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1. 发明申请

US20050136500A1 Flow-through assay devices 审中-公开
标题翻译：流通测定装置
公开(公告)号：US20050136500A1
公开(公告)日：2005-06-23
申请号：US10742590
申请日：2003-12-19
申请人： Kaiyuan Yang , RameshBabu Boga , Shawn Feaster , Rosann Marie Kaylor , David Cohen
发明人： Kaiyuan Yang , RameshBabu Boga , Shawn Feaster , Rosann Marie Kaylor , David Cohen
IPC分类号： G01N33/52 , G01N33/543 , G01N33/558 , C12Q1/54
CPC分类号： G01N33/558 , G01N33/52 , G01N33/5438
摘要： A flow-through assay device capable of detecting the presence or quantity of an analyte of interest is provided that is accurate, reliable, and easy-to-use. The device contains a substrate printed with a channel to facilitate the flow of a test sample to a detection working electrode. The detection working electrode communicates with affinity reagents, such as redox mediators and capture ligands. For instance, capture ligands that are specific binding members for the analyte of interest are applied to the detection electrode to serve as the primary location for detection of the analyte.
摘要翻译：提供了能够检测感兴趣的分析物的存在或数量的流通测定装置，其是准确，可靠和易于使用的。该装置包含印刷有通道以便于将测试样品流动到检测工作电极的基底。检测工作电极与亲和试剂如氧化还原介体和捕获配体连通。例如，将作为感兴趣的分析物的特异性结合成员的捕获配体施加到检测电极，以用作检测分析物的主要位置。

2. 发明申请

US20050136550A1 Flow control of electrochemical-based assay devices 审中-公开
标题翻译：基于电化学的测定装置的流量控制
公开(公告)号：US20050136550A1
公开(公告)日：2005-06-23
申请号：US10742589
申请日：2003-12-19
申请人： Kaiyuan Yang , Charles Hughes , Xuedong Song , Rosann Marie Kaylor
发明人： Kaiyuan Yang , Charles Hughes , Xuedong Song , Rosann Marie Kaylor
IPC分类号： C12Q1/54 , G01N33/543 , G01N33/558
CPC分类号： G01N33/54373
摘要： Various techniques for controlling the flow of a test sample through an electrochemical-based assay device are provided. The assay device contains a porous membrane provided with certain properties to selectively control the flow of a test sample to a detection working electrode. The detection working electrode communicates with affinity reagents, such as redox mediators and capture ligands. For instance, capture ligands that are specific binding members for the analyte of interest are applied to the detection electrode to serve as the primary location for detection of the analyte.
摘要翻译：提供了用于通过基于电化学的测定装置来控制测试样品的流动的各种技术。测定装置包含具有某些性质的多孔膜，以选择性地将测试样品的流动控制到检测工作电极。检测工作电极与亲和试剂如氧化还原介体和捕获配体连通。例如，将作为感兴趣的分析物的特异性结合成员的捕获配体施加到检测电极，以用作检测分析物的主要位置。

3. 发明授权

US07914701B2 Lateral flow diagnostic device that contains a phosphorescent material encapsulated in a crosslinked polymer matrix 有权
标题翻译：包含封装在交联聚合物基质中的磷光材料的侧流诊断装置
公开(公告)号：US07914701B2
公开(公告)日：2011-03-29
申请号：US11772499
申请日：2007-07-02
申请人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
发明人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
IPC分类号： G01N33/533
CPC分类号： C08K5/0041 , C08F214/06 , C08K9/08 , C08L53/00 , C09K11/02 , C09K11/06 , C09K2211/185 , Y10T428/2998 , C08L2666/02
摘要： There is provided a lateral flow diagnostic device that employs a phosphorescent particle. The particle includes, for example, an organic phosphorescent material encapsulated in a cross-linked halogen-containing polymeric matrix. The cross-linked halogen-containing polymeric matrix has at least one percent by mass weight of halogen atoms, and the cross-linked halogen-containing polymeric matrix shields the encapsulated phosphorescent material from phosphorescence quenchers.
摘要翻译：提供了一种使用磷光颗粒的侧流诊断装置。颗粒包括例如包封在交联的含卤聚合物基质中的有机磷光材料。交联的含卤素聚合物基质具有至少1质量％的卤素原子，并且交联的含卤聚合物基质屏蔽磷光发光材料与磷光猝灭剂。

4. 发明授权

US06436651B1 Optical diffraction biosensor 有权
$Optical diffraction biosensor$
标题翻译：光学衍射生物传感器
公开(公告)号：US06436651B1
公开(公告)日：2002-08-20
申请号：US09503554
申请日：2000-02-11
申请人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
发明人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
IPC分类号： G01N3353
CPC分类号： A61F13/42 , C23F1/02 , C23F1/40 , G01N21/4788 , G03H1/0244 , G03H1/182 , G03H2001/0044 , G03H2001/0491 , G03H2001/2655 , G03H2270/55 , Y10S435/808 , Y10S436/805
摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
摘要翻译：本发明提供了用于检测和定量存在于介质中的分析物的廉价且敏感的装置和方法。该装置包括金属化膜，在其上印刷特定的预定图案的分析物特异性受体。在将目标分析物附着到选择受体的塑料薄膜的选择区域时，透射和/或反射光的衍射通过分析物的物理尺寸和定义的精确放置而发生。产生可以用眼睛或可选地用感测装置容易地看到的衍射图像。

5. 发明授权

US6060256A Optical diffraction biosensor 失效
$Optical diffraction biosensor$
公开(公告)号：US6060256A
公开(公告)日：2000-05-09
申请号：US991644
申请日：1997-12-16
申请人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
发明人： Dennis S. Everhart , Mark L. Jones , Rosann Marie Kaylor
IPC分类号： A61F13/42 , B41M3/00 , G01N21/47 , G01N33/567 , G01N21/00 , G01N33/48 , G01N33/566
CPC分类号： A61F13/42 , G01N21/4788 , G03H1/0244 , G03H1/182 , G03H2001/0044 , G03H2001/0491 , G03H2001/2655 , G03H2270/55 , Y10S435/808 , Y10S436/805
摘要： The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.

6. 发明授权

US06827080B2 Pressure activated reaction vessel and package 失效
公开(公告)号：US06827080B2
公开(公告)日：2004-12-07
申请号：US10263503
申请日：2002-10-03
申请人： Jeffrey E. Fish , Naveen Agarwal , Rosann Marie Kaylor , Lei Huang , John Shuty
发明人： Jeffrey E. Fish , Naveen Agarwal , Rosann Marie Kaylor , Lei Huang , John Shuty
IPC分类号： A62M3500
CPC分类号： A61F7/03 , A45D2200/155 , A47J36/28 , A61F7/106 , A61F2007/0098 , A61F2007/0276 , B65D81/3266 , B65D81/3484 , C09K5/16 , F25D5/02
摘要： This invention relates to a reaction vessel constructed of a flexible material including at least two reactant chambers containing two isolated reactants. The reactant chambers and reactants are separated by a frangible seal which opens under pressure, allowing the reactants to mix and react. The reaction produces a desired reactive effect on the environment surrounding the reaction vessel and any articles in that environment. A package in combination with a reaction vessel can be used to cause a reactive effect on an article within the package. The reactive effect can include a temperature change of the article or foaming a material to coat the article.

7. 发明授权

US06613029B1 Vapor swept diaper 失效
标题翻译：蒸气扫尿布
公开(公告)号：US06613029B1
公开(公告)日：2003-09-02
申请号：US09301492
申请日：1999-04-28
申请人： Rosann Marie Kaylor , James Arthur Davis , Andrew Edsel Huntoon , Michael Tod Morman , Mary Garvie Weber
发明人： Rosann Marie Kaylor , James Arthur Davis , Andrew Edsel Huntoon , Michael Tod Morman , Mary Garvie Weber
IPC分类号： A61F1315
CPC分类号： A61F13/84 , A61F13/42 , A61F13/8405
摘要： There is provided a personal care product having a vapor sweep comprising a material which reacts with water or urine to form vapor at a rate capable of displacing at least 5, and preferably at least 10, percent of the air volume within said product per minute. This vapor generation sweeps water vapor and humidity from the personal care product, such as a diaper, and so it's believed will contribute to skin health. Materials that, upon reaction with water or urine, produce large volumes of carbon dioxide may be incorporated into the various components of standard personal care products to achieve the objective of this invention. Such materials include leavening agents. Additionally, a seal may be added to the personal care product to encourage the generated vapor to travel a longer path prior to exiting the product in order to maximize water vapor removal.
摘要翻译：提供了一种具有蒸气扫描的个人护理产品，其包括与水或尿反应以以每分钟的速率能够置换所述产品中的空气体积的至少5％，优选至少10％的速率形成蒸气的材料。这种蒸汽产生从个人护理产品（例如尿布）中扫除水蒸气和湿气，因此据信将有助于皮肤健康。与水或尿反应产生大量二氧化碳的材料可以并入到标准个人护理产品的各种组分中以实现本发明的目的。这些材料包括发酵剂。此外，密封件可以被添加到个人护理产品中，以便在离开产品之前鼓励产生的蒸气行进更长的路径，以便最大限度地减少水蒸汽的去除。

8. 发明授权

US5855788A Chemically charged-modified filter for removing particles from a liquid and method thereof 失效
标题翻译：用于从液体中除去颗粒的化学充电改性过滤器及其方法
公开(公告)号：US5855788A
公开(公告)日：1999-01-05
申请号：US594879
申请日：1996-02-07
申请人： Dennis Stein Everhart , Elizabeth Deibler Gadsby , Rosann Marie Kaylor , Kristi Lynn Kiick-Fischer
发明人： Dennis Stein Everhart , Elizabeth Deibler Gadsby , Rosann Marie Kaylor , Kristi Lynn Kiick-Fischer
IPC分类号： B01D39/16 , A61L2/02 , B01D39/08 , B01D39/14 , D04H1/42 , D06M15/15 , D06M15/61 , D06M23/00 , B01D61/00 , B01D39/02
CPC分类号： D06M23/005 , A61L2/022 , B01D39/1623 , D04H1/413 , D04H1/4374 , D06M15/15 , B01D2239/0208 , B01D2239/0216 , B01D2239/0421 , B01D2239/0428 , B01D2239/0478 , B01D2239/0609 , B01D2239/0618 , B01D2239/0622 , B01D2239/0636 , B01D2239/064 , B01D2239/065 , B01D2239/086
摘要： A chemically charged-modified filter for removing charged, micron to sub-micron sized particles from an aqueous liquid, the filter being composed of a filter sheet having a plurality of individual exposed surfaces, at least a portion of which having a surface energy of less than about 45 dynes per centimeter; amphiphilic macromolecules adsorbed onto at least some individual exposed surfaces having a surface energy of less than about 45 dynes per centimeter; and chemical charge modifiers incorporated onto at least a portion of the amphiphilic macromolecules; so that when said charge-modified substrate is in contact with the aqueous liquid containing the charged, micron to sub-micron sized particles, said particles are adsorbed onto the chemically charge-modified filter. Also disclosed is a method of removing charged, micron to sub-micron sized particles from an aqueous liquid in which an aqueous liquid containing charged, micron to sub-micron sized particles is passed through a chemically charge-modified filter.
摘要翻译：一种用于从水性液体中去除带电微米级至亚微米级颗粒的化学电荷改性过滤器，该过滤器由具有多个单独暴露表面的过滤片组成，其至少部分表面能较少比约45达因/厘米; 吸附在表面能小于约45达因/厘米的至少一些个别暴露表面的两亲大分子; 和掺入到至少一部分两亲性大分子上的化学电荷改性剂; 使得当所述电荷改性基底与含有带电微米到亚微米尺寸的颗粒的含水液体接触时，所述颗粒被吸附到化学电荷改性的过滤器上。还公开了一种从含水液体中除去带电微米级至亚微米级颗粒的方法，其中含有带电微米至亚微米级颗粒的水性液体通过化学电荷改性过滤器。

9. 发明申请

US20090127509A1 CROSS-LINKED ENCAPSULATED PHOSPHORSCENT MOLECULES 有权
标题翻译：交联粘附的磷光体分子
公开(公告)号：US20090127509A1
公开(公告)日：2009-05-21
申请号：US11772499
申请日：2007-07-02
申请人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
发明人： Lei Huang , Xuedong Song , Bin Wu , Rosann Marie Kaylor
IPC分类号： C09K11/02
CPC分类号： C08K5/0041 , C08F214/06 , C08K9/08 , C08L53/00 , C09K11/02 , C09K11/06 , C09K2211/185 , Y10T428/2998 , C08L2666/02
摘要： There is provided herein cross-linked, phosphorescent micro- and nanoparticles and applications of those particles. The invention uses halogen-containing polymers and co-polymers (HCPs) as an encapsulation matrix for organic and organometallic phosphorescent compounds to form micro- or nanoparticles. The phosphorescence of these encapsulated phosphorescent particles is substantially unaffected by phosphorescence quenchers such as oxygen and water molecules at ambient conditions. The invention provides methods of making cross-linked phosphorescent particles. HCPs may be directly cross-linked through linking moieties that are a part of the polymer, or cross-linked through other separate bridging or cross-linking materials Cross-linked particles are more stable than the non-cross-linked counterparts and more resistant to temperature, surfactants, and organic solvents.
摘要翻译：本文提供了交联的磷光微粒和纳米颗粒以及这些颗粒的应用。本发明使用含卤聚合物和共聚物（HCP）作为有机和有机金属磷光化合物的包封基质以形成微米或纳米颗粒。这些包封的磷光颗粒的磷光在环境条件下基本上不受磷光猝灭剂如氧和水分子的影响。本发明提供制备交联磷光颗粒的方法。 HCP可以通过作为聚合物的一部分的连接部分直接交联，或者通过其它单独的桥连或交联材料交联。交联颗粒比非交联对应物更稳定，并且更耐抗温度，表面活性剂和有机溶剂。

10. 发明授权

US07244393B2 Diagnostic device and system 有权
标题翻译：诊断设备和系统
公开(公告)号：US07244393B2
公开(公告)日：2007-07-17
申请号：US10026415
申请日：2001-12-21
申请人： Rosann Marie Kaylor , Chibueze O. Chidebelu-Eze , Robert John Lyng , Stephen Quirk
发明人： Rosann Marie Kaylor , Chibueze O. Chidebelu-Eze , Robert John Lyng , Stephen Quirk
IPC分类号： G01N33/48
CPC分类号： B01L3/5023 , B01L3/502723 , B01L2200/0642 , B01L2200/16 , B01L2300/048 , B01L2300/0654 , B01L2300/069 , B01L2300/0803 , B01L2300/0809 , B01L2300/0825 , B01L2300/0861 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , G01N21/4788
摘要： Diagnostic devices, systems and methods for detecting the presence of an analyte in a sample are provided. In one embodiment, the device comprises a substrate, a binder printed in a pattern onto a surface of the substrate, and a means for directing a sample towards the surface of the substrate that is printed with the binder. Systems of the present invention further include a light source that can be directed through the aforementioned means or another opening to the binder-printed surface to test for diffraction.
摘要翻译：提供用于检测样品中分析物的存在的诊断装置，系统和方法。在一个实施例中，该装置包括基板，以图案印刷到基板的表面上的粘合剂，以及用于将样品朝向印刷有粘合剂的基材的表面引导的装置。本发明的系统还包括可以通过上述装置或粘合剂印刷表面的另一个开口引导的光源以测试衍射。

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