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1. 发明授权

US4507232A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US4507232A
公开(公告)日：1985-03-26
申请号：US562439
申请日：1983-12-16
申请人： Masaharu Tamai , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura , Nobuhiko Katunuma
发明人： Masaharu Tamai , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura , Nobuhiko Katunuma
IPC分类号： C07K1/113 , A61K38/00 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/083 , C12Q1/37 , C07C103/52
CPC分类号： C12Q1/37 , C07K5/06034 , C07K5/06078 , C07K5/06095 , C07K5/0808 , A61K38/00 , C12Q2337/12 , C12Q2337/22 , C12Q2337/30 , G01N2333/96466 , Y02P20/55
摘要： This invention is directed to novel peptide derivatives. Said peptide derivatives are useful as a substrate for the activity assay of enzymes of the group EC 3. 4. 22, for example, cathepsin L, cathepsin B and cathepsin H. Said peptide derivatives which contain L-methionine radical are prepared according to the methods conventional in peptide chemistry. As typical examples are mentioned D-leucyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, .beta.-alanyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate and succinyl-L-tyrosyl-L-methionine-p-nitroanilide.
摘要翻译：本发明涉及新型肽衍生物。所述肽衍生物可用作组EC 3. 4.22的酶的活性测定的底物，例如组织蛋白酶L，组织蛋白酶B和组织蛋白酶H.所述含有L-甲硫氨酸基团的肽衍生物根据肽化学中常规的方法。作为典型实例，提及D-亮氨酰-L-酪氨酰-L-甲硫氨酸-β-萘甲酰胺甲酸盐，β-丙氨酰-L-酪氨酰-L-甲硫氨酸-β-萘甲酰胺甲酸盐和琥珀酰-L-酪氨酰-L-甲硫氨酸-p 硝基苯胺。

2. 发明授权

US4333879A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US4333879A
公开(公告)日：1982-06-08
申请号：US109410
申请日：1980-01-03
申请人： Masaharu Tamai , Takashi Adachi , Shigeo Morimoto , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
发明人： Masaharu Tamai , Takashi Adachi , Shigeo Morimoto , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
IPC分类号： C07D303/48 , A61K31/335 , A61K31/336 , A61K38/00 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/065 , C07K14/81 , C07C103/52 , C07D405/12
CPC分类号： C07K5/06078 , C07K5/06043 , A61K38/00
摘要： An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl or cycloalkyl having 3-6 carbon atoms or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.
摘要翻译：其中R 1为氢，碱金属，具有1-2个碳原子的烷基，具有5-6个碳原子的环烷基或苄基，R2为具有3-4个碳原子的烷基或苄基，R3表示下式的环氧琥珀酸衍生物氢或甲基，R4为具有1-10个碳原子的烷基，苯基，苄基，苯乙基或具有3-6个碳原子的环烷基或R3和R4与它们所连接的氮原子一起形成5-6元杂环环或被保护的羧基取代的所述杂环。

3. 发明授权

US4474800A Epoxysuccinyl amino acid derivatives 失效
标题翻译：环氧琥珀酰氨基酸衍生物
公开(公告)号：US4474800A
公开(公告)日：1984-10-02
申请号：US149312
申请日：1980-05-13
申请人： Masaharu Tamai , Shigeo Morimoto , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
发明人： Masaharu Tamai , Shigeo Morimoto , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
IPC分类号： C07D303/48 , A61K31/335
CPC分类号： C07D303/48
摘要： An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, benzyl or cycloalkyl having 5 to 6 carbon atoms, R.sup.2 is alkyl having 3 to 4 carbon atoms, R.sup.3 is hydrogen, benzyloxycarbonyl, acetyl or benzoyl, and n is an integer of 2 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.
摘要翻译：式中，R 1为氢，碱金属，苄基或碳原子数5〜6的环烷氧基烷基氨基酸衍生物，R2为碳原子数3〜4的烷基，R3为氢，苄氧羰基，乙酰基或苯甲酰基， n是2至7的整数。本发明化合物对于硫酸蛋白酶，特别是对于患有肌营养不良的哺乳动物的肌肉组织中存在过量的钙激活的中性硫醇蛋白酶表现出抑制活性。

4. 发明授权

US4418075A Epoxysuccinyl amino acid derivatives 失效
标题翻译：环氧琥珀酰氨基酸衍生物
公开(公告)号：US4418075A
公开(公告)日：1983-11-29
申请号：US320113
申请日：1981-11-10
申请人： Masaharu Tamai , Shigeo Morimoto , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
发明人： Masaharu Tamai , Shigeo Morimoto , Takashi Adachi , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
IPC分类号： A61K31/335 , A61K31/336 , A61K31/34 , A61P43/00 , C07D303/48 , C12N9/99
CPC分类号： C07D303/48 , Y10S514/907
摘要： An epoxysuccinyl amino acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen or alkali metal, R.sup.2 is isobutyl, R.sup.3 is hydrogen or benzyloxycarbonyl, and n is an integer of 5 to 7. The subject compounds exhibit inhibitory activity towards thiol protease, especially, calcium-activated neutral thiol protease which exists in excess in muscle tissues of mammals afflicted with muscular dystrophy.
摘要翻译：式IMAMA的环氧琥珀酰基氨基酸衍生物，其中R 1是氢或碱金属，R 2是异丁基，R 3是氢或苄氧基羰基，n是5到7的整数。本发明化合物对硫醇蛋白酶表现出抑制活性，特别是，钙激活的中性硫醇蛋白酶，其在肌肉营养不良的哺乳动物的肌肉组织中过量存在。

5. 发明授权

US4382889A Epoxysuccinic acid derivatives 失效
标题翻译：环氧琥珀酸衍生物
公开(公告)号：US4382889A
公开(公告)日：1983-05-10
申请号：US335700
申请日：1981-12-30
申请人： Masahuru Tamai , Takashi Adachi , Shigeo Morimoto , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
发明人： Masahuru Tamai , Takashi Adachi , Shigeo Morimoto , Kiyoshi Oguma , Kazunori Hanada , Sadafumi Omura
IPC分类号： C07D303/48 , A61K31/335 , A61K31/336 , A61K38/00 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/065 , C07K14/81 , C07C103/52
CPC分类号： C07K5/06078 , C07K5/06043 , A61K38/00
摘要： An epoxysuccinic acid derivative of the formula ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkyl having 1-2 carbon atoms, cycloalkyl having 5-6 carbon atoms or benzyl, R.sup.2 is alkyl having 3-4 carbon atoms or benzyl, R.sup.3 is hydrogen or methyl, and R.sup.4 is alkyl having 1-10 carbon atoms, phenyl, benzyl, phenethyl, cycloalkyl having 3-6 carbon atoms or a group of the formula ##STR2## wherein R.sup.5 is hydrogen, alkyl having 1-4 carbon atoms or said alkyl substituted with hydroxy, methylmercapto, phenyl, hydroxyphenyl, indolyl, an optionally protected carboxy, an optionally protected amino or an optionally protected guanidino, and R.sup.6 is hydroxy, alkalimetaloxy, alkoxy having 1-2 carbon atoms, benzyloxy, amino or dimethylamino, or R.sup.3 and R.sup.4 taken together with the nitrogen atom to which they are attached form a 5-6 membered heterocyclic ring, or said heterocyclic ring substituted with a protected carboxy.
摘要翻译：其中R 1为氢，碱金属，具有1-2个碳原子的烷基，具有5-6个碳原子的环烷基或苄基，R2为具有3-4个碳原子的烷基或苄基，R3表示下式的环氧琥珀酸衍生物氢或甲基，R 4是具有1-10个碳原子的烷基，苯基，苄基，苯乙基，具有3-6个碳原子的环烷基或下式的基团：其中R5是氢，具有1-4个碳原子的烷基或所述烷基被羟基，甲基巯基，苯基，羟基苯基，吲哚基，任选保护的羧基，任选保护的氨基或任选被保护的胍基取代，R 6是羟基，碱金属氧基，具有1-2个碳原子的烷氧基，苄氧基，氨基或二甲基氨基，或者R 3和R 4与它们所连接的氮原子一起形成5-6元杂环，或被被保护的羧基取代的所述杂环。

6. 发明授权

US5474923A Method for the biological preparation of hydroxyvitamin D compounds 失效
标题翻译：羟基维生素D化合物的生物制备方法
公开(公告)号：US5474923A
公开(公告)日：1995-12-12
申请号：US711988
申请日：1991-06-07
申请人： Koji Takeda , Kiyoshi Kimura , Kazuhiko Okamura , Rokuro Okamoto , Joji Sasaki , Takashi Adachi , Sadafumi Omura
发明人： Koji Takeda , Kiyoshi Kimura , Kazuhiko Okamura , Rokuro Okamoto , Joji Sasaki , Takashi Adachi , Sadafumi Omura
IPC分类号： C12P7/02 , C12R1/01 , C12R1/365
CPC分类号： C12P7/02
摘要： A method for introducing hydroxyl groups into vitamin D compound at the 1.alpha.- and/or 25-positions in the presence of a cyclodextrin compound by the use of a reaction mixture containing a microorganism being capable of hydroxylating vitamin D compound or a enzyme produced from the microorganism, is disclosed.
摘要翻译：在环糊精化合物的存在下，在1α和/或25位上将羟基引入维生素D化合物的方法是使用含有能够使维生素D化合物羟化的微生物的反应混合物或由该微生物被公开。

7. 发明授权

US4975370A Process for preparing 14-hydroxy-6-O-methyl-erythromycin A 失效
标题翻译：制备14-羟基-6-O-甲基红霉素A的方法
公开(公告)号：US4975370A
公开(公告)日：1990-12-04
申请号：US43536
申请日：1987-04-28
申请人： Joji Sasaki , Kazutoshi Mizoue , Takashi Adachi , Takatoshi Nagate , Shigeo Morimoto , Sadafumi Omura
发明人： Joji Sasaki , Kazutoshi Mizoue , Takashi Adachi , Takatoshi Nagate , Shigeo Morimoto , Sadafumi Omura
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , C12P19/62 , C12R1/785
CPC分类号： C07H17/08 , C12P19/62 , C12R1/785 , Y10S435/822 , Y10S435/931
摘要： Mucor circinelloides f. griseo-cyanus IFO 4563 is cultivated in a medium containing 6-O-methylerythromycin A as a substrate to obtain 14-hydroxy-6-O-methyl-erythromycin A. This compound and its salt have anti-bacterial activity.

8. 发明授权

US4496717A Erythromycin B derivatives 失效
标题翻译：红霉素B衍生物
公开(公告)号：US4496717A
公开(公告)日：1985-01-29
申请号：US444170
申请日：1982-11-24
申请人： Takashi Adachi , Shigeo Morimoto , Yoko Takahashi , Yoshiaki Watanabe , Sadafumi Omura
发明人： Takashi Adachi , Shigeo Morimoto , Yoko Takahashi , Yoshiaki Watanabe , Sadafumi Omura
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08 , Y02P20/55
摘要： Novel erythromycin B derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each hydrogen or methyl, and the pharmaceutically acceptable acid addition salts thereof are disclosed. They exhibit excellent in vivo antibacterial activity against Gram-positive bacteria.
摘要翻译：其中R1和R2相同或不同并且各自为氢或甲基的新颖的红霉素B衍生物及其药学上可接受的酸加成盐。它们对革兰氏阳性菌表现出优异的体内抗菌活性。

9. 发明授权

US07318784B2 Bicycle derailleur 有权
标题翻译：自行车拨链器
公开(公告)号：US07318784B2
公开(公告)日：2008-01-15
申请号：US10871746
申请日：2004-06-17
申请人： Takumi Onogi , Takashi Adachi , Yoshihiro Kinose
发明人： Takumi Onogi , Takashi Adachi , Yoshihiro Kinose
IPC分类号： B62M9/12 , F16H9/24
CPC分类号： B62M9/126 , B62M9/1242
摘要： An apparatus for achieving the return of a chain to a rear derailleur tension pulley more easily by means of pedaling action when the chain falls off from the tension pulley is provided. The rear derailleur is equipped with a base component, a link mechanism, a movable component, Outer Plate 20, Inner Plate 21, Guide Pulley 22, Tension Pulley 23, and Chain Return Section 32. The base component is a component which is mounted on the frame. The link mechanism is a mechanism of which one end is mounted on the base component. The movable component is a component which is mounted on the other end of the link mechanism, and which can be relatively displaced from the base component. The outer plate is a component which is mounted on the movable component so as to undulate like a see-saw. The inner plate is a component which is installed so as to face the outer plate. The guide pulley is a pulley which is mounted onto a portion on one edge of the plates, between the plates, so as to freely rotate and move in the axial direction, and which can be engaged with the chain. The tension pulley is a pulley which can be engaged with the chain, and is mounted onto a portion on the other edge of the plates, between the plates, so as to freely rotate. The chain return section is installed at a position on the inner plate which is proximal to the position at which the tension pulley is mounted, in a manner so that the clearance from the chain at this position is narrower as compared to the clearance at other positions.
摘要翻译：提供一种用于当链条从张力滑轮脱落时，通过踩踏动作更容易地将链条返回到后拨链器张紧轮的装置。后拨链器配备有基座部件，连杆机构，可动部件，外板20，内板21，导向皮带轮22，张紧滑轮23和链条返回部件32。基座部件是安装在框架上的部件。连杆机构是其一端安装在基座部件上的机构。可移动部件是安装在连杆机构的另一端上并且可以相对于基部部件移位的部件。外板是安装在可移动部件上的部件，以便像跷跷板那样起伏。内板是以与外板相对的方式安装的部件。引导轮是安装在板的一个边缘上的部分之间的滑轮，以便在轴向方向上自由旋转并且可以与链条接合。张力滑轮是可以与链条接合并且被安装在板之间的另一边缘上的部分之间的滑轮，以便自由旋转。链条返回部分安装在内板上靠近安装张紧轮的位置的位置处，使得与该其它位置处的间隙相比，该位置处的链条的间隙较窄。

10. 发明申请

US20070297481A1 LASER DEVICE AND OPTICAL AMPLIFIER 有权
标题翻译：激光器件和光放大器
公开(公告)号：US20070297481A1
公开(公告)日：2007-12-27
申请号：US11764271
申请日：2007-06-18
申请人： Takashi Adachi
发明人： Takashi Adachi
IPC分类号： H01S3/10 , H01S3/14 , H01S3/091 , H01S3/092
CPC分类号： H01S3/07 , H01S3/0604 , H01S3/09415 , H01S3/1118 , H01S3/1611 , H01S3/163 , H01S3/1668 , H01S2301/04 , H01S2301/08
摘要： Laser light emission across a wide bandwidth emission spectrum is enabled in a laser device equipped with solid gain media. The laser device is equipped with: a resonator; a plurality of solid gain media, having fluorescent spectra that at least partially overlap with each other, provided within the resonator; and pumping means, for pumping the plurality of solid gain media. The entire fluorescent spectrum width of the plurality of solid gain media is greater than the fluorescent spectrum width of each solid gain medium.
摘要翻译：在配备有固体增益介质的激光设备中，能够实现宽带宽发射光谱的激光发射。激光装置配有：谐振器; 多个固体增益介质，其具有设置在所述谐振器内的至少部分彼此重叠的荧光光谱; 以及用于泵送多个固体增益介质的泵送装置。多个固体增益介质的整个荧光光谱宽度大于每个固体增益介质的荧光光谱宽度。

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