明的单体和二聚体化合物具有医学上有用的性质，例如抗微生物性质，更具体地，例如抗疟疾和抗病毒性质。本发明的单体化合物也可用作合成新型二聚芳基异喹啉生物碱的结构单元或中间体。本发明的单体和二聚体化合物可以通过从合成或天然存在的化合物的全部合成，部分合成或衍生化，以及通过从Dioncophyllaceae和Ancistrocladaceae家族的植物中分离和纯化而以基本上纯的形式获得。

6. 发明授权

US5998587A Anti-cyanovirin antibody 失效
标题翻译：抗花青素抗体
公开(公告)号：US5998587A
公开(公告)日：1999-12-07
申请号：US969249
申请日：1997-11-13
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： C12N15/09 , A61K35/14 , A61K36/02 , A61K38/00 , A61K38/16 , A61K38/46 , A61K47/48 , A61K48/00 , A61L2/00 , A61L2/18 , A61P31/12 , C07K14/195 , C07K14/405 , C07K16/14 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/84 , C12R1/91 , C07K16/08
CPC分类号： A61K47/48315 , A61K38/164 , A61K47/48438 , A61L2/0088 , A61L2/18 , C07K14/195 , Y10S514/841
摘要： The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
摘要翻译：本发明提供了抗病毒蛋白质（统称为氰洛维林），其结合物，结束这些试剂的DNA序列，含有这些DNA序列的宿主细胞，针对这些试剂的抗体，包含这些试剂的组合物，以及获得和使用这些试剂的方法。

7. 发明授权

US5869522A Antiviral naphthoquinone compounds, compositions and uses thereof 失效
标题翻译：抗病毒萘醌化合物，其组合物和用途
公开(公告)号：US5869522A
公开(公告)日：1999-02-09
申请号：US455679
申请日：1995-05-31
申请人： Michael R. Boyd , John H. Cardelina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parsons , Lewis Pannell , James B. McMahon , Gordon M. Cragg
发明人： Michael R. Boyd , John H. Cardelina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parsons , Lewis Pannell , James B. McMahon , Gordon M. Cragg
IPC分类号： C07D211/46 , A61K31/00 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/505 , A61K31/52 , A61K31/70 , A61K38/00 , A61K38/17 , A61K38/21 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/18 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/46 , C07D311/54 , C07D311/56 , C07D311/92 , A01N43/16 , C07C50/04 , C07D311/02 , C07D311/04
CPC分类号： C07D311/92 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/70 , A61K38/1774 , A61K38/212 , A61K45/06 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/56
摘要： The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供了新的抗病毒萘醌化合物，其可以根据本发明的方法从科氏菌属植物中分离或者化学合成。抗病毒萘醌酮化合物，其衍生物及其前药可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合使用，以抑制病毒如逆转录病毒，特别是人的生长或复制免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

8. 发明授权

US5843882A Antiviral proteins and peptides 失效
标题翻译：抗病毒蛋白和肽
公开(公告)号：US5843882A
公开(公告)日：1998-12-01
申请号：US429965
申请日：1995-04-27
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： C12N15/09 , A61K35/14 , A61K36/02 , A61K38/00 , A61K38/16 , A61K38/46 , A61K47/48 , A61K48/00 , A61L2/00 , A61L2/18 , A61P31/12 , C07K14/195 , C07K14/405 , C07K16/14 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/84 , C12R1/91 , A61K38/08 , A61K38/10
CPC分类号： A61K47/48315 , A61K38/164 , A61K47/48438 , A61L2/0088 , A61L2/18 , C07K14/195 , Y10S514/841
摘要： The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供抗病毒蛋白，肽和缀合物，以及获得这些试剂的方法。本发明的抗病毒蛋白质，肽和缀合物可以单独使用或与组合物中的其它抗病毒药物组合使用，例如药物组合物，以抑制病毒（例如逆转录病毒）的感染性，复制和细胞病变效应，特别是人类免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

9. 发明授权

US5789594A Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof 失效
公开(公告)号：US5789594A
公开(公告)日：1998-08-04
申请号：US674359
申请日：1996-07-01
申请人： Gerhard Bringmann , Sven Harmsen , Michael R. Boyd
发明人： Gerhard Bringmann , Sven Harmsen , Michael R. Boyd
IPC分类号： C07D217/02 , C07D217/04 , C07D401/10
CPC分类号： C07D217/04 , C07D217/02
摘要： The present invention provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.

10. 发明授权

US5763613A Monomeric naphthylisoquinoline alkaloids and synthesis methods thereof 失效
标题翻译：单体萘基异喹啉生物碱及其合成方法
公开(公告)号：US5763613A
公开(公告)日：1998-06-09
申请号：US674362
申请日：1996-07-01
申请人： Gerhard Bringmann , Roland Gotz , Michael R. Boyd
发明人： Gerhard Bringmann , Roland Gotz , Michael R. Boyd
IPC分类号： C07D217/02 , C07D217/04
CPC分类号： C07D217/02 , C07D217/04
摘要： The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The invention also provides new, medically useful naphthylisoquinoline compounds and derivatives thereof.
摘要翻译：本发明提供了制备单体萘基异喹啉生物碱的方法，其中包括抗寄生虫菊胺和相关化合物，以及非焦甲酸等单体萘基异喹啉生物碱。本发明还提供了新的，医学上有用的萘基异喹啉化合物及其衍生物。

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