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    • 3. 发明申请
    • Methods and apparatus for treating end-stage renal disease
    • 治疗终末期肾病的方法和装置
    • US20060212076A1
    • 2006-09-21
    • US11368949
    • 2006-03-06
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • A61N1/18
    • A61N1/05A61N1/0551A61N1/327A61N1/40
    • Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    • 提供了用于通过脉冲电场经由刺激电场,经由局部药物递送,经由高频超声波,经由热技术等来治疗终末期肾脏疾病的方法和装置。这种神经调节可以实现不可逆的电穿孔或 电融合,坏死和/或诱导凋亡,基因表达改变,动作电位减弱或阻断,细胞因子上调和靶神经纤维中的其他条件的变化。 在一些实施方案中,神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中,这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比,双侧肾神经调节可以在一些患者中提供增强的治疗效果,即与在支配单个肾脏的神经组织上进行的肾神经调节相比。
    • 5. 发明申请
    • Methods and apparatus for treating acute myocardial infarction
    • 治疗急性心肌梗死的方法和装置
    • US20060206150A1
    • 2006-09-14
    • US11368971
    • 2006-03-06
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • A61N1/00
    • A61N1/05A61N1/0551A61N1/327A61N1/40
    • Methods and apparatus are provided for treating acute myocardial infarction, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    • 提供了用于通过脉冲电场,经由刺激电场,经由局部药物递送,经由高频超声波,经由热技术等来治疗急性心肌梗塞的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合, 凋亡的坏死和/或诱导,基因表达的改变,动作电位衰减或阻断,细胞因子上调的变化和靶神经纤维中的其他条件。 在一些实施方案中,神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中,这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比,双侧肾神经调节可以在一些患者中提供增强的治疗效果,即与在支配单个肾脏的神经组织上进行的肾神经调节相比。
    • 7. 发明申请
    • Methods and apparatus for treating congestive heart failure
    • 治疗充血性心力衰竭的方法和装置
    • US20060212078A1
    • 2006-09-21
    • US11368553
    • 2006-03-06
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • Denise DemaraisHanson GiffordMark DeemDouglas SuttonHoward LevinMark Gelfand
    • A61N1/40A61N1/18
    • A61N1/05A61N1/0551A61N1/327A61N1/40
    • Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    • 提供了用于经由脉冲电场,经由刺激电场,经由局部药物递送,经由高频超声波,经由热技术等治疗充血性心力衰竭的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合, 凋亡的坏死和/或诱导,基因表达的改变,动作电位衰减或阻断,细胞因子上调的变化和靶神经纤维中的其他条件。 在一些实施方案中,神经调节被应用于有助于肾功能的神经纤维。 在一些实施方案中,这种神经调节以双向方式进行。 与单侧执行的肾神经调节相比,双侧肾神经调节可以在一些患者中提供增强的治疗效果,即与在支配单个肾脏的神经组织上进行的肾神经调节相比。