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1. 发明申请

US20060045950A1 Mineral preparation, raw material for the preparation, and methods for producing the mineral preparation and the raw material 审中-公开
标题翻译：矿物制剂，制备原料，以及矿物制剂和原料的制备方法
公开(公告)号：US20060045950A1
公开(公告)日：2006-03-02
申请号：US11066347
申请日：2005-02-25
申请人： Kenichi Inoue , Shinsaku Takaoka
发明人： Kenichi Inoue , Shinsaku Takaoka
IPC分类号： C12H1/04
CPC分类号： A61K36/185 , A61K33/00 , A61K33/06 , A61K2300/00
摘要： A raw material for a mineral preparation of the present invention can be obtained by calcining defatted sesame, and a mineral preparation containing minerals that can be absorbed into the body effectively can be obtained by recovering minerals from this raw material.
摘要翻译：本发明的矿物质制剂的原料可以通过煅烧脱脂芝麻得到，通过从该原料中回收矿物质，能够有效地吸收到体内的能够吸收的矿物质的矿物质制剂。

2. 发明授权

US07435565B2 Bacillus natto culture extract 有权
标题翻译：纳豆芽孢杆菌培养提取物
公开(公告)号：US07435565B2
公开(公告)日：2008-10-14
申请号：US11389481
申请日：2006-03-27
申请人： Shinsaku Takaoka
发明人： Shinsaku Takaoka
IPC分类号： C12P7/66
CPC分类号： C12N9/12 , C12P7/66
摘要： A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μ/g or less of vitamin K2/g dry weight is obtained.
摘要翻译：用壳聚糖处理纳豆芽孢杆菌培养物，然后过滤，浓缩并干燥。根据该方法，得到含有纳豆激酶和1μg/ g以下维生素K2 / g干重的纳豆芽孢杆菌培养提取物。

3. 发明申请

US20060141095A1 Method for producing foods from culture of Bacillus natto 有权
标题翻译：从纳豆芽孢杆菌培养物生产食物的方法
公开(公告)号：US20060141095A1
公开(公告)日：2006-06-29
申请号：US11296942
申请日：2005-12-08
申请人： Shinsaku Takaoka , Masaharu Yoshida
发明人： Shinsaku Takaoka , Masaharu Yoshida
IPC分类号： A23L1/10 , C12P7/66 , C12N1/20
CPC分类号： A23L33/15
摘要： The present invention provides a method for producing a food product containing nattokinase but containing little or none vitamin K2, comprising treating a Bacillus natto culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant (excluding chitosan). As the inorganic coagulant, calcium chloride or poly aluminum chloride is preferable, and their mixtures with a phosphorus coagulant are also preferably used. As the cationic polymer coagulant, cationic polysaccharides, hexamethylenediamine/epichlorohydrin polycondensates or dimethylamine/epichlorohydrin polycondensates are preferably used, and their mixtures with a polyacrylate are also preferably used.
摘要翻译：本发明提供一种生产含有纳豆激酶但含有很少或不含维生素K2的食品的方法，包括用至少一种选自无机凝结剂和阳离子聚合物凝结剂的凝结剂处理纳豆芽孢杆菌培养物或培养上清液不含壳聚糖）。作为无机凝结剂，优选使用氯化钙或聚氯化铝，也优选使用与磷混凝剂的混合物。作为阳离子聚合物凝结剂，优选使用阳离子多糖，六亚甲基二胺/表氯醇缩聚物或二甲胺/表氯醇缩聚物，并且也优选使用它们与聚丙烯酸酯的混合物。

4. 发明授权

US07014851B2 Process for inhibiting platelet aggregation 有权
标题翻译：抑制血小板聚集的方法
公开(公告)号：US07014851B2
公开(公告)日：2006-03-21
申请号：US10932806
申请日：2004-09-02
申请人： Hiroyoshi Moriyama , Shinsaku Takaoka
发明人： Hiroyoshi Moriyama , Shinsaku Takaoka
IPC分类号： A61K38/45 , A61K38/48 , A23L1/30
CPC分类号： A61K38/45 , A23L33/135 , A23V2002/00 , A23V2250/206
摘要： An object of the present invention is to provide a platelet aggregation inhibitor without side effects and a supplement food effective for inhibiting platelet aggregation. The platelet aggregation inhibitor has nattokinase as an active ingredient and has Bacillus natto culture extract, containing a high proportion of nattokinase containing 1 μg/g or less of vitamin K2 on a dry weight basis, as an active ingredient. The supplement food effective for inhibiting platelet aggregation has nattokinase as an active ingredient and has Bacillus natto culture extract, containing a high proportion of nattokinase containing 1 μg/g or less of vitamin K2 on a dry weight basis, as an active ingredient.
摘要翻译：本发明的目的是提供一种没有副作用的血小板聚集抑制剂和有效抑制血小板聚集的补充食品。血小板聚集抑制剂具有纳豆激酶作为活性成分，并且具有纳豆芽孢杆菌培养物提取物，其以干重为基准，含有高比例的含有1ug / g或更少维生素K 2 N 2的纳豆激酶作为活性成分成分。抑制血小板聚集有效的补充食品具有纳豆激酶作为活性成分，并具有纳豆芽孢杆菌培养物提取物，其含有高比例的含有1ug / g或更少维生素K 2 N 2重量的纳豆激酶，作为活性成分。

5. 发明授权

US07018630B2 Bacillus natto culture extract 有权
公开(公告)号：US07018630B2
公开(公告)日：2006-03-28
申请号：US10761430
申请日：2004-01-22
申请人： Shinsaku Takaoka
发明人： Shinsaku Takaoka
IPC分类号： C12P7/66 , A23K1/28 , A61K38/45
CPC分类号： C12P7/66 , C12P1/04 , C12R1/07
摘要： A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μg or less of vitamin K2/g dry weight is obtained.

6. 发明授权

US06730504B2 Bacillus natto culture extract 有权
标题翻译：纳豆芽孢杆菌培养提取物
公开(公告)号：US06730504B2
公开(公告)日：2004-05-04
申请号：US10060658
申请日：2002-01-30
申请人： Shinsaku Takaoka
发明人： Shinsaku Takaoka
IPC分类号： A23L128
CPC分类号： C12P7/66 , C12P1/04 , C12R1/07
摘要： A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 &mgr;g or less of vitamin K2/g dry weight is obtained.
摘要翻译：用壳聚糖处理纳豆芽孢杆菌培养物，然后过滤，浓缩并干燥。根据该方法，得到含有纳豆激酶的纳豆芽孢杆菌培养物提取物，1kg以下的维生素K2 / g干重。

7. 发明授权

US08603552B2 Method for producing foods from culture of Bacillus natto 有权
标题翻译：从纳豆芽孢杆菌培养物生产食物的方法
公开(公告)号：US08603552B2
公开(公告)日：2013-12-10
申请号：US11296942
申请日：2005-12-08
申请人： Shinsaku Takaoka , Masaharu Yoshida
发明人： Shinsaku Takaoka , Masaharu Yoshida
IPC分类号： A23L1/10
CPC分类号： A23L33/15
摘要： A method for producing a food product containing nattokinase but containing little or none vitamin K2, comprising treating a Bacillus natto culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant (excluding chitosan). As the inorganic coagulant, calcium chloride or poly aluminum chloride is preferable, and their mixtures with a phosphorus coagulant are also preferably used. As the cationic polymer coagulant, cationic polysaccharides, hexamethylenediamine/ephichlorohydrin polycondensates or dimethylamine/epichlorohydrin polycondensates are preferably used, and their mixtures with a polyacrylate are also preferably used.
摘要翻译：一种含有纳豆激酶但含有很少或不含有维生素K2的食品的方法，包括用至少一种选自无机凝结剂和阳离子聚合物凝结剂（不包括壳聚糖）的凝结剂处理纳豆芽孢杆菌培养物或培养上清液。作为无机凝结剂，优选使用氯化钙或聚氯化铝，也优选使用与磷混凝剂的混合物。作为阳离子聚合物凝结剂，优选使用阳离子多糖，六亚甲基二胺/对氯醇缩聚物或二甲胺/表氯醇缩聚物，并且优选使用它们与聚丙烯酸酯的混合物。

8. 发明授权

US08114642B2 Method for producing vitamin K2 from culture of Bacillus natto 有权
标题翻译：从纳豆芽孢杆菌培养物生产维生素K2的方法
公开(公告)号：US08114642B2
公开(公告)日：2012-02-14
申请号：US11823769
申请日：2007-06-28
申请人： Shinsaku Takaoka , Masaharu Yoshida
发明人： Shinsaku Takaoka , Masaharu Yoshida
IPC分类号： C12P7/66
CPC分类号： A23L33/15
摘要： A method for producing vitamin K2 comprising: culturing Bacillus natto in a liquid medium to obtain a Bacillus natto culture or culture supernatant thereof, wherein the culture or culture supernatant contains vitamin K2; treating the culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant, with the proviso that the coagulant excludes chitosan, so as to obtain a treated coagulant to which vitamin K2 is absorbed or aggregated; separating the treated coagulant from the treated culture or culture supernatant, and obtaining an oily product that contains vitamin K2 from the separated coagulant.
摘要翻译：一种生产维生素K2的方法，包括：在液体培养基中培养纳豆芽孢杆菌以获得纳豆芽孢杆菌培养物或其培养物上清液，其中培养物或培养物上清液含有维生素K2; 用选自无机凝结剂和阳离子聚合物凝结剂的至少一种凝结剂处理培养物或培养物上清液，条件是凝结剂不含壳聚糖，以获得维生素K2被吸收或聚集的处理过的凝结剂 ; 从经处理的培养物或培养上清液中分离经处理的凝结剂，从分离的凝结剂中获得含有维生素K2的油状产物。

9. 发明申请

US20090136648A1 PLATELET AGGREGATION INHIBITOR AND HEALTH FOOD EFFECTIVE IN INHIBITING PLATELET AGGREGATION 审中-公开
标题翻译： PLATELET AGIGIGATION抑制剂和健康食品有效抑制血小板聚集
公开(公告)号：US20090136648A1
公开(公告)日：2009-05-28
申请号：US12066792
申请日：2005-10-17
申请人： Hiroyoshi Moriyama , Katsuya Satoh , Shinsaku Takaoka
发明人： Hiroyoshi Moriyama , Katsuya Satoh , Shinsaku Takaoka
IPC分类号： A61K38/00 , A61P7/02 , A23L1/30
CPC分类号： A61K38/02 , A23L33/10 , A23L33/17
摘要： It is intended to provide a platelet aggregation inhibitor which can be easily processed into a pharmaceutical preparation and can be stored for a long time, and a health food effective in inhibiting platelet aggregation. The platelet aggregation inhibitor comprises, as an active ingredient, a degradation product obtained by reacting fibrin with nattokinase, wherein the degradation product has a molecular weight of 10,000 daltons or less. The fibrin is obtained by reacting fibrinogen with thrombin.
摘要翻译：本发明提供一种可以容易地加工成药物制剂并长时间储存的血小板聚集抑制剂，以及有效抑制血小板聚集的保健食品。血小板聚集抑制剂含有通过使纤维蛋白与纳豆激酶反应而得到的降解产物作为活性成分，其中，降解产物的分子量为10,000道尔顿以下。纤维蛋白是通过纤维蛋白原与凝血酶反应获得的。

10. 发明申请

US20070254347A1 Method for producing vitamin K2 from culture of Bacillus natto 有权
标题翻译：从纳豆芽孢杆菌培养物生产维生素K2的方法
公开(公告)号：US20070254347A1
公开(公告)日：2007-11-01
申请号：US11823769
申请日：2007-06-28
申请人： Shinsaku Takaoka , Masaharu Yoshida
发明人： Shinsaku Takaoka , Masaharu Yoshida
IPC分类号： C12P7/66
CPC分类号： A23L33/15
摘要： A method for producing vitamin K2 comprising: culturing Bacillus natto in a liquid medium to obtain a Bacillus natto culture or culture supernatant thereof, wherein the culture or culture supernatant contains vitamin K2; treating the culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant, with the proviso that the coagulant excludes chitosan, so as to obtain a treated coagulant to which vitamin K2 is absorbed or aggregated; separating the treated coagulant from the treated culture or culture supernatant, and obtaining an oily product that contains vitamin K2 from the separated coagulant.
摘要翻译：一种生产维生素K2的方法，包括：在液体培养基中培养纳豆芽孢杆菌以获得纳豆芽孢杆菌培养物或其培养物上清液，其中培养物或培养物上清液含有维生素K2; 用选自无机凝结剂和阳离子聚合物凝结剂的至少一种凝结剂处理培养物或培养物上清液，条件是凝结剂不含壳聚糖，以获得维生素K2被吸收或聚集的处理过的凝结剂 ; 从经处理的培养物或培养上清液中分离经处理的凝结剂，从分离的凝结剂中获得含有维生素K2的油状产物。

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