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1. 发明申请

US20060127314A1 Method and arrangement for producing contrast agent for magnetic resonance imaging 审中-公开
标题翻译：用于产生磁共振成像造影剂的方法和装置
公开(公告)号：US20060127314A1
公开(公告)日：2006-06-15
申请号：US10526240
申请日：2003-08-29
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Maurice Goldman , Haukur Johannesson
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Maurice Goldman , Haukur Johannesson
IPC分类号： A61B5/055
CPC分类号： G01R33/28 , A61K49/10 , G01R33/445 , G01R33/56 , G01R33/5605
摘要： The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (105) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (110: 705) the contrast agent to a magnetic field cycling profile adapted for enhancing the contrasting effects of the contrast agent. The magnetic field cycling profile comprises an initial decrease of the magnetic field followed by at least one increase of the magnetic field, which increase should be arranged as to give a non-adiabatic (diabatic) remagnetisation of the contrast agent.
摘要翻译：本发明涉及一种用于提供造影剂的装置和方法。 MRI（磁共振成像）和NMR（核磁共振）应用。根据本发明的方法包括以下步骤：获得（100）可氢化不饱和基底化合物的溶剂中的溶液和用于氢化底物化合物的催化剂，氢化（105）基底与氢气（H

2. 发明申请

US20060127313A1 Method and apparatus for producing contrast agents for magnetic resonance imaging 审中-公开
标题翻译：用于产生磁共振成像造影剂的方法和装置
公开(公告)号：US20060127313A1
公开(公告)日：2006-06-15
申请号：US10526134
申请日：2003-08-29
申请人： Maurice Goldman , Oskar Axelsson , Haukur Johannesson , Jan Ardenkjaer-Larsen
发明人： Maurice Goldman , Oskar Axelsson , Haukur Johannesson , Jan Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61B5/055
CPC分类号： A61K49/10 , G01R33/282 , G01R33/5601
摘要： The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.
摘要翻译：本发明涉及一种用于提供造影剂的装置和方法。 MRI（磁共振成像）和NMR（核磁共振）应用。根据本发明的方法包括以下步骤：获得（100）可氢化不饱和基底化合物的溶剂中的溶液和用于氢化底物化合物的催化剂，用氢气氢化（110）基底（H

3. 发明申请

US20060104906A1 Method and apparatus for producing contrast agents for magnetic resonance imaging 审中-公开
标题翻译：用于产生磁共振成像造影剂的方法和装置
公开(公告)号：US20060104906A1
公开(公告)日：2006-05-18
申请号：US10526238
申请日：2003-08-29
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Haukur Johannesson
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Haukur Johannesson
IPC分类号： A61B5/055
CPC分类号： A61K49/1815
摘要： The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120, 305) the contrast agent to a sequence of pulses of magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing pulses of magnetic field.
摘要翻译：本发明涉及一种用于提供造影剂的装置和方法。 MRI（磁共振成像）和NMR（核磁共振）应用。根据本发明的方法包括以下步骤：获得（100）可氢化不饱和基底化合物的溶剂中的溶液和用于氢化底物化合物的催化剂，用氢气氢化（110）基底（H

4. 发明申请

US20060192559A1 Methods and devices for polarized NMR samples 审中-公开
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20060192559A1
公开(公告)日：2006-08-31
申请号：US11191140
申请日：2005-07-28
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and methods for melting a solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup in a strong magnetic field in a polarising means in a cryostat and then melted inside the cryostat by melting means such as a laser connected by an optical fibre to the interior of the cryostat.
摘要翻译：本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。在本发明的一个实施例中，样品在低温恒温器中的偏振装置中的强磁场中的样品保持杯中极化，然后通过诸如通过光纤连接到内部的激光器的熔化装置在低温恒温器内熔化的低温恒温器。

5. 发明申请

US20050225328A1 Methods and devices for polarised NMR samples 有权
标题翻译：用于极化NMR样品的方法和装置
公开(公告)号：US20050225328A1
公开(公告)日：2005-10-13
申请号：US11062882
申请日：2005-02-22
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01N1/44 , G01R33/28 , G01R33/30 , G01R33/62 , G01V3/00 , G01J4/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译：本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置如激光器在低温恒温器2内熔化 8通过光纤4连接到低温恒温器的内部。

6. 发明申请

US20050152840A1 Process 有权
标题翻译：处理
公开(公告)号：US20050152840A1
公开(公告)日：2005-07-14
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢的氢气（H 2 S 2 H 2）的室中，）和/或邻 - 氘（o-2 H 2 H 2），由此氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

7. 发明授权

US06574496B1 Magnetic resonance imaging 失效
标题翻译：磁共振成像
公开(公告)号：US06574496B1
公开(公告)日：2003-06-03
申请号：US09572949
申请日：2000-05-18
申请人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
发明人： Klaes Golman , Oskar Axelsson , Haukur Johannesson
IPC分类号： A61B505
CPC分类号： G01R33/5601 , G01R33/56308
摘要： A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.
摘要翻译：通过（i）使富氘氢与可氢化MR显像剂前体反应以产生氢化（即氘代）MR成像剂，对样品进行磁共振研究的方法; （ii）任选地，使氢化MR成像剂经受低磁场;（iii）向该样品施用氢化MR显像剂; （iv）将所述样品暴露于所选择的用于激发所述氢化MR成像剂中选定的非零核自旋核的核自旋跃迁的频率的辐射; （v）从所述样品检测所选择的非零核自旋核的磁共振信号; 和（vi）可选地，从检测到的信号生成图像或生物功能数据或动态流量数据。

8. 发明授权

US07459144B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US07459144B2
公开(公告)日：2008-12-02
申请号：US11002864
申请日：2004-12-02
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61B5/055 , B01J10/00
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供了一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述液滴形式的溶液引入含有富氢对二氢（p-1H 2）和/或邻 - 氘（o-2H 2）的氢气（H 2）的室中，从而氢化所述底物以形成氢化显像剂; iii）任选地使所述氢化成像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述显影剂的溶液在所述水性介质中分离; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和vii）任选地将所述成像剂的溶液冷冻在所述水性介质中。

9. 发明申请

US20090238768A1 MULTIMERIC MAGNETIC RESONANCE CONTRAST AGENTS 审中-公开
标题翻译：多功能磁共振对比剂
公开(公告)号：US20090238768A1
公开(公告)日：2009-09-24
申请号：US12095218
申请日：2006-12-01
申请人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
发明人： Oskar Axelsson , Haukur Johannesson , Andreas Meijer , Andreas Olsson , Tim Stahlberg , Mikkel Thaning , Duncan Wynn , Anders Brathe
IPC分类号： A61K49/10 , C07F5/00
CPC分类号： C07D403/12 , C07D257/02
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

10. 发明授权

US06872380B2 Process for preparation of MR contrast agents 有权
标题翻译：制备MR造影剂的方法
公开(公告)号：US06872380B2
公开(公告)日：2005-03-29
申请号：US09990537
申请日：2001-11-16
申请人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
发明人： Oskar Axelsson , Charlotte Olofsson , Axel Morgenstjerne , Georg Hansson , Haukur Johannesson , Jan-Henrik Ardenkjaer-Larsen
IPC分类号： A61K49/00 , A61K49/18 , C07C67/303 , C07C69/675 , G01R33/28 , G01R33/483 , A61B5/055 , C07C69/02
CPC分类号： A61K49/1815
摘要： The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.
摘要翻译：本发明提供一种制备MR造影剂的方法，所述方法包括：i）获得在可氢化不饱和底物化合物的溶剂中的溶液和用于所述底物化合物氢化的催化剂; ii）将所述溶液以液滴形式进入含有富氢对氢（对 - 氢）和/或邻 - 氘（o- 2 H 2）的氢气（H 2）和/或邻 - 氘（o- 2 H 2）的室中，由此氢化所述基底以形成氢化显像剂 iii）任选地使所述氢化显像剂经受场强低于地球环境场强的磁场; iv）任选地将所述成像剂溶解在水性介质中; v）任选地将所述催化剂与所述成像剂在所述水性介质; vi）任选地将所述溶剂与所述显影剂的溶液在所述水性介质中分离; 和任选地将所述显像剂的溶液冷冻在所述水性介质中。

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