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    • 6. 发明申请
    • COMPOSITE MOLDED PRODUCT
    • 复合模制产品
    • US20100261025A1
    • 2010-10-14
    • US12746617
    • 2008-12-18
    • Yasumitsu MiyamotoNobuyuki Matsunaga
    • Yasumitsu MiyamotoNobuyuki Matsunaga
    • B32B15/09B29C45/14
    • B29C45/14311B29C45/0005B29K2705/00C08J5/043C08J2367/02C08K7/14C08L67/02C08L67/025Y10T428/31681C08L2666/18C08L2666/02
    • Provided is a composite molded product of polybutylene terephthalate resin and metal, having sufficient adhesion strength and being moldable at a mold temperature of 100° C. or lower. Specifically, the composite molded product containing a polybutylene terephthalate resin composition comprising a fibrous reinforcing agent, a polybutylene terephthalate resin and a thermoplastic elastomer, or a modified polybutylene terephthalate resin composition comprising a modified polybutylene terephthalate resin composed of a copolymer of polybutylene terephthalate and isophthalic acid, containing 3 to 50% by mole of isophthalic acid component to the total amount of all the dicarboxylic acid components and a fibrous reinforcing agent and a metal (layer) having a finished finely uneven surface, integrally combined with the composition.
    • 本发明提供聚对苯二甲酸丁二醇酯树脂和金属的复合成型体,其具有足够的粘合强度,并且可以在100℃以下的模具温度下成型。 具体而言,包含含有纤维增强剂,聚对苯二甲酸丁二醇酯树脂和热塑性弹性体的聚对苯二甲酸丁二醇酯树脂组合物或改性聚对苯二甲酸丁二醇酯树脂组合物的复合模塑制品包含由聚对苯二甲酸丁二醇酯和间苯二甲酸共聚物组成的改性聚对苯二甲酸丁二醇酯树脂 含有3〜50摩尔%的间苯二甲酸成分相对于所有二羧酸成分的总量和纤维增强剂以及具有精加工的细小凹凸表面的金属(层),与组合物整体结合。
    • 9. 发明申请
    • Substituted Pyrrole Derivative
    • 取代的吡咯衍生物
    • US20080176906A1
    • 2008-07-24
    • US11793113
    • 2005-12-13
    • Nobuyuki MatsunagaTakenori Hitaka
    • Nobuyuki MatsunagaTakenori Hitaka
    • A61K31/4439C07D401/06C07D413/12A61P35/00A61K31/40C07D207/32
    • C07D207/327C07D207/34C07D401/06C07D413/14
    • The present invention provides a novel pyrrole derivative having excellent androgen receptor antagonism, which is represented by the formula: wherein R1 represents a hydrogen atom, a cyano group or a group represented by the formula COORA (wherein RA represents an optional substituted C1-6 alkyl group), R2 and R4 are the same or different, and each represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a trifluoromethyl group, an amino-C1-6 alkyl group, a mono- or di-substituted amino-C1-6 alkyl group, an optionally halogenated C1-6 alkyl group substituted with an optionally substituted hydroxyl group, a C2-6 alkenyl group substituted with an optionally substituted hydroxyl group, a C1-6 alkyl group substituted with an optionally substituted and optionally oxidized thiol group, an optionally substituted with and optionally oxidized thiol group, a cyano group, an acyl group, an optionally substituted oxazolyl group or a 1,3-dioxolan-2-yl group, R3 represents a group represented by the formula: (wherein X represents a halogen atom, Y represents a carbon atom or a nitrogen atom, Alk represents an optionally substituted C1-4 alkylene group, and RB represents a hydrogen atom or an acyl group), and R5 represents a phenyl group which has a cyano group at a 4-position or a 3-position thereof, and may be further substituted, or a salt thereof. The present invention also provides an androgen receptor antagonist containing the pyrrole derivative, or a salt thereof.
    • 本发明提供具有优异雄激素受体拮抗作用的新型吡咯衍生物,其由下式表示:其中R 1表示氢原子,氰基或由式COOR < A (其中R A表示任选的取代的C 1-6烷基),R 2和R 4 各自相同或不同,各自表示氢原子,C 1-6烷基,C 3-6环烷基,三氟甲基 氨基-C 1-6烷基,一取代或二取代的氨基-C 1-6烷基,任意卤代的C 1〜 被任选取代的羟基取代的6个C 1 -C 6烷基,被任意取代的羟基取代的C 2-6-6烯基,C 1-6烷基 被任选取代的和任选被氧化的硫醇基团取代的基团,任选地被任选地被氧化物取代 硫醇基,氰基,酰基,任选取代的恶唑基或1,3-二氧戊环-2-基,R 3表示由下式表示的基团:(其中X 表示卤原子,Y表示碳原子或氮原子,Alk表示任选取代的C 1-4 - 亚烷基,R B表示氢原子或 酰基),R 5表示在4位或3位具有氰基的苯基,可以进一步被取代,或其盐。 本发明还提供含有吡咯衍生物或其盐的雄激素受体拮抗剂。