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1. 发明申请

US20050197319A1 Allergen inactivating agent 有权
标题翻译：过敏原灭活剂
公开(公告)号：US20050197319A1
公开(公告)日：2005-09-08
申请号：US11045328
申请日：2005-01-31
申请人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri , Hiroyuki Yanagida , Fumiko Okuda
发明人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri , Hiroyuki Yanagida , Fumiko Okuda
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K31/715 , A61K47/10 , A61K47/18 , A61K47/24 , A61Q17/00 , A61Q19/00 , A62B18/00 , A61K31/717 , A61K31/716
CPC分类号： A61Q17/00 , A61K8/0208 , A61K8/0212 , A61K8/0229 , A61K8/046 , A61K8/731 , A61K9/0014 , A61K31/715 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/24 , A61Q19/00 , A62B18/00
摘要： An allergen inactivating agent is provided which has no adverse effects on the human body and which does not cause problems such as color development. An allergen inactivating agent containing a polysaccharide derivative as its effective component, wherein said polysaccharide derivative has a cellulose ether or a starch ether as its backbone, and some or all of hydrogen atoms in the hydroxy group of the polysaccharide derivative are substituted by a group represented by the following general formula (1): -E1-(OA)n-E2-R (1) wherein E1 represents an alkylene containing 1 to 6 carbon atoms optionally substituted with hydroxy group or oxo group; n represents a number of 0 to 50; A independently represents an alkylene containing 1 to 6 carbon atoms, the number of A being n; E2 represents ether bond or oxycarbonyl group; R represents an alkyl group containing 4 to 30 carbon atoms optionally substituted with hydroxy group, a sulfoalkyl group containing 1 to 5 carbon atoms optionally substituted with hydroxy group, or a salt thereof.
摘要翻译：提供了对人体没有不良影响并且不会引起颜色发展等问题的过敏原灭活剂。一种含有多糖衍生物作为其有效成分的变应原灭活剂，其中所述多糖衍生物具有纤维素醚或淀粉醚作为其主链，并且多糖衍生物的羟基中的部分或全部氢原子被代表的基团取代通过以下通式（1）：<？in-line-formula description =“In-line Formulas”end =“lead”？> - E ^{- （OA） R（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中E <1> 表示任选被羟基或氧代基取代的含有1至6个碳原子的亚烷基; n表示0〜50的数; A独立地表示含有1至6个碳原子的亚烷基，A的数目为n; E 2表示醚键或氧羰基; R表示任选被羟基取代的含有4〜30个碳原子的烷基，可以被羟基取代的含有1〜5个碳原子的磺基烷基或其盐。}

2. 发明授权

US08133991B2 Allergen inactivating agent 有权
标题翻译：过敏原灭活剂
公开(公告)号：US08133991B2
公开(公告)日：2012-03-13
申请号：US11045328
申请日：2005-01-31
申请人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri , Hiroyuki Yanagida , Fumiko Okuda
发明人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri , Hiroyuki Yanagida , Fumiko Okuda
IPC分类号： C07H1/00 , C08B31/08 , C08B11/08 , A61K31/715
CPC分类号： A61Q17/00 , A61K8/0208 , A61K8/0212 , A61K8/0229 , A61K8/046 , A61K8/731 , A61K9/0014 , A61K31/715 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/24 , A61Q19/00 , A62B18/00
摘要： An allergen inactivating agent is provided which has no adverse effects on the human body and which does not cause problems such as color development.An allergen inactivating agent containing a polysaccharide derivative as its effective component, wherein said polysaccharide derivative has a cellulose ether or a starch ether as its backbone, and some or all of hydrogen atoms in the hydroxy group of the polysaccharide derivative are substituted by a group represented by the following general formula (1): -E1-(OA)n-E2-R (1) wherein E1 represents an alkylene containing 1 to 6 carbon atoms optionally substituted with hydroxy group or oxo group; n represents a number of 0 to 50; A independently represents an alkylene containing 1 to 6 carbon atoms, the number of A being n; E2 represents ether bond or oxycarbonyl group; R represents an alkyl group containing 4 to 30 carbon atoms optionally substituted with hydroxy group, a sulfoalkyl group containing 1 to 5 carbon atoms optionally substituted with hydroxy group, or a salt thereof.
摘要翻译：提供了对人体没有不良影响并且不会引起颜色发展等问题的过敏原灭活剂。一种含有多糖衍生物作为其有效成分的变应原灭活剂，其中所述多糖衍生物具有纤维素醚或淀粉醚作为其主链，多糖衍生物的羟基中的部分或全部氢原子被代表的基团取代通式（1）表示：-E1-（OA）n-E2-R（1）其中E1表示任选被羟基或氧代基取代的含有1至6个碳原子的亚烷基; n表示0〜50的数; A独立地表示含有1至6个碳原子的亚烷基，A的数目为n; E2表示醚键或氧羰基; R表示任选被羟基取代的含有4〜30个碳原子的烷基，可以被羟基取代的含有1〜5个碳原子的磺基烷基或其盐。

3. 发明申请

US20050256082A1 Allergen inactivator 审中-公开
标题翻译：过敏原灭活剂
公开(公告)号：US20050256082A1
公开(公告)日：2005-11-17
申请号：US10519474
申请日：2003-07-02
申请人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri
发明人： Mami Nonomura , Kimihiko Hori , Hiroshi Nojiri
IPC分类号： A61K8/02 , A61K8/04 , A61K8/73 , A61K31/715 , A61K47/10 , A61K47/18 , A61K47/24 , A61P37/08 , A61Q17/00 , A61Q19/00 , A62B18/00 , A61K31/717 , A61K31/716
CPC分类号： A61K8/732 , A61K8/0229 , A61K8/731 , A61K9/0014 , A61K31/715 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/24 , A61Q19/00 , A62B18/00 , C08L1/26 , C08L1/284 , C08L1/32 , C08L3/08
摘要： This invention relates to an allergen inactivating agent containing a polysaccharide derivative as its effective component, wherein said polysaccharide derivative has a cellulose ether or a starch ether as its backbone, and some or all of hydrogen atoms in the hydroxy group of the polysaccharide derivative are substituted by a group represented by the following general formula (1): -E1-(OA)n-E2-R (1) wherein E1 represents an alkylene containing 1 to 6 carbon atoms optionally substituted with hydroxy group or oxo group; n represents a number of 0 to 50; A independently represents an alkylene containing 1 to 6 carbon atoms, the number of A being n; E2 represents ether bond or oxycarbonyl group; R represents an alkyl group containing 4 to 30 carbon atoms optionally substituted with hydroxy group, a sulfoalkyl group containing 1 to 5 carbon atoms optionally substituted with hydroxy group, or a salt thereof. By using such allergen inactivating agent, house dust and other environmental allergens can be inactivated with no adverse effects on the human body and without causing problems such as color development.
摘要翻译：本发明涉及含有多糖衍生物作为其有效成分的变应原灭活剂，其中所述多糖衍生物具有纤维素醚或淀粉醚作为其主链，多糖衍生物的羟基中的一部分或全部氢原子被取代由以下通式（1）表示的基团：<？in-line-formula description =“In-line Formulas”end =“lead”？> - E <1> - （OA）（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中E 1 代表任选被羟基或氧代基取代的含有1至6个碳原子的亚烷基; n表示0〜50的数; A独立地表示含有1至6个碳原子的亚烷基，A的数目为n; E 2表示醚键或氧羰基; R表示任选被羟基取代的含有4〜30个碳原子的烷基，可以被羟基取代的含有1〜5个碳原子的磺基烷基或其盐。通过使用这种过敏原灭活剂，可以灭活房屋尘埃和其他环境过敏原，对人体没有不利影响，并且不会引起颜色发展等问题。

4. 发明授权

US06960359B2 Interleukin-4 production inhibitors 有权
公开(公告)号：US06960359B2
公开(公告)日：2005-11-01
申请号：US10279936
申请日：2002-10-25
申请人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
发明人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
IPC分类号： A61K8/00 , A61K8/30 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/68 , A61K8/92 , A61K31/045 , A61K31/22 , A61K36/00 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/328 , A61K36/53 , A61K36/54 , A61K36/61 , A61K36/67 , A61K36/81 , A61K36/899 , A61K36/9068 , A61K45/06 , A61P17/00 , A61P37/08 , A61Q19/10 , A61K35/78
CPC分类号： A61Q19/10 , A61K8/0216 , A61K8/34 , A61K8/342 , A61K8/347 , A61K8/37 , A61K8/922 , A61K31/045 , A61K31/22 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/328 , A61K36/53 , A61K36/54 , A61K36/61 , A61K36/67 , A61K36/899 , A61K36/9068 , A61K45/06 , A61K2800/70 , A61K2300/00
摘要： This invention relates to IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains at one or more compounds selected from the group consisting of hydroxyl-containing monoterpenes, hydroxyl-containing sesquiterpenes and their acylated derivatives. This invention is also concerned with IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains an essential oil such as cedarwood oil. This invention is also concerned with bath medicine compositions, each of which contains one or more ingredients selected from cedrol, cedrenol, farnesol, patchouli alcohol and vetiverol.

5. 发明授权

US06495171B2 Interleukin-4 production inhibitors 有权
标题翻译：白细胞介素-4产生抑制剂
公开(公告)号：US06495171B2
公开(公告)日：2002-12-17
申请号：US09865517
申请日：2001-05-29
申请人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
发明人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
IPC分类号： A61K3578
CPC分类号： A61Q19/10 , A61K8/0216 , A61K8/34 , A61K8/342 , A61K8/347 , A61K8/37 , A61K8/922 , A61K31/045 , A61K31/22 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/328 , A61K36/53 , A61K36/54 , A61K36/61 , A61K36/67 , A61K36/899 , A61K36/9068 , A61K45/06 , A61K2800/70 , A61K2300/00
摘要： This invention relates to IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains at one or more compounds selected from the group consisting of hydroxyl-containing monoterpenes, hydroxyl-containing sesquiterpenes and their acylated derivatives. This invention is also concerned with IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains an essential oil such as cedarwood oil. This invention is also concerned with bath medicine compositions, each of which contains one or more ingredients selected from cedrol, cedrenol, farnesol, patchouli alcohol and vetiverol.
摘要翻译：本发明涉及IL-4生产抑制剂，抗过敏剂和特应性皮炎预防剂和改进剂，其中每一种含有一种或多种选自含羟基的单萜，含羟基的倍半萜烯及其酰化衍生物的化合物。本发明还涉及IL-4生产抑制剂，抗过敏剂和特应性皮炎预防剂和改进剂，其中每种含有诸如雪松油的精油。本发明还涉及浴用药物组合物，每种药物组合物含有选自雪松汁，雪佛利醇，法呢醇，广藿香醇和香叶醇中的一种或多种成分。

6. 发明授权

US06974596B2 Interleukin-4 production inhibitors 有权
标题翻译：白细胞介素-4产生抑制剂
公开(公告)号：US06974596B2
公开(公告)日：2005-12-13
申请号：US10279935
申请日：2002-10-25
申请人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
发明人： Norikazu Iwase , Norihiro Tanaka , Hirotaka Sato , Kazuyuki Fukuda , Mami Nonomura , Yoshiaki Ichikawa , Kimihiko Hori
IPC分类号： A61K8/00 , A61K8/30 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/68 , A61K8/92 , A61K31/045 , A61K31/22 , A61K36/00 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/328 , A61K36/53 , A61K36/54 , A61K36/61 , A61K36/67 , A61K36/81 , A61K36/899 , A61K36/9068 , A61K45/06 , A61P17/00 , A61P37/08 , A61Q19/10 , A61K35/78
CPC分类号： A61Q19/10 , A61K8/0216 , A61K8/34 , A61K8/342 , A61K8/347 , A61K8/37 , A61K8/922 , A61K31/045 , A61K31/22 , A61K36/15 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/328 , A61K36/53 , A61K36/54 , A61K36/61 , A61K36/67 , A61K36/899 , A61K36/9068 , A61K45/06 , A61K2800/70 , A61K2300/00
摘要： This invention relates to IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains at one or more compounds selected from the group consisting of hydroxyl-containing monoterpenes, hydroxyl-containing sesquiterpenes and their acylated derivatives. This invention is also concerned with IL-4 production inhibitors, antiallergic agents and atopic dermatitis preventives and improvers, each of which contains an essential oil such as cedarwood oil. This invention is also concerned with bath medicine compositions, each of which contains one or more ingredients selected from cedrol, cedrenol, farnesol, patchouli alcohol and vetiverol.
摘要翻译：本发明涉及IL-4生产抑制剂，抗过敏剂和特应性皮炎预防剂和改进剂，其中每一种含有一种或多种选自含羟基的单萜，含羟基的倍半萜烯及其酰化衍生物的化合物。本发明还涉及IL-4生产抑制剂，抗过敏剂和特应性皮炎预防剂和改进剂，其中每种都含有诸如雪松油之类的精油。本发明还涉及浴用药物组合物，每种药物组合物含有选自雪松汁，雪佛利醇，法呢醇，广藿香醇和香叶醇中的一种或多种成分。

7. 发明授权

US4670585A Process for preparing 2-carboxydibenzoylmethanes 失效
标题翻译： 2-羧基二苯甲酰甲烷的制备方法
公开(公告)号：US4670585A
公开(公告)日：1987-06-02
申请号：US898714
申请日：1986-08-21
申请人： Kimihiko Hori , Koichi Nakamura , Naotake Takaishi
发明人： Kimihiko Hori , Koichi Nakamura , Naotake Takaishi
IPC分类号： C07C65/32 , C07C51/00 , C07C51/083 , C07C51/347 , C07C65/34 , C07C65/40 , C07C67/00 , C07C59/84
CPC分类号： C07C51/347
摘要： 2-Carboxydibenzoylmethanes of the following formula ##STR1## in which R.sub.1 and R.sub.2 are independently a substituent joined to any position of the benzene nucleus and represent a hydrogen atom, a halogen atom, a linear or branched alkyl or alkenyl group having from 1 to 18 carbon atoms, or a linear or branched, saturated or unsaturated alkoxy group having from 1 to 18 carbon atoms, m is an integer of from 1 to 4, and n is an integer of from 1 to 5 are prepared inexpensively with ease in high yield by a novel process characterized by reaction between phthalic anhydrides and acetophenones in the presence of bases.The 2-carboxydibenzoylmethanes are useful as an inhibitor of the root geotropic response of plants or a growth regulator for plants, or a stabilizer for halogen-containing resins.
摘要翻译：下式“IMAGE”的2-羧基二苯甲酰甲烷，其中R 1和R 2独立地是连接到苯核的任何位置并且表示氢原子，卤素原子，具有1至18个碳原子的直链或支链烷基或烯基的取代基碳原子或具有1至18个碳原子的直链或支链，饱和或不饱和的烷氧基，m为1至4的整数，并且n为1至5的整数，以高产率容易地制备通过特征在于在碱存在下邻苯二甲酸酐与苯乙酮之间的反应的新方法。 2-羧基二苯甲酰甲烷可用作植物根系地应力反应抑制剂或植物生长调节剂或含卤树脂稳定剂。

8. 发明授权

US4704473A 4-methoxy-2'-carboxydibenzoylmethane and its salts 失效
标题翻译： 4-甲氧基-2'-羧基二苯甲酰甲烷及其盐
公开(公告)号：US4704473A
公开(公告)日：1987-11-03
申请号：US804598
申请日：1985-12-04
申请人： Koichi Nakamura , Kimihiko Hori , Michihiro Hattori , Toru Tejima , Genji Imokawa , Naotake Takaishi
发明人： Koichi Nakamura , Kimihiko Hori , Michihiro Hattori , Toru Tejima , Genji Imokawa , Naotake Takaishi
IPC分类号： C07C65/32 , A61K8/368 , A61Q17/04 , C07C51/00 , C07C51/373 , C07C65/40 , C07C67/00 , C07C59/90
CPC分类号： C07C65/40 , A61K8/368 , A61Q17/04 , C07C51/373
摘要： 4-methoxy-2'-carboxydibenzoylmethane of the following general formula (I) ##STR1## is prepared by reacting p-methoxyacetophenone (III) with phthalic anhydride (II) in accordance with the following reaction equation. ##STR2##The compound (I) and its salts absorb both UV-A and UV-B, and exhibit prominent effects as a ultraviolet absorber for cosmetic formulations such as skin cosmetic formulations and hair cosmetic formulations.
摘要翻译：通过使对甲氧基苯乙酮（III）与邻苯二甲酸酐（II）按照以下反应式反应制备下列通式（I）的4-甲氧基-2'-羧基二苯甲酰基甲烷。化合物（I）及其盐吸收UV-A和UV-B两者，并且作为化妆品制剂如皮肤化妆品配方和头发化妆品配方的紫外线吸收剂具有显着的效果。

9. 发明授权

US4698435A Process for preparing 3-phenacylidene phthalides 失效
标题翻译： 3-苯亚基亚苯基酯的制备方法
公开(公告)号：US4698435A
公开(公告)日：1987-10-06
申请号：US909297
申请日：1986-09-19
申请人： Naotake Takaishi , Kimihiko Hori
发明人： Naotake Takaishi , Kimihiko Hori
IPC分类号： C07D307/88
CPC分类号： C07D307/88
摘要： A novel process for preparing a 3-phenacylidene phthalide of the general formula (II) ##STR1## which comprises reacting a halogenating reagent with a 2-carboxydibenzoylmethane.The 2-carboxydibenzoylmethane can be inexpensively prepared, so that the 3-phenacylidene phthalides which are useful as a growth regulant for plants and a safering agent to reduce herbicidal injury to plants can be readily obtained economically in high yield.
摘要翻译：一种制备通式（II）的3-苯亚基亚苯基苯酞的新颖方法（II），其包括使卤化试剂与2-羧基二苯甲酰甲烷反应。可以廉价地制备2-羧基二苯甲酰甲烷，从而可以以高产率经济地获得用作植物生长调节剂的3-苯亚基亚苯基酯和减轻植物除草损伤的更安全剂。

10. 发明授权

US06878378B1 External skin care composition 有权
标题翻译：外用护肤品
公开(公告)号：US06878378B1
公开(公告)日：2005-04-12
申请号：US09564549
申请日：2000-05-04
申请人： Kazuhiro Yamaki , Tomohiko Sano , Kimihiko Hori , Yutaka Takagi , Yukihiro Ohashi
发明人： Kazuhiro Yamaki , Tomohiko Sano , Kimihiko Hori , Yutaka Takagi , Yukihiro Ohashi
IPC分类号： A61K8/00 , A61K8/58 , A61K8/67 , A61K8/68 , A61K8/73 , A61K8/81 , A61K8/86 , A61K8/891 , A61K8/894 , A61K8/898 , A61K8/96 , A61K8/97 , A61K36/61 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q3/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/021 , A61K7/04 , A61K7/42 , A61K9/14
CPC分类号： A61K8/894 , A61K8/585 , A61K8/675 , A61K8/73 , A61K8/8152 , A61K8/8176 , A61K8/86 , A61K8/891 , A61K8/97 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q3/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： The invention relates to an external skin care composition comprising a ceramide production-accelerating agent and a film-forming polymer. The external skin care composition can enhance the barrier function of the skin and has an excellent skin roughness-improving effect.
摘要翻译：本发明涉及包含神经酰胺生产促进剂和成膜聚合物的外用皮肤护理组合物。外用护肤组合物可以增强皮肤的屏障功能，并且具有优异的皮肤粗糙度改善效果。

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