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1. 发明申请

US20070004984A1 METHOD AND APPARATUS FOR PREPARING ORGANS AND TISSUES FOR LAPAROSCOPIC SURGERY 有权
标题翻译：制备用于手术的器官和组织的方法和装置
公开(公告)号：US20070004984A1
公开(公告)日：2007-01-04
申请号：US11464118
申请日：2006-08-11
申请人： Lawrence Crum , Peter Kaczkowski , Stuart Mitchell , Michael Bailey
发明人： Lawrence Crum , Peter Kaczkowski , Stuart Mitchell , Michael Bailey
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B8/06 , A61B8/13 , A61B8/4272 , A61B17/320092 , A61B2017/00243 , A61B2017/00575 , A61F7/02
摘要： High intensity ultrasound (HIU) is used to facilitate surgical procedures, such as a laparoscopic partial nephrectomy, with minimal bleeding. An apparatus is configured to emit HIU from one or more transducers that are attached to a minimally invasive surgical instrument. Such a tool preferably can provide sufficient clamping pressure to collapse blood vessels' walls, so that they will be sealed by the application of the HIU, and by the resulting thermal ablation and tissue cauterization. Such an instrument can provide feedback to the user that the lesion is completely transmural and that blood flow to the region distal of the line of thermal ablation has ceased. Similar instruments having opposed arms can be configured for use in conventional surgical applications as well. Instruments can be implemented with transducers on only one arm, and an ultrasound reflective material disposed on the other arm.
摘要翻译：高强度超声（HIU）用于促进外科手术，如腹腔镜部分肾切除术，出血少。一种装置被配置为从附接到微创外科器械的一个或多个换能器发射HIU。这种工具优选地可以提供足够的夹紧压力来折叠血管的壁，使得它们将通过施加HIU而被密封，并且由此产生的热消融和组织烧灼。这样的仪器可以向使用者提供病变完全透壁并且到达热消融线的远端区域的血液流动已经停止的反馈。具有相对臂的类似器械也可以被配置为用于常规外科应用。仪器可以在仅一个臂上的换能器和设置在另一个臂上的超声反射材料实现。

2. 发明申请

US20100160781A1 DOPPLER AND IMAGE GUIDED DEVICE FOR NEGATIVE FEEDBACK PHASED ARRAY HIFU TREATMENT OF VASCULARIZED LESIONS 审中-公开
标题翻译：用于负反馈的多普勒和图像引导装置相位阵列治疗血管扩张
公开(公告)号：US20100160781A1
公开(公告)日：2010-06-24
申请号：US12634599
申请日：2009-12-09
申请人： Stephen Carter , Lawrence Crum , Peter Kaczkowski , John Kucewicz , Mike Bailey , Steve Langer
发明人： Stephen Carter , Lawrence Crum , Peter Kaczkowski , John Kucewicz , Mike Bailey , Steve Langer
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/06 , A61B8/13 , A61B8/463 , A61B8/469 , A61B2090/378
摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU), where the HIFU is targeted Doppler ultrasound data, and a duration of the therapy is automatically controlled using a negative feedback loop provided by Doppler ultrasound data collected during the HIFU therapy. A portion of the vasculature providing blood flow to the undesired tissue is selected by a clinician, or automatically selected based on Doppler data, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.
摘要翻译：一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。可以通过用高强度聚焦超声（HIFU）选择性地治疗脉管系统的特定部分来封闭脉管系统的选定部分中的血流，其中HIFU是靶向多普勒超声数据，并且使用负反馈自动控制治疗的持续时间由HIFU治疗期间收集的多普勒超声数据提供循环。向临床医生选择向不想要的组织提供血液流动的血管系统的一部分，或者基于多普勒数据自动选择，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的该部分的血流。

3. 发明申请

US20110263967A1 ULTRASOUND BASED METHOD AND APPARATUS FOR STONE DETECTION AND TO FACILITATE CLEARANCE THEREOF 有权
标题翻译：基于超声波的方法和设备，用于石材检测和便于其清除
公开(公告)号：US20110263967A1
公开(公告)日：2011-10-27
申请号：US13092811
申请日：2011-04-22
申请人： Michael Bailey , John Kucewicz , Wei Lu , Oleg Sapozhnikov , Paul Illian , Anup Shah , Barbrina Dunmire , Neil Owen , Bryan Cunitz , Peter Kaczkowski , Marla Paun
发明人： Michael Bailey , John Kucewicz , Wei Lu , Oleg Sapozhnikov , Paul Illian , Anup Shah , Barbrina Dunmire , Neil Owen , Bryan Cunitz , Peter Kaczkowski , Marla Paun
IPC分类号： A61B5/055 , A61B8/00 , A61N7/00
CPC分类号： A61B17/225 , A61B5/055 , A61B5/7232 , A61B6/03 , A61B6/485 , A61B8/085 , A61B8/488 , A61B17/2256 , A61B2017/22005 , A61B2090/378 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0082 , G01S7/52071 , G01S15/899
摘要： Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.
摘要翻译：这里描述了用于通过超声检测石块的方法和装置，其中相对于来自血液或组织的超声波反射优先选择和加强来自石头的超声反射。本文还描述了将推进超声应用于体内石块或其它物体的方法和装置，以便于去除这样的体内物体。

4. 发明授权

US09204859B2 Ultrasound based method and apparatus for stone detection and to facilitate clearance thereof 有权
标题翻译：基于超声波的方法和设备，用于石材检测和便于清除
公开(公告)号：US09204859B2
公开(公告)日：2015-12-08
申请号：US13092811
申请日：2011-04-22
申请人： Michael Bailey , John Kucewicz , Wei Lu , Oleg Sapozhnikov , Paul Illian , Anup Shah , Barbrina Dunmire , Neil Owen , Bryan Cunitz , Peter Kaczkowski , Marla Paun
发明人： Michael Bailey , John Kucewicz , Wei Lu , Oleg Sapozhnikov , Paul Illian , Anup Shah , Barbrina Dunmire , Neil Owen , Bryan Cunitz , Peter Kaczkowski , Marla Paun
IPC分类号： A61B5/055 , A61B8/08 , A61B17/225 , A61B17/22 , A61B19/00 , G01S7/52 , G01S15/89 , A61B5/00
CPC分类号： A61B17/225 , A61B5/055 , A61B5/7232 , A61B6/03 , A61B6/485 , A61B8/085 , A61B8/488 , A61B17/2256 , A61B2017/22005 , A61B2090/378 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0082 , G01S7/52071 , G01S15/899
摘要： Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.
摘要翻译：这里描述了用于通过超声检测石块的方法和装置，其中相对于来自血液或组织的超声波反射优先选择和加强来自石头的超声反射。本文还描述了将推进超声应用于体内石块或其它物体的方法和装置，以便于去除这样的体内物体。

5. 发明申请

US20070106157A1 NON-INVASIVE TEMPERATURE ESTIMATION TECHNIQUE FOR HIFU THERAPY MONITORING USING BACKSCATTERED ULTRASOUND 有权
标题翻译：非侵入式温度估算技术，用于使用后置超声波进行HIFU治疗监测
公开(公告)号：US20070106157A1
公开(公告)日：2007-05-10
申请号：US11537416
申请日：2006-09-29
申请人： Peter Kaczkowski , Ajay Anand
发明人： Peter Kaczkowski , Ajay Anand
IPC分类号： A61B8/00
CPC分类号： A61B5/015 , A61B8/485 , A61B8/5223 , A61B8/587 , A61N7/02
摘要： Ultrasound data are collected from a thermal source and a mass of tissue before initiating therapy to measure two parameters of the bio-heat transfer equation (BHTE). The parameters are the thermal diffusivity (K) of the tissue and the magnitude of the thermal source (Q). Once the parameters have been obtained, the BHTE can be calibrated to the specific mass of tissue and the specific thermal source. The calibrated BHTE can be used to generate a temperature dependence curve calibrated to the thermal source and tissue, and spatio-temporal temperature maps, to facilitate pre-therapy planning. During therapy, ultrasound data are collected to determine if Q changes during therapy, and if so, the BHTE is recalibrated using the new Q value, increasing an accuracy of the temperature estimations.
摘要翻译：在开始治疗之前，从热源和组织块收集超声数据，以测量生物传热方程（BHTE）的两个参数。参数是组织的热扩散系数（K）和热源的大小（Q）。一旦获得了参数，就可以将BHTE校准到组织的特定质量和特定的热源。校准的BHTE可用于产生校准到热源和组织以及时空温度图的温度依赖曲线，以便于治疗前计划。在治疗期间，收集超声数据以确定治疗期间Q是否发生变化，如果是，则使用新的Q值重新校准BHTE，从而提高温度估计的准确度。

6. 发明申请

US20060184074A1 Solid hydrogel coupling for ultrasound imaging and therapy 审中-公开
公开(公告)号：US20060184074A1
公开(公告)日：2006-08-17
申请号：US11369281
申请日：2006-03-07
申请人： Shahram Vaezy , Adrian Prokop , Roy Martin , Peter Kaczkowski , Misty Noble
发明人： Shahram Vaezy , Adrian Prokop , Roy Martin , Peter Kaczkowski , Misty Noble
IPC分类号： A61H1/00 , A61B8/12
CPC分类号： A61K41/0028 , A61B8/4281 , A61B2017/2253 , A61K49/226 , A61N7/02
摘要： The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.

7. 发明授权

US07070565B2 Solid hydrogel coupling for ultrasound imaging and therapy 失效
公开(公告)号：US07070565B2
公开(公告)日：2006-07-04
申请号：US10449819
申请日：2003-05-30
申请人： Shahram Vaezy , Adrian Prokop , Roy W. Martin , Peter Kaczkowski , Misty Noble
发明人： Shahram Vaezy , Adrian Prokop , Roy W. Martin , Peter Kaczkowski , Misty Noble
IPC分类号： A61B8/14
CPC分类号： A61K41/0028 , A61B8/4281 , A61B2017/2253 , A61K49/226 , A61N7/02
摘要： The present invention employs hydrogels as acoustic couplings for clinical applications of ultrasound imaging and therapy, but is particularly applicable to high intensity focused ultrasound (HIFU) based therapy. While other materials can be used, it has been determined that polyacrylamide is sufficiently robust and transmissive to withstand the high temperatures encountered in HIFU therapy. One embodiment of a hydrogel coupling is configured in shape and size (length) to ensure that a focal region of an ultrasound transducer is disposed proximate the target area when the distal tip of the transducer is in contact with tissue. These couplings can be shaped to correspond to the beam focus characteristics of specific transducers. Water can be applied to hydrate the tip of the hydrogel coupling during use, and medication absorbed into the hydrogel material can be applied to the tissue in contact with the distal surface of the hydrogel.

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