专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090118499A1 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 有权
公开(公告)号：US20090118499A1
公开(公告)日：2009-05-07
申请号：US12244947
申请日：2008-10-03
申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： C07D487/04
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

2. 发明申请

US20120077979A1 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 失效
标题翻译： 6,6-双环取代杂双环蛋白激酶抑制剂
公开(公告)号：US20120077979A1
公开(公告)日：2012-03-29
申请号：US13308694
申请日：2011-12-01
申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： C07D487/04 , C07F5/02
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译：其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。

3. 发明申请

US20120196847A1 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 有权
公开(公告)号：US20120196847A1
公开(公告)日：2012-08-02
申请号：US13446629
申请日：2012-04-13
申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： A61K31/4985 , A61K31/53 , A61P35/00 , A61K31/5377 , A61K31/551 , C07D487/04 , A61K31/519
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

4. 发明申请

US20090325928A1 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 有权
标题翻译： 6,6-双环取代杂双环蛋白激酶抑制剂
公开(公告)号：US20090325928A1
公开(公告)日：2009-12-31
申请号：US12540047
申请日：2009-08-12
申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： C07D471/04 , A61K31/495 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/04
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译：其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。

5. 发明申请

US20060235031A1 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors 有权
标题翻译： 6,6-双环取代杂双环蛋白激酶抑制剂
公开(公告)号：US20060235031A1
公开(公告)日：2006-10-19
申请号：US11095162
申请日：2005-03-31
申请人： Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： A61K31/52
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译：下式的化合物及其药学上可接受的盐，其中X 1，X 2，X 3，X 4， X 5，X 6，X 7，R 1和Q 1 在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防过度增殖性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢的疾病和状况神经系统。

6. 发明申请

US20060084654A1 Imidazopyrazine tyrosine kinase inhibitors 有权
标题翻译：咪唑吡嗪酪氨酸激酶抑制剂
公开(公告)号：US20060084654A1
公开(公告)日：2006-04-20
申请号：US10965182
申请日：2004-10-14
申请人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译：式I化合物及其药学上可接受的盐，其中Q 1和R 1在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。

7. 发明申请

US20080227788A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS 有权
标题翻译：咪唑吡嗪类激酶激酶抑制剂
公开(公告)号：US20080227788A9
公开(公告)日：2008-09-18
申请号：US10965182
申请日：2004-10-14
申请人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人： Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译：式I化合物及其药学上可接受的盐，其中Q 1和R 1在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。

8. 发明授权

US07662844B2 Naphthylene derivatives as cytochrome P450 inhibitors 失效
标题翻译：萘衍生物作为细胞色素P450抑制剂
公开(公告)号：US07662844B2
公开(公告)日：2010-02-16
申请号：US10889520
申请日：2004-07-12
申请人： Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Anne Beck , Arlindo L. Castelhano
发明人： Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Anne Beck , Arlindo L. Castelhano
IPC分类号： A61K31/50 , A61K31/415 , C07D231/00 , C07D233/00
CPC分类号： C07D233/64
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.
摘要翻译：其中n1，n2，n3，n4，G1，Q1，Z3，R1，R2，R3，R4a，R4b，R5a和R5b在本文中定义的式和其药学上可接受的盐的化合物抑制细胞色素P450RAI酶，可用于治疗和/或预防响应于类视黄醇和天然存在的视黄酸的治疗的各种疾病和病症。

9. 发明申请

US20060009645A1 Naphthylene derivatives as cytochrome P450 inhibitors 失效
标题翻译：萘衍生物作为细胞色素P450抑制剂
公开(公告)号：US20060009645A1
公开(公告)日：2006-01-12
申请号：US10889520
申请日：2004-07-12
申请人： Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Beck , Arlindo Castelhano
发明人： Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Beck , Arlindo Castelhano
IPC分类号： C07D249/08 , C07D233/61
CPC分类号： C07D233/64
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.
摘要翻译：下式的化合物及其药学上可接受的盐，其中n 1，n 2，n 3，n 4，G 1，Q 1，Z，R 1 R 2，R 3，R 4，R 4a，R 4b，R 5a，本文定义的R 5b是抑制细胞色素P 450 RAI酶，并且可用于治疗和/或预防响应于维甲酸和天然的治疗的各种疾病和病症发生视黄酸。

10. 发明申请

US20060224618A1 Data transfer and transformation system and method 审中-公开
标题翻译：数据传输与转换系统及方法
公开(公告)号：US20060224618A1
公开(公告)日：2006-10-05
申请号：US11447700
申请日：2006-06-06
申请人： Peter Garden , Darren Rowley , Anthony Nigro
发明人： Peter Garden , Darren Rowley , Anthony Nigro
IPC分类号： G06F7/00
CPC分类号： G06F16/258
摘要： A method for processing data. Meta-data descriptors (15, 18) are defined to describe the data either by the user (17) or automatically using a meta-data connector (16). A meta-data descriptor describes the structure of data including field names (1, 4). A meta-data connector describes how to access the data. Different types of meta-data connectors (10, 11, 12) exist for different types of data such as JDBC and XML. An interactive user application (23) is utilised to facilitate the definition of a process. A process consists of certain operations (7) in relation to meta-data descriptors (2, 5) such as transformation of data from one field name to another. A component (8, 26) is provided to process data in accordance with the defined process. A computer system and software for implementing the method is also disclosed.
摘要翻译：一种处理数据的方法。元数据描述符（15,18）被定义为用户（17）或自动使用元数据连接器（16）来描述数据。元数据描述符描述包括字段名称的数据的结构（1,4）。元数据连接器描述如何访问数据。对于不同类型的数据（如JDBC和XML），存在不同类型的元数据连接器（10,11,12）。利用交互式用户应用程序（23）来促进过程的定义。过程包括与元数据描述符（2,5）相关的某些操作（7），例如将数据从一个字段名称转换到另一个字段名称。提供组件（8,26）以根据所定义的过程来处理数据。还公开了一种用于实现该方法的计算机系统和软件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式