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    • 3. 发明授权
    • Novel process for producing thiolsulfonic acid derivatives
    • 制备硫醇磺酸衍生物的新方法
    • US4910331A
    • 1990-03-20
    • US257125
    • 1988-10-07
    • Kazuaki KiharaMakoto KurodaToshiyuki Nakamura
    • Kazuaki KiharaMakoto KurodaToshiyuki Nakamura
    • C07D295/08C07C67/00C07C303/36C07C325/00C07C381/04C07D295/088C07D339/04
    • C07D295/088C07D339/04
    • This invention relates to a process for producing a thiolsulfonic acid derivative of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently a lower alkyl group or a 5- or 6-membered cycloalkyl group, or alternatively R.sub.1 and R.sub.2 together with the adjacent nitrogen atom form a 5- or 6-membered heterocyclic group which may further contain an oxygen, sulfur or nitrogen atom; and R.sub.3 is (1) an aryl group which may optionally be substituted by a lower alkyl group, a halogen, a lower alkoxy group or a lower alkylthio group, (2) a lower alkyl group which may optionally be substituted by a lower alkoxy group, (3) an aralkyl group or (4) a cycloalkyl group, or a salt thereof, which comprises reacting a compound of the general formula: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, or a salt thereof with a compound of the general formula:R.sub.3 SO.sub.2 H (II)wherein R.sub.3 is as defined above, or a salt thereof under an acid condition.The compound (I) or a salt thereof is produced in high purity and in high yield according to the process of this invention.
    • 本发明涉及一种制备下列通式的硫醇磺酸衍生物的方法:其中R1和R2各自独立地为低级烷基或5-或6-元环烷基,或者R1和 R2与相邻的氮原子一起形成可以进一步含有氧,硫或氮原子的5-或6-元杂环基; R 3为(1)可以被低级烷基,卤素,低级烷氧基或低级烷硫基取代的芳基,(2)可以被低级烷氧基取代的低级烷基 ,(3)芳烷基或(4)环烷基或其盐,其包括使下式的化合物或其盐与下式化合物反应:其中R 1和R 2如上所定义, 在酸性条件下,通式为R 3 SO 2 H(II)的化合物或其盐,其中R 3如上定义。 根据本发明的方法,化合物(I)或其盐以高纯度和高产率制备。
    • 4. 发明授权
    • Method of producing 1,2,3-trithiane compounds
    • 制备1,2,3-三噻烷化合物的方法
    • US4614821A
    • 1986-09-30
    • US819483
    • 1986-01-16
    • Kazuaki KiharaMakoto Kuroda
    • Kazuaki KiharaMakoto Kuroda
    • C07D339/04C07D341/00C07D409/04C07D413/04
    • C07D341/00C07D339/04
    • This invention relate to a process for producing a 1,2,3-trithiane compound of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently a lower alkyl group, or alternatively, R.sub.1 and R.sub.2 together with the adjacent nitrogen atom form a 5- or 6-membered heterocyclic group which may further contain an oxygen, sulfur or nitrogen atom, or a salt thereof, which comprises reacting a compound of the general formula: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, or a salt thereof with a compound of the general formula:Me.sub.2 S (II)wherein Me is hydrogen, an alkali metal atom or an ammonium radical under an acid condition.The compound (I) or a salt thereof is produced in high purity and high yield.
    • 本发明涉及一种制备下列通式的1,2,3-三噻烷化合物的方法:其中R 1和R 2各自独立地为低级烷基,或者R 1和R 2与 相邻的氮原子形成可以进一步含有氧,硫或氮原子或其盐的5-或6-元杂环基,其包括使通式如下的化合物:其中R1和R2 或其盐与通式为Me 2 S(II)的化合物,其中Me为氢,碱金属原子或铵基,在酸性条件下。 化合物(I)或其盐以高纯度和高产率制备。