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1. 发明授权

US09851303B2 System and method for inducing and detecting multi-photon processes in a sample 有权
公开(公告)号：US09851303B2
公开(公告)日：2017-12-26
申请号：US15316568
申请日：2015-06-03
申请人： Ludwig-Maximilians-Universität München
发明人： Robert Alexander Huber , Sebastian Karpf , Matthias Eibl
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/0218 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6408 , G01N21/65 , G01N2021/6484 , G01N2201/06146 , G01N2201/0635 , G01N2201/105 , G01N2201/11 , G01N2201/12 , H01S3/06712 , H01S3/06754 , H01S3/094007 , H01S3/10015 , H01S3/1618 , H01S3/2316 , H01S3/302 , H01S2301/02
摘要： Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

2. 发明授权

US09515452B2 Coherent dynamically controllable narrow band light source 有权
标题翻译：相干动态可控窄带光源
公开(公告)号：US09515452B2
公开(公告)日：2016-12-06
申请号：US14890093
申请日：2014-05-09
申请人： Ludwig-Maximilians-Universität München
发明人： Robert Alexander Huber , Sebastian Karpf , Matthias Eibl
IPC分类号： H01S3/30 , H01S3/108 , H01S3/067 , H01S3/16 , H01S3/107 , H01S3/23
CPC分类号： H01S3/1086 , H01S3/067 , H01S3/06733 , H01S3/06754 , H01S3/06758 , H01S3/107 , H01S3/108 , H01S3/1618 , H01S3/2375 , H01S3/30 , H01S3/302
摘要： Disclosed herein is a coherent dynamically controllable narrow band light source (10), comprising a first sub-light source (12), said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, a Raman active medium (30) suitable to cause Raman scattering of light having said first wavelength, a second sub-light source (20) capable of emitting light with a second wavelength, said second wavelength being longer than said first wavelength, and an optical fiber or wave guide, wherein said light emitted by said first and second sub-light sources traverses a length of said optical fiber (30) or wave guide in a feed-forward configuration to facilitate a non-linear wavelength conversion step involving said Raman-active medium. At least one of said first and second sub-light sources (12, 20) has a coherence length longer than 0.05 mm, preferably longer than 0.5 mm and most preferably longer than 2 mm.
摘要翻译：本文公开了一种相干的可动态控制的窄带光源（10），包括第一子光源（12），所述第一子光源是电可控制的，以便产生可控的时间依赖的光强度图案，其具有第一适于引起具有所述第一波长的光的拉曼散射的拉曼活性介质（30），能够发射具有第二波长的光的第二子光源（20），所述第二波长长于所述第一波长，以及光纤或波导，其中由所述第一和第二子光源发射的所述光以前馈配置穿过所述光纤（30）或波导的长度，以促进涉及所述光纤（30）或波导的非线性波长转换步骤拉曼活性介质。所述第一和第二子光源（12,20）中的至少一个具有长于0.05mm，优选长于0.5mm，最优选长于2mm的相干长度。

3. 发明申请

US20160118765A1 A Coherent Dynamically Controllable Narrow Band Light Source 有权
标题翻译：相干动态可控窄带光源
公开(公告)号：US20160118765A1
公开(公告)日：2016-04-28
申请号：US14890093
申请日：2014-05-09
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
发明人： Robert Alexander Huber , Sebastian Karpf , Matthias Eibl
IPC分类号： H01S3/30 , H01S3/16 , H01S3/107 , H01S3/067 , H01S3/108
CPC分类号： H01S3/1086 , H01S3/067 , H01S3/06733 , H01S3/06754 , H01S3/06758 , H01S3/107 , H01S3/108 , H01S3/1618 , H01S3/2375 , H01S3/30 , H01S3/302
摘要： Disclosed herein is a coherent dynamically controllable narrow band light source (10), comprising a first sub-light source (12), said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, a Raman active medium (30) suitable to cause Raman scattering of light having said first wavelength, a second sub-light source (20) capable of emitting light with a second wavelength, said second wavelength being longer than said first wavelength, and an optical fiber or wave guide, wherein said light emitted by said first and second sub-light sources traverses a length of said optical fiber (30) or wave guide in a feed-forward configuration to facilitate a non-linear wavelength conversion step involving said Raman-active medium. At least one of said first and second sub-light sources (12, 20) has a coherence length longer than 0.05 mm, preferably longer than 0.5 mm and most preferably longer than 2 mm.
摘要翻译：本文公开了一种相干的可动态控制的窄带光源（10），包括第一子光源（12），所述第一子光源是电可控制的，以便产生可控的时间依赖的光强度图案，其具有第一适于引起具有所述第一波长的光的拉曼散射的拉曼活性介质（30），能够发射具有第二波长的光的第二子光源（20），所述第二波长长于所述第一波长，以及光纤或波导，其中由所述第一和第二子光源发射的所述光以前馈配置穿过所述光纤（30）或波导的长度，以促进涉及所述光纤（30）或波导的非线性波长转换步骤拉曼活性介质。所述第一和第二子光源（12,20）中的至少一个具有长于0.05mm，优选长于0.5mm，最优选长于2mm的相干长度。

4. 发明申请

US20170146458A1 A System and Method for Inducing and Detecting Multi-Photon Processes in a Sample 有权
公开(公告)号：US20170146458A1
公开(公告)日：2017-05-25
申请号：US15316568
申请日：2015-06-03
申请人： Ludwig-Maximilians-Universität München
发明人： Robert Alexander Huber , Sebastian Karpf , Matthias Eibl
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/0218 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6408 , G01N21/65 , G01N2021/6484 , G01N2201/06146 , G01N2201/0635 , G01N2201/105 , G01N2201/11 , G01N2201/12 , H01S3/06712 , H01S3/06754 , H01S3/094007 , H01S3/10015 , H01S3/1618 , H01S3/2316 , H01S3/302 , H01S2301/02
摘要： Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

5. 发明授权

US09638638B2 System and method for stimulated raman spectroscopy 有权
公开(公告)号：US09638638B2
公开(公告)日：2017-05-02
申请号：US14890109
申请日：2014-05-09
申请人： Ludwig-Maximilians-Universität München
发明人： Robert Alexander Huber , Thomas Klein , Wolfgang Wieser , Sebastian Karpf , Matthias Eibl
IPC分类号： G01J3/44 , G01N21/65 , H01S3/067 , H01S3/10 , H01S3/23 , H01S3/30 , H01S3/0941 , H01S3/16 , H01S3/00 , H01S3/094
CPC分类号： G01N21/65 , G01J3/44 , G01J3/4412 , G01N2021/655 , G01N2201/06113 , G01N2201/0683 , G01N2201/0697 , H01S3/0064 , H01S3/0078 , H01S3/06758 , H01S3/094069 , H01S3/09415 , H01S3/10015 , H01S3/1618 , H01S3/2391 , H01S3/302
摘要： Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern. The detection means (24) is capable of recording said transmitted or reflected light signal, in particular stimulated Raman signal, as a function of time.

6. 发明申请

US20160091429A1 System and Method for Stimulated Raman Spectroscopy 有权
标题翻译：刺激拉曼光谱的系统和方法
公开(公告)号：US20160091429A1
公开(公告)日：2016-03-31
申请号：US14890109
申请日：2014-05-09
申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
发明人： Robert Alexander Huber , Thomas Klein , Wolfgang Wieser , Sebastian Karpf , Matthias Eibl
IPC分类号： G01N21/65 , G01J3/44
CPC分类号： G01N21/65 , G01J3/44 , G01J3/4412 , G01N2021/655 , G01N2201/06113 , G01N2201/0683 , G01N2201/0697 , H01S3/0064 , H01S3/0078 , H01S3/06758 , H01S3/094069 , H01S3/09415 , H01S3/10015 , H01S3/1618 , H01S3/2391 , H01S3/302
摘要： Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern. The detection means (24) is capable of recording said transmitted or reflected light signal, in particular stimulated Raman signal, as a function of time.
摘要翻译：本文公开了一种用于测量光诱导的透射或反射变化的系统（10），特别是由于受激的拉曼发射。该系统包括用于产生具有第一波长的第一光信号的第一光源（12），用于产生具有第二波长的第二光信号的第二光源（14），用于叠加所述第一波长的光学组件以及检测装置（24），用于检测发射或反射的光信号，特别是当位于所述采样位置时由拉曼活性介质引起的受激拉曼信号。这里，第一和第二光源（12,14）中的至少一个是主要可控制的一个或两个以发射时间控制的光图案或基本上以CW模式操作，并且设置有用于产生的额外的空腔调制装置（64）时间控制的光图案。检测装置（24）能够作为时间的函数记录特定的受激拉曼信号的所述发射或反射的光信号。

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