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1. 发明申请

US20060281684A1 Polymyxin B analogs for LPS detoxification 失效
标题翻译：多粘菌素B类似物用于LPS解毒
公开(公告)号：US20060281684A1
公开(公告)日：2006-12-14
申请号：US11398915
申请日：2006-04-06
申请人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noelle Mistretta , Tino Krell
发明人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noelle Mistretta , Tino Krell
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/54 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as polymyxin B does. The dimeric structure is maintained by a pair of disulphide bonds involving the two cystein residues present in the peptide sequence, which does not exceed 17 amino acids and essentially comprises cationic and hydrophobic amino acid residues. In the dimers of the invention, peptides may have a parallel or anti-parallel orientation. As a matter of example, a dimer of the invention is constituted by a peptide of formula NH2-Lys-Thr-Lys-Cysl-Lys-Phe-Leu-Leu-Leu-Cys2-COOH, either in a parallel or antiparallel dimeric form. SAEP II dimers are useful for treating or preventing septic shock and related disorders generated by Gram-negative bacteria infection. The invention also relates to LPS-peptide complexes in which LPS and SAEP II diners are non-covalently bound together. These complexes are useful as vaccinal agents against Gram-negative bacteria infection.
摘要翻译：本发明涉及模拟多粘菌素B i.a.的SAEP II肽二聚体。在其以高亲和力非共价结合革兰氏阴性细菌的脂多糖（LPS）的能力，因此使LPS作为多粘菌素B解毒。二聚体结构通过涉及肽序列中存在的两个半胱氨酸残基的一对二硫键来维持，其不超过17个氨基酸并且基本上包含阳离子和疏水氨基酸残基。在本发明的二聚体中，肽可以具有平行或反平行取向。作为实例，本发明的二聚体由式NH2-Lys-Thr-Lys-Cys1-Lys-Phe-Leu-Leu-Leu-Leu-Cys2-COOH的肽构成，以平行或反向平行的二聚体形式。 SAEP II二聚体可用于治疗或预防由革兰氏阴性菌感染引起的败血性休克和相关疾病。本发明还涉及其中LPS和SAEP II食用者非共价结合在一起的LPS-肽复合物。这些复合物可用作抗革兰氏阴性菌感染的疫苗。

2. 发明申请

US20090203881A1 Polymyxin B Analogs for LPS Detoxification 审中-公开
标题翻译：多粘菌素B类似物用于LPS解毒
公开(公告)号：US20090203881A1
公开(公告)日：2009-08-13
申请号：US12369983
申请日：2009-02-12
申请人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noelle Mistretta , Tino Krell
发明人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noelle Mistretta , Tino Krell
IPC分类号： C07K1/14
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/54 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要： The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as polymyxin B does. The dimeric structure is maintained by a pair of disulphide bonds involving the two cystein residues present in the peptide sequence, which does not exceed 17 amino acids and essentially comprises cationic and hydrophobic amino acid residues. In the dimers of the invention, peptides may have a parallel or anti-parallel orientation. As a matter of example, a dimer of the invention is constituted by a peptide of formula NH2-Lys-Thr-Lys-Cys1-Lys-Phe-Leu-Leu-Leu-Cys2-COOH, either in a parallel or antiparallel dimeric form. SAEP II dimers are useful for treating or preventing septic shock and related disorders generated by Gram-negative bacteria infection. The invention also relates to LPS-peptide complexes in which LPS and SAEP II dimers are non-covalently bound together. These complexes are useful as vaccinal agents against Gram-negative bacteria infection.
摘要翻译：本发明涉及模拟多粘菌素B i.a.的SAEP II肽二聚体。在其以高亲和力非共价结合革兰氏阴性细菌的脂多糖（LPS）的能力，因此使LPS作为多粘菌素B解毒。二聚体结构通过涉及肽序列中存在的两个半胱氨酸残基的一对二硫键来维持，其不超过17个氨基酸并且基本上包含阳离子和疏水氨基酸残基。在本发明的二聚体中，肽可以具有平行或反平行取向。作为实例，本发明的二聚体由式NH2-Lys-Thr-Lys-Cys1-Lys-Phe-Leu-Leu-Leu-Leu-Cys2-COOH的肽构成，其平行或反向平行的二聚体形式。 SAEP II二聚体可用于治疗或预防由革兰氏阴性菌感染引起的败血性休克和相关疾病。本发明还涉及其中LPS和SAEP II二聚体非共价结合在一起的LPS-肽复合物。这些复合物可用作抗革兰氏阴性菌感染的疫苗。

3. 发明授权

US07507718B2 Polymyxin B analogs for LPS detoxification 失效
标题翻译：多粘菌素B类似物用于LPS解毒
公开(公告)号：US07507718B2
公开(公告)日：2009-03-24
申请号：US11398915
申请日：2006-04-06
申请人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noëlle Mistretta , Tino Krell
发明人： Massimo Porro , Massimo Velucchi , Alessandro Rustici , Monique Moreau , Noëlle Mistretta , Tino Krell
IPC分类号： A61K38/08 , A61K38/10
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/54 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The invention relates to SAEP II peptide dimers that mimic polymyxin B i.a. in its ability to bind non-covalently the lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS. The dimeric structure is maintained by a pair of disulphide bonds between two cystein residues present in the peptide sequence, which does not exceed 17 amino acids and essentially comprises cationic and hydrophobic amino acid residues. The peptides in the dimers may have a parallel or anti-parallel orientation. SAEP II dimers are useful for treating or preventing septic shock and related disorders generated by Gram-negative bacteria infection. The invention also relates to LPS-peptide complexes in which LPS and SAEP II diners are non-covalently bound together. These complexes are useful as vaccinal agents against Gram-negative bacteria infection.
摘要翻译：本发明涉及模拟多粘菌素B i.a.的SAEP II肽二聚体。在其以高亲和力非共价结合革兰氏阴性细菌的脂多糖（LPS）的能力，因此解毒LPS。二聚体结构通过存在于肽序列中的两个半胱氨酸残基之间的一对二硫键保持，肽序列不超过17个氨基酸并且基本上包含阳离子和疏水氨基酸残基。二聚体中的肽可以具有平行或反平行取向。 SAEP II二聚体可用于治疗或预防由革兰氏阴性菌感染引起的败血性休克和相关疾病。本发明还涉及其中LPS和SAEP II食用者非共价结合在一起的LPS-肽复合物。这些复合物可用作抗革兰氏阴性菌感染的疫苗。

4. 发明授权

US07056519B2 Methods for inducing HIV-neutralizing antibodies 失效
标题翻译：诱导HIV中和抗体的方法
公开(公告)号：US07056519B2
公开(公告)日：2006-06-06
申请号：US10438691
申请日：2003-05-15
申请人： Florence Boudet , Raphaëlle El Habib , Tino Krell , Régis Sodoyer , Michel Chevalier
发明人： Florence Boudet , Raphaëlle El Habib , Tino Krell , Régis Sodoyer , Michel Chevalier
IPC分类号： A61K39/385
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C07K16/1063 , C12N2740/16122
摘要： The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide represented by the formula N-L-C, in which: N represents the amino acid sequence 25–81 of gp41, C represents the amino acid sequence 112–157 of gp41, and L represents a flexible linking sequence comprising from 2 to 30 amino acids.
摘要翻译：本发明涉及一种用于诱导在哺乳动物中中和HIV初级分离物的抗体的方法，包括给予包含由式NLC表示的多肽的药物组合物，其中：N代表gp41的氨基酸序列25-81，C代表 gp41的氨基酸序列112-157，L代表包含2-30个氨基酸的柔性连接序列。

5. 发明授权

US06861253B2 Polypeptide inducing antibodies neutralizing HIV 失效
标题翻译：多肽诱导中和HIV的抗体
公开(公告)号：US06861253B2
公开(公告)日：2005-03-01
申请号：US10040349
申请日：2002-01-07
申请人： Robert Brasseur , Benoit Charloteaux , Michel Chevalier , Raphaelle El Habib , Tino Krell , Regis Sodoyer
发明人： Robert Brasseur , Benoit Charloteaux , Michel Chevalier , Raphaelle El Habib , Tino Krell , Regis Sodoyer
IPC分类号： A61K39/00 , C07K14/16 , C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , Y10S530/826
摘要： The present invention thus provides a polypeptide capable of forming a structure corresponding to or mimicking the intermediate of gp41 as well as its use in a vaccine for treating or preventing HIV infections.
摘要翻译：因此，本发明提供了能够形成对应于或模拟gp41中间体的结构的多肽，以及其在疫苗中用于治疗或预防HIV感染的用途。

6. 发明授权

US06821723B2 GP41 antigen 失效
标题翻译： GP41抗原
公开(公告)号：US06821723B2
公开(公告)日：2004-11-23
申请号：US10263103
申请日：2002-10-02
申请人： Michel Chevalier , Raphaëlle El Habib , Tino Krell , Règis Sodoyer
发明人： Michel Chevalier , Raphaëlle El Habib , Tino Krell , Règis Sodoyer
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C12N2740/16122
摘要： The present invention comprises novel polypeptide antigens that can be used for therapeutic and prophylactic immunization against HIV-related infections. The polypeptide of the invention mimics the intermediate state of gp41 and is capable of inducing antibodies which neutralize primary isolates of HIV. The invention also comprises compositions comprising the polypeptide and methods of using it.
摘要翻译：本发明包括可用于针对HIV相关感染的治疗和预防性免疫的新型多肽抗原。本发明的多肽模拟gp41的中间状态，并能够诱导中和HIV分离株的抗体。本发明还包括包含多肽的组合物及其使用方法。

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