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1. 发明申请

US20060058296A1 Treatment of osteolytic lesions associated with multiple myeloma by inhibition of p38 map kinase 审中-公开
标题翻译：通过抑制p38图激酶治疗与多发性骨髓瘤相关的溶骨性病变
公开(公告)号：US20060058296A1
公开(公告)日：2006-03-16
申请号：US11208481
申请日：2005-08-19
申请人： Linda Higgins , Andrew Protter
发明人： Linda Higgins , Andrew Protter
IPC分类号： A61K31/695 , A61K31/5377 , A61K31/454
CPC分类号： A61K31/395 , A61K31/454 , A61K31/5377 , A61K31/695
摘要： The present invention provides a method to treat osteolytic lesions associated with multiple myeloma by the administration of one or more p38 MAP kinase inhibitors.
摘要翻译：本发明提供了通过施用一种或多种p38 MAP激酶抑制剂治疗与多发性骨髓瘤相关的溶骨性病变的方法。

2. 发明申请

US20060052390A1 Treatment of multiple myeloma by p38 MAP kinase and proteasome inhibition 审中-公开
标题翻译：通过p38 MAP激酶和蛋白酶体抑制治疗多发性骨髓瘤
公开(公告)号：US20060052390A1
公开(公告)日：2006-03-09
申请号：US11208055
申请日：2005-08-19
申请人： George Schreiner , Andrew Protter , Linda Higgins
发明人： George Schreiner , Andrew Protter , Linda Higgins
IPC分类号： A61K31/496 , A61K31/454
CPC分类号： A61K45/06 , A61K31/454 , A61K31/496 , A61K2300/00
摘要： The present invention provides a method to treat multiple myeloma by the co-administration of one or more p38 MAP kinase inhibitors with one or more proteosome inhibitors.
摘要翻译：本发明提供了通过一种或多种p38 MAP激酶抑制剂与一种或多种蛋白酶体抑制剂共同给药来治疗多发性骨髓瘤的方法。

3. 发明申请

US20130245024A1 Combination of PPARy Agonist and a Dipeptidyl Peptidase-Inhibitor for the Treatment of Diabetes and Obesity 审中-公开
标题翻译： PPARγ激动剂和二肽基肽酶抑制剂联合用于治疗糖尿病和肥胖
公开(公告)号：US20130245024A1
公开(公告)日：2013-09-19
申请号：US12921058
申请日：2009-03-06
申请人： Dennis Lanfear , Linda Higgins
发明人： Dennis Lanfear , Linda Higgins
IPC分类号： A61K31/47 , A61K31/40 , A61K31/4985
CPC分类号： A61K31/47 , A61K31/40 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions and methods for the treatment of diabetes, obesity or disorders related to diabetes or obesity. The compositions comprise a combination of a particular PPARγ agonist and a particular dipeptidyl peptidase-IV (DPP-IV) inhibitor. The methods include the administration of the combination of a particular PPARγ agonist and a particular dipeptidyl peptidase-IV (DPP-IV) inhibitor.
摘要翻译：本发明涉及用于治疗与糖尿病或肥胖相关的糖尿病，肥胖症或病症的药物组合物和方法。组合物包含特定的PPARγ激动剂和特定的二肽基肽酶-IV（DPP-IV）抑制剂的组合。所述方法包括施用特定的PPARγ激动剂和特定的二肽基肽酶-IV（DPP-IV）抑制剂的组合。

4. 发明申请

US20060258582A1 Method of treating myelodysplastic syndromes 审中-公开
标题翻译：治疗骨髓增生异常综合征的方法
公开(公告)号：US20060258582A1
公开(公告)日：2006-11-16
申请号：US11267813
申请日：2005-11-04
申请人： Mario Navas , Linda Higgins
发明人： Mario Navas , Linda Higgins
IPC分类号： A61K38/54 , G01N33/574
CPC分类号： A61K31/404 , A61K31/496 , C12Q1/485 , G01N33/6896 , G01N2800/28
摘要： The disclosed invention is directed to methods and compounds useful in treating a myelodysplastic syndrome (MDS) using p38 MAP kinase inhibitors either alone or in combination with other chemotherapeutic compounds. A role for p38 kinase inhibition as a treatment modality for combating MDS is discussed herein. Relating to a preferred embodiment, compounds of the invention have been found to inhibit p38 kinase, the α-isoform in particular, and are useful in treating MDS.
摘要翻译：所公开的发明涉及可用于单独使用p38 MAP激酶抑制剂或与其它化学治疗化合物组合治疗骨髓增生异常综合征（MDS）的方法和化合物。本文讨论了p38激酶抑制作为对抗MDS的治疗方式的作用。关于优选的实施方案，已经发现本发明的化合物特别抑制p38激酶，特别是α-亚型，并且可用于治疗MDS。

5. 发明申请

US20060019971A1 Treatment of cardiovascular disease with inhibitors of p38 kinase 审中-公开
标题翻译：用p38激酶抑制剂治疗心血管疾病
公开(公告)号：US20060019971A1
公开(公告)日：2006-01-26
申请号：US10956402
申请日：2004-09-30
申请人： Linda Higgins , Moon Lim
发明人： Linda Higgins , Moon Lim
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K31/415 , A61K31/42 , A61K31/425
摘要： The present invention concerns methods of treatment for acute coronary syndrome using a pharmaceutically effective amount of an inhibitor of p38 MAP kinase. More specifically, the invention concerns the treatment of cardiovascular disorders associated with atherosclerosis.
摘要翻译：本发明涉及使用药学有效量的p38 MAP激酶抑制剂治疗急性冠状动脉综合征的方法。更具体地，本发明涉及与动脉粥样硬化相关的心血管疾病的治疗。

6. 发明申请

US20070112711A1 Computer-implemented system and method for facilitating and evaluating user thinking about an arbitrary problem 有权
标题翻译：计算机实现的系统和方法，用于方便和评估用户对任意问题的思考
公开(公告)号：US20070112711A1
公开(公告)日：2007-05-17
申请号：US11486157
申请日：2006-07-13
申请人： James Heidenreich , Linda Higgins
发明人： James Heidenreich , Linda Higgins
IPC分类号： G06N5/00
CPC分类号： G06N5/02 , G06N5/00
摘要： Preferred embodiments of the invention provide a computer-implemented system and method for facilitating user thinking about an arbitrary problem. The system includes first means to facilitate the user specification of the problem to populate a problem structure. It also includes second means to facilitate the user specification of a conclusion, related to the problem specification, to populate a conclusion structure. It also includes third means to facilitate the user specification of knowledge, related to at least one of the problem specification and the conclusion specification, to populate a knowledge structure. Certain embodiments include controlling means to persuade user interaction with the first, second and third means to a sequence of interactions within a predefined set of interaction sequences, wherein the predefined set of interaction sequences define an archetype process for thinking about the problem. In certain embodiments, the archetype process is dynamic and changes in response to user interactions and to the content or structure of the problem structure, conclusion structure and knowledge structure.
摘要翻译：本发明的优选实施例提供了一种用于促使用户思考任意问题的计算机实现的系统和方法。该系统包括便利用户指定问题以填充问题结构的第一手段。它还包括方便用户指定与问题规范相关的结论的第二手段来填写结论结构。它还包括促进用户对与问题规范和结论规范中的至少一个有关的知识的规范以填充知识结构的第三手段。某些实施例包括控制装置，以说服用户与第一，第二和第三装置的交互作用到预定义的一组交互序列内的一系列交互，其中预定义的一组交互序列定义用于思考该问题的原型过程。在某些实施例中，原型过程是动态的并且响应于用户交互以及对问题结构，结论结构和知识结构的内容或结构的变化。

7. 发明申请

US20050245508A1 Treatment of malignant gliomas with TGF-beta inhibitors 审中-公开
标题翻译：用TGF-β抑制剂治疗恶性胶质瘤
公开(公告)号：US20050245508A1
公开(公告)日：2005-11-03
申请号：US11021640
申请日：2004-12-22
申请人： Michael Weller , Sundeep Dugar , Linda Higgins , David Liu , George Schreiner , Sarvaji Chakravarty
发明人： Michael Weller , Sundeep Dugar , Linda Higgins , David Liu , George Schreiner , Sarvaji Chakravarty
IPC分类号： A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/55
CPC分类号： A61K31/519 , A61K31/505 , A61K31/517 , A61K31/53 , A61K31/55
摘要： The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-β the TGF-β signaling pathway, including molecules preferably binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-β-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-β.
摘要翻译：本发明涉及通过施用TGF-β的TGF-β信号转导途径的抑制剂，包括优选结合I型TGF-β受体（TGFβ-R1）的分子来治疗恶性胶质瘤的方法。优选地，抑制剂是非肽小分子，包括喹唑啉衍生物。本发明还涉及用于逆转TGF-β介导的对胶质瘤细胞的作用以使其对信号传导和其他免疫细胞的折射较少的方法，包括使体内或体外的胶质瘤细胞或组织与TGF-β的抑制剂接触。

8. 发明申请

US20050154691A1 System and method of facilitating and evaluating user thinking about an arbitrary problem 有权
公开(公告)号：US20050154691A1
公开(公告)日：2005-07-14
申请号：US10513900
申请日：2003-11-10
申请人： Linda Higgins , James Heidenreich
发明人： Linda Higgins , James Heidenreich
IPC分类号： G06F17/00 , G06N5/00 , G06N5/02 , G09B19/00
CPC分类号： G06N5/02 , G06N5/00
摘要： Preferred embodiments of the invention provide systems and methods of facilitating and evaluating user thinking about an arbitrary problem. The system includes first logic to facilitate user specification of the problem to populate a problem statement structure. It also includes second logic to facilitate user specification of a conclusion, related to the problem specification, to populate a conclusion statement structure. It also includes third logic to facilitate user creation and specification of knowledge, related to at least one of the problem specification and the conclusion specification, to populate a knowledge structure. Certain embodiments include control logic to persuade user interaction with the first through third logic to a sequence of interactions within a predefined set of interaction sequences, wherein the predefined set of interactions define an archetype process for user thinking about the problem. Other embodiments the first through third logic to construct a user model structure of user development and population of the user model structure, conclusion statement structure, and knowledge structure, and structure analysis logic to analyze the user model structure relative to an archetype model structure. Some embodiments include model logic to track user interaction with the first through third logic to construct a user model structure of user development and population of the problem structure, conclusion statement structure, and knowledge structure; and visual feedback logic to depict an archetype problem-solution structure and to depict the user model structure. And other embodiments include tracking logic to monitor user interactions with the first through third logic and to build a corresponding model of such interactions so that the model, and the corresponding user thinking process, may be evaluated. The system may monitor the user's process of problem solving and the structure of the user's problem solving approach and make suggestions to the user.

9. 发明授权

US09675603B2 Solid pharmaceutical compositions of ppary modulator 有权
公开(公告)号：US09675603B2
公开(公告)日：2017-06-13
申请号：US13824776
申请日：2011-09-19
申请人： Kathleen M. Lee , Linda Higgins , Dennis Lanfear
发明人： Kathleen M. Lee , Linda Higgins , Dennis Lanfear
IPC分类号： A61K31/47 , A61K31/497 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/18
CPC分类号： A61K31/47 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K31/18 , Y10T428/2982
摘要： Provided are pharmaceutical compositions in solid form comprising a selective modulator of PPAR-γ suitable for oral dosage to treat subjects having PPAR-γ mediated conditions. Provided further are methods of manufacturing the compositions, and methods of treating a PPAR-γ mediated condition.

10. 发明申请

US20130243865A1 Antidiabetic Solid Pharmaceutical Compositions 审中-公开
标题翻译：抗糖尿病固体药物组合物
公开(公告)号：US20130243865A1
公开(公告)日：2013-09-19
申请号：US13824776
申请日：2011-09-19
申请人： Kathleen M. Lee , Linda Higgins , Dennis Lanfear
发明人： Kathleen M. Lee , Linda Higgins , Dennis Lanfear
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/4858 , A61K9/4866 , A61K31/18 , Y10T428/2982
摘要： Provided are pharmaceutical compositions in solid form comprising a selective modulator of PPAR-Y suitable for oral dosage to treat subjects having PPAR-Y mediated conditions. Provided further are methods of manufacturing the compositions, and methods of treating a PPAR-Y mediated condition.
摘要翻译：提供了固体形式的药物组合物，其包含适于口服剂量的PPAR-Y选择性调节剂以治疗具有PPAR-Y介导的病症的受试者。进一步提供制备组合物的方法和治疗PPAR-Y介导的病症的方法。

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