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1. 发明授权

US6077714A Method for the preparation of free radical pharmaceuticals diagnostics and devices using selenium conjugates 失效
标题翻译：用于制备自由基药物诊断和使用硒共轭物的装置的方法
公开(公告)号：US6077714A
公开(公告)日：2000-06-20
申请号：US12156
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2.sup..cndot.-), hydrogen peroxide, the hydroxyl radical (.cndot.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，羧酸，磷酸酯，硫酸酯，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能与所述化合物形成共价键的成分的载体所述硒化合物的反应性基团产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒性活性氧，以便共同形成基于催化硒阴离子RSe-的局部自由基药理学。

2. 发明授权

US6043098A Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates 失效
公开(公告)号：US6043098A
公开(公告)日：2000-03-28
申请号：US12061
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.

3. 发明授权

US5783454A Method for the preparation of free radical pharmaceuticals using selenium conjugates 失效
标题翻译：使用硒共轭物制备自由基药物的方法
公开(公告)号：US5783454A
公开(公告)日：1998-07-21
申请号：US432584
申请日：1995-05-09
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , G01N33/553
CPC分类号： A61K31/13 , A61K31/095 , A61K33/04 , A61K47/48023
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2.sup..-), hydrogen peroxide, the hydroxyl radical (.sup.. OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，磷酸根，硫酸根，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能够与所述反应性基团形成共价键的成分的载体的硒化合物以产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒性活性氧，以便共同形成基于催化硒阴离子RSe-的局部自由基药理学。

4. 发明授权

US6040197A Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates 失效
标题翻译：用于制备自由基药物的方法，诊断和使用硒共轭物的装置
公开(公告)号：US6040197A
公开(公告)日：2000-03-21
申请号：US12149
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，磷酸根，硫酸根，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能够与所述反应性基团形成共价键的成分的载体的硒化合物以产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒性活性氧，以便共同形成基于催化硒阴离子RSe-的局部自由基药理学。

5. 发明授权

US6033917A Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates 失效
标题翻译：用于制备自由基药物的方法，诊断和使用硒共轭物的装置
公开(公告)号：US6033917A
公开(公告)日：2000-03-07
申请号：US12146
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.31.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，羧酸，磷酸酯，硫酸酯，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能与所述化合物形成共价键的成分的载体所述硒化合物的反应性基团产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒活性氧，以共同形成基于催化硒阴离子RSe的局部自由基药理学。

6. 发明授权

US6043099A Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates 失效
标题翻译：用于制备自由基药物的方法，诊断和使用硒共轭物的装置
公开(公告)号：US6043099A
公开(公告)日：2000-03-28
申请号：US12154
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，羧酸，磷酸酯，硫酸酯，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能与所述化合物形成共价键的成分的载体所述硒化合物的反应性基团产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒性活性氧，以便共同形成基于催化硒阴离子RSe-的局部自由基药理学。

7. 发明授权

US5994151A Selenium carrier conjugates 失效
标题翻译：硒载体缀合物
公开(公告)号：US5994151A
公开(公告)日：1999-11-30
申请号：US12161
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/533
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.-.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，羧酸，磷酸酯，硫酸酯，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能与所述化合物形成共价键的成分的载体所述硒化合物的反应性基团产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒性活性氧，以便共同形成基于催化硒阴离子RSe-的局部自由基药理学。

8. 发明申请

US20100143876A1 TRANSPLANT MEDIA 审中-公开
标题翻译：运输媒体
公开(公告)号：US20100143876A1
公开(公告)日：2010-06-10
申请号：US12564555
申请日：2009-09-22
申请人： Christopher J. Murphy , Jonathan F. McAnulty , Ted W. Reid
发明人： Christopher J. Murphy , Jonathan F. McAnulty , Ted W. Reid
IPC分类号： A01N1/02 , C12N5/071
CPC分类号： A01N1/0221 , A01N1/021 , A01N1/0215
摘要： The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers, macromolecular oncotic agents, energy sources, impermeant anions, ATP substrates. The media find use for the storage and preservation of internal organs prior to transplant.
摘要翻译：本发明涉及含有纯化的抗微生物多肽如防御素和/或细胞表面受体结合蛋白的培养基。培养基还可能含有缓冲液，大分子成膜剂，能源，不透水阴离子，ATP底物。媒体可以在移植之前用于储存和保存内脏。

9. 发明授权

US5616562A Methods and compositions using substance P to promote wound healing 失效
标题翻译：使用物质P促进伤口愈合的方法和组合物
公开(公告)号：US5616562A
公开(公告)日：1997-04-01
申请号：US279991
申请日：1994-07-25
申请人： Christopher J. Murphy , Ted W. Reid , Mark J. Mannis
发明人： Christopher J. Murphy , Ted W. Reid , Mark J. Mannis
IPC分类号： A61K38/04 , A61K38/22 , A61K38/10
CPC分类号： A61K38/04 , A61K38/046 , A61K38/225
摘要： Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as substance P, substance K, and the like, as well as calcitonin gene-related peptides. The compositions include a carrier or vehicle suitable for topical application and are utilized by applying to the site of the wound. Wounds resulting from trauma, surgery, and disease may be treated. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.
摘要翻译：可以通过施用某些神经肽，任选地与已知的生长促进激素组合来增强哺乳动物组织中伤口的愈合。示例性神经肽包括速激肽，例如物质P，物质K等，以及降钙素基因相关肽。组合物包括适于局部施用的载体或载体，并通过施用于伤口部位来使用。创伤，手术和疾病引起的创伤可能会被治疗。除了刺激细胞增殖之外，组合物促进细胞基质的细化和细胞附着机制的发展。

10. 发明授权

US5242902A Defensin peptide compositions and methods for their use 失效
标题翻译：防卫素肽组合物及其使用方法
公开(公告)号：US5242902A
公开(公告)日：1993-09-07
申请号：US404249
申请日：1989-09-06
申请人： Christopher J. Murphy , Ted W. Reid , Mark J. Mannis , Bradley A. Foster , James S. Cullor , Michael E. Selsted , Robert I. Lehrer , Tomas Ganz
发明人： Christopher J. Murphy , Ted W. Reid , Mark J. Mannis , Bradley A. Foster , James S. Cullor , Michael E. Selsted , Robert I. Lehrer , Tomas Ganz
IPC分类号： A61K38/17 , C07K14/47
CPC分类号： C07K14/4723 , A61K38/1709 , Y10S514/887 , Y10S514/912 , Y10S514/914 , Y10S930/19
摘要： A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having both a mitogenic activity capable of stimulating cell growth and an antimicrobial activity capable of inhibiting the growth of a wide variety of pathogens. In addition to therapeutic use, the defensins are useful as mitogens in cell and tissue culture media.
摘要翻译：用于治疗皮肤和角膜伤口以及某些微生物相关疾病的方法包括将防御素肽局部施用于受影响的组织。组合物包含具有能够刺激细胞生长的促有丝分裂活性和能够抑制多种病原体生长的抗微生物活性的天然的，合成的或类似的防御素分子。除了治疗用途之外，防御素可用作细胞和组织培养基中的有丝分裂原。

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