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1. 发明授权

US08926543B2 Immunoactivation blood perfusion filter for the treatment of malignant tumors 有权
标题翻译：免疫活化血液灌注过滤器治疗恶性肿瘤
公开(公告)号：US08926543B2
公开(公告)日：2015-01-06
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nosé
发明人： Yukihiko Nosé , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
IPC分类号： A61M1/16 , A61M1/36 , A61K31/727 , A61M1/14 , A61K31/135 , A61M1/34 , B01J20/00 , B01D15/00 , B01J20/22
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译：本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。

2. 发明申请

US20130046225A1 IMMUNOACTIVATION BLOOD PERFUSION FILTER FOR THE TREATMENT OF MALIGNANT TUMORS 有权
标题翻译：用于治疗恶性肿瘤的免疫血液灌注过滤器
公开(公告)号：US20130046225A1
公开(公告)日：2013-02-21
申请号：US13394765
申请日：2010-10-07
申请人： Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba , Ako Nose
发明人： Yukihiko Nose , Kazuhide Ohta , Hiroshi Miyamoto , Junji Takaba
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61K31/727 , A61K31/135 , A61M1/14 , A61M1/16 , A61M1/3486 , A61M1/3496 , A61M1/3621 , B01D15/00 , B01J20/00 , B01J20/22 , B01J2220/4825 , B01J2220/4831 , A61K2300/00
摘要： The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.
摘要翻译：本发明提供了一种通过使他与生物相容性生物材料进行约1小时的分离程序来在人体内产生天然的免疫活性状态的方法。为了安全地控制由该程序引起的免疫休克，将该人全身麻醉约6小时，包括分离时间，此后至少另外5小时。这种免疫激活可用于治疗恶性肿瘤和与免疫抑制相关的疾病，如艾滋病。本发明还提供使用含有血液灌注过滤器的生物相容性材料用于治疗恶性肿瘤和感染性疾病的单采血液柱。

3. 发明授权

US08405912B2 Headup display device and method for controlling the same 有权
标题翻译：前置显示装置及其控制方法
公开(公告)号：US08405912B2
公开(公告)日：2013-03-26
申请号：US12928020
申请日：2010-12-01
申请人： Kazuhide Ohta , Tatsuya Sasaki
发明人： Kazuhide Ohta , Tatsuya Sasaki
IPC分类号： G02B27/14
CPC分类号： G02B26/0816 , G02B7/1827 , G02B27/0093 , G02B27/01 , G02B2027/014 , G02B2027/0181
摘要： A reflection unit reflects an image indicated on an indicator and projects the image on a combiner to indicate a virtual image of the image at a position viewable for a user. A stepping motor rotates the reflection unit to move the virtual image continuously in a predetermined section of the combiner. A control unit controls a driving power of the stepping motor such that a smoothness parameter becomes less than a predetermined value. The smoothness parameter is defined by a division of a difference between the maximum speed of the virtual image and an average speed of the virtual image, when the virtual image moves continuously in the predetermined section, by the average speed.
摘要翻译：反射单元反映指示符上指示的图像，并将图像投影到组合器上，以在可以为用户查看的位置处指示图像的虚拟图像。步进电机旋转反射单元以在组合器的预定部分中连续移动虚像。控制单元控制步进电动机的驱动力，使得平滑度参数变得小于预定值。平滑度参数是通过虚拟图像的最大速度与虚拟图像的平均速度之间的差的除法来定义的，当虚拟图像在预定部分中连续移动平均速度时。

4. 发明申请

US20080081828A1 Agent for Curing Chronic Obstructive Pulmonary Disease 有权
标题翻译：治疗慢性阻塞性肺疾病的药物
公开(公告)号：US20080081828A1
公开(公告)日：2008-04-03
申请号：US11760345
申请日：2007-06-08
申请人： Kazuo Sekiguchi , Katsumi Ikezono , Kazuhide Ohta , Takashi Maeda , Hisashi Nagamoto
发明人： Kazuo Sekiguchi , Katsumi Ikezono , Kazuhide Ohta , Takashi Maeda , Hisashi Nagamoto
IPC分类号： A61K31/4439 , A61P11/00
CPC分类号： A61K31/4439 , A61K31/427
摘要： The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof represented by the general formula (1), wherein, R1 is a phenyl group which may have 1 to 3 lower alkoxy groups as the substituents on the phenyl ring; R2 is a pyridyl group which may have 1 to 3 carboxyl groups as the substituents on the pyridine ring.
摘要翻译：本发明提供了用于治疗慢性阻塞性肺疾病的有用和高度安全的药物，其包含作为有效成分的至少一种选自由通式（1）表示的噻唑衍生物及其盐的化合物，其中，R 1是可以具有1〜3个低级烷氧基作为苯环上的取代基的苯基; R 2是可以具有1至3个羧基作为吡啶环上的取代基的吡啶基。

5. 发明授权

US07777038B2 Carbostyril compound 有权
标题翻译：碳青霉烯化合物
公开(公告)号：US07777038B2
公开(公告)日：2010-08-17
申请号：US10582014
申请日：2005-09-26
申请人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
发明人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
IPC分类号： C07D215/38
CPC分类号： C07D471/08 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要翻译：本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

6. 发明授权

US6056509A Contra-rotating bearing device for contra-rotating propeller 有权
标题翻译：反转螺旋桨的反转轴承装置
公开(公告)号：US6056509A
公开(公告)日：2000-05-02
申请号：US809339
申请日：1998-08-10
申请人： Mikihiko Nakayama , Shinichi Ohtani , Kazuhide Ohta , Masayasu Matsuda , Keiichi Nitta , Satoshi Keirimbo , Satoshi Ashida , Hideki Shibuya
发明人： Mikihiko Nakayama , Shinichi Ohtani , Kazuhide Ohta , Masayasu Matsuda , Keiichi Nitta , Satoshi Keirimbo , Satoshi Ashida , Hideki Shibuya
IPC分类号： B63H5/10 , B63H23/32 , F16C17/18 , F16C32/06 , F16C33/10 , F01D1/24
CPC分类号： F16C32/0651 , B63H21/386 , B63H23/321 , B63H5/10 , F16C17/02 , F16C17/18 , F16C33/1065 , F16C33/1075 , B63H2005/106 , B63H2023/323
摘要： A hollow portion is provided on the core of an inner shaft (2) to form an oil feed port (3), a plurality of oil feed holes (4) which are connected with both of the outer peripheral face of the inner shaft (2) within a range (L) of the bearing surface of the inner shaft (2) and the oil feed port (3) are radially provided in a line , and axial oil grooves (5) each of which includes an inner shaft surface side opening portion (4a) of the oil feed hole (4) are provided on the outer peripheral face of the inner shaft to form a contra-rotating bearing device for a contra-rotating propeller which causes the inner shaft (2) and an outer shaft (2) to contra-rotate mutually. In place of the oil grooves, a plurality of concave-convex portions may be formed in the axial direction of a contra-rotating bearing on the inner peripheral face of the bearing and circular portions may be provided on both axial ends of the concavo-convex portions to form the contra-rotating bearing device for a contra-rotating propeller. Thus, a sufficient oil film is formed on the bearing surface of the contra-rotating bearing in an area where the inner shaft and the outer shaft rotate in mutually opposite directions at almost equal speeds so that an excellent bearing function can be obtained.
摘要翻译： PCT No.PCT / JP95 / 01761 Sec。 371日期：1998年8月10日 102（e）日期1998年8月10日PCT 1997年3月6日PCT公布。公开号WO96 / 07832 日期：1996年3月14日在内轴（2）的芯部上设置有中空部，形成供油口（3），多个供油孔（4）在内轴（2）的支承面和供油口（3）的范围（L）内的内轴（2）沿径向设置成一条直线，轴向油槽（5）供油孔（4）的内轴面侧开口部（4a）设置在内轴的外周面上，形成反转螺旋桨的反转轴承装置，该反转轴承装置使内轴（2）和外轴（2）相互旋转。代替油槽，可以在轴承的内周面上的反转轴承的轴向上形成多个凹凸部，并且可以在凹凸的两个轴向端部设置圆形部分部分以形成反向旋转的螺旋桨的反转轴承装置。因此，在反转轴承的轴承面上，在内轴和外轴以相等的速度相互相反的方向旋转的区域形成有充分的油膜，从而能够获得优异的轴承功能。

7. 发明授权

US09539418B2 Proteoglycan-containing microneedle array 有权
标题翻译：含蛋白多糖的微针阵列
公开(公告)号：US09539418B2
公开(公告)日：2017-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M37/00 , A61K9/00 , A61Q19/00 , A61Q19/08 , A61K8/98
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：提供了一种微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）在皮肤表面层和/或角质层中不产生疼痛或出血的细度和柔韧性微针的插入部位，（3）皮肤下的微针部分的溶解度或生物降解性。微针阵列通过使用蛋白多糖作为基材形成微针来制造。

8. 发明授权

US08362252B2 Carbostyril compound 失效
标题翻译：碳青霉烯化合物
公开(公告)号：US08362252B2
公开(公告)日：2013-01-29
申请号：US12611921
申请日：2009-11-03
申请人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
发明人： Takeshi Kuroda , Takahito Yamauchi , Tomoichi Shinohara , Kunio Oshima , Chiharu Kitajima , Hitoshi Nagao , Tae Fukushima , Takahiro Tomoyasu , Hironobu Ishiyama , Kazuhide Ohta , Masaaki Takano , Takumi Sumida
IPC分类号： C07D215/38
CPC分类号： C07D471/08 , C07D417/04 , C07D417/06 , C07D417/14 , C07D487/04 , C07D495/04
摘要： The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
摘要翻译：本发明提供由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; R3是氢原子等。本发明的喹诺酮化合物或其盐诱导TFF的产生，因此可用于治疗和/或预防诸如消化道疾病，口腔疾病，上呼吸道疾病疾病，呼吸道疾病，眼睛疾病，癌症和伤口。

9. 发明申请

US20130012882A1 PROTEOGLYCAN-CONTAINING MICRONEEDLE ARRAY 有权
标题翻译：含蛋白质包含微阵列
公开(公告)号：US20130012882A1
公开(公告)日：2013-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
IPC分类号： A61M5/00 , B29C47/06
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin.[Method for Achieving the Object]The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译：本发明的目的是提供一种新颖的微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）细度和柔韧性，使皮肤无疼痛或出血表面层和/或角质层在微针的插入位置，和（3）皮肤下的微针部分的溶解度或生物降解性。 [实现对象的方法]微针阵列通过使用蛋白多糖作为基材形成微针来制造。

10. 发明申请

US20110134498A1 Headup display device and method for controlling the same 有权
标题翻译：前置显示装置及其控制方法
公开(公告)号：US20110134498A1
公开(公告)日：2011-06-09
申请号：US12928020
申请日：2010-12-01
申请人： Kazuhide Ohta , Tatsuya Sasaki
发明人： Kazuhide Ohta , Tatsuya Sasaki
IPC分类号： G02B27/01 , G02B26/10
CPC分类号： G02B26/0816 , G02B7/1827 , G02B27/0093 , G02B27/01 , G02B2027/014 , G02B2027/0181
摘要： A reflection unit reflects an image indicated on an indicator and projects the image on a combiner to indicate a virtual image of the image at a position viewable for a user. A stepping motor rotates the reflection unit to move the virtual image continuously in a predetermined section of the combiner. A control unit controls a driving power of the stepping motor such that a smoothness parameter becomes less than a predetermined value. The smoothness parameter is defined by a division of a difference between the maximum speed of the virtual image and an average speed of the virtual image, when the virtual image moves continuously in the predetermined section, by the average speed.
摘要翻译：反射单元反映指示符上指示的图像，并将图像投影在组合器上，以在可以为用户可见的位置处指示图像的虚拟图像。步进电机旋转反射单元以在组合器的预定部分中连续移动虚像。控制单元控制步进电动机的驱动力，使得平滑度参数变得小于预定值。平滑度参数是通过虚拟图像的最大速度与虚拟图像的平均速度之间的差的除法来定义的，当虚拟图像在预定部分中连续移动平均速度时。

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