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1. 发明授权

US07132827B2 Magnetic resonance imaging method using a partial parallel acquisition technique with non-Cartesian occupation of k-space 有权
标题翻译：磁共振成像方法采用部分并行采集技术与非笛卡尔占空比k空间
公开(公告)号：US07132827B2
公开(公告)日：2006-11-07
申请号：US11126690
申请日：2005-05-11
申请人： Mark Griswold , Robin Heidemann , Gunnar Krüger
发明人： Mark Griswold , Robin Heidemann , Gunnar Krüger
IPC分类号： G01V3/00
CPC分类号： G01R33/5611
摘要： In a method for magnetic resonance imaging using a partial parallel acquisition technique with a non-Cartesian occupation of k-space, a number of antennas disposed around an imaging volume for reception of magnetic resonance signals and the magnetic resonance signals in the imaging volume are spatially coded by magnetic gradient fields, such that k-space for each antenna is only incompletely occupied with magnetic resonance signals with at least one trajectory proceeding around the origin of k-space. From the reception signals of each antenna, missing sample values of the trajectory that lie on a straight-line segment extending from the origin are determined in k-space according to a weighting with weighting factors from sample values of the trajectory that likewise lie on the straight lines, such that each k-space is completely occupied. A partial image of the imaging area is generated from each completely occupied k-space by means of a Fourier transformation. An image of the imaging volume is generated from the partial images.
摘要翻译：在使用具有非笛卡尔k空间的部分并行捕获技术的磁共振成像方法中，设置在用于接收磁共振信号的成像体积周围的多个天线和成像体积中的磁共振信号在空间上由磁梯度场编码，使得每个天线的k空间仅仅被磁共振信号完全占据，其中至少一个轨迹围绕k空间的原点进行。根据每个天线的接收信号，根据来自同一位于同一位置的轨迹的样本值的加权因子的加权，在k空间中确定位于从原点延伸的直线段上的轨迹的缺失采样值直线，使得每个k空间被完全占用。通过傅里叶变换从每个完全占用的k空间生成成像区域的部分图像。从部分图像生成成像体积的图像。

2. 发明申请

US20100086184A1 Method for Automatic Quality Control of Data in In-Vivo Images 有权
标题翻译：体内图像数据自动质量控制方法
公开(公告)号：US20100086184A1
公开(公告)日：2010-04-08
申请号：US12569965
申请日：2009-09-30
申请人： Gunnar Krüger , Bénédicte Mortamet
发明人： Gunnar Krüger , Bénédicte Mortamet
IPC分类号： G06K9/46 , G06T7/00
CPC分类号： G01R33/54 , G01R33/5608
摘要： A method for quality control assessment in single time-point in-vivo imaging data related to imaging of objects, includes acquiring an in-vivo image of the object with imaging apparatus, defining a background image corresponding to an imaged air of the in-vivo image, defining an object image corresponding to the in-vivo image from which the background image has been removed, obtaining the background and object images by atlas-based registration, reflecting an intensity distribution of the background image with a histogram, fitting a noise mathematical model to part of the histogram intensity distribution, deriving background quality characteristics from the noise mathematical model, reflecting an intensity distribution of the object image with a further histogram, fitting a signal mathematical model to the further histogram intensity distribution, deriving object quality characteristics from the signal mathematical model, and automatically deriving signal-to-noise and contrast-to-noise ratios of in-vivo imaging data from the object quality and background quality characteristics.
摘要翻译：用于与物体成像相关的单个时间点体内成像数据中的质量控制评估的方法包括：利用成像装置获取对象的体内图像，定义对应于体内成像空气的背景图像图像，定义与去除了背景图像的体内图像相对应的对象图像，通过基于图集的注册获得背景和对象图像，用直方图反映背景图像的强度分布，拟合噪声数学模型到直方图强度分布的一部分，从噪声数学模型导出背景质量特征，反映具有另外的直方图的对象图像的强度分布，将信号数学模型拟合到另外的直方图强度分布，从信号数学模型，并自动导出信噪比和对比噪声来自对象质量和背景质量特征的体内成像数据的比例。

3. 发明授权

US07215119B2 Method and MR apparatus for dynamic frequency detection in MR spectroscopy 有权
标题翻译： MR光谱中动态频率检测的方法和MR装置
公开(公告)号：US07215119B2
公开(公告)日：2007-05-08
申请号：US11119470
申请日：2005-04-29
申请人： Gunnar Krüger , Stefan Röll
发明人： Gunnar Krüger , Stefan Röll
IPC分类号： G01V3/00
CPC分类号： G01R33/483
摘要： In a method for dynamic frequency detection of the resonance frequency in magnetic resonance spectroscopy, by measuring navigator signals at the same point in time in each of a number of successive sequence passes, and by comparing the navigator signals, a frequency shift of the resonance frequency is determined on the basis of which the respective individual spectrum obtained from each sequence repetition is corrected with respect to the measured frequency shift.
摘要翻译：在磁共振波谱中的共振频率的动态频率检测方法中，通过在多个连续序列遍中的每一个中测量相同时间点的导航信号，并且通过比较导航信号，共振频率的频移根据该方法确定从每个序列重复获得的各个频谱相对于测量的频移被校正。

4. 发明申请

US20100080460A1 METHOD FOR AUTOMATIC DETECTION OF DATA IN IN-VIVO IMAGES 失效
标题翻译：用于自动检测图像内数据的方法
公开(公告)号：US20100080460A1
公开(公告)日：2010-04-01
申请号：US12569961
申请日：2009-09-30
申请人： Gunnar Krüger , Bénédicte Mortamet
发明人： Gunnar Krüger , Bénédicte Mortamet
IPC分类号： G06K9/34 , G01R33/48
CPC分类号： G01R33/54 , G01R33/5608
摘要： A method for detecting, in single time-point, in-vivo imaging data related to artifacts in the imaging of objects, includes acquiring at least one in-vivo image with imaging apparatus. A background image corresponds to imaged air of the in-vivo image. The background image is obtained in two steps. A first step includes establishing an object-air boundary and a second step is an atlas-based refinement of a background volume of interest. A histogram reflects an intensity distribution of the background image. The background image is formed of a set of voxels where artifacts are detected. Intensities above a definable intensity value provide an initial estimate of a range of artifacts intensities. A modified morphological opening operation is executed, formed of an erosion of a set of voxels and a dilation, performed iteratively and constrained to voxels intensity above the intensity value, so that the opening operation provides natural definition of artifacts regions.
摘要翻译：用于在单个时间点中检测与物体成像中的假象有关的体内成像数据的方法包括使用成像装置获取至少一个体内图像。背景图像对应于体内图像的成像空气。背景图像分为两个步骤。第一步包括建立对象空中边界，第二步是基于图集的细化背景音量。直方图反映背景图像的强度分布。背景图像由检测到伪像的一组体素形成。高于可定义强度值的强度提供了伪像强度范围的初始估计。执行修改的形态打开操作，其由迭代的一组体素和扩张的侵蚀形成，并且被约束到高于强度值的体素强度，使得打开操作提供假象区域的自然定义。

5. 发明授权

US07689262B2 Method and magnetic resonance tomography apparatus for correcting changes in the basic magnetic field 有权
标题翻译：用于校正基本磁场变化的方法和磁共振断层摄影装置
公开(公告)号：US07689262B2
公开(公告)日：2010-03-30
申请号：US10887413
申请日：2004-07-08
申请人： Gunnar Krüger , Stefan Thesen
发明人： Gunnar Krüger , Stefan Thesen
IPC分类号： A61B5/05
CPC分类号： G01R33/56563 , G01R33/243 , G01R33/56581
摘要： In the examination of a subject with a magnetic resonance tomography apparatus, data for a slice of the subject to be examined are obtained with a sequence of a fast MRT imaging method that includes at least three phase correction scans and measurement signals of the respective phase correction scans as well as of the slice are obtained. The phase difference of corresponding data points of two phase correction scans are calculated point-by-point, the average phase difference between the phase correction scans is evaluated, and the frequency offset between the actual resonance frequency relative to the adjusted resonance frequency is calculated based on the average phase difference and the echo time difference between the phase correction scans used. A B0 field map is calculated dependent on the frequency offset and, the measurement data for the slice are corrected using the calculated B0 field map.
摘要翻译：在用磁共振断层摄影装置检查对象的情况下，用快速MRT成像方法的序列获得要检查对象的切片的数据，该方法包括至少三个相位校正扫描和各个相位校正的测量信号获得扫描以及切片。逐点计算两个相位校正扫描的相应数据点的相位差，评估相位校正扫描之间的平均相位差，并且基于调整的共振频率来计算实际谐振频率之间的频率偏移在相位校正扫描之间的平均相位差和回波时间差。根据频率偏移计算B0场图，并使用计算的B0场图校正切片的测量数据。

6. 发明授权

US08315451B2 Method for segmentation of an MRI image of a tissue in presence of partial volume effects and computer program implementing the method 失效
标题翻译：在存在部分体积效应的情况下对组织的MRI图像进行分割的方法和实现该方法的计算机程序
公开(公告)号：US08315451B2
公开(公告)日：2012-11-20
申请号：US12486077
申请日：2009-06-17
申请人： Gunnar Krüger , Bénédicte Mortamet
发明人： Gunnar Krüger , Bénédicte Mortamet
IPC分类号： G06K9/00
CPC分类号： G06T7/10
摘要： A method and computer program for segmentation of an MRI image of tissue in presence of partial volume effects, include storing the MRI image in K-space representation as raw dataset, reconstructing N images, each represented by N sets of voxels and N sets of light intensity values, dividing each voxel into a fixed number of subvoxels equal in size, assigning the light intensity value of the voxel to its subvoxels, classifying each subvoxel according to light intensity value, identifying a totality of subvoxels classified with equal probability for a totality of tissue types, labeling the subvoxels as partial volume subvoxels, shifting N−1 images starting with the second image by one subvoxel relatively to the preceding image and gene-rating a new set of overlay subvoxels, determining a new set of probability values for the new set of overlay subvoxels and creating an overlay image of the new set of overlaid subvoxels.
摘要翻译：用于在存在部分体积效应的情况下对组织的MRI图像进行分割的方法和计算机程序包括将MRI图像存储在K空间表示中作为原始数据集，重建N个图像，每个N个图像由N组体素和N组光强度值，将每个体素划分成固定数量的等于大小的子体素，将体素的光强度值分配给其子体素，根据光强度值对每个子体素进行分类，识别以等概率分类的总体素数组织类型，将子体系标记为部分体积子体素，将相对于先前图像的第二图像开始的N-1个图像移位一个子体素，并且对新的一组覆盖子体素进行基因评估，确定新的新的一组概率值一组覆盖子体素，并创建一组叠加的子体素的叠加图像。

7. 发明授权

US08249323B2 Method for automatic quality control of data in in-vivo images 有权
标题翻译：用于体内图像数据自动质量控制的方法
公开(公告)号：US08249323B2
公开(公告)日：2012-08-21
申请号：US12569965
申请日：2009-09-30
申请人： Gunnar Krüger , Bénédicte Mortamet
发明人： Gunnar Krüger , Bénédicte Mortamet
IPC分类号： G06K9/00 , G06K9/46
CPC分类号： G01R33/54 , G01R33/5608
摘要： A method for quality control assessment in single time-point in-vivo imaging data related to imaging of objects, includes acquiring an in-vivo image of the object with imaging apparatus, defining a background image corresponding to an imaged air of the in-vivo image, defining an object image corresponding to the in-vivo image from which the background image has been removed, obtaining the background and object images by atlas-based registration, reflecting an intensity distribution of the background image with a histogram, fitting a noise mathematical model to part of the histogram intensity distribution, deriving background quality characteristics from the noise mathematical model, reflecting an intensity distribution of the object image with a further histogram, fitting a signal mathematical model to the further histogram intensity distribution, deriving object quality characteristics from the signal mathematical model, and automatically deriving signal-to-noise and contrast-to-noise ratios of in-vivo imaging data from the object quality and background quality characteristics.
摘要翻译：用于与物体成像相关的单个时间点体内成像数据中的质量控制评估的方法包括：利用成像装置获取对象的体内图像，定义对应于体内成像空气的背景图像图像，定义与去除了背景图像的体内图像相对应的对象图像，通过基于图集的注册获得背景和对象图像，用直方图反映背景图像的强度分布，拟合噪声数学模型到直方图强度分布的一部分，从噪声数学模型导出背景质量特征，反映具有另外的直方图的对象图像的强度分布，将信号数学模型拟合到另外的直方图强度分布，从信号数学模型，并自动导出信噪比和对比噪声来自对象质量和背景质量特征的体内成像数据的比例。

8. 发明授权

US08139859B2 Method for automatic detection of data in in-vivo images 失效
标题翻译：自动检测体内图像数据的方法
公开(公告)号：US08139859B2
公开(公告)日：2012-03-20
申请号：US12569961
申请日：2009-09-30
申请人： Gunnar Krüger , Bénédicte Mortamet
发明人： Gunnar Krüger , Bénédicte Mortamet
IPC分类号： G06K9/00 , G06K9/34
CPC分类号： G01R33/54 , G01R33/5608
摘要： A method for detecting, in single time-point, in-vivo imaging data related to artifacts in the imaging of objects, includes acquiring at least one in-vivo image with imaging apparatus. A background image corresponds to imaged air of the in-vivo image. The background image is obtained in two steps. A first step includes establishing an object-air boundary and a second step is an atlas-based refinement of a background volume of interest. A histogram reflects an intensity distribution of the background image. The background image is formed of a set of voxels where artifacts are detected. Intensities above a definable intensity value provide an initial estimate of a range of artifacts intensities. A modified morphological opening operation is executed, formed of an erosion of a set of voxels and a dilation, performed iteratively and constrained to voxels intensity above the intensity value, so that the opening operation provides natural definition of artifacts regions.
摘要翻译：用于在单个时间点中检测与物体成像中的假象有关的体内成像数据的方法包括使用成像装置获取至少一个体内图像。背景图像对应于体内图像的成像空气。背景图像分为两个步骤。第一步包括建立对象空中边界，第二步是基于图集的细化背景音量。直方图反映背景图像的强度分布。背景图像由检测到伪像的一组体素形成。高于可定义强度值的强度提供了伪像强度范围的初始估计。执行修改的形态打开操作，其由迭代的一组体素和扩张的侵蚀形成，并且被约束到高于强度值的体素强度，使得打开操作提供假象区域的自然定义。

9. 发明授权

US07265545B2 Method and apparatus for accelerated spiral-coded imaging in magnetic resonance tomography 有权
标题翻译：磁共振断层扫描中加速螺旋编码成像的方法和装置
公开(公告)号：US07265545B2
公开(公告)日：2007-09-04
申请号：US11314118
申请日：2005-12-21
申请人： Gunnar Krüger , Cecile Mohr , Stefan Thesen
发明人： Gunnar Krüger , Cecile Mohr , Stefan Thesen
IPC分类号： G01V3/00
CPC分类号： G01R33/4824 , G01R33/561
摘要： In a method and apparatus for accelerated spiral-coded imaging (scanning k-space with a spiral trajectory) in magnetic resonance tomography, the user-defined sequence forming the basis of the spiral scanning is modified such that the k-matrix forming the basis of the sequence is scanned only in a sub-region, the sub-region being defined by a symmetrical shortening on both sides of the k-space matrix in a first direction as well as by a one-sided shortening of the k-space matrix in a second direction orthogonal to the first direction.
摘要翻译：在磁共振断层摄影中用于加速螺旋编码成像（扫描具有螺旋轨迹的k空间）的方法和装置中，修改形成螺旋扫描基础的用户定义序列，使得k矩阵形成该序列仅在子区域中扫描，该子区域由在第一方向上的k空间矩阵的两侧上的对称缩短以及通过单面缩短k空间矩阵来定义与第一方向正交的第二方向。

10. 发明授权

US06759848B2 Magnetic resonance method and apparatus for spatially resolved presentation of change in the functional activities of a brain 失效
标题翻译：用于空间分辨呈现脑功能活动变化的磁共振方法和装置
公开(公告)号：US06759848B2
公开(公告)日：2004-07-06
申请号：US10428553
申请日：2003-05-02
申请人： Gunnar Krüger
发明人： Gunnar Krüger
IPC分类号： G01V300
CPC分类号： G01R33/4806
摘要： In a method and magnetic resonance tomography apparatus for spatially resolved presentation of a change of functional activities in the brain of a living subject by means of magnetic resonance, temporally successive magnetic resonance images of the brain of the subject stimulated with a stimulus are produced upon variation of at least one of the excitation angle and the echo time, a noise part for each pixel is calculated referenced to identical pixels of the temporally successive images, the noise part of each pixel is resolved into a first noise component independent of the excitation angle and a second noise component dependent on the excitation angle, the second noise component of the noise part of each pixel is resolved into a third noise component independent of the echo time and a fourth noise component dependent on the echo time, and the fourth noise component of the noise part of each pixel obtained in this way is employed for detecting neural activity changes in the brain of the living subject under observation.
摘要翻译：在用于通过磁共振在空间上分辨呈现活体受试者的功能活动变化的方法和磁共振断层摄影装置中，用刺激刺激的受试者的脑的时间上连续的磁共振图像在变化时产生至少一个激发角和回波时间中的每个像素的噪声部分被计算参考时间连续图像的相同像素，每个像素的噪声部分被分解成独立于激发角的第一噪声分量，并且取决于激发角的第二噪声分量，每个像素的噪声部分的第二噪声分量被分解成独立于回波时间的第三噪声分量和取决于回波时间的第四噪声分量，并且第四噪声分量以这种方式获得的每个像素的噪声部分用于检测脑中的神经活动变化正在观察的活体。

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