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1. 外观设计

USD329862S Combined instant camera and printer 失效
公开(公告)号：USD329862S
公开(公告)日：1992-09-29
申请号：US541295
申请日：1990-06-20
申请人： Kenji Watanabe , Takanobu Kameda , Hideto Yokota , Tetsuo Yamaguchi , Tomoyuki Yamaguchi , Yuichiro Taniguchi , Atsuko Yamaguchi
设计人： Kenji Watanabe , Takanobu Kameda , Hideto Yokota , Tetsuo Yamaguchi , Tomoyuki Yamaguchi , Yuichiro Taniguchi , Atsuko Yamaguchi

3. 外观设计

USD331018S Combined clock, timer and schedule manager 失效
公开(公告)号：USD331018S
公开(公告)日：1992-11-17
申请号：US540808
申请日：1990-06-20
申请人： Kenji Watanabe , Takanobu Kameda , Hideto Yokota , Tetsuo Yamaguchi , Tomoyuki Yamaguchi , Yuichiro Taniguchi , Atsuko Yamaguchi
设计人： Kenji Watanabe , Takanobu Kameda , Hideto Yokota , Tetsuo Yamaguchi , Tomoyuki Yamaguchi , Yuichiro Taniguchi , Atsuko Yamaguchi

4. 发明申请

US20130028890A1 METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION 审中-公开
标题翻译：使用作为指示剂的脂肪酸受体4的表达来检测调节性T细胞的方法，使用检测方法治疗疾病的方法，用于免疫的药物组合物和使用组合物治疗疾病的方法
公开(公告)号：US20130028890A1
公开(公告)日：2013-01-31
申请号：US13617027
申请日：2012-09-14
申请人： Shimon Sakaguchi , Keiji Hirota , Tomoyuki Yamaguchi
发明人： Shimon Sakaguchi , Keiji Hirota , Tomoyuki Yamaguchi
IPC分类号： A61K39/395 , A61P37/04 , A61P35/00
CPC分类号： C07K16/28 , A61K2039/505 , G01N33/56972
摘要： An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce the number of Treg cells in vivo and effectively express the immune response of activated T cells.In the method of the present invention, Treg cells are detected from test cells containing (i) regulatory T cells and (ii) at least one type of cell selected from the group consisting of naive T cells and activated T cells, wherein expressions of folate receptor 4 on the surfaces of cells are measured and Treg cells are detected using the expressions as an indicator. The present invention uses anti-folate receptor 4 antibody or folate receptor 4-binding fragment as an active ingredient contained in a pharmaceutical composition for immunostimulation.
摘要翻译：本发明的目的是提供一种在活体状态下区分Treg细胞和活化的T细胞的技术。本发明的另一个目的是提供用于免疫刺激的药物组合物，其可以减少体内Treg细胞的数量并有效表达活化的T细胞的免疫应答。在本发明的方法中，从含有（i）调节性T细胞的试验细胞和（ii）至少一种选自初始T细胞和活化的T细胞的细胞中检测Treg细胞，其中叶酸的表达测定细胞表面的受体4，使用表达作为指标检测Treg细胞。本发明使用抗叶酸受体4抗体或叶酸受体4结合片段作为用于免疫刺激的药物组合物中含有的活性成分。

5. 发明申请

US20100122360A1 Organ regeneration method utilizing blastocyst complementation 审中-公开
标题翻译：器官再生方法利用囊胚互补
公开(公告)号：US20100122360A1
公开(公告)日：2010-05-13
申请号：US12583559
申请日：2009-08-21
申请人： Hiromitsu Nakauchi , Toshihiro Kobayashi , Younsu Lee , Joichi Usui , Tomoyuki Yamaguchi , Sanae Hamanaka
发明人： Hiromitsu Nakauchi , Toshihiro Kobayashi , Younsu Lee , Joichi Usui , Tomoyuki Yamaguchi , Sanae Hamanaka
IPC分类号： A01K67/00 , C12N5/07 , A01N1/02
CPC分类号： A01K67/0271 , A01K2207/20 , A61L27/3834
摘要： An object of the present invention is to produce a mammalian organ having a complicated cellular composition composed of multiple kinds of cells, such as kidney, pancreas, thymus and hair, in the living body of a non-human animal. The inventors of the present invention applied the chimeric animal assay described above, to a novel solid organ production method. More specifically, the inventors has shown that a model mouse which is deficient of kidney, pancreas, thymus or hair due to the dysfunction of the metanephric mesenchyme that is differentiated into most of an adult kidney, is rescued by blastocyst complementation by the chimeric animal assay, and whereby a kidney, a pancreas, thymus or hair can be newly produced.
摘要翻译：本发明的目的是在非人动物的活体中制备由多种细胞如肾，胰腺，胸腺和毛发组成的细胞组成复杂的哺乳动物器官。本发明的发明人将上述嵌合动物实验应用于新型的固体器官生产方法。更具体地，本发明人已经表明，由分化成大部分成年肾脏的间质间质的功能障碍引起的肾，胰腺，胸腺或毛发缺陷的模型小鼠通过嵌合动物试验通过囊胚互补来拯救，由此可以新生产肾，胰腺，胸腺或毛发。

6. 发明申请

US20070062919A1 Laser processing method and processing device 失效
标题翻译：激光加工方法及加工装置
公开(公告)号：US20070062919A1
公开(公告)日：2007-03-22
申请号：US11598708
申请日：2006-11-14
申请人： Shiro Hamada , Jiro Yamamoto , Tomoyuki Yamaguchi
发明人： Shiro Hamada , Jiro Yamamoto , Tomoyuki Yamaguchi
IPC分类号： B23K26/38 , B23K26/06
CPC分类号： B23K26/0652 , B23K26/0622 , B23K26/0626 , B23K26/0648 , B23K26/066 , B23K26/0732 , B23K26/082 , B23K26/0853 , B23K26/364 , B23K26/382 , B23K26/40 , B23K26/60 , B23K2101/40 , B23K2103/42 , B23K2103/50
摘要： Laser beam is irradiated to a surface of a processing target after reforming a cross section of the laser beam with a mask having a pierced hole by concentrating the laser beam passing through the pierced hole by a lens to form an image of the pierced hole of the mask on the surface of the processing target. The laser beam passing through the lens is scanned to move an irradiating position of the laser beam on the surface of the processing target, and the image of the pierced hole of the mask is formed on the surface of the processing target during the scanning for processing the processing target. A high quality laser process can be carried out.
摘要翻译：在通过使透镜穿过穿孔的激光束聚焦以形成透镜的穿孔的图像之后，通过具有穿孔的掩模对激光束的横截面进行重整后，将激光束照射到处理对象的表面掩模在加工对象的表面上。扫描通过透镜的激光束，将激光束的照射位置移动到处理对象物的表面，并且在扫描处理期间将掩模的穿孔的图像形成在处理对象的表面上处理目标。可以进行高质量的激光加工。

7. 发明授权

US06446146B1 Line terminating device 有权
标题翻译：线路终端设备
公开(公告)号：US06446146B1
公开(公告)日：2002-09-03
申请号：US09296841
申请日：1999-04-22
申请人： Tomoyuki Yamaguchi , Jyoei Kamoi , Iwao Tada
发明人： Tomoyuki Yamaguchi , Jyoei Kamoi , Iwao Tada
IPC分类号： G06F1300
CPC分类号： H04L49/606 , G06F13/4086 , H04J3/0685 , H04J2203/0089 , H04L12/5601 , H04L49/3081 , H04L2012/5674
摘要： To reduce a scale of the circuit, a number of the external terminals, processing steps in developing a firmware, and a scale of the firmware, a line terminator provided in a device for terminating SONET/SDH lines, each having a different line speed, terminates plural lines, each having a different line speed, and includes a clock generator generating a clock corresponding to each line speed, a line switching circuit for specifying one of the plural lines, a selector for outputting data of one of the plural lines, which is specified by the line switching circuit, and a common processing circuit for processing data of the one line output from the selector, according to a clock corresponding to the line speed generated in the clock generator.
摘要翻译：为了减少电路的规模，多个外部终端，开发固件的处理步骤和固件的规模，设置在用于终止SONET / SDH线路的设备中的线路终端器，每个线路终端器具有不同的线路速度，终止多行，每行具有不同的线速度，并且包括产生与每行线速度相对应的时钟的时钟发生器，用于指定多条线之一的线切换电路，用于输出多条线之一的数据的选择器，由线路切换电路指定，以及公共处理电路，用于根据对应于在时钟发生器中产生的线路速度的时钟处理从选择器输出的一行的数据。

8. 发明授权

US06212186B1 Cell bandwidth control apparatus 失效
标题翻译：单元带宽控制装置
公开(公告)号：US06212186B1
公开(公告)日：2001-04-03
申请号：US08979431
申请日：1997-11-26
申请人： Iwao Tada , Jyoei Kamoi , Tomoyuki Yamaguchi , Naoki Aihara
发明人： Iwao Tada , Jyoei Kamoi , Tomoyuki Yamaguchi , Naoki Aihara
IPC分类号： H04L1256
CPC分类号： H04L49/3081 , H04L2012/5636 , H04Q11/0478
摘要： The invention concerns an ATM exchange, and is directed in particular to the provision of a cell bandwidth control apparatus for performing bandwidth control for ATM cells sent from the ATM exchange onto the line side. The cell bandwidth control apparatus includes forced empty cell inserting means for forcibly inserting empty cells in a highway connected to an ATM switch. The forced empty cell inserting means inserts forced empty cells in an outgoing highway leading from the ATM switch to a line adapter and thereby limits the line bandwidth of the outgoing highway to within the bandwidth of the line accommodated in the line adapter.
摘要翻译：本发明涉及ATM交换机，特别涉及提供一种用于对从ATM交换机发送到线路侧的ATM信元进行带宽控制的小区带宽控制装置。小区带宽控制装置包括用于在连接到ATM交换机的高速公路中强制插入空单元的强制空单元插入装置。强制空单元插入装置将从ATM交换机引出的输出高速公路中的强制空单元插入线路适配器，从而将输出高速公路的线路带宽限制在线路适配器中线路的带宽内。

9. 发明申请

US20060077898A1 Transmission base flow control device 有权
标题翻译：变速箱底座流量控制装置
公开(公告)号：US20060077898A1
公开(公告)日：2006-04-13
申请号：US11284669
申请日：2005-11-22
申请人： Tomoyuki Yamaguchi , Shinji Wakasa , Yasuyuki Mitsumori
发明人： Tomoyuki Yamaguchi , Shinji Wakasa , Yasuyuki Mitsumori
IPC分类号： H04J1/16
CPC分类号： H04L47/39 , H04L45/22 , H04L47/10 , H04L47/18
摘要： A transmission base flow control device performs data transmission/reception based on a packet form between a transmission device and a reception device having a redundant structure by utilizing a credit value to carry out a flow control of a credit base on a flow basis. The transmission base flow control device includes: a first credit counter, which is shared by an active system and a preparatory system of the reception device, for managing the credit value of the active system; a second credit counter and a third credit counter for counting the credit values for each system of the active system and the preparatory system of the reception device; a differential counter for holding a difference between the credit value counted by the second credit counter and the credit value counted by the third credit counter; and a control unit for matching, according to the difference held by the differential counter, the credit values of the first credit counter and the second credit counter or the credit values of the first credit counter and the third credit counter with a credit value corresponding to the reception device of a new active system after switching the system of the reception device.
摘要翻译：发送基站流量控制装置通过利用信用值在发送装置与具有冗余结构的接收装置之间基于分组形式进行数据发送/接收，以流量为基础进行信用卡的流量控制。传输基本流量控制装置包括：由活动系统共享的第一信用计数器和接收装置的预备系统，用于管理活动系统的信用值; 第二信用计数器和用于对活动系统的每个系统和接收装置的预备系统的信用值进行计数的第三信用计数器; 用于保存由第二信用计数器计数的信用值与由第三信用计数器计数的信用值之间的差的差分计数器; 以及控制单元，用于根据差分计数器所保持的差异，匹配第一信用计数器和第二信用计数器的信用值或第一信用计数器和第三信用计数器的信用值，其信用值对应于在切换接收设备的系统之后的新的主动系统的接收设备。

10. 发明授权

US06275472B1 Method and apparatus for achieving pass control of transmission cells 失效
标题翻译：用于实现传输单元的通过控制的方法和装置
公开(公告)号：US06275472B1
公开(公告)日：2001-08-14
申请号：US09016457
申请日：1998-01-30
申请人： Tomoyuki Yamaguchi , Naoki Aihara
发明人： Tomoyuki Yamaguchi , Naoki Aihara
IPC分类号： H04L1226
CPC分类号： H04L43/0847 , H04L43/16 , H04L49/205 , H04L49/3009 , H04L49/552 , H04L69/40 , H04L2012/5647 , H04L2012/5673 , H04L2012/5674
摘要： An apparatus for pass control of transmission cells for preventing cells having headers including a specific pattern of multi-bit error from being erroneously transmitted. The pass control apparatus is operated by a method comprising (i) a step of monitoring a communication quality of each received frame; (ii) a step of temporarily buffering one monitored frame's worth of cells for each frame; (iii) a step of determining whether or not the communication quality of the monitored frame exceeds a predetermined threshold level; and (iv) a step of erasing all of the cells including one-bit error and multi-bit error in their headers from one frame's worth of buffered cells when the communication quality deteriorates exceeding the predetermined threshold level, while passing the buffered cells as they are when it does not exceed the threshold level.
摘要翻译：一种传输单元的通过控制装置，用于防止具有包含特定多比特错误模式的头部的小区被错误地发送。通过控制装置通过以下方法操作：（i）监视每个接收帧的通信质量的步骤; （ii）为每个帧临时缓冲一个被监视帧的小区的步骤; （iii）确定被监视帧的通信质量是否超过预定阈值水平的步骤; 以及（iv）当通信质量恶化超过预定阈值水平时，同时通过缓冲的小区，从一帧的缓冲单元的头部中删除包括一位错误和多位错误的所有单元的步骤，当它不超过阈值水平时。

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