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1. 发明授权

US06825180B2 Pyridopyrimidine compounds and their uses 失效
公开(公告)号：US06825180B2
公开(公告)日：2004-11-30
申请号：US09859503
申请日：2001-05-18
申请人： Marc J. McKennon , J. Peter Klein , Michael Coon
发明人： Marc J. McKennon , J. Peter Klein , Michael Coon
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： Novel pyridopyrimidine-based compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling.

2. 发明授权

US07247630B2 Uses of tricyclic compounds 失效
标题翻译：使用三环化合物
公开(公告)号：US07247630B2
公开(公告)日：2007-07-24
申请号：US10349935
申请日：2003-01-24
申请人： Baoqing Gong , J. Peter Klein , Michael Coon
发明人： Baoqing Gong , J. Peter Klein , Michael Coon
IPC分类号： A61P29/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P3/10
CPC分类号： C07D487/14 , A61K31/522 , A61K31/675 , C07D513/14
摘要： Novel tricyclic compounds are disclosed having the general structure of Formulas I or II: were R1, R2 and R3 are defined in the written description of the invention. The compounds are useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by intracellular cytokine signaling.
摘要翻译：公开了具有式I或II的通式结构的新型三环化合物：R1，R2和R3在本发明书面描述中定义。该化合物可用于治疗或预防与由细胞内细胞因子信号传导影响的疾病或病症相关的症状或表现。

3. 发明授权

US06586429B2 Tricyclic fused xanthine compounds and their uses 有权
标题翻译：三环稠合黄嘌呤化合物及其用途
公开(公告)号：US06586429B2
公开(公告)日：2003-07-01
申请号：US09725016
申请日：2000-11-29
申请人： Baoqing Gong , J. Peter Klein , Michael Coon
发明人： Baoqing Gong , J. Peter Klein , Michael Coon
IPC分类号： C07D48714
CPC分类号： C07D487/14 , A61K31/522 , A61K31/675 , C07D513/14
摘要： Novel tricyclic compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling. The compounds have the following formulas where R1, R2 and R3 are defined in the written description of the invention.
摘要翻译：发现新的三环化合物可用于治疗或预防与受细胞因子细胞内信号传导影响的疾病或病症相关的症状或表现。这些化合物具有下式，其中R1，R2和R3在本发明的书面描述中定义。

4. 发明申请

US20050059685A1 Pyridopyrimidine compounds and their uses 审中-公开
标题翻译：吡啶并嘧啶化合物及其用途
公开(公告)号：US20050059685A1
公开(公告)日：2005-03-17
申请号：US10921293
申请日：2004-08-19
申请人： Marc McKennon , J. Klein , Michael Coon
发明人： Marc McKennon , J. Klein , Michael Coon
IPC分类号： A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P43/00 , C07D471/04 , A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： Novel pyridopyrimidine-based compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling.
摘要翻译：发现新的吡啶并嘧啶类化合物可用于治疗或预防与受细胞因子细胞内信号传导影响的疾病或病症相关的症状或表现。

5. 发明授权

US07431736B2 Device and method for positioning an eccentric humeral head of a humerus prosthesis for a shoulder arthroplasty 有权
标题翻译：用于定位用于肩关节置换术的肱骨假体的偏心肱骨头的装置和方法
公开(公告)号：US07431736B2
公开(公告)日：2008-10-07
申请号：US10844208
申请日：2004-05-12
申请人： Brian Maroney , Michael Coon , Jeffrey Ondrla , Todd Durniak , Joseph Iannotti , Gerald Williams
发明人： Brian Maroney , Michael Coon , Jeffrey Ondrla , Todd Durniak , Joseph Iannotti , Gerald Williams
IPC分类号： A61F2/30 , A61F2/40
CPC分类号： A61B17/1684 , A61B17/1659 , A61F2/4014 , A61F2/4657 , A61F2/4684 , A61F2002/30332 , A61F2002/30616 , A61F2002/30617 , A61F2002/30714 , A61F2002/30827 , A61F2002/30884 , A61F2002/30902 , A61F2002/4018 , A61F2002/4051 , A61F2002/4062 , A61F2002/4077 , A61F2002/4681 , A61F2220/0033 , A61F2250/0064 , A61F2250/0089 , A61F2250/0097
摘要： A kit and associated method is for implanting a prosthetic device in a resected bone such as a humerus. The kit includes a trial assembly including a trial body portion having a trial bore defined therein, and a trial head portion having (i) a trail head member which includes a trial offset indicia, and (ii) an eccentrically located trial stem extending from the trial head member, the trial head stem being configured to be received within the trial bore. The kit also includes a final prosthesis assembly including a final body portion having a final bore defined therein, and a final head portion having (i) a final head member which includes a final offset indicia, and (ii) an eccentrically located final head stem extending from the final head portion, the final head stem being configured to be received within the final bore.
摘要翻译：试剂盒和相关方法用于将假体装置植入切除的骨骼，例如肱骨。试剂盒包括试验组合件，其包括其中限定有试验孔的试验体部分和试验头部分，其具有（i）包括试验偏移标记的尾部头部构件，以及（ii）偏心定位的试验杆，试验头部成员，试验头部杆被配置为在试验孔内被接收。套件还包括最终假体组件，其包括具有限定在其中的最终孔的最终主体部分，以及最终头部部分，其具有（i）包括最终偏移标记的最终头部构件，以及（ii）偏心定位的最终头部杆从最终头部延伸，最终头部杆构造成被容纳在最终的孔内。

6. 发明授权

US5448833A Cutting instrument or tool 失效
标题翻译：切割仪器或工具
公开(公告)号：US5448833A
公开(公告)日：1995-09-12
申请号：US139875
申请日：1993-10-22
申请人： Michael Coon
发明人： Michael Coon
IPC分类号： B23D51/01 , B26B9/02 , B28D1/12 , B26B3/08
CPC分类号： B28D1/127 , B23D51/01 , B26B9/02
摘要： A hand saw principally for use on sheet rock or gypsum wall board having a bi-partite handle and a thumb stop. The saw blade is provided with in-line teeth which cut on the forward and backward motion of the saw and which are provided with large cleanouts. The cutting teeth are also in line and the saw blade itself is thicker on the cutting surfaces than on the top. The arrangement permits a higher grade of premium steel to be used and the teeth can be readily sharpened. The saw may also have a blade that is sharpened on the top to a cutting edge resulting in an all purpose cutting instrument.
摘要翻译：手锯主要用于具有双分柄和拇指止挡的板岩或石膏墙板上。锯片设置有切割锯的向前和向后运动并且具有大清洁件的直列齿。切割齿也在一起，锯片本身在切割表面上比在顶部更厚。该装置允许使用较高等级的优质钢，并且可以容易地磨削牙齿。锯还可以具有在顶部被切割成切割边缘的刀片，从而形成通用的切割工具。

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