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1. 发明申请

US20110275686A1 NANOPARTICLE CARRIER SYSTEMS BASED ON POLY(DL-LACTIC-CO-GLYCOLIC ACID) (PLGA) FOR PHOTODYNAMIC THERAPY (PDT) 审中-公开
标题翻译：基于聚合（DL-LACTIC-CO-GLYCOLIC ACID）（PLGA）用于光化学治疗（PDT）的纳米载体系统
公开(公告)号：US20110275686A1
公开(公告)日：2011-11-10
申请号：US12941447
申请日：2010-11-08
申请人： Klaus Langer , Thomas Knobloch , Beate Röder , Annegret Preuß , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
发明人： Klaus Langer , Thomas Knobloch , Beate Röder , Annegret Preuß , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
IPC分类号： A61K31/409 , A61P35/00 , A61K9/113 , A61K9/14 , A61P29/00 , B82Y5/00
CPC分类号： A61K9/5153 , A61K33/20 , A61K41/0071
摘要： Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for clinical use in photodynamic therapy comprising a hydrophobic photosensitizer, poly(lactic-co-glycolic) acid and stabilizing agents are provided. These nanoparticulate pharmaceutical formulations provide therapeutically effective amounts of photosensitizer for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers, whose efficacy and safety are enhanced by such nanoparticulate formulations. It also teaches the method of preparing PLGA-based nanoparticles under sterile conditions. In one of the preferred embodiments of the present invention PLGA-based nanoparticles have a mean particle size less than 500 nm and the photosensitizer is temoporfin, 5,10,15,20-tetrakis(3-hydroxyphenyl)-chlorin (mTHPC). In another embodiment, the photosensitizer 2,3-dihydroxy-5,10,15,20-tetrakis(3-hydroxyphenyl)-chlorin (mTHPD-OH) is formulated as a nanoparticle for parenteral administration. Yet, in another embodiment preferred photosensitizer is 5,10,15,20-tetrakis(3-hydroxyphenyl)-porphyrin (mTHPP). The formulations can be used for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.
摘要翻译：提供了在储存中稳定的组合物以及用于临床用于光动力疗法的基于药物的纳米颗粒制剂的制备方法，其包括疏水性光敏剂，聚（乳酸 - 乙醇酸）酸和稳定剂。这些纳米颗粒药物制剂提供治疗有效量的用于肠胃外给药的光敏剂。特别地，四吡咯衍生物可以用作光敏剂，其功效和安全性通过这种纳米颗粒制剂增强。它还教导了在无菌条件下制备基于PLGA的纳米颗粒的方法。在本发明的一个优选实施方案中，基于PLGA的纳米颗粒具有小于500nm的平均粒度，光敏剂是temoporfin，5,10,15,20-四（3-羟基苯基） - 氯化物（mTHPC）。在另一个实施方案中，将光敏剂2,3-二羟基-5,10,15,20-四（3-羟基苯基） - 青霉素（mTHPD-OH）配制成用于肠胃外给药的纳米颗粒。然而，在另一个实施方案中，优选的光敏剂是5,10,15,20-四（3-羟基苯基） - 卟啉（mTHPP）。制剂可用于治疗过度和肿瘤的病症，炎症问题，更具体地用于靶向肿瘤细胞。

2. 发明申请

US20110142948A1 Nanoparticle Carrier Systems based on Human Serum Albumin for Photodynamic Therapy 有权
标题翻译：基于人血清白蛋白的纳米粒子载体系统用于光动力疗法
公开(公告)号：US20110142948A1
公开(公告)日：2011-06-16
申请号：US12941350
申请日：2010-11-08
申请人： Klaus Langer , Matthias Wacker , Beate Röder , Annegret Preuss , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
发明人： Klaus Langer , Matthias Wacker , Beate Röder , Annegret Preuss , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
IPC分类号： A61K31/409 , A61K9/00 , A61K9/14 , A61P35/00 , A61P17/00 , A61P27/02 , A61P13/00 , A61P19/02 , A61P29/00 , A61P31/04 , B82Y5/00
CPC分类号： A61K31/409 , A61K9/5169 , A61K41/0071
摘要： Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.
摘要翻译：提供了在储存中稳定的组合物以及用于光动力疗法的药物基纳米颗粒制剂的制备方法，其包括疏水性光敏剂，人血清白蛋白（HSA）和稳定剂。这些纳米颗粒制剂提供用于胃肠外给药的治疗有效量的光敏剂（PS）。特别地，四吡咯衍生物可以用作光敏剂，其功效和安全性通过这样的纳米颗粒制剂增强。还提供了在无菌条件下制备基于HSA的纳米颗粒的方法。在本发明的一个优选实施方案中，一种疏水性PS被配制成用于肠胃外给药的纳米颗粒。该制剂可用于治疗过度和肿瘤状况，炎症问题，更具体地涉及靶向肿瘤细胞。

3. 发明授权

US09211283B2 Nanoparticle carrier systems based on human serum albumin for photodynamic therapy 有权
标题翻译：基于人血清白蛋白的纳米粒子载体系统进行光动力学治疗
公开(公告)号：US09211283B2
公开(公告)日：2015-12-15
申请号：US12941350
申请日：2010-11-08
申请人： Klaus Langer , Matthias Wacker , Beate Röder , Annegret Preuss , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
发明人： Klaus Langer , Matthias Wacker , Beate Röder , Annegret Preuss , Volker Albrecht , Susanna Gräfe , Arno Wiehe , Hagen von Briesen , Karin Löw , Sylvia Wagner
IPC分类号： A61K9/51 , A61K31/409 , A61K33/20 , A61K41/00
CPC分类号： A61K31/409 , A61K9/5169 , A61K41/0071
摘要： Compositions, which are stable in storage, and a method of production of pharmaceutical based nanoparticulate formulations for photodynamic therapy comprising a hydrophobic photosensitizer, human serum albumin (HSA) and stabilizing agent are provided. These nanoparticulate formulations provide therapeutically effective amounts of photosensitizer (PS) for parenteral administration. In particular, tetrapyrrole derivatives can be used as photosensitizers whose efficacy and safety are enhanced by such nanoparticulate formulations. A method of preparing the HSA-based nanoparticles under sterile conditions is also provided. In one of the preferred embodiments of the present invention temoporfin, a hydrophobic PS, is formulated as a nanoparticle for parenteral administration. The formulations are useful for treating hyperplasic and neoplasic conditions, inflammatory problems, and more specifically to target tumor cells.
摘要翻译：提供了在储存中稳定的组合物以及用于光动力疗法的药物基纳米颗粒制剂的制备方法，其包括疏水性光敏剂，人血清白蛋白（HSA）和稳定剂。这些纳米颗粒制剂提供用于胃肠外给药的治疗有效量的光敏剂（PS）。特别地，四吡咯衍生物可以用作光敏剂，其功效和安全性通过这样的纳米颗粒制剂增强。还提供了在无菌条件下制备基于HSA的纳米颗粒的方法。在本发明的一个优选实施方案中，一种疏水性PS被配制成用于肠胃外给药的纳米颗粒。该制剂可用于治疗过度和肿瘤状况，炎症问题，更具体地涉及靶向肿瘤细胞。

4. 发明申请

US20120263739A1 ANTI INTEGRIN ANTIBODIES LINKED TO NANOPARTICLES LOADED WITH CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：与用化学药剂负载的纳米颗粒连接的抗体整合抗体
公开(公告)号：US20120263739A1
公开(公告)日：2012-10-18
申请号：US13509492
申请日：2010-10-21
申请人： Klaus Langer , Marion Anhorn , Joerg Kreuter , Florian Rothweiler , Hagen von Briesen , Sylvia Wagner , Martin Michaelis , Jindrich Cinatl
发明人： Klaus Langer , Marion Anhorn , Joerg Kreuter , Florian Rothweiler , Hagen von Briesen , Sylvia Wagner , Martin Michaelis , Jindrich Cinatl
IPC分类号： C07K19/00 , A61P35/00 , A61K39/44
CPC分类号： B82Y5/00 , A61K47/6935
摘要： The invention relates to anti-integrin antibodies which are covalently linked to nanoparticles, wherein these nanoparticles were prior loaded with chemotherapeutic/cytotoxic agents. The antibody-chemotherapeutic agent-nanoparticle conjugates according to the invention, especially wherein the antibody is MAb DI17E6 and the cytotoxic agent is doxorubicin show a significant increase of tumor cell toxicity.
摘要翻译：本发明涉及与纳米颗粒共价连接的抗整联蛋白抗体，其中这些纳米颗粒之前已经加载有化学治疗/细胞毒性剂。根据本发明的抗体 - 化学治疗剂 - 纳米颗粒缀合物，特别是其中抗体是MAb DI17E6，细胞毒性剂是多柔比星显示肿瘤细胞毒性的显着增加。

5. 发明申请

US20080095857A1 Carrier system in the form of protein-based nanoparticles for the cell-specific enrichment of pharmaceutically active substances 审中-公开
标题翻译：以蛋白质为基础的纳米颗粒形式的载体系统用于细胞特异性富集药物活性物质
公开(公告)号：US20080095857A1
公开(公告)日：2008-04-24
申请号：US10590601
申请日：2005-03-02
申请人： Sabine Balthasar , Hagen Von Briesen , Norbert Dinauer , Jorg Kreuter , Klaus Langer , Heidrun Wartlick
发明人： Sabine Balthasar , Hagen Von Briesen , Norbert Dinauer , Jorg Kreuter , Klaus Langer , Heidrun Wartlick
IPC分类号： A61K9/50 , A61K39/44 , A61K47/48
CPC分类号： A61K9/5169 , A61K9/5192 , A61K47/551 , A61K47/62 , A61K47/6849 , A61K47/6855 , A61K47/6931 , B82Y5/00
摘要： A carrier system in the form of protein-based nanoparticles for the cell-specific, intracellular enrichment of at least one pharmacologically active substance. The system has structures that are coupled by reactive groups. The structures enable a cell-specific attachment and cellular absorption of the nanoparticles.
摘要翻译：一种以蛋白质为基础的纳米颗粒形式的载体系统，用于细胞特异性，胞内富集至少一种药理学活性物质。该系统具有通过反应组耦合的结构。该结构使细胞特异性附着和纳米颗粒的细胞吸收。

6. 发明申请

US20110200555A1 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 有权
标题翻译：羟丙基淀粉和蛋白质的结合
公开(公告)号：US20110200555A1
公开(公告)日：2011-08-18
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： A61K38/21 , C07K14/565 , C07K14/535 , C12N9/96 , C07K14/81 , C07K14/755 , C07K1/107 , C12P21/00 , A61K38/19 , A61K38/48 , A61K38/57 , A61K38/37 , A61P25/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P17/00 , A61P7/04
CPC分类号： A61K47/61 , A61K47/50
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译：本文提供羟烷基淀粉和蛋白质的缀合物。缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。本文还提供了产生缀合物的方法和缀合物的用途。

7. 发明授权

US06526794B1 Plate for the spin drum of a centrifuge with spacers and process for its manufacture 有权
标题翻译：用于离心机的旋转鼓的板用间隔件和其制造方法
公开(公告)号：US06526794B1
公开(公告)日：2003-03-04
申请号：US09589219
申请日：2000-06-07
申请人： Klaus Langer , Klaus Pardess , Dittmar Holm , Albrecht Gruneisen
发明人： Klaus Langer , Klaus Pardess , Dittmar Holm , Albrecht Gruneisen
IPC分类号： B21B2706
CPC分类号： B04B7/14 , B21D22/16
摘要： The invention relates to a plate for a spin drum in a centrifuge. The plates contain integrally formed spacers. These plate spacers are comprised of plate material thickenings and are designed to maintain an intermediate space between two or more plates stacked on top of each other. To create this design, the invention includes a process for the manufacture of the plate as defined above. This process includes the step of roll-pressing a blank over a cone shaped mandrel provided with depressions conforming to the shapes of the spacers of the plate. During this rolling process, the spacers are formed when the depressions in the mandrel are filled with the material of the blank. To ease in the formation of these spacers, the blank may be heated prior to rolling.
摘要翻译：本发明涉及一种用于离心机中旋转鼓的板。这些板包含一体形成的间隔件。这些板间隔件由板材增厚构成，并被设计成保持彼此堆叠在两个或多个板之间的中间空间。为了创建这种设计，本发明包括如上所述制造板的方法。该方法包括在设置有符合板的间隔件的形状的凹部的圆锥形心轴上辊压坯料的步骤。在该轧制过程中，当心轴中的凹陷被坯料的材料填充时，形成间隔件。为了便于形成这些间隔物，坯料可以在轧制之前加热。

8. 发明授权

US4136457A Pin micrometer adapter 失效
标题翻译：针式千分尺适配器
公开(公告)号：US4136457A
公开(公告)日：1979-01-30
申请号：US885542
申请日：1978-03-13
申请人： Klaus Langer
发明人： Klaus Langer
IPC分类号： G01B3/00 , G01B3/18
CPC分类号： G01B3/18 , G01B3/002
摘要： An adapter for a pin-anvil micrometer, such as used to measure wall thicknesses of small tubing. The jaws of pin micrometers can normally hold a pin of 1/16" minimum diameter while flexing approximately 0.001" and can therefore be used to measure, for example, wall thicknesses of tubing having a 1/16" diameter bore. The range adapter is an anvil extender that snugly fits over the micrometer jaws and extends the effective jaw length to near the spindle center line. Anvil pins of approximately 0.015" may then be used without flexing and the micrometer can then accurately measure distances from 1/64" holes or slots.
摘要翻译：用于针砧千分尺的适配器，例如用于测量小管道的壁厚。针微米的钳口可以正常地保持1/16“最小直径的销，同时弯曲约0.001”，因此可用于测量例如具有1/16“直径孔的管道的壁厚。范围适配器是一个砧座延伸器，紧贴在千分尺钳口上，并将有效钳口长度延伸到主轴中心线附近。然后可以在不弯曲的情况下使用约0.015“的砧座销，并且千分尺可以精确地测量1/64”孔或狭槽的距离。

9. 发明授权

US08017739B2 Conjugates of hydroxyalkyl starch and a protein 失效
标题翻译：羟烷基淀粉和蛋白质的共轭物
公开(公告)号：US08017739B2
公开(公告)日：2011-09-13
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： C12N9/00 , C12N9/96 , A61K31/715 , A61K38/43 , A61K47/36 , A61K38/16
CPC分类号： A61K47/61 , A61K47/50
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译：本文提供羟烷基淀粉和蛋白质的缀合物。缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。本文还提供了产生缀合物的方法和缀合物的用途。

10. 发明申请

US20100028446A1 TRANSPORT OF DRUGS VIA THE BLOOD-BRAIN BARRIER BY MEANS OF APOLIPOPROTEINS 审中-公开
标题翻译：通过APOLIPOPROTEINS通过血脑屏障的药物运输
公开(公告)号：US20100028446A1
公开(公告)日：2010-02-04
申请号：US12449408
申请日：2008-02-01
申请人： Jörg Kreuter , Klaus Langer , Sebastian Dreis , Telli Hekmatara
发明人： Jörg Kreuter , Klaus Langer , Sebastian Dreis , Telli Hekmatara
IPC分类号： A61K9/14 , A61K38/16 , A61K38/43 , A61K39/395
CPC分类号： A61K9/0019 , A61K47/42
摘要： Combination preparations comprising at least one apolipoprotein as one component, and a medicinal agent to be transported via the blood-brain barrier to the central nervous system as a further component. The components are administered simultaneously, separately or sequentially. A method for administering a medicinal agent to the central nervous system is also provided.
摘要翻译：包含至少一种载脂蛋白作为一种组分的组合制剂和通过血脑屏障转运至中枢神经系统的药剂作为另外的组分。组分同时，分别或顺序施用。还提供了向中枢神经系统施用药剂的方法。

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