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1. 发明授权

US4327685A Air-fuel intake system for internal combustion engines 失效
标题翻译：内燃机空燃系统
公开(公告)号：US4327685A
公开(公告)日：1982-05-04
申请号：US102899
申请日：1979-12-12
申请人： Kenichi Akutagawa , Hitoshi Yoshida , Tadashi Hattori , Akira Takata , Tamotsu Fukuda
发明人： Kenichi Akutagawa , Hitoshi Yoshida , Tadashi Hattori , Akira Takata , Tamotsu Fukuda
IPC分类号： C22F1/043 , C22C21/00 , C22F1/00 , F02M9/127 , F02M69/04 , F02M69/46 , F02D9/12
CPC分类号： F02M69/46 , F02M69/043 , F02M9/127
摘要： An intake system for internal combustion engines comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposed relation with the injection valve and a hollow valve body mounted in the intake pipe for movement in the axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The stationary valve body includes a frusto-conical portion and a cylindrical portion, of which lower edge is in the form of sinusoidal wave to cooperate with the hollow valve body in producing the valve opening of gradually increasing opening area.
摘要翻译：用于内燃机的进气系统包括安装在燃料喷射阀和进气歧管之间的进气管中的节流系统，所述节流系统包括固定在进气管中的与喷射阀相对的静止阀体和中空阀主体安装在进气管中，用于沿进气管的轴向移动。中空阀体具有围绕固定阀体的向下收敛的内壁表面，以在其间限定可变开口面积的阀开口。固定阀体包括截头圆锥形部分和圆柱形部分，其下边缘为正弦波形状，以与中空阀体协作以产生逐渐增加的开口面积的阀门开口。

2. 发明授权

US4419972A Air-fuel intake system for an internal combustion engine 失效
标题翻译：用于内燃机的空气燃料进气系统
公开(公告)号：US4419972A
公开(公告)日：1983-12-13
申请号：US75683
申请日：1979-09-13
申请人： Tadashi Hattori , Hitoshi Yoshida , Keichi Akutagawa , Akira Takata , Tamotsu Fukuda
发明人： Tadashi Hattori , Hitoshi Yoshida , Keichi Akutagawa , Akira Takata , Tamotsu Fukuda
IPC分类号： F02M9/127 , F02D9/12
CPC分类号： F02M9/1275
摘要： An intake system for an internal combustion engine comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposition to the injection valve and a hollow valve body mounted in the intake pipe movably in an axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The axial movement of the hollow valve body causes the change in the opening area of the valve opening to control an amount of air-fuel mixture charged therethrough into the engine.
摘要翻译：一种用于内燃机的进气系统包括安装在燃料喷射阀和进气歧管之间的进气管中的节流系统，所述节流系统包括固定在进气管中的与喷射阀相对的静止阀体和中空阀主体安装在进气管中，沿进气管的轴向可移动。中空阀体具有围绕固定阀体的向下收敛的内壁表面，以在其间限定可变开口面积的阀开口。中空阀体的轴向运动导致阀开口的开口面积的变化来控制通过其进入发动机的空气燃料混合物的量。

3. 发明授权

US4345569A Intake system for internal combustion engines 失效
标题翻译：内燃机进气系统
公开(公告)号：US4345569A
公开(公告)日：1982-08-24
申请号：US107638
申请日：1979-12-27
申请人： Tadashi Hattori , Siniti Mukainakano , Hitoshi Yoshida
发明人： Tadashi Hattori , Siniti Mukainakano , Hitoshi Yoshida
IPC分类号： F02M29/04 , F02M31/12 , F02M31/135 , F02M31/18 , F02M69/04 , F02M31/00
CPC分类号： F02M29/04 , F02M31/135 , F02M31/18 , F02M69/04 , Y02T10/126
摘要： An intake system for an internal combustion engine comprises an intake pipe structure connected through an intake manifold to cylinders of the engine, a fuel injection valve for injecting fuel into the intake pipe structure to form an air-fuel mixture, a throttle valve disposed in the intake pipe structure, and a baffle plate disposed in the intake pipe structure between the fuel injection valve and the throttle valve for promoting fuel atomization. The baffle plate has a surface which faces the fuel injection valve with a predetermined distance from the latter in order that the fuel injected from the fuel injection valve may impinge on the surface, and an outer edge spaced from an inner wall surface of the intake pipe structure to define a mixture passage therebetween. The baffle plate is made of a ceramic material having positive resistance-temperature characteristic and definite Curie point and adapted to be heated when electric current is applied thereto, so that it may be maintained at a temperature appropriate to cause preferable atomization of the fuel impinged on the baffle plate surface.
摘要翻译：用于内燃机的进气系统包括通过进气歧管连接到发动机的气缸的进气管结构，用于将燃料喷射到进气管结构中以形成空气燃料混合物的燃料喷射阀，设置在该内燃机中的节流阀进气管结构，以及设置在燃料喷射阀和节流阀之间的进气管结构中的用于促进燃料雾化的挡板。挡板具有面向燃料喷射阀的表面，距离燃料喷射阀具有预定距离，以便从燃料喷射阀喷射的燃料可能撞击在表面上，并且与进气管的内壁表面间隔开的外边缘结构以在其间限定混合通道。挡板由具有正电阻温度特性和确定居里点的陶瓷材料制成，适用于在施加电流时被加热的陶瓷材料，从而可将其保持在适合于使撞击的燃料优选雾化的温度挡板表面。

4. 发明授权

US08124406B2 Method for modifying chromosomes 有权
标题翻译：染色体修饰方法
公开(公告)号：US08124406B2
公开(公告)日：2012-02-28
申请号：US12979823
申请日：2010-12-28
申请人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
发明人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
IPC分类号： C12N5/00 , C12N5/02 , C12N15/01 , C12N15/64 , C07H21/04
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N15/90 , C12N15/907 , C12N2800/30
摘要： The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要翻译：本发明涉及一种生产修饰的外源染色体或其片段的方法，其包括以下步骤：（a）制备包含外来染色体或其片段的微细胞并通过与所述微细胞融合将所述外源染色体或片段转移到具有高同源重组效率的细胞中; （b）在具有高同源重组效率的所述细胞中，通过同源重组将靶向载体插入所述外源染色体或其片段的所需位点和/或染色体的所需位点，衍生自具有高同源重组效率的所述细胞，从而标记所述期望的位点; 和（c）在具有高同源重组效率的所述细胞中，导致在所述外源染色体或其片段的标记位点发生缺失和/或易位。

5. 发明授权

US08110671B2 Isolated human chromosome 14 fragment encoding immunoglobulin genes 有权
标题翻译：分离的人染色体14片段编码免疫球蛋白基因
公开(公告)号：US08110671B2
公开(公告)日：2012-02-07
申请号：US11797904
申请日：2007-05-08
申请人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
发明人： Kazuma Tomizuka , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida
IPC分类号： C07H21/04
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C07K16/00 , C07K16/18 , C07K2317/21 , C12N15/8509 , C12N15/90 , C12N2517/02 , C12N2800/30
摘要： The specification relates to a method for producing a chimeric non-human animal, which comprises preparing a microcell containing a foreign chromosome(s) or a fragment(s) thereof and transferring the foreign chromosome(s) or fragment(s) thereof into a pluripotent cell by fusion with the microcell; a chimeric non-human animal which can be produced by the above method and its progeny; tissues and cells derived therefrom; and a method for using the same. Further, a pluripotent cell containing a foreign chromosome(s) or a fragment(s) thereof, a method for producing the same, and a method for using the same are also provided. Moreover, a pluripotent cell in which at least two endogenous genes are disrupted, and a method for producing the same by homologous recombination are provided.
摘要翻译：本说明书涉及嵌合非人动物的制造方法，其包括制备含有外来染色体或其片段的微细胞，并将其外来的染色体或片段转移到多细胞与微细胞融合; 可以通过上述方法及其后代产生的嵌合非人动物; 从其衍生的组织和细胞; 及其使用方法。此外，还提供了含有外来染色体或其片段的多能细胞，其制备方法及其使用方法。此外，提供其中至少两个内源基因被破坏的多能细胞，以及通过同源重组产生其的方法。

6. 发明授权

US07476536B2 Artificial human chromosome containing human antibody a light chain gene 有权
标题翻译：含有人抗体的人造人染色体为轻链基因
公开(公告)号：US07476536B2
公开(公告)日：2009-01-13
申请号：US10477471
申请日：2002-05-10
申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： C12N15/63 , C12N21/02 , C12N15/00
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/243 , C07K2317/21 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2800/30
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要翻译：本发明涉及一种以高效率遗传传播到下一代的人类人造染色体及其使用方法。更具体地，本发明涉及：人类人造染色体，其中含有源自人染色体22的抗体λ轻链基因的约3.5Mb至约1Mb区域与染色体片段结合，所述染色体片段可通过生殖系的非人类动物，所述染色体片段衍生自另一个人染色体; 携带人类人造染色体的非人类动物及其后代; 一种生产非人动物的方法; 使用非人动物或其后代生产人抗体的方法; 和携带人类人造染色体的人抗体生产小鼠。

7. 发明申请

US20090007282A1 METHOD FOR MODIFYING CHROMOSOMES 有权
标题翻译：修饰色素的方法
公开(公告)号：US20090007282A1
公开(公告)日：2009-01-01
申请号：US12116294
申请日：2008-05-07
申请人： Kazuma TOMIZUKA , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
发明人： Kazuma TOMIZUKA , Hitoshi Yoshida , Kazunori Hanaoka , Mitsuo Oshimura , Isao Ishida , Yoshimi Kuroiwa
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N15/90 , C12N15/907 , C12N2800/30
摘要： The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
摘要翻译：本发明涉及一种生产修饰的外源染色体或其片段的方法，其包括以下步骤：（a）制备包含外来染色体或其片段的微细胞并通过与所述微细胞融合将所述外源染色体或片段转移到具有高同源重组效率的细胞中; （b）在具有高同源重组效率的所述细胞中，通过同源重组将靶向载体插入所述外源染色体或其片段的所需位点和/或染色体的所需位点，衍生自具有高同源重组效率的所述细胞，从而标记所述期望的位点; 和（c）在具有高同源重组效率的所述细胞中，导致在所述外源染色体或其片段的标记位点发生缺失和/或易位。

8. 发明申请

US20080317743A1 Human Artificial Chromosome Containing Human Antibody Lambda Light Chain Gene And Non-Human Animal Containing The Human Artificial Chromosome Capable Of Genetic Transmission 有权
标题翻译：含人源性人类染色体的人类抗体λ轻链基因和含有能够进行遗传传播的人类人造染色体的非人动物
公开(公告)号：US20080317743A1
公开(公告)日：2008-12-25
申请号：US12140009
申请日：2008-06-16
申请人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： A61K39/395 , A01K67/027 , C12P21/08
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2217/054 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/243 , C07K2317/21 , C12N15/8509 , C12N15/87 , C12N15/90 , C12N2800/30
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
摘要翻译：本发明涉及一种以高效率遗传传播到下一代的人类人造染色体及其使用方法。更具体地，本发明涉及：人类人造染色体，其中含有源自人染色体22的抗体λ轻链基因的约3.5Mb至约1Mb区域与染色体片段结合，所述染色体片段可通过生殖系的非人类动物，所述染色体片段衍生自另一个人染色体; 携带人类人造染色体的非人类动物及其后代; 一种生产非人动物的方法; 使用非人动物或其后代生产人抗体的方法; 和携带人类人造染色体的人抗体生产小鼠。

9. 外观设计

USD577855S1 Spot light irradiator 有权
标题翻译：点光源
公开(公告)号：USD577855S1
公开(公告)日：2008-09-30
申请号：US29260896
申请日：2006-06-05
申请人： Hitoshi Yoshida
设计人： Hitoshi Yoshida

10. 发明申请

US20060126208A1 Disk drive with improved format efficiency and control method thereof 失效
公开(公告)号：US20060126208A1
公开(公告)日：2006-06-15
申请号：US11294996
申请日：2005-12-05
申请人： Nobuhito Kitamura , Hitoshi Yoshida
发明人： Nobuhito Kitamura , Hitoshi Yoshida
IPC分类号： G11B5/09 , G11B15/12 , G11B5/596
CPC分类号： G11B20/1217 , G11B5/3967 , G11B5/59655 , G11B2005/0002 , G11B2020/1277 , G11B2020/1287 , G11B2020/1292 , G11B2220/2516
摘要： Embodiments of the invention provide a magnetic disk drive and its control method capable of effectively using the unrecordable area which is caused due to the composite magnetic head's gap between the read head and the write head. In one embodiment, a disk drive comprises a composite magnetic head structured in such a manner that during write the write head WH reaches each servo area earlier than the read head RH, and a read write control unit to control the write and read done by the composite magnetic head. On the disk, common servo data SP to be used both during read and during write, write servo data SW to be used during write and read servo data SR to be used during read are recorded in this order in each servo area. During write, the read write control unit starts the write head recording data at the timing when reading write servo data SW from the servo area is completed.

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