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    • 5. 发明授权
    • Local inking with gray pixels
    • 本地墨迹与灰色像素
    • US5905488A
    • 1999-05-18
    • US729119
    • 1996-10-11
    • Alan J. DemersRonald A. FrederickChristian P. JacobiChristopher A. KantarjievRobert T. KrivacicMark D. Weiser
    • Alan J. DemersRonald A. FrederickChristian P. JacobiChristopher A. KantarjievRobert T. KrivacicMark D. Weiser
    • G06F3/033G06F3/048G09G5/00
    • G06F3/0488
    • As an electronic pen (16) moves across a display screen (12), a position resolver (14) generates a series of x,y-coordinate positions which are sent to a remote computer system (20) having a relatively high latency or time delay before the positions are processed and intended display information is returned to the memory cells of a memory array (24) which controls the display on the display screen (12). During the time delay, a temporary display of the trajectory is created, preferably in light gray or another distinguishable color. Each x,y-coordinate position is compared (32) with an immediately preceding coordinate position to determine whether the pen has moved. If so, the new coordinate is stored in a memory (36) which stores a preselected number of the most recent coordinate positions and to a toggle circuit (38) which toggles a preselected bit of the display information stored in the corresponding memory cell of the memory array. After a preselected time, determined by clocking the recent coordinate position memory (36), the oldest stored coordinate position is clocked out and display information in the memory cell corresponding to the clocked out coordinate position is retrieved (42) and analyzed (44). If the toggled bit is still in the toggled position, the toggle circuit (38) toggles it back to the initial state. If the preselected bit has been reset by the intended drawing in the interim, it is not altered.
    • 当电子笔(16)在显示屏幕(12)上移动时,位置解析器(14)产生一系列x,y坐标位置,这些位置被发送到具有相对高的等待时间或时间的远程计算机系统(20) 在处理位置之前的延迟,并且将预期显示信息返回到控制显示屏幕(12)上的显示的存储器阵列(24)的存储单元。 在时间延迟期间,创建轨迹的临时显示,优选地以浅灰色或另一种可区分的颜色。 将每个x,y坐标位置与前一个坐标位置进行比较(32),以确定笔是否已移动。 如果是,则将新的坐标存储在存储预定数量的最近的坐标位置的存储器(36)中,并且将切换电路(38)切换到存储在存储单元中的显示信息的预选位 内存阵列 在通过对最近的坐标位置存储器(36)计时确定的预选时间之后,将最早存储的坐标位置计时,并且检索与时钟输出坐标位置相对应的存储单元中的显示信息(42)并进行分析(44)。 如果切换位仍处于切换位置,则切换电路(38)将其切换回初始状态。 如果预选的位在过渡期间被预定的图形重置,则不会改变。
    • 6. 发明授权
    • Apparatus and method for detecting and locating rare cells
    • 用于检测和定位稀有细胞的装置和方法
    • US07277569B2
    • 2007-10-02
    • US10616366
    • 2003-07-09
    • Richard H. BruceDouglas N. CurryRobert T. KrivacicHuangpin B. Hsieh
    • Richard H. BruceDouglas N. CurryRobert T. KrivacicHuangpin B. Hsieh
    • G06K9/00
    • B82Y20/00B82Y5/00B82Y10/00G01N15/1468G01N2015/0065
    • In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.
    • 根据本申请的一个方面,公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。 成像器台支持样品。 光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。 光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。 扫描辐射源被布置在与输入孔相对的固定相对位置。 扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。 辐射束与样品相互作用以产生被信号反射,散射,透射,再发射或以其它方式收集和接收的光信号,并通过光纤束传输到输出孔。 扫描辐射源将辐射束照射在样品的选定区域上。 光检测器被设置为检测远端束端处的光信号,并且处理器处理检测到的光信号。
    • 7. 发明授权
    • Light source modulator
    • 光源调制器
    • US06707481B1
    • 2004-03-16
    • US09487544
    • 2000-01-19
    • Robert T. KrivacicAlan G. BellDouglas N. Curry
    • Robert T. KrivacicAlan G. BellDouglas N. Curry
    • B41J247
    • H04N1/40043G06K15/1223H04N1/40037
    • A light source modulator and method of modulating a light source use a lower bandwidth input signal during rendering of image data, which is less susceptible to systematic error. The modulation scheme improves the efficiency of use of high speed memory by limiting a number of intensity level transitions to a single transition per output pixel. In conjunction with the limitation of transitions per rendering of each output pixel, data is provided to the modulator that indicates an intensity level to be provided by the modulator and a timing of a transition to that intensity level. In accordance with the exemplary embodiments of the invention, an intensity level may be a minimum intensity level, a maximum intensity level and at least one intermediate intensity level which is intermediate between the minimum and maximum intensity levels.
    • 光源调制器和调制光源的方法在渲染图像数据期间使用较低带宽的输入信号,其不太容易受到系统误差的影响。 调制方案通过将多个强度电平转换限制到每个输出像素的单个转换来提高使用高速存储器的效率。 结合每个输出像素的每个渲染的转换的限制,数据被提供给调制器,其指示要由调制器提供的强度水平和转换到该强度水平的定时。 根据本发明的示例性实施例,强度水平可以是最小强度水平,最大强度水平和处于最小和最大强度水平之间的至少一个中间强度水平。
    • 9. 发明授权
    • Method of scanning and light collection for a rare cell detector
    • 稀有细胞检测器的扫描和光采集方法
    • US07280261B2
    • 2007-10-09
    • US11017440
    • 2004-12-20
    • Douglas N. CurryRichard H. BruceRobert T. Krivacic
    • Douglas N. CurryRichard H. BruceRobert T. Krivacic
    • G02B26/08
    • G01N21/6456G01N21/6428G01N2021/6484G01N2201/1085
    • An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.
    • 装置对表面进行成像。 成像器台具有用于支撑样品的平坦表面。 光纤束具有平行的第一光纤端的第一端,其布置成限定用于观察成像器台上的样品的输入孔。 远侧束端布置成限定远离成像器台布置的输出孔。 扫描辐射源沿着与成像器台上的样品垂直的路径扫描辐射束。 光纤束的输入孔径接收由成像器台样品的辐射源扫描产生的光信号。 光信号被传输到束输出孔径。 光电检测器检测远侧束端处的光信号,并且处理器处理检测到的光。