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1. 发明申请

US20080075789A1 Genes differentially expressed in bipolar disorder and/or schizophrenia 审中-公开
标题翻译：在双相型精神障碍和/或精神分裂症中差异表达的基因
公开(公告)号：US20080075789A1
公开(公告)日：2008-03-27
申请号：US11712827
申请日：2007-02-28
申请人： Marquis Vawter , Ling Shao
发明人： Marquis Vawter , Ling Shao
IPC分类号： A61K33/24 , A61K31/13 , A61K31/335 , A61K31/435 , A61K31/4523 , A61P25/00 , C12Q1/02 , A61K31/496 , A61K31/5415 , A61K31/55 , A61K31/551
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： This invention provides molecular markers that are prognostic and/or diagnostic for a psychiatric disorder. In particular, genes are identified whose expression is altered in schizophrenia and/or bipolar disorder thereby providing prognostic and diagnostic markers for the disorder. In addition genes are identified whose dysregulation provides markers that allow diagnostic distinction between schizophrenia and bipolar disorder.
摘要翻译：本发明提供了对精神疾病进行预后和/或诊断的分子标志物。特别地，鉴定其表达在精神分裂症和/或双相性障碍中改变的基因，从而为病症提供预后和诊断标记。此外，鉴定出其失调调节提供允许精神分裂症和双相情感障碍之间的诊断区别的标志物的基因。

2. 发明申请

US20060257903A1 Compositions and methods for diagnosing and treating neuropsychiatric disorders 有权
标题翻译：用于诊断和治疗神经精神障碍的组合物和方法
公开(公告)号：US20060257903A1
公开(公告)日：2006-11-16
申请号：US11396050
申请日：2006-03-31
申请人： Huda Akil , Mary Atz , William Bunney , William Byerley , Kathleen Casey , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , Richard Myers , Brandi Rollins , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
发明人： Huda Akil , Mary Atz , William Bunney , William Byerley , Kathleen Casey , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , Richard Myers , Brandi Rollins , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/573 , G01N33/6896 , G01N2500/00 , G01N2500/04 , G01N2800/28 , G01N2800/30 , G01N2800/302 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译：本发明提供了用于诊断精神障碍（例如精神病性障碍如精神分裂症和情绪障碍如重性抑郁障碍和双相情感障碍）的方法。本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。

3. 发明申请

US20090019557A1 FGF2-RELATED METHODS FOR DIAGNOSING AND TREATING DEPRESSION 审中-公开
公开(公告)号：US20090019557A1
公开(公告)日：2009-01-15
申请号：US11559398
申请日：2006-11-13
申请人： Huda Akil , Stanley Watson , Simon Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
发明人： Huda Akil , Stanley Watson , Simon Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
IPC分类号： A01K67/00 , C12Q1/68 , C12Q1/02 , G01N33/68 , A61K38/17
CPC分类号： C12Q1/6883 , A61K38/03 , A61K38/10 , A61K38/1774 , A61K38/1825 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/304
摘要： The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.

4. 发明申请

US20080199866A1 SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS 审中-公开
标题翻译：表征和处理双极性疾病及其他物质的SNP检测及其他方法
公开(公告)号：US20080199866A1
公开(公告)日：2008-08-21
申请号：US11868456
申请日：2007-10-05
申请人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
发明人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.
摘要翻译：本申请涉及使用SNP和差异外显子表达来表征，诊断或治疗双相情感障碍和其他精神疾病，如重度抑郁障碍和精神分裂症。

5. 发明申请

US20050209181A1 Compositions and methods for diagnosing and treating mental disorders 审中-公开
标题翻译：精神障碍诊断和治疗的组成和方法
公开(公告)号：US20050209181A1
公开(公告)日：2005-09-22
申请号：US10982556
申请日：2004-11-04
申请人： Huda Akil , Mary Atz , William Bunney , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , Richard Myers , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
发明人： Huda Akil , Mary Atz , William Bunney , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , Richard Myers , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
IPC分类号： A61B20060101 , A61K31/519 , A61K48/00 , C12Q1/68
CPC分类号： A61K31/519 , A61K31/7088 , G01N33/6893 , G01N2800/30 , G01N2800/302
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译：本发明提供了用于诊断精神障碍（例如精神病性精神障碍如精神分裂症）的方法。本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。

6. 发明申请

US20060205650A1 Treatment of neuropsychiatric disease with protease and neuraminidase inhibitors 审中-公开
标题翻译：用蛋白酶和神经氨酸酶抑制剂治疗神经精神疾病
公开(公告)号：US20060205650A1
公开(公告)日：2006-09-14
申请号：US11355257
申请日：2006-02-14
申请人： Marquis Vawter , William Freed
发明人： Marquis Vawter , William Freed
IPC分类号： A61K38/54 , A61K31/7008
CPC分类号： G01N33/6896 , A61K31/551 , A61K31/7008 , A61K38/05 , A61K38/06 , A61K38/55 , A61K38/57 , A61K45/06 , G01N2800/52 , A61K2300/00
摘要： The present invention provides a method of treating a neuropsychiatric disease characterized by an abnormally elevated level of a fragment of an isoform of a neural cell adhesion molecule, N-CAM, in the brain or cerebrospinal fluid of an affected human subject, comprising administering a therapeutically effective amount of at least one compound selected from the group consisting of protease inhibitors and neuraminidase inhibitors, whereby administering the compound to the subject treats the human subject. The present invention further provides a method of monitoring the efficacy of treatment with the method of the present invention. Moreover, the present invention provides a method of screening for compounds effective in treating neuropsychiatric disease associated with an abnormally elevated level of a fragment of a neural cell adhesion molecule in the cerebrospinal fluid of an affected human subject. Further provided are fragments of an isoform of N-CAM in the cerebrospinal fluid of human subjects.
摘要翻译：本发明提供一种治疗神经精神疾病的方法，其特征在于在受影响的人类受试者的脑或脑脊髓液中神经细胞粘附分子N-CAM的同种型的片段异常升高的水平，包括施用治疗有效量的至少一种选自蛋白酶抑制剂和神经氨酸酶抑制剂的化合物，其中向受试者施用该化合物治疗人受试者。本发明还提供了用本发明的方法监测治疗效果的方法。此外，本发明提供一种筛选与受影响人类受试者的脑脊液中的神经细胞粘附分子的片段异常升高相关的神经精神疾病有效治疗的化合物的方法。还提供了人受试者脑脊液中N-CAM同种型的片段。

7. 发明申请

US20060051786A1 Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder 有权
标题翻译：在双相障碍和/或重度抑郁障碍中差异表达的基因和途径
公开(公告)号：US20060051786A1
公开(公告)日：2006-03-09
申请号：US11158530
申请日：2005-06-21
申请人： Huda Akil , William Bunney , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , David Lyons , Margherita Molnar , Richard Myers , Alan Schatzberg , Richard Stein , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
发明人： Huda Akil , William Bunney , Prabhakara Choudary , Simon Evans , Edward Jones , Jun Li , Juan Lopez , David Lyons , Margherita Molnar , Richard Myers , Alan Schatzberg , Richard Stein , Robert Thompson , Hiroaki Tomita , Marquis Vawter , Stanley Watson
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , A61K31/713 , A61K38/1825 , C07K16/22 , C12N15/1136 , C12N2310/14 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
摘要翻译：本发明提供了诊断精神障碍的方法。本发明还提供识别精神障碍调节剂的方法以及使用这些调节剂治疗患有精神障碍的患者的方法。

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