会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明授权
    • Federation of composite applications
    • 复合应用联合会
    • US08332459B2
    • 2012-12-11
    • US12388648
    • 2009-02-19
    • Michael BlumPeter FischerHendrik HaddorpStefan HepperStefan LiescheMichael MarksThomas Stober
    • Michael BlumPeter FischerHendrik HaddorpStefan HepperStefan LiescheMichael MarksThomas Stober
    • G06F15/16
    • G06F9/5038G06F9/44521G06F9/505Y02D10/22
    • A predetermined business task of a composite application can be fulfilled. The composite application can include a set of components. The composite application is instantiated by a template means and a predefined collaborative context module controls the interaction of the set of components during the runtime of the composite application. A set of components fulfilling individual services on individual different server systems is leveraged by the composite application. During the instantiation of the composite application from a template, the referenced components (as types) are instantiated leading to runtime instances of these components. The interaction of the different components is controlled on individual different server systems utilizing a primary context module. The primary context module communicates with an appropriate collaborative module implemented locally on the respective set of servers, where the local context modules act as secondary context modules in relation to the primary context modules. For each of the secondary context modules, local components communicate to control the interaction of components.
    • 组合应用程序的预定业务任务可以满足。 复合应用程序可以包括一组组件。 复合应用程序由模板手段实例化,预定义的协作上下文模块控制组合应用程序运行时期间组件集的交互。 复合应用程序利用一组满足个别不同服务器系统上个性化服务的组件。 在从模板实例化复合应用程序期间,引用的组件(作为类型)被实例化,导致这些组件的运行时实例。 利用主上下文模块,在不同的服务器系统上控制不同组件的交互。 主上下文模块与在相应的服务器集合上本地实现的适当的协作模块进行通信,其中本地上下文模块作为相对于主上下文模块的辅助上下文模块。 对于每个辅助上下文模块,本地组件进行通信以控制组件的交互。
    • 7. 发明申请
    • INTEGRATED MULTI-CHANNEL TIME-TO-DIGITAL CONVERTER FOR TIME-OF-FLIGHT PET
    • 用于飞行时间飞行器的集成多通道时数转换器
    • US20090250616A1
    • 2009-10-08
    • US12304135
    • 2007-05-29
    • Torsten J. SolfPeter Fischer
    • Torsten J. SolfPeter Fischer
    • G01T1/166G01R35/00H03H11/26G01J5/10
    • G01T1/2985A61B6/037G04F10/005
    • In a radiation detector (10) for a time of flight positron emission tomography (PET) scanner (2), a radiation sensitive member (20) generates a signal (22) indicative of a radiation detection event. A time to digital converter (34) includes digital delay elements (40) operatively interconnected as a ring oscillator (36, 36′) and readout circuitry (50, 52, 60, 82, 84, 86, 88) configured to generate a timestamp for the radiation detection event based at least on a state of the ring oscillator when the signal is generated. Delay trim elements (46) operatively connected to the digital delay elements set a substantially common delay for the digital delay elements. Additionally or alternatively, the digital delay elements (40) include readout buffers (48′) having transition times substantially longer than a delay of the digital delay elements, analog to digital converters (82, 84) digitize values of the delay elements, and decoding circuitry (86, 88) computes the state of the ring oscillator (36′) based on the digitized values.
    • 在用于飞行时间正电子发射断层摄影(PET)扫描仪(2)的放射线检测器(10)中,辐射敏感部件(20)产生指示辐射检测事件的信号(22)。 时间到数字转换器(34)包括作为环形振荡器(36,36')可操作地互连的数字延迟元件(40)和被配置为生成时间戳的读出电路(50,52,60,82,84,86,88) 用于当产生信号时至少基于环形振荡器的状态的辐射检测事件。 可操作地连接到数字延迟元件的延迟微调元件(46)为数字延迟元件设置基本上公用的延迟。 附加地或替代地,数字延迟元件(40)包括读出缓冲器(48'),其具有比数字延迟元件的延迟更多的转换时间,模数转换器(82,84)数字化延迟元件的值,并且解码 电路(86,88)基于数字化值来计算环形振荡器(36')的状态。
    • 10. 发明申请
    • Cyclin groove inhibitors
    • US20060281687A1
    • 2006-12-14
    • US11408905
    • 2006-04-21
    • Martin AndrewsCampbell McInnesGeorge KontopidisPeter Fischer
    • Martin AndrewsCampbell McInnesGeorge KontopidisPeter Fischer
    • A61K38/08C07K7/06
    • C07K14/4738A61K38/00G01N33/5011G01N33/6872G01N2333/4739G01N2333/91205G01N2500/02
    • The present invention relates to a compound of formula I, or a variant thereof, A-(B)m-C-(D)n-E  (I)wherein m and n are each independently 0 or 1 and A, B, C, D and E are each independently linked to the respective adjacent residue by a linker group independently selected from carboxamide, reduced carboxamide, sulfonamide, imine, semicarbazone, oxime and ethanolamine; A is (i) a natural or unnatural amino acid residue having a side chain comprising at least one H-bond acceptor moiety and at least one H-bond donor moiety, or a derivative thereof; or (ii) R(CO), wherein R is a C1-C24 hydrocarbyl group comprising at least one H-bond acceptor moiety and optionally one or more H-bond donor moieties, and where R optionally contains one or more heteroatoms selected from S, O, and N, and is optionally substituted by one or more substituents selected from halogen, OMe, CN, CF3, and NO2; each of B and D is independently an amino acid residue selected from arginine, 4-(guanidinyl)phenylalanine (4-(Gu)Phe), piperidinylglycine (PipGly), piperidinylalanine (PipAla), pyridinylalanine, histamine, N,N-(dimethyl) lysine (DMLys), citrulline, glutamine, serine, lysine, asparagine, isoleucine and alanine, or a derivative thereof; C is NH—X—CO, where X is a C1-C4 alkylene group substituted by a straight-chain or branched C1-C6 alkylene group, said C1-C6 alkylene group optionally containing a H-bond donor or H-bond acceptor moiety; E is (i) a natural or unnatural amino acid residue having an aryl or heteroaryl side chain, or a derivative thereof; or (ii) NHR′, where R′ is a C1-C24 hydrocarbyl group, optionally containing one or more heteroatoms selected from N, O, and S, and optionally comprising one or more H-bond acceptor or donor moieties; said hydrocarbyl group further comprising a pendent C4-C12 aryl or heteroaryl group, which itself may be optionally substituted by one or more substituents selected from a H-bond donor moiety, a H-bond acceptor moiety, a halogen, Me, Et, iPr, CF3, CN and NO2; wherein at least one of A and E is other than a natural or unnatural amino acid residue when A, B, C, D and E are each linked to the respective adjacent residue by a carboxamide group.